Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2774889 | Groin and hip pain due to fractures at or near the pubic symphysis. | 1989 Sep | Three patients with fractures at or near the pubic symphysis presented with groin pain simulating hip fracture or arthritis. A 71-year-old osteoarthritic woman was treated with a nonsteroidal antiinflammatory drug (NSAID) and exercises for right-sided sciatic pain after a minor fall, but developed left groin pain and tenderness over the pubic symphysis after two days of exercise. She had an impacted fracture of the left pubic symphysis which responded to use of a cane. The second patient was a 90-year-old woman with rheumatoid arthritis (on steroids) who complained of right hip pain after a series of falls in her home. Initially treated with Buck traction for a presumed hip fracture, she was later treated with heat and exercises after negative hip x-rays were obtained. Retrospective analysis of pelvic films and bone scan revealed a right pubic symphysis fracture. The third patient was an 83-year-old rheumatoid arthritic woman with inability to walk secondary to left groin pain. Pubic tomograms revealed disruption of the superior aspect, and bone scan showed increased uptake of the left pubic bone. She was treated with moist heat, rest, and NSAID. Twenty-four cases of os pubis fractures without major trauma or symphysis disruption have been reported. All patients had osteoporosis, and six had rheumatoid arthritis. Our three cases are presented to increase awareness of pubic symphysis fractures as a cause for groin pain, especially in patients with osteoporosis and rheumatoid arthritis. | |
| 27523541 | Fasting, vegetarian diet helps arthritis. | 1991 Oct 23 | A vegetarian diet, preceded by a period of fasting, can be a useful supplement to conventional treatment of rheumatoid arthritis, a medical team from Oslo has claimed. | |
| 3095782 | 19S IgM rheumatoid factor-7S IgG rheumatoid factor immune complexes isolated in sera of pa | 1986 Oct | 19S IgM rheumatoid factors (RF) and hidden 19S IgM RF have been associated with increased disease activity in juvenile rheumatoid arthritis (JRA). Recently, immune complexes (IC) were isolated from JRA sera by several methods which demonstrated the presence of 19S IgM RF. The present study evaluates 25 JRA patients' sera by separation on a Sepharose 4B column to which were bound F(ab')2 fragments of goat IgG antihuman IgM antibody to separate IgM-containing IC. The columns were sequentially eluted with 1 M ammonia and 0.1 M glycine-HCl buffer, pH 3.0. The isolated fractions were assayed for 19S IgM RF and 7S IgM RF by ELISA, IgG levels by immunodiffusion, and by preparative isoelectric focusing. The ammonia eluate from the alpha HIgM column revealed IgG, 19S IgM RF in six patients, and IgM RF in four patients. All were polyarticular-onset JRA patients. In the glycine-HCl eluate of sera, 19S IgM RF and IgG were also detected in 15 patients, all six seropositive, polyarticular-onset, six seronegative, polyarticular-onset, and three pauciarticular-onset patients. Significant 7S IgG RF titers were demonstrated in the glycine-HCl eluates of six patients, five seropositive, polyarticular-onset patients, and one seronegative, polyarticular-onset patient. Analysis by preparative isoelectric focusing of the IgM RF and IgG RF positive ammonia and glycine-HCl eluates showed IgM RF throughout the pH range (4-10), but the highest amount of IgM RF was in the pH range 4.0-5.5. Significant IgG RF titers were detected only in this restricted spectrotypic area of pH 4.0-5.5.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 11188599 | The validity and reliability of parental ratings of disease activity in juvenile rheumatoi | 1991 Sep | This study assessed the validity and reliability of parental ratings of morning stiffness, activity limitations, and pain complaints on a sample of 31 patients with juvenile rheumatoid arthritis (JRA). Parental ratings were found to be significant predictors of active joint counts, accounting for 40% of the variance in joint counts. Internal consistency reliability was moderately high (0.819), but test-retest reliability was moderate to low; this is not unexpected given the fluctuations in symptoms of JRA over time. The results suggest that parental ratings are valid and moderately reliable measures of disease activity in JRA. Regular monitoring of symptoms by parents could be a useful source of information for health care providers in making treatment decisions and can increase parental and patient involvement in the treatment process. | |
| 1837255 | [Sjögren's syndrome: therapeutic trends]. | 1991 Nov 15 | Sjögren syndrome is an autoimmune, mostly benign disorder characterized by functional impairment of exocrine glands, especially of the salivary and lacrimal glands. Symptomatic treatment with recourse to hygienic measures and topical therapy permits to attenuate secondary disorders due to hyposecretion. Among drugs used, hydrochloroquine has proved apt to bring about marked improvement in some laboratory test results although it has scarce effect on the clinical picture. Corticosteroids and immunodepressant agents are indicated in severe forms of the disease with accompanying extraglandular and systemic manifestations. Some authors have reported interesting findings concerning the usefulness of a low lipid diet which is said to reduce inflammation and lymphocyte infiltration of the glands involved; these findings deserve further research. | |
| 3053016 | Update: treatment of rheumatoid disease. | 1988 Oct | The treatment of rheumatoid arthritis is, of necessity, highly individualized and thus invites the full application of the art of medicine. Patient education, physical therapy, NSAIDs, DMARDs, and surgical therapy all potentially play a role in the management of this syndrome. Careful and repeated assessment of signs and symptoms will identify patients who are likely to benefit from the wide array of helpful but imperfect drugs currently in use. The availability of increasingly effective therapy means that early referral and treatment are more important than ever in treatment of rheumatoid arthritis. | |
| 1947287 | Radiographic methods of assessment (scoring) of rheumatic disease. | 1991 Aug | The major features of various global and detailed methods of assessment (scoring) of the hands and wrists of patients with rheumatoid arthritis are reviewed. Relative advantages and disadvantages of the methods are presented. Detailed radiographic scores relate best to other measures of patient status. Although scoring is not a difficult skill, the work is tiring, tedious, and time-consuming. Quantitative methods have done much to further our understanding of rheumatoid arthritis; they hold the promise of further discoveries. | |
| 20144102 | On the etiology of growth disturbance of the mandible in juvenile rheumatoid arthritis. | 1987 | One case of congenital micrognathia unaccompanied by any other congenital malformations was discovered among 33, 000 school children surveyed. This case showed roentgenological evidence of condylar aplasia. The same change had been noted earlier in some cases of juvenile rheumatoid arthritis associated with micrognathia. The conclusion is drawn that in some of the children with RA associated with micrognathia, this latter has a congenital basis whereas, in other cases, it is due to affection of the temporomandibular joint. | |
| 2663508 | Sjogren syndrome in childhood: report of two cases. | 1989 Apr | A 12-year-old boy who developed primary Sjogren syndrome and a girl, whose diagnosis of secondary Sjogren syndrome was established at the age of 3, are reported. The importance of some unusual manifestations at disease onset and possible differences in expression between children and adults are briefly discussed. | |
| 3668981 | The frequency of sicca syndrome in an elderly female population. | 1987 Aug | In a population of 103 elderly Caucasian women, 39% had sicca symptoms and 24% had abnormal Schirmer's tear tests. Two (2%) satisfied criteria for Sjögren's syndrome and 12 (12%) were felt to have possible Sjögren's syndrome. Fifty percent of those with sicca were taking medications that might induce mucosal dryness. Fibrosis was noted on all 23 labial minor salivary gland biopsy specimens obtained. Mucosal drying medications and senile salivary gland atrophy seemed to contribute to the high frequency of sicca in this population with a lesser proportion of the subjects demonstrating previously undiagnosed Sjögren's and possible Sjögren's syndrome. | |
| 2093438 | Antimalarials in rheumatic diseases. | 1990 Dec | The antimalarials hydroxychloroquine and chloroquine remain established and effective agents for the treatment of rheumatoid arthritis and systemic lupus erythematosus. Although the mechanisms of action remain uncertain, evidence is accumulating that the antirheumatic and immunological effects of the antimalarials are related to their massive distribution into the cellular acid-vesicle system. These drugs are attracting new interest because their relative safety recommends their use in early rheumatoid arthritis and as a component of second-line antirheumatic drug combinations. The absence of data examining the effect of antimalarials upon radiological progression of rheumatoid arthritis needs to be rectified. Recent understanding of the pharmacokinetics of these drugs reveals that steady-state concentrations are not achieved for at least 3-4 months. Preliminary information also suggests a relationship between blood concentrations and effect. Taken together, these data suggest that more effective dosage regimens will be possible when therapeutic concentration ranges are properly established. | |
| 2754525 | [A diagnostic and etiologic studies of Sjögren's syndrome--I. Sialographical and histopat | 1989 Mar | This work was an attempt to elucidate the diagnostic evaluation of sialography+ and histopathological examination of the salivary gland in Sjögren's syndrome. The author investigated the correlation of the sialography and histopathology features of the salivary gland in 89 confirmed cases of Sjögren's syndrome and 26 suspected cases, a total of 115 subjects and the following results were obtained. 1) In determining the histopathological severity of the salivary gland lesions from sialography, the parotid sialography was more useful than the submaxillary sialography. 2) The severity of parotid sialography correlated well that of labial gland histopathology. 3) Biopsy of the labial gland was useful for histopathological diagnosis on Sjögren's syndrome but the histopathological change occurred to a greater degree in the submaxillary gland than in the labial gland. 4) From above results, in histopathological examination of severe case of Sjögren's syndrome, biopsy of the labial gland will be sufficient, but biopsy of the submaxillary gland must be employed for studying mild cases. | |
| 1810047 | [Still's syndrome in adults as one of the causes of fever of unknown origin]. | 1991 | Based on their own investigations and reported data, the authors describe the clinical and laboratory signs of Still's syndrome in adults. Special attention is paid to an analysis of the feverish syndrome. The clinical cases of Still's syndrome running its course under the mask of fever of obscure genesis for a long time are provided. The possibilities of early diagnosis of the disease are under discussion. | |
| 3093958 | [A model and 3 examples for understanding HLA and diseases: cis and trans complementation | 1986 Jun | The heterozygous effect observed for the HLA and disease association in insulin dependent diabetes, juvenile rheumatoid arthritis and coeliac disease is interpreted in the view of recent cellular and molecular data of MHC class II molecules demonstrating the existence of hybrid HLA DQ molecules and conformational determinants created by Trans (or Cis) complementation. It is postulated that unique determinants created de novo by such mechanisms represent the structural basis for the altered immune response leading to the pathogenesis of these auto-immune diseases. | |
| 2351196 | Facial growth and oral function in a case of juvenile rheumatoid arthritis during an 8-yea | 1990 May | The present report is a detailed analysis of facial growth and oral function in a girl with juvenile rheumatoid arthritis of the temporomandibular joints. She was followed from 9 to 17 years of age prior to and after orthognathic surgery. Facial growth was assessed by facial photographs, dental casts, and roentgencephalometry, and oral function was assessed clinically by electromyography, kinesiography, and bite force. In addition, histological and histochemical analysis was performed on biopsy material from her masseter muscle obtained at the time of surgery. The study showed a clear relationship between facial growth and oral function. Dysplastic growth of the mandible led to an increasingly unstable occlusion with poor working conditions for the masticatory muscles. The muscles became weak, and even revealed marked structural histological and histochemical changes. Based on these observations it is suggested that the conventional treatment strategy with postponement of orthodontic or orthognathic surgical treatment until cessation of growth is abandoned and that early treatment should be undertaken to maintain occlusal stability throughout the growth period. | |
| 3264580 | In vitro immunoglobulin production by lymphocytes of patients with juvenile rheumatoid art | 1988 Oct | Pokeweed mitogen (PWM) and Staphylococcus aureus Cowan I (SAC) were used to stimulate in vitro IgG and IgM production by lymphocytes of 27 patients with juvenile rheumatoid arthritis (JRA). Twelve had reduced stimulation indices for PWM stimulated cultures of T and non-T cells. Stimulation with SAC resulted in increased IgM production in half (5/10); and partial removal of monocytes resulted in improved PWM induced IgM production in 5/7. IgG production was less easily improved. The results of our study suggest that while PWM induced Ig production may be reduced, B cells responding to SAC may function normally in some patients with JRA. In others, monocyte mediated suppression may account for reduced responses to PWM. | |
| 2059256 | Basal ganglia mass lesions in juvenile rheumatoid arthritis. | 1991 Mar | A 2-year-old boy suffered aphasia, hypotonia, dystonia, and loss of activity and spontaneous speech during an active stage of juvenile rheumatoid arthritis with pericarditis, fever, anemia, and a high antinuclear antibody titer. These neurologic signs slowly improved with corticosteroid treatment but fluctuated over 1 year. The neuroimaging studies revealed irregular mass lesions in the basal ganglia bilaterally mainly involving the globus pallidus. They gradually decreased in size and almost disappeared after 1 year. A stereotactic brain biopsy revealed a slight proliferation of astrocytes. Chorioretinitis was also observed during the clinical course. A chronic inflammatory process involving cerebral vessels was suspected, although angiography did not demonstrate cerebral vasculitis. The possibility of central nervous system lymphoma could not be eliminated. The type of aphasia and the relation to the lesion sites are discussed. | |
| 3797989 | Reactivity of autonomic nervous control of heart rate in diabetes mellitus and juvenile rh | 1986 Dec | Autonomic cardiac control of children with diabetes mellitus (DM, n = 12), juvenile rheumatoid arthritis (JRA, n = 12) and healthy controls (n = 12) was studied by a procedure consisting of a deep breathing test and an intermittent tilting test. Frequency selective entrainment of HR could be produced by tilting and deep breathing. No statistically significant intergroup differences were detected in the patterns of average heart rate (HR), overall or beat-to-beat heart rate variability (HRV) or HRV spectra. The DM group had an 8% higher HR and a limited short-term HRV response in relation to HR throughout the whole test procedure compared to controls. This increased HR causes an extra load to the cardiovascular system. We conclude that in spite of elevated HR and changed short-term chronotropic HR control in DM no features of autonomic failure could be detected in children with JRA. | |
| 2615724 | [Therapeutic strategy in the acute onset phase of infantile rheumatoid arthritis. Comparis | 1989 Oct | The effectiveness of some anti-inflammatory drugs has been compared in a series of 35 patients suffering from infant rheumatoid arthritis at onset and at the third month of disease. The results show that the clinical response to the various therapeutic protocols differs with the protocol and the stage of the disease in consideration, that disease monitoring in the early stage benefits from the serological examinations and that there is a low incidence of significant side-effects. | |
| 2746598 | Sporothrix tenosynovitis--differential diagnosis of granulomatous inflammatory disease of | 1989 Apr | Sporothrix tenosynovitis is difficult to distinguish from rheumatoid arthritis--the organisms are scarce in biopsy specimens, and both diseases cause a granulomatous synovitis which can affect multiple joints, have associated subcutaneous nodules, similar radiographic findings, and respond to heat and salicylates. This report describes a patient treated for over 2 years as having rheumatoid arthritis. Multiple tenosynovectomy specimens revealed granulomatous synovitis with sterile cultures. Eventually a fungal culture was positive for Sporothrix. This report discusses the histopathologic features of Sporothrix synovitis, and stresses the importance of repeated fungal cultures from patients with granulomatous synovitis unresponsive to steroids. |