Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2208873 | Growth abnormalities in children with juvenile rheumatoid arthritis. | 1990 Oct | Growth abnormalities in juvenile rheumatoid arthritis can be divided into two groups: local and systemic. Local disorders of growth often result in increased bone length and bone age or in marked decreases in longitudinal growth due to immobilization, premature epiphyseal closure, or fusion. Common growth defects seen in the knee, hand, wrist, hip, spine, and jaw are discussed. Systemic growth delay is most commonly secondary to active disease or treatment with corticosteroids. Nutritional aspects such as decreased appetite, reduced caloric intake, metabolic caloric requirements greater than available intake, or lack of essential vitamins could be the cause for decreased weight and stature. | |
| 2290160 | Prevalence of antibody to Borrelia burgdorferi in children with juvenile rheumatoid arthri | 1990 Sep | Lyme arthritis and juvenile rheumatoid arthritis (JRA) share a number of clinical features. Our study was performed in order to determine the prevalence of antibody to Borrelia burgdorferi in 50 children with JRA who reside in a nonendemic area. Three patients were weakly reactive and one patient was reactive when tested using an enzyme immunoassay to detect serum antibody to B. burgdorferi. No patient, however, had definitive serologic evidence of B. burgdorferi infection by Western blot analysis. We conclude that the prevalence of antibody to B. burgdorferi is very low in children with JRA who reside in a nonendemic area. | |
| 3377867 | Reduced mandibular dimensions and asymmetry in juvenile rheumatoid arthritis. Pathogenetic | 1988 May | The pathogenesis of reduced mandibular dimensions and asymmetry was studied in 103 patients with juvenile rheumatoid arthritis. Abnormalities of the temporomandibular joint were intimately related to mandibular growth disturbances. Unilateral joint abnormality resulted in jaw asymmetry and underdevelopment on the affected side. Duration of disease and of corticosteroid therapy, age at disease onset, and age when the data were recorded were correlated with the size of the mandible. Our findings did not support a hypothesis of cervical spine involvement as an etiologic factor of reduced mandibular size. | |
| 2756708 | Sjogren's syndrome: implications for the primary care physician. | 1989 Jul | Sjogren's syndrome (SS) is a common immunologically-mediated disorder that will afflict a great proportion of our population in future years. The primary care physician undoubtedly will be confronted with such patients, many of whom will have complaints and findings not generally believed to be due to SS. In this communication, case reports of four patients with SS as well as a literature review are presented. Two patients had presentations that were classic for SS; however, the other two were diagnostic challenges. Emphasis is placed on the atypical and unusual way SS can present so that the primary care physician can more easily make the diagnosis and initiate therapy. | |
| 1767146 | [Still's disease in adults]. | 1991 Dec | Retrospective case series for the last five years have focussed the attention of the authors on some clinical and biological patterns of adult onset Still's disease. Its diagnosis is made difficult because of the great diversity of clinical and biological signs. Organ failures complicate sometimes the disease, and may be fatal. Major high levels of plasma ferritin associated with an haemophagocytic syndrome occur in 20 percent of the acute cases: this association could eventually respond well to an immunodepressive therapy. | |
| 3757353 | Excision of pisiform in pisotriquetral arthritis. | 1986 Sep | Eight patients (nine cases) with pisotriquetral arthritis were treated by pisiform excision after they had failed to respond to splints, antiinflammatory agents, and local steroid injection. Associated with pisotriquetral arthritis were cases of ulnar neuritis, rheumatoid arthritis, pisotriquetral joint loose bodies, and an anomalous muscle. In seven of eight patients, pisiform excision with release of Guyon's canal afforded prompt relief of pain. A palmar approach was necessary for simultaneous ulnar tunnel release and pisiform excisions. One patient with rheumatoid arthritis required a further operative procedure (Darrach) before pain was eliminated. Pisotriquetral arthritis, diagnosed by clinical and radiographic criteria, may be associated with other disorders, in particular ulnar neuritis. Immobilization, antiinflammatories, and local steroid injections may be of temporary assistance. Pisiform excision produces satisfactory relief of pain. | |
| 2213397 | Safety and efficacy of methotrexate therapy for juvenile rheumatoid arthritis. | 1990 Oct | Twenty-nine children with juvenile rheumatoid arthritis were studied to determine the safety and efficacy of methotrexate therapy. The initial dose of methotrexate averaged 7.1 mg/m2/wk and was given as a single, oral weekly dose or as three divided doses, each separated by 12 hours. Current antiinflammatory medications were continued; 25 of 29 children had had lack of efficacy, and 8 of 29 had toxic effects, with one or more prior drugs such as intramuscularly or orally administered gold, hydroxychloroquine, or D-penicillamine. Intolerable corticosteroid dependency or toxic effects were present in 18 of 29 cases. Methotrexate-treated patients were examined monthly; minimum treatment duration required to assess efficacy and toxicity was 6 months. The range of treatment duration was 8 to 39 months (mean 18.5 months). Efficacy was assessed by comparing pretreatment versus posttreatment fever and rash, swollen-joint counts, articular indexes, duration of morning stiffness, functional class, hemoglobin levels, and platelet counts. Treatment with methotrexate effectively controlled fever and rash in 83% of children with systemic juvenile rheumatoid arthritis, reduced morning stiffness by 63%, eliminated recalcitrant joint restriction in 48%, and reduced numbers of swollen joints and swelling indexes by 46% and 52%, respectively. No significant toxic effects were observed. Juvenile rheumatoid arthritis of long duration, or with major erosions, was more likely to be refractory to methotrexate therapy. We recommend earlier consideration of methotrexate in place of other slow-acting antirheumatic drugs for juvenile rheumatoid arthritis not responding well to usual therapy. Future studies should address potential methotrexate toxic effects in the lungs and reproductive system, as well as outcome after discontinuation of methotrexate treatment. | |
| 3351844 | Enzyme linked (ELISA) immunoabsorbent assay for the detection of hidden 19S IgM rheumatoid | 1988 Jan | Determination of hidden IgM rheumatoid factors (RF) in juvenile rheumatoid arthritis (JRA) offers advantages for diagnosis and in following disease activity. Sera from 30 patients with JRA were assayed for RF by latex fixation test (LFT), sensitized sheep cell agglutination test (SCAT), nephelometry, and by ELISA. IgM containing fractions were prepared by chromatography and assayed for hidden RF by the hemolytic method and ELISA. Ten patients were seropositive by LFT. All of them gave positive tests on the serum for RF with the SCAT, nephelometry, and ELISA, and on the IgM containing fractions by the hemolytic assay and ELISA. Seventeen patients seronegative by LFT were positive for hidden RF by the hemolytic test and ELISA on the IgM containing fraction. When unfractionated serum was used, 15 were positive by ELISA. Three patients were seronegative and also negative for hidden RF by the hemolytic assay and ELISA. Thus, only 2 of 30 patients had discordant results between the hemolytic assay on the IgM containing fraction and the ELISA on the serum. Our results indicate the ELISA on the serum in conjunction with the LFT offers a simple, rapid, alternative test for hidden 19S IgM RF in JRA patients. | |
| 1844032 | Juvenile rheumatoid arthritis: cases from the coalfields. | 1991 Oct | Juvenile rheumatoid arthritis can result in destruction of the temporomandibular joints producing a characteristic facial growth deficiency. Features include loss of vertical ramus height, marked antegonial notching and a Class II malocclusion frequently with an anterior open bite. Two cases are presented, both treated surgically utilizing bilateral autologous costochondral grafts to replace the temporomandibular joints and increase the vertical ramus height. Postoperative orthodontic therapy was employed to close the surgically created posterior open bite in each case. Autologous dermis was used in the most recently treated case as an interpositional soft tissue layer between the glenoid fossa and the costochondral graft. | |
| 2637463 | [A clinical assessment of whole blood chemoluminescence in juvenile rheumatoid arthritis]. | 1989 Oct | A considerable rise in indices of chemoluminescence (CL) of the whole blood in children with juvenile rheumatoid arthritis was noted. A correlation of CL with clinico-laboratory indices of the disease activity was revealed. The highest level of CL was observed in the articulovisceral form and in the maximum degree of the disease activity. There was a significant difference in CL intensity in the minimum degree of the disease activity and remission of the pathological process. | |
| 1767084 | Arthroplasty of the hip and knee in juvenile rheumatoid arthritis. | 1991 Nov | The primary reason for total hip and total knee replacement in patients with juvenile rheumatoid arthritis is marked functional impairment. Secondary reasons are severe disabling pain and deformity. By the time a patient is ready for arthroplasty, alternatives to surgery have already been considered; synovectomies, soft-tissue releases, and osteotomies have already been performed, or the destructive process is too advanced for any form of therapy to have a considerable effect. | |
| 3511921 | The value of biopsy in patients with monarticular juvenile rheumatoid arthritis of recent | 1986 Jan | The histopathology of arthroscopic biopsy material from the knees of 8 patients with monarticular juvenile rheumatoid arthritis (JRA) of recent onset and of 4 control patients was examined using a histochemical method for acid alpha-naphthyl acetate esterase and an avidin-biotin-peroxidase complex method for different cell subtype-specific surface antigens. According to results of our prospective, single-blind study, nonspecific synovitis was observed in those biopsy samples obtained early in the course of disease. The samples were also characterized by cellular changes that are quite distinct from those described in patients with chronic rheumatoid synovitis. JRA must be considered the cause of symptoms if no orthopedic or infectious disease is found at arthroscopy in children with monarticular symptoms of recent onset and if nonspecific synovitis is observed in the histopathologic specimen. This pathologic description, however, does not correspond to that of classic rheumatoid synovitis. In our studies, we found that mononuclear cells displaying diffuse cytoplasmic esterase and surface Ia formed a large proportion of all inflammatory cells in situ. There were comparatively few activated Ia+ T cells and plasma cells. These observations suggest that exudative features and nonspecific cellular inflammation are prominent at onset of JRA. The immune response, in the form of immunocompetent T and B cells, seems to be more extensively involved in chronic JRA and may represent secondary features of the disease. | |
| 3327056 | [Iridocyclitis and juvenile rheumatoid arthritis]. | 1987 Sep | Iridocyclitis is a common complication of juvenile rheumatoid arthritis. It affects particularly female patients with mono-oligoarthritis. A positivity of ANA-test is usually observed, representing a marker for the disease. The course is chronic, leading potentially to scarring and blindness. The insidious onset, often not parallel to arthritis, requires careful ophthalmologic examination of all patients at risk, in order to achieve early diagnosis and treatment. | |
| 22556538 | Astromedicine in the treatment of rheumatoid arthritis. | 1991 Apr | One patient of rheumatoid arthritis was treated according to astromedicine. Wearing of Coral beads had remarkable effect on the disease. The interesting finding are reported in this paper. | |
| 3485431 | Anti-Ro (SS-A) and anti-La (SS-B) in patients with Sjögren's syndrome. | 1986 Feb | Clinical, serologic, and genetic findings in Sjögren's syndrome patients were correlated with quantitative determinations for antibody against Ro (SS-A), La (SS-B), and nRNP (Sm) using newly developed, sensitive solid-phase assays. In 86 Sjögren's syndrome patient sera, more than 96% had anti-Ro (SS-A), and 87% had anti-La (SS-B), spanning a 4.8 log10 range of autoantibody concentration, whereas only 95% of the patients had anti-nRNP (Sm). Low levels of anti-Ro (SS-A) and anti-La (SS-B) were found in 10% and 12.5%, respectively, of the 40 normal control sera. In Sjögren's syndrome patients, the level of anti-Ro (SS-A) correlated strongly with that of anti-La (SS-B) (r = 0.80; P less than 0.0001) but not with the level of anti-nRNP (Sm). We found much higher levels of anti-Ro (SS-A) and anti-La (SS-B) in patients with purpura, leukopenia, lymphopenia, and increased polyclonal gamma globulins than in those without these conditions (between 4.3-fold and 17-fold higher; P less than 0.001 to P less than 0.05). Anti-Ro (SS-A) and anti-La (SS-B) levels correlated with the rheumatoid factor titer and with the concentrations of total globulin, IgG, and IgA, but not with the IgM concentration. The association of rheumatoid factor titer with levels of anti-Ro (SS-A) and anti-La (SS-B) occurred only in patients with primary Sjögren's syndrome. Antinuclear antibody titers correlated with levels of anti-Ro (SS-A) and anti-nRNP (Sm). HLA-DR3-positive patients had higher levels of anti-Ro (SS-A) and anti-La (SS-B). | |
| 2530010 | Markers of collagen metabolism in sera of patients with various rheumatic diseases. | 1989 Aug 31 | The activity of galactosylhydroxylysyl glucosyltransferase (S-GGT) and concentration of the amino-terminal propeptide of type III procollagen, measured with two different radioimmunoassays, S-Pro(III)-N-P and S-Fab, were determined in the sera of 209 patients with various rheumatic diseases. The mean values for all these three assays were elevated in the patients with rheumatoid arthritis, whereas only the mean value for S-GGT was elevated in osteoarthrosis. The mean S-GGT but not S-Pro(III)-N-P or S-Fab was also elevated in psoriatic arthritis, ankylosing spondylitis and systemic lupus erythematosus. S-GGT correlated significantly both with S-Pro(III)-N-P and S-Fab in the pooled group of all the patients and in the cases of rheumatoid arthritis and psoriatic arthritis, and also with S-Fab in the cases of osteoarthrosis. S-Pro(III)-N-P and S-Fab correlated with each other in every disease group. The ratio S-Fab:S-Pro(III)-N-P was significantly higher in the patients with osteoarthrosis, ankylosing spondylitis and systemic lupus erythematosus than in those with rheumatoid arthritis. The data indicate that definite changes can be seen in the values of serum markers of collagen metabolism in rheumatoid arthritis, psoriatic arthritis, osteoarthrosis, ankylosing spondylitis and systemic lupus erythematosus, the most sensitive indicator being S-GGT. | |
| 3953279 | Ferritinemia as an indicator of systemic disease activity in children with systemic juveni | 1986 Jan | Twenty children with systemic juvenile rheumatoid arthritis, aged 0.9-13.7 years, were studied with regard to their serum ferritin concentration at diagnosis and during follow-up, ranging from 2 to 9 years. At diagnosis, during fever, the concentration was extremely high. The median value was 935 micrograms/l. The values were unrelated to other manifestations of the disease or laboratory findings. During glucocorticoid treatment, the serum ferritin concentrations normalized rapidly, usually within a few weeks. The rate of normalization reflected the response of the fever to treatment. Later, subnormal concentrations were found, which were unrelated to the activity of the arthritis. Thus, serum ferritin is a useful guide when tapering glucocorticoid dosage. | |
| 3178909 | Jaw deformity caused by juvenile rheumatoid arthritis and its correction. | 1988 Oct | An underdeveloped mandible and resulting micrognathia and malocclusion may occur in some children with juvenile rheumatoid arthritis. Combined orthodontic and surgical procedures can now greatly improve esthetics and function in such children. We describe corrective treatment and followup of 7 patients. | |
| 20144104 | Clearance of (125)i-labelled urographin from knee joints in rheumatoid arthritis. | 1987 | (125)I-labelled Urographin has been used intra-articularly as tracer and 60 per cent Urographin as contrast in ten knee joints of patients with classical rheumatoid arthritis. Nine traumatic knees served as controls. The rapid rate of disappearance of the contrast from joints with rheumatoid inflammation was higher than in controls. Over the rheumatoid joints the radioactivity had decreased to half the initial value in 2.85 hrs. and over the traumatic joints in 3.70 hrs. In the radiographs clear evidence of absorption of contrast by the synovial membrane, the hyaline cartilage and the fibrocartilaginous tissue of the menisci was demonstrated. In one case visual proof was obtained of drainage of the contrast through the local lymphatics. The series of arthrograms taken from this knee indicate that this drainage was rapid. | |
| 1767077 | Immune abnormalities in the pathogenesis of juvenile rheumatoid arthritis. | 1991 Nov | Juvenile rheumatoid arthritis (JRA) is the most common rheumatic disease of childhood. Although the etiology remains unknown, immunoregulatory imbalances are thought to be important in the pathogenesis of JRA. Numerous immunologic abnormalities have been described in these patients, but it remains unclear which are fundamental to the pathogenesis of the disease and which are secondary. In this article, the authors review lymphocyte and lymphokine abnormalities in children with JRA with emphasis on the possible role of these immune abnormalities in the pathogenesis of JRA. |