Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3186321 | Coexistent transient pulmonary edema and pericardial effusion. | 1988 | Eight (23%) of 35 children with acute pericardial effusions due to infection or juvenile rheumatoid arthritis (JRA) had associated transient pulmonary edema demonstrated on plain chest radiographs. The presence or absence of radiographic pulmonary edema correlated well with clinical and hemodynamic parameters in patients with JRA but not in those with infectious pericarditis. There was no definite relationship between radiographic edema and amount of pericardial fluid as estimated echocardiographically or removed at pericardiocentesis. Rapidity of pericardial fluid accumulation could not be assessed in this study. Children of young age with underlying JRA were the most likely subjects to have radiographic pulmonary edema in conjunction with an acute pericardial effusion. | |
| 3602941 | C-reactive protein in the assessment of disease activity in juvenile rheumatoid arthritis | 1987 | Disease activity in 31 children with JRA and 12 with JSA was investigated clinically and by serial measurements of serum CRP and ESR over a one-year period. Prior mean duration of disease was 4.3 years. There was a significant correlation of CRP with ESR and both parameters correlated significantly with clinical disease activity. CRP concentrations and ESR in active disease were significantly higher than in moderately active and inactive disease, though neither parameter showed any significant difference between moderately active and inactive disease. Clinical scoring was more sensitive in detection of moderate disease activity than were CRP and ESR. However, in systemic JRA without articular involvement, laboratory parameters were more useful for assessing disease activity. | |
| 1774602 | A filter affinity transfer method for the analysis of rheumatoid factors. | 1991 | Transfer of serum proteins separated by thin layer agarose electrophoresis onto nitrocellulose sheets precoated with purified human polyclonal IgG followed by revelation with enzyme-coupled anti-mu or anti-alpha antisera resulted in the specific detection of rheumatoid factors (RF) belonging to the IgM or IgA classes. Mono- or polyclonality of such RF can be evaluated from the patterns of the blots (sharp bands). In addition, their light chain type can be determined using affinity filters coated with a gamma heavy chain disease protein or with IgG Fc fragments. This simple and rapid procedure allows an easy characterization of monoclonal RF, even if they are present in minute amount amongst polyclonal RF as in certain sera from rheumatoid arthritis patients. | |
| 2054759 | Massive intrapelvic synovial cyst as a complication of total hip replacement arthroplasty: | 1991 Jun | The authors report a case of massive intrapelvic synovial cyst complicating total hip arthroplasty in a 35-year-old woman with rheumatoid arthritis. The clinical presentation raised the possibility of a coincidental soft-tissue malignant tumour. This was ruled out by ultrasonography, computed tomography, fine-needle aspiration with examination of cells and culture and, ultimately, by image intensification in the operating room during aspiration of the cyst and injection of the adjacent hip joint with Hypaque. The authors conclude that perforation of the acetabular floor at total hip arthroplasty was likely the precipitating event. After 1 year there was no indication for surgical excision of the cyst. | |
| 3602947 | Infections and related risk factors of arthritis in children. A case-control study. | 1987 | We used a parent-completed questionnaire to record the clinical signs of infection preceding the onset of joint symptoms by 1 month or less in 334 children with arthritis or other joint disease. An upper respiratory tract infection (URTI) often preceded the onset of arthritis (51%) but also arthralgia (56%) and even trauma or orthopedic disease (43%). The results of a case-control analysis of 165 patients and community controls matched for age and sex were in favour of a preceding URTI having an etiologic or triggering role in acute transient arthritis of other joints than the hip only (odds ratio of preceding URTI, 7.0), juvenile rheumatoid arthritis (odds ratio 3.3) and transient synovitis of the hip (odds ratio 3.0). The form of day-care differed significantly from that of controls only in patients with transient synovitis of the hip who attended a day-care centre more often than controls (odds ratio 3.5). | |
| 3266117 | Production of interleukin 1 in the joint during the development of antigen-induced arthrit | 1988 Dec | Antigen-induced arthritis in the rabbit closely resembles rheumatoid arthritis. The levels of interleukin 1 (IL-1) in the synovial fluid and the synthesis of IL-1 by infiltrating cells in synovial fluid and by the synovial lining from control and inflamed joints has been assessed during the first month of this disease. A number of biological assays have been used to measure rabbit IL-1. Of these, only the assay using the murine thymoma cell line (EL-4 NOB-1) was able to detect IL-1 activity in the synovial fluid of arthritic joints, which was present only in the very early lesion. The leucocytes infiltrating the synovial cavity produced little IL-1 ex vivo in the acute lesion but released large amounts when arthritis was established. A similar finding was made with respect to the production of IL-1 by the synovial lining. | |
| 3814199 | Immunohistochemical characterization of synovial cells in arthritic MRL-lpr/lpr mice. | 1987 Jan | MRL-lpr/lpr (MRL/l) mice spontaneously develop an autoimmune disease associated with arthritic manifestations. We used a recently developed mild demineralization procedure, followed by immunohistochemical staining of frozen sections, to investigate cell patterns in the hindlimbs of MRL/l mice at various stages of arthritic disease. Large numbers of Mac-1 (Mas 034)-positive, macrophage-like cells were seen both within the thickened synovial lining layer and in the deeper layers of the synovial tissue in all stages of arthritis. Ia-expressing cells were scarce in the lining layer, but occurred in moderate numbers in the deeper layers of synovial tissue. Lymphocytes were totally absent in MRL/l joints in all stages of arthritis, as demonstrated by lack of staining with Ly-1, Lyt-2, GK 1,5, and antiimmunoglobulin antibodies. Our findings are discussed and related to other types of experimental arthritis and to rheumatoid arthritis in humans. | |
| 3740983 | Spontaneous and pokeweed mitogen induced production of rheumatoid factor and immunoglobuli | 1986 Jul | In order to evaluate functional lymphocyte defects in type II essential mixed cryoglobulinaemia (EMC) in vitro production of immunoglobulins (Ig) and rheumatoid factor (RF) has been studied in basal conditions and under pokeweed mitogen (PWM) stimulation in 15 patients and in 17 control subjects. The major finding was a significantly high basal and inducible production of RF by EMC lymphocytes as compared with the RF production in controls, while synthesis of polyclonal Ig was unaffected. A good correlation existed between in vitro production and serum levels of RF. Peripheral blood SmIg+ and Ia+ cells were also significantly increased. The possibility that EMC shares some pathogenetic mechanism with rheumatoid arthritis on the one hand and with lymphoproliferative diseases on the other is considered. | |
| 2930277 | Presence of glycosaminoglycans in purified AA type amyloid fibrils associated with juvenil | 1989 Mar | Previous studies have strongly suggested an association between glycosaminoglycans and tissue deposits of amyloid. The present study was aimed at studying this association in purified preparations of hepatic amyloid fibrils obtained from human AA type secondary amyloidosis. Glycosaminoglycans were isolated by gradient ion exchange chromatography of purified amyloid fibrils treated with pronase. Degradation with specific enzymes identified the glycosaminoglycans as chondroitin sulphate, dermatan sulphate, and heparin/heparan sulphate. The total amount of glycosaminoglycans specifically coisolated with the amyloid fibrils was 15 micrograms/mg fibril weight. The presence of glycosaminoglycans in amyloid may play a part in the incorporation of structurally diverse protein precursors into amyloid fibrils of identical ultrastructure. | |
| 2241285 | Juvenile psoriatic arthritis and HLA antigens. | 1990 Sep | The clinical, laboratory, and radiological features, including histocompatibility typing, of 28 patients with juvenile psoriatic arthritis are reported. The most common presentation was that of psoriasis preceding or occurring simultaneously with arthritis. The most common course of juvenile psoriatic arthritis was to start as an oligoarthritis and progress, usually to polyarthritis. No patients with juvenile psoriatic arthritis had uveitis. Overall, most patients had a good outcome (93% in functional class I and II), though 8/28 (29%) did require disease modifying drugs over a mean period of 8.8 years of follow up. The clinical features of these patients were very similar to those of a group of 158 adult patients with psoriatic arthritis with the same disease duration followed up in the clinic. Although there was an increased prevalence of B17 in both juvenile and adult psoriatic arthritis, juvenile psoriatic arthritis showed increased prevalence of A2, whereas adult psoriatic arthritis showed increased prevalence of B27, Bw39, and Cw6. This HLA association differed from that reported in other forms of juvenile arthritis. | |
| 2718148 | [Assessment and course of 110 patients with mono-arthritis]. | 1989 Apr | This is a follow up study of 110 patients referred to the hospital because of mono-arthritis of unknown etiology. Patients with mechanical synovitis and infectious arthritis have been excluded from this study initially. From a total of 110 patients (100%) a diagnosis could be made in 49 patients (44.6%), namely in 24 (21.8%) by the initial very thorough work up or by the repeated examinations during the follow up period in 25 patients (22.8%). In 61 patients (55.4%) the cause of the disease remained unknown despite extensive investigations and follow up controls for many years. Of these 61 cases three (2.7%) developed polyarthritis and six (5.5%) oligoarthritis still of unknown origin. The rest, namely 52 (47.2%) remained mono-arthritis and are called mono-arthritis of unknown origin ("Arthritis unbekannter Ursache"). 67% of these 52 patients with mono-arthritis of unknown origin went into complete remission after one year and 80% after two years. 13 patients (11.8%) of the 110 developed rheumatoid arthritis within one month up to three years. Arthroscopy was important in making some diagnosis initially. Twelve patients had relief of symptoms after arthroscopy, ten of the group with mono-arthritis of unknown origin. 19 patients claimed that the initiating factor was a trauma to the joint. | |
| 1725690 | Thiol-containing compounds inhibit the production of monocyte/macrophage-derived angiogeni | 1991 Nov | Macrophage (M phi)-mediated angiogenesis is believed to play an important role in the pathogenesis of rheumatoid arthritis. Gold sodium thiomalate, which is used in the treatment of rheumatoid arthritis, is a potent inhibitor of the production of m phi-derived angiogenic activity. To determine the mechanism of this inhibition, we studied the effects of thiol containing compounds (TCCs) on elicited mouse peritoneal m phi and lipopolysaccharide stimulated normal human monocytes. Monocyte/m phi conditioned media were potently angiogenic when assayed in rat corneas, while conditioned media from viable monocyte/m phi s treated with TCCs (at concentrations of 8.3-16.6 x 10(-5) M) were not. TCCs inhibited production of angiogenic activity by the m phi s rather than affecting other components of the angiogenic response such as the angiogenic factors or the target microvasculature of the rat cornea. Levels of the angiogenic mediator tumor necrosis factor-alpha (TNF-alpha) were not decreased in conditioned media of monocyte/m phi s treated with TCCs. We conclude that TCCs are potent inhibitors of the production of m phi-mediated angiogenic activity. This action of TCCs on m phi s may be in part responsible for the mechanism of action of therapeutic gold compounds in rheumatoid arthritis. | |
| 2396867 | Chemotaxis and chemiluminescence responses of synovial fluid polymorphonuclear leucocytes | 1990 Aug | The chemotaxis and chemiluminescence responses of polymorphonuclear leucocytes (PMN) of synovial fluid and peripheral blood from patients with acute reactive arthritis were studied. Rates of chemotactic and chemokinetic migration of synovial fluid PMN were significantly decreased. In addition, chemiluminescence responses tended to be depressed, suggesting that the cells were deactivated for both chemotaxis and production of oxygen derived free radicals. Such deactivation has been described previously as a characteristic of synovial fluid PMN in rheumatoid arthritis. Compared with those with a mild disease, patients with severe acute reactive arthritis had higher chemiluminescence responses of synovial fluid PMN to phorbol myristate acetate during acute disease and developed increased migration of peripheral blood PMN towards zymosan treated serum after recovery from the disease. This supports the view that hyperreactive PMN contribute to the development of severe inflammatory symptoms in acute reactive arthritis. | |
| 2026537 | Juvenile-onset polyarthritis syndrome in Akitas. | 1991 Mar 1 | Two young Akitas were examined because of manifestation of a juvenile-onset form of polyarthritis. A search of medical records at the New York State College of Veterinary Medicine found 6 more similarly affected Akitas. The clinical manifestations were marked by cyclic febrile illness and signs of profound joint-related pain. Two dogs had concurrent aseptic meningitis. The syndrome resembles juvenile rheumatoid arthritis in human beings, although it shares features with systemic lupus erythematosus. Pedigree analysis of affected Akitas supported a heritable component to the syndrome. Treatment with immunosuppressive drugs was effective in 2 dogs that achieved complete remission, and in 2 dogs that achieved only partial remission. Classification of this syndrome is difficult and may represent an "overlap" syndrome commonly described in human beings. | |
| 3495471 | Histopathology of intestinal inflammation related to reactive arthritis. | 1987 Apr | This study has identified a group of patients with inflammatory chronic, or relapsing acute arthritis who even in the absence of gastrointestinal symptoms have histological evidence of ileocolitis. At colonoscopy simultaneous biopsies of the terminal ileum and colon were taken from 108 patients with reactive arthritis (n = 55) or ankylosing spondylitis (n = 53), 47 patients with other rheumatic diseases and 19 control patients suffering from colonic polyps, adenocarcinoma, or chronic constipation. All control patients and all but one patient with rheumatoid arthritis, juvenile chronic arthritis, systemic lupus erythematosus, lumbar back ache, and psoriatic arthritis did not have histological evidence of acute or chronic inflammatory bowel disease. In contrast, in 30 of 35 (56.6%) patients with ankylosing spondylitis, and in 37 of 55 (67%) patients with reactive arthritis, regardless of HLA B27 phenotype, there was histological evidence of inflammatory bowel disease with features either of acute enterocolitis, or early Crohn's disease. Only 18 of 67 (27%) of the patients with histological gut inflammation, however, had intestinal symptoms. | |
| 2338269 | Agalactosyl IgG in inflammatory bowel disease: correlation with C-reactive protein. | 1990 Apr | The proportion of oligosaccharide chains on the Fc fragment of IgG which terminate with N-acetylglucosamine (GlcNAc) rather than galactose is increased in rheumatoid arthritis and tuberculosis, and in sera from patients with Crohn's disease, probably because of decreased activity of a galactosyltransferase in B lymphocytes. We have assayed the prevalence of agalactosyl oligosaccharides on IgG in sera from 67 patients with inflammatory bowel disease (32 ulcerative colitis and 35 Crohn's disease). The prevalence of agalactosyl IgG significantly increases in the majority of Crohn's patients (19/35 patients), and correlates with the level of C-reactive protein (r = 0.79), and inversely with the concentration of serum albumin. Sera from ulcerative colitis patients show less frequent (nine of 32) and less marked rises in agalactosyl IgG, and sera with high C-reactive protein values can contain normal levels. Thus in ulcerative colitis no correlation was seen between the two assays. The diseases in which the percentage of agalactosyl IgG is raised (rheumatoid arthritis, tuberculosis, Crohn's disease and some ulcerative colitis) are characterised by simultaneous T cell mediated granulomatous tissue damage, and acute phase responses. Levels are normal in less tissue damaging granulomatous conditions, including sarcoidosis, and leprosy (except during episodes of erythema nodosum leprosum). We suggest therefore that a raised percentage of agalactosyl IgG is a correlate of a particular type of T cell mediated pathology which may be relevant to the pathogenesis of inflammatory bowel disease. | |
| 2183804 | Auranofin in the treatment of juvenile rheumatoid arthritis. Results of the USA-USSR doubl | 1990 Apr | A 6-month double-blind, parallel, randomized, placebo-controlled multicenter trial of auranofin (0.15-0.20 mg/kg/day) was conducted in 231 children with juvenile rheumatoid arthritis (JRA) in the United States and in the Union of Soviet Socialist Republics. Approximately 80% of the children had polyarticular disease. The auranofin-treated patients showed greater mean decreases from baseline in 11 of the 12 articular disease indices measured than did the placebo-treated subjects after 3 months of therapy, and in 9 of the 12 indices after 6 months. However, the actual intergroup mean differences were relatively small and were not statistically significant. According to the physician's global assessment, 69% of the auranofin-treated patients and 61% of the placebo-treated patients demonstrated clinically significant improvement from baseline after 6 months (P = 0.24). Children whose disease onset occurred less than 2 years prior to entry improved more than did those who had arthritis for a longer period. In addition, those with polyarticular involvement at baseline improved more than did patients with mild disease. However, these relationships were observed in both the auranofin- and placebo-treated groups, and again, there were no significant intergroup differences. Diarrhea was the most common adverse effect of auranofin. We conclude that the clinical efficacy of auranofin is modestly higher than that of placebo in the treatment of JRA, as evidenced by the consistent trends observed in the data. However, the magnitude of the individual intergroup differences is not statistically significant. Auranofin appears to be very safe in children with JRA. | |
| 3021038 | Arthritis, vasculitis, and cryoglobulinemia associated with relapsing hepatitis A virus in | 1986 Nov | Hepatitis A virus, unlike hepatitis B virus, has rarely been associated with extrahepatic features. Two patients developed relapsing hepatitis A complicated by arthritis in both cases and cutaneous vasculitis in one. Both patients had cryoglobulinemia, with cryocrit values of 4.3% and 8.6%. Serologic studies showed that the cryoglobulin consisted of polyclonal IgM and IgG. The washed cryoglobulin was analyzed by sucrose density gradient ultracentrifugation under neutral (pH 7.4) and acidic (pH 2.8) conditions. Enzyme-linked immunosorbent assay techniques were used to characterize the native and dissociated cryoglobulin. The cryoglobulin contained acid-dissociable IgG complexes greater than 19S, and high molecular weight rheumatoid factors of both IgG and IgM isotypes that could be dissociated to 7S and 19S forms, respectively. Dissociation of the cryoglobulin augmented 7S anti-hepatitis A virus IgG 2.27-fold, but augmented total 7S IgG only 1.12-fold, suggesting enrichment of antiviral antibody in the cryoglobulin. | |
| 3266068 | Low molecular weight IgM in juvenile chronic arthritis. | 1988 Dec | Low molecular weight IgM, the monomeric subunit of pentameric IgM, was clearly detected by immunoblotting and filtration chromatographic techniques in six patients with juvenile chronic arthritis and in trace quantities in a further eight of 24 patients studied. This low molecular weight IgM moiety contributed up to 33% of the total circulating IgM and was strongly associated with raised serum concentrations of IgM and the presence of antinuclear antibodies, extractable antinuclear antibodies, and rheumatoid factor. Immunoblot analysis of positive serum samples showed small quantities of other low molecular weight oligomers of IgM in addition to monomeric IgM. It is postulated that the presence of low molecular weight IgM in the serum of patients with juvenile chronic arthritis reflects a disorder of the intracellular assembly of IgM subunits during a stimulated IgM immune response. The pathogenetic role of low molecular weight IgM remains uncertain. | |
| 2200940 | [Rheumatological aspects of infection with human immunodeficiency virus (HIV)]. | 1990 Apr | Since 1987, some works have been devoted to rheumatological manifestations appearing during the course of the HIV infection. If neurotropism of this retrovirus explains some misleading pseudo radicular aspects of the disease, sometimes revealing, inflammatory neuro-arthropathies are still under discussion. In Tropical Africa, increase of reactive arthritis of REITER's type seems to be correlated with the present epidemic outbreak. It is also admitted that HIV has a direct arthritic effect. These two facts lead to elaborate several pathogenic hypothesis concerning rheumatoid arthritis and spondylarthritis. On the other side, some systemic diseases may appear or be simulated at the occasion of the HIV infection, in particular, some lupoid manifestations. During AIDS, lymphocytic depletion may be at the origin of series of biological abnormalities that have to be known in order to mislead diagnosis. |