Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3647190 | School problems and teacher responsibilities in juvenile rheumatoid arthritis. | 1987 May | Juvenile rheumatoid arthritis (JRA) may cause a variety of school problems. Twenty-four children with JRA, 24 of their parents, and 14 of their teachers completed questionnaires regarding the frequency of 40 potential school problems and the extent of the teacher's responsibility in helping children deal with 28 medical, academic, or social issues. Though respondents viewed school problems as occurring infrequently, parents and children more frequently than teachers noted that problems occurred (p less than .05). Children felt problems with self-concept and peer relationships occurred most frequently, while parents and teachers emphasized physical health and activity-related problems. Children's ratings regarding extent of teacher's responsibility were lower than those of parents' or teachers' ratings (p less than .05). While parents and teachers viewed the teacher as responsible for helping children deal with psychosocial issues, children felt that teachers should deal primarily with academic areas. Children viewed teachers as being responsible for withholding information about arthritis from their classmates, and did not want their teacher to encourage peer interaction. Results indicate major differences exist between perceptions of children with JRA, and their parents and teachers, regarding frequency of problems and extent of the teacher's responsibility. Since children may resist assistance from teachers in psychosocial areas, their views should be considered before planning interventions to resolve such problems. | |
| 3274169 | [Recent advances in diagnosis of Sjogren's syndrome]. | 1988 Oct | In this paper the authors review the classification and the clinical features of primary and secondary Sjogren's syndrome. Particular attention in focused on differential diagnosis, on clinical examination of the patients with chronic xerostomia and on its functional and pathological sequelae: rampant dental caries and oral candidiasis. Advanced in diagnostic procedures are described: salivary flow rate, salivary gland scintigraphy, parotid and submandibular scialography, Schirmer's test, Rose Bengal staining, minor salivary gland biopsy and serum immunological examinations. The relationships between scintigraphic and histologic result are discussed. The clinical features and the course of the disease provide further insight into the immunological pathogenesis of this syndrome. | |
| 3046829 | Acute rheumatoid factor positive (IgM) polyarthritis associated with a Klebsiella pneumoni | 1988 Jun | The authors report a case of a patient suffering from acute polyarthritis with a high rheumatoid factor titre, associated with a Klebsiella pneumonitis. A polyclonal B lymphocyte activation or a possible cross reaction between rheumatoid factor and an antigen related to Klebsiella may explain the elevated production of rheumatoid factor observed. | |
| 1751314 | New developments in Sjögren's syndrome. | 1991 Oct | Over the past months, noteworthy contributions to our understanding of the clinical manifestations of Sjögren's syndrome have been made. Scintigraphic and echographic techniques have been refined to document xerostomia. Various systemic complications, such as nervous system involvement, pulmonary lesions, gastric and pancreatic dysfunction, and Raynaud's phenomenon have been further described. Mast cells have been shown to participate in the salivary gland infiltration, together with T lymphocytes, of which the majority are of the memory helper/inducer phenotype. Antinuclear antibodies are directed to SS-A/Ro and SS-B/La particles. Two studies have been devoted to the cloning of the DNA encoding the 52-kD component of the former, and a series of SS-B/La DNA fragments have been generated to analyze the peptides of the latter. Virologic data have been provided, particularly the detection of anti-human immunodeficiency virus type 1 p24 protein in a number of Sjögren's syndrome patients, and the discovery of a human intracisternal A-type retroviral particle in lymphoblastoid cells exposed to homogenates of salivary tissue from patients with Sjögren's syndrome. | |
| 2245522 | Diagnostic criteria for Sjögren's syndrome: the state of the art. | 1990 Jul | The diagnostic approach to Sjögren's syndrome (SS) is devoted to the assessment of glandular and extraglandular features of the disorder. Although this syndrome has been attracting growing interest from many investigators in the last few decades, complete agreement on the diagnostic tools to be used for this syndrome has not yet been reached. Finding a rational diagnostic approach to Sjögren's syndrome is even further complicated by the fact that this disease may exist alone, or in association with a number of extraglandular systemic manifestations or a well-defined systemic autoimmune disease. In this paper the entire matter has been critically reviewed in order to evidentiate the differences among the various diagnostic procedures proposed by different authors and to underline the need for a uniform classification criteria for SS. | |
| 2404432 | Sjogren's syndrome: a rheumatic disorder with prominent respiratory manifestations. | 1990 Jan | Sjogren's syndrome is an autoimmune condition with extraordinary and unique involvement in the eyes and respiratory tract. These patients frequently present or are referred to an allergist for evaluation. Recognition of the syndrome is critical for effective management. | |
| 2075349 | [Clinico-immunologic heterogeneity of chronic arthritis in children]. | 1990 Oct | The authors present the results of immunological examination of 29 children with reactive arthritis, 26 patients with different forms of juvenile rheumatoid arthritis and 25 practically healthy children. Considerable differences between the groups in the subpopulation composition of T- and B-lymphocytes were revealed. Direct relationship between the absolute value of OCT4/OCT8 ratio and the clinical severity of the process was noted. | |
| 1684922 | Takayasu's arteritis associated with Still's disease in an adult. | 1991 Nov | We report a new case of association between adult Still's disease and Takayasu's arteritis (TA). This association is infrequent and raises again the controversy of the origin of Takayasu's arteritis. | |
| 1757943 | Longitudinal analysis of HLA associated risks for iridocyclitis in juvenile rheumatoid art | 1991 Sep | The risk of iridocyclitis in children with early onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA) has been shown to be associated with certain HLA haplotypes. Our report contains an actuarial analysis, using one-year intervals, of 161 subjects and estimates haplotype specific risks. Individuals who possess the major susceptibility haplotype HLA-DR5 (11) developed eye disease earlier and with a greater frequency than did those with the protective HLA-DR1 haplotype. Highly significant differences were found between the resulting life-table curves for HLA-DR5 and HLA-DR1 positive subjects (p = 0.00003). These time oriented risk estimates may aid clinicians in determining more precisely the probability of iridocyclitis throughout the course of the disease in children with EOPA-JRA. | |
| 2600951 | An unusual presentation of Lyme arthritis. | 1989 Nov | A patient eventually found to have Lyme arthritis presented with a symmetrical polyarthritis clinically resembling both rheumatoid arthritis and an enthesopathy but with a negative RA latex test. A history of tick bite was obtained only on followup questioning. Her Lyme serology was positive and her response to antibiotic treatment was complete. | |
| 2208870 | Soluble mediators of articular cartilage degradation in juvenile rheumatoid arthritis. | 1990 Oct | Juvenile rheumatoid arthritis (JRA) involves a wide range of joint tissues. Tissue changes include proliferation of synovial cells, alterations in synovial fluid, and degradation of articular cartilage. Synovial cell proliferation results in increased numbers of fibroblasts and lymphocytes. Changes in the synovial fluid include increased content of antibodies, altered complement ratios, increased levels of factors stimulating cartilage-mediated proteoglycan degradation, and decreased levels of insulinlike growth factor I. Levels of cytokine such as interleukin-1 and interleukin-2 vary with cell culture and assay technique. Cartilage degradation is apparent from increased quantities of proteoglycan and glycosaminoglycan in serum and synovial fluid. Type II collagen peptide antibodies are also prevalent in JRA patients. Cartilage degradation appears linked to factors in JRA synovial fluid. Conditioned medium of peripheral blood mononuclear cells from patients with JRA also stimulates increased release of cartilage proteoglycan. Thus, the outcome in JRA likely reflects activities of interacting soluble factors that directly influence cartilage homeostasis. | |
| 2082017 | Immunogenetics of early onset pauciarticular juvenile rheumatoid arthritis. | 1990 Nov | Certain major histocompatibility complex (MHC) class I and class II genes are uniquely associated with early onset pauciarticular juvenile rheumatoid arthritis (JRA). As in other autoimmune diseases, these associations are likely to reflect contributions of the MHC to a trimolecular complex formed by HLA, lymphocyte T cell receptor and the putative antigen. The HLA genes associated with JRA are currently the best understood component of this complex. Recent findings demonstrated that combinations of genes, even within class II, play an important role. Data generated by DNA sequencing techniques have clarified the splits of given genes involved in disease, e.g., the HLA-DRw8 allele, HLA-DRB1*0801 rather than HLA-DRB1*0802, which does not carry an increased risk for disease. Recent findings suggest that aberrant sequences in particular genes are unimportant. Substantial challenges remain; including establishing the particular HLA DNA nucleotides critical to antigen presentation. It is probable that new and specific therapeutic approaches will be developed which will utilize the immunogenetic data now being accumulated. | |
| 2963881 | Immunologic studies in identical twins concordant for juvenile rheumatoid arthritis but di | 1988 Mar | Identical twins concordant for juvenile rheumatoid arthritis but discordant for monoclonal gammopathy and amyloidosis were the subjects of a study done with mixed leukocyte culture, anti-idiotypic antisera against serum and urinary M component from the amyloid-affected twin, and in vitro estimations of M-component idiotype synthesis by peripheral blood mononuclear cells. Immunohistochemical analysis of renal amyloid deposits in the affected twin showed AL amyloid of the lambda-II variable region subgroup. M-component idiotypes were confined only to the twin with serum and urine M components. | |
| 2184456 | [Hemophilic osteoarthropathy with special reference to the elbow joint]. | 1990 Mar | Hemophilia is a rare disorder, whereby recurrent bleedings into the joint can result in osteoarthropathy. Radiological changes consist of osteoporosis, enlargement of the epiphyses, irregularity of the subchondral bone surface, narrowing of the joint space, cysts, erosions, joint incongruence and joint deformity. The earlier and the more frequent bleedings have occurred that have not been treated adequately, the more of the changes mentioned above are present. In children, osteoarthropathy of the elbow is present in only about 50% of cases, and in the remaining cases the degree is mostly minimal or moderate. Differential diagnosis consists of juvenile rheumatoid arthritis in children, and rheumatoid arthritis and osteoarthritis in adults. | |
| 2629139 | [The development and testing of diagnostic criteria in psoriatic arthritis]. | 1989 | The paper is concerned with diagnostic criteria of psoriatic arthritis developed by the expert method. The criteria include 14 signs with the aid of which one can diagnose classical, definite and probable psoriatic arthritis. The sensitivity of the developed diagnostic criteria tried in 108 patients afflicted with psoriatic arthritis constitutes 99.2%, whereas the specificity tested in patients suffering from related diseases (reactive arthritides, ankylosing spondyloarthritis, seronegative rheumatoid arthritis) amounts up to 77.8%. | |
| 2922211 | Even children have arthritis. | 1989 Jan | Children experience a number of problems related to juvenile rheumatoid arthritis (JRA), including pain, stiffness, and loss of mobility that interferes with normal growth and development. Innovative nursing in a variety of settings is needed to manage the child with this chronic illness. | |
| 2022732 | Rheumatoid factors isolated from patients with autoimmune disorders are derived from germl | 1991 May | To better understand the structural basis for rheumatoid factor activity, the nucleotide sequence of the light chain variable regions of nine human monospecific IgM rheumatoid factors were analyzed. Rheumatoid factors were isolated from three patients with rheumatoid arthritis, a patient with systemic lupus erythematosus, and a normal individual. The VL gene segments used by these rheumatoid factors are not as restricted as previous work on mixed cryoglobulin rheumatoid factors had suggested. Each of the different VK families is represented and there are two examples where a V lambda gene segment is used. Molecules with structures similar to those of the Wa and Po CRI, characteristic of mixed cryoglobulin rheumatoid factors, are not common among these rheumatoid factors isolated from patients with rheumatoid arthritis. While there are clear examples of rheumatoid factors that are direct copies of germline genes, most of the sequence data suggest that the processes of antigenic selection and somatic mutation contribute significantly to the generation of monospecific rheumatoid factors in patients with autoimmune disease. | |
| 3486226 | Role of interleukin 1 and interleukin 2 in rat and mouse arthritis models. | 1986 Jun 1 | The production of interleukin 1 (IL 1) and interleukin 2 (IL 2) by macrophages and lymphocytes from three animal models commonly used for rheumatoid arthritis, viz. adjuvant-induced and type II collagen-induced rat arthritis, and MRL/1 murine arthritis was studied. Although the peritoneal macrophages from adjuvant-arthritic rats in culture produced increased amounts of prostaglandin E2 (PGE2) and lower levels of IL 1 than the control group, cells from collagen-arthritic rats released normal levels of PGE2, but increased amounts of IL 1. After activation with lipopolysaccharides, the IL 1 production by macrophages from all groups was comparable. Addition of indomethacin did not significantly change the IL 1 production in any of these groups. In the absence of any exogenous mitogen, IL 2 production by the lymphocytes of adjuvant-arthritic rats was low, but could be restored to the normal levels when phytohemagglutinin A (PHA) or concanavalin A (Con A) was added. The lymphocytes from collagen-arthritic rats were capable of producing IL 2 without the need of any T cell mitogen. The lymphocytes from MRL/1 mice seemed to lack the functionality in terms of IL 2 production. The macrophagic IL 1 production in these animals was normal. Our data suggest that the type II collagen arthritis model may closely resemble human rheumatoid arthritis in which IL 1 and IL 2 production by the mononuclear cells is significantly enhanced. | |
| 2251510 | Nutritional status and growth in juvenile rheumatoid arthritis. | 1990 Oct | The specific cause of short stature in juvenile rheumatoid arthritis (JRA) is unknown. One hypothesis links altered growth to inadequate dietary intake. In this study, nutritional status was assessed in 34 children with JRA (8 with systemic JRA, 14 with polyarticular JRA, and 12 with pauciarticular JRA) and 9 healthy controls using 3-day diet records, anthropometrics, and biochemical analyses. Differences in growth were found among the three types of JRA. One third of all subjects were at or below the 10th percentile in height for age (these being predominantly among the systemic and polyarticular groups). With few exceptions, the mean dietary intake for calories and essential nutrients was found to be adequate for each of the three groups. However, more than half of those with systemic JRA reportedly consumed less than the recommended caloric intake for their age and weight. No significant correlations were found linking dietary intake to growth percentiles in any of the groups studied. Biochemical abnormalities were found among the systemic and polyarticular groups. These abnormalities included low plasma levels of vitamins A and C, proteins (albumin, prealbumin, and retinol binding protein) and zinc; and increased levels of copper and glutathione peroxidase activity. Plasma selenium and vitamin E levels were unchanged. The discrepancy between intake and certain circulating nutrient levels may reflect alterations in the requirements, absorption, or use of these nutrients in the presence of chronic inflammation. | |
| 2336939 | Test results in patients with Sjögren's syndrome defined by the Japanese criteria. | 1990 Feb | We examined 123 patients (mean age, 63.4 years) with Sjögren's syndrome at Shimane Medical University Hospital from 1980 to 1988. According to the Japanese criteria for Sjögren's syndrome, there were 106 definite and 17 probable cases. Female patients were predominant (74.8% to 25.5%). Most patients reported dry eye symptoms and had positive results on the Schirmer's, rose-bengal, and fluorescein tests. Although most patients described dry mouth symptoms, not all showed positive sialogram results, lymphocytic infiltrate on minor salivary glands, decreased salivary secretion, and salivary gland swelling. Connective tissue diseases were present in 28 patients. Most patients had positive antinuclear antibody reactions. Most of our patients who were diagnosed as having Sjögren's syndrome by the Japanese criteria could not be classified as such by the California, Copenhagen, or Greek criteria. |