Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3570527 | Binding of monoclonal IgM rheumatoid factor to streptococci via the antibody combining sit | 1987 | Radiolabelled monoclonal IgM rheumatoid factors, four from patients with type II essential cryoglobulinaemia and one originating from a patient with rheumatoid arthritis, were tested for binding to group A, B, C and G streptococci and Escherichia coli. Two of the preparations exhibited different binding patterns for the streptococci, whereas the remaining three were not reactive. The binding of one of the factors to group A streptococci type 15 was inhibited by F(ab')2-fragments of anti-idiotypic antibodies but not anti-IgM Fc or F(ab')2 of normal rabbit IgG, indicating that the reaction was mediated via the antibody combining sites. | |
| 3429653 | Late effects of JRA on the hip. | 1987 Nov | Osseous changes at the hips were seen in the radiographs of 36 children with long-standing juvenile rheumatoid arthritis (JRA) and no significant steroid therapy. Seven boys and one girl had progressive primary inflammatory destruction of the hip with erosive arthritis and progressive joint space narrowing. Twenty-one girls and seven boys revealed adaptive developmental changes in the growing skeleton without erosion. Both courses resulted in secondary osteoarthritis and functional disability. Early recognition of adaptive, developmental changes may identify a group of children who may benefit from orthopedic intervention to maintain concentric, congruent reduction at the hip. | |
| 3330294 | Immunological abnormalities in juvenile chronic arthritis. | 1987 | The immunological alterations that have been reported in juvenile chronic arthritis are reviewed. Their role in patient management and classification as well as their possible etiopathogenetic relevance are discussed. | |
| 2512582 | Localization of a critical restriction site on the I-A beta chain that determines suscepti | 1989 Dec | Type II collagen-induced arthritis (CIA) in mice is an autoimmune experimental model for rheumatoid arthritis. Susceptibility to CIA is associated with certain major histocompatibility complex class II haplotypes. The two very closely related haplotypes H-2q and H-2p differ in susceptibility to CIA. Only mice of H-2q (DBA/1, B10G strains) but not mice of H-2p-expressing strains (like strain B10P) develop CIA and an autoimmune response to type II collagen (CII) after immunization with CII. In contrast to H-2p, the H-2q haplotype does not express I-E molecules. The purpose of the present study was to identify, at the molecular level, the structures on major histocompatibility complex class II molecules determining susceptibility to CIA and CII responsiveness. We first excluded the possible suppressive involvement of Ep or Ap molecules by showing that F1 hybrids between H-2p and H-2q haplotype strains, expressing Ep and Ap, are responders to CII and fully susceptible to CIA. Secondly, because A alpha chains appear identical, we sequenced the A beta first-domain exons of p and q allotypes and found only four diverging amino acids in the predicted amino acid sequence. These variable residues were closely located at positions 85, 86, 88, and 89 at the end of the postulated alpha-helix, which is of importance for interactions with the antigenic peptide and the T-cell receptor. We suggest that this region is a critical major histocompatibility complex restriction site for CIA and CII responsiveness in H-2q mice as compared with H-2p mice. The CIA will now be an excellent autoimmune model for studies on interactions between autoantigenic peptide, autoreactive T cells, and a particular major histocompatibility complex molecule, as has been postulated to be the initial event also in rheumatoid arthritis. | |
| 3046200 | [Effect of intraperitoneal administration of Streptococcus group A and its cell fractions | 1988 May | The effect produced by the intraperitoneal injection of live and heat-killed group A streptococci, the fractions of their cell walls (both intact and sonicated) and cytoplasm was studied on 450 white rats with experimental adjuvant arthritis (AA). The injection of live streptococci into rats with AA decreased the swelling of joints (by 70-80% in the second half of the experiment), reduced the titers of rheumatoid-like factor (RLF), and inhibited the development of polyarthritis. The use of heat-killed streptococci gave a less pronounced antiarthritic effect, while the fraction of streptococcal cell walls, similarly to live streptococci, decreased the swelling of joints (by 27-64%); at the same time a considerable drop in the titers of RLF was observed in 3 experiments, and the development of polyarthritis was registered in 38% of the test animals and in 62% of the control animals. In rats with AA the cytoplasm not subjected to ultracentrifugal purification decreased the swelling of joints (by 21-50%) and the titers of RLF. In this case the development of polyarthritis was observed in 48% of the test animals and in 70% of the control animals. | |
| 2786625 | [Possibilities of current therapy of rheumatoid arthritis]. | 1989 | In cases of systemic diseases such as arthritis, the choice of surgical treatment places demands upon the physician. Any organ system may be involved; not only joints, but also the skin, bone marrow, kidneys, and the vascular or nervous systems. The cervical column is often affected; the elasticity of connective tissue is reduced, and osteoporosis is a predominant feature. The medication used is potent. Surgical treatment of arthritis is of two main categories: reconstructive surgery, which accounts for 60-80 per cent of cases; and synovectomy, for its inhibitory effect on joint destruction, which at most clinics is used in 20-40 per cent of cases. | |
| 3698338 | Circulating immune complexes associated with decreased complement-mediated inhibition of i | 1986 Feb | The sera of patients with bacterial endocarditis frequently contain high levels of circulating immune complexes. In in vitro assays these sera have been shown to be deficient in the complement mediated inhibition of immune precipitation (immune complex solubilization) although C3 and C4 levels were often normal. The deficiency is due to the presence of a factor which also inhibits the ability of normal serum to solubilize immune complexes. This inhibitor is possibly rheumatoid factor which is frequently detected in endocarditis. Serial studies on 16 patients showed the levels of immune complexes, the ability to prevent immune precipitation and rheumatoid factor to correlate with disease activity. The similarity of the findings to those in rheumatoid arthritis are discussed. | |
| 2959290 | Complement C3b receptors on erythrocytes in patients with juvenile rheumatoid arthritis. | 1987 Sep | Forty patients with juvenile rheumatoid arthritis (JRA) were examined for C3b receptor (CR1) levels on erythrocytes (by an enzyme-linked immunosorbent assay), levels of circulating immune complexes (IC) (by a polyethylene glycol precipitation-complement consumption method), C3d split products (by intermediate gel rocket immunoelectrophoresis), and HLA-A, B, and C (by microdroplet lymphocytotoxicity test). Lower CR1 levels were found predominantly among patients with JRA (mean 57%) compared with 40 age-matched controls (mean 68%) (P = 0.008). The CR1 levels differed when the JRA patients were grouped by mode of disease onset and by clinical state at the time of testing (levels in patients with pauciarticular disease were higher than those in patients with polyarticular disease, and levels in patients with polyarticular disease were higher than those in patients with systemic disease) or by sex (girls had higher levels than boys; P = 0.01). The levels of circulating IC and C3d were elevated in 25% and 40% of JRA patients, respectively, and were mutually correlated (P less than 0.05, tau = 0.20). A negative correlation was found between levels of C3d and the numbers of CR1 (P less than 0.01, tau = -0.28), but concentrations of circulating IC did not correlate with CR1 values. CR1 levels were the same in 6 HLA-B27 positive and 25 HLA-B27 negative patients. These findings do not represent conclusive evidence that the number of CR1 on erythrocytes serves as a predictor of disease severity or as an indicator of disease activity in patients with JRA. | |
| 2033325 | Pancreatic ductal morphology and function in primary Sjögren's syndrome. | 1991 Feb | In six patients with primary Sjögren's syndrome defined with HLA-antigens and no clinical signs of pancreatitis, the pancreatic ductal morphology (as described by endoscopic retrograde pancreatography), serum pancreatic enzymes, and fecal fat excretion were examined and secretin test was carried out. Further, oral glucose tolerance test with concomitant determination of serum insulin and C-peptide were done. All patients had at least two pathological signs of exocrine function and/or ductal morphology. There was no evidence of endocrine malfunction. The findings are suggestive of the existence of a clinically silent pancreatitis, perhaps of autoimmune etiology. | |
| 2309104 | Sjögren's syndrome in systemic sclerosis. A clinical study of 26 patients. | 1990 | Features of Sjögren's syndrome were sought in 26 patients with systemic sclerosis and in age- and sex-matched control subjects. The assessments included a structured history to establish symptoms of dry eyes and dry mouth. Schirmer's I and II tear tests. Rose Bengal staining with slit lamp microscopy of the eyes, measurement of basal and stimulatory salivary secretion. We measured sweat secretion rates from the skin. Salivary scintigraphy and skin biopsies were performed on the patients. Only one patient showed the complete picture of Sjögren's syndrome with both clinical and investigational evidence of lacrimal and salivary gland involvement. A further patient had an abnormal Schirmer's II test and xerostomia with reduced salivary secretion and an abnormal scan, but no ocular symptoms and no keratoconjunctivitis sicca on ophthalmological examination. Two patients had reduced salivary flow and a dry mouth. A number of patients and control subjects showed various individual symptoms and signs of lacrimal and salivary disorders. These features alone are not sufficient for the diagnosis of Sjögren's syndrome. There is a clear need to adopt strict criteria for diagnosing the condition. The association of Sjögren's syndrome with systemic sclerosis seems doubtful and if it does occur it is very much less common than previously suggested. | |
| 2715407 | Annular erythema: a possible association with primary Sjögren's syndrome. | 1989 Apr | In four patients with primary Sjögren's syndrome a distinct annular erythema developed, which was characterized by a wide, elevated border (which can be likened to a doughnut ring) and central pallor. Histologically, there was a coat sleeve-like infiltration of lymphocytes around blood vessels and nuclear debris in the connective tissue. Vasculitis or epidermal changes suggestive of lupus erythematosus were not observed, and there was no immunoglobulin deposition along the basement membrane zone. This annular erythema may be a cutaneous manifestation of Sjögren's syndrome. | |
| 2059079 | Cytidine deaminase activity, C reactive protein, histidine, and erythrocyte sedimentation | 1991 Jun | Cytidine deaminase activity, C reactive protein, histidine, and erythrocyte sedimentation rate were measured in 36 subjects with psoriatic arthritis of varying disease duration and severity. Although cytidine deaminase activity may provide an integrated measure of synovial inflammation in rheumatoid arthritis, neutrophil accumulation in psoriatic plaques compromises this measure in psoriatic arthritis. Low histidine concentrations confirm that this amino acid provides a non-specific index of synovial inflammation. In psoriatic arthritis high C reactive protein concentrations seem to be associated with extensive joint destruction. In this study the erythrocyte sedimentation rate was found to be the best laboratory guide to clinical disease activity in psoriatic arthritis. | |
| 3024557 | Subacute sensory neuronopathy secondary to dorsal root ganglionitis in primary Sjögren's | 1986 Oct | Sensory neuropathies, particularly trigeminal neuropathy, have been recognized as neurological complications of Sjögren's syndrome, but the pathogenesis has not been established. We describe a woman with primary Sjögren's syndrome who developed a progressive debilitating subacute sensory neuronopathy. Results of electrophysiological studies were consistent with involvement of the trigeminal and dorsal root ganglia. A thoracic dorsal root ganglion biopsy showed lymphocytic infiltration and degeneration of ganglion cells. We believe that this is the first description of biopsy-documented dorsal root ganglionitis in a subacute sensory neuronopathy associated with Sjögren's syndrome and that the finding suggests an immunopathogenic basis. | |
| 1966921 | [Identification of crystals in synovial fluid]. | 1990 | The basic principles of the determination of crystals in synovial fluid by means of the polarisation microscope are described. The presence of crystals in synovial fluid was determined in 48 patients with the following clinical diagnoses: rheumatoid arthritis, gout, pseudogout, reactive arthritis, in patients with a diagnosis of extraarticular rheumatism: peritendinitis, in patients with reactive arthritis and in 2 patients with injured knee joint. Crystals of Na urate, Ca-pyrophosphate dihydrate and cholesterol were found. The analysis of synovial fluid for the presence of crystals in an important diagnostic procedure contributing greatly to the quick and correct diagnosis of arthritis. | |
| 3321753 | Laboratory features of psoriatic arthritis. | 1987 Sep | Psoriatic arthritis (PA) is regarded as a disease which belongs to the seronegative polyarthritis with a broad clinical pattern. Because of the involvement of the skin and the inflammatory processes in the joints, the disease is of interest to both the rheumatologist and the dermatologist. There are no laboratory findings which are specific to PA, although some abnormalities have been published in the literature with different bases for comparison: PA and healthy people, PA and rheumatoid arthritis (RA), or PA and skin psoriasis. The most probable reason for some of the divergent data found in the literature might be the heterogeneity of the disease, whereby the results represent a mixture of the subtypes of PA. The present paper summarizes the main findings in PA that have been reported in the literature, including the "traditional laboratory findings" and some immunological and biochemical data. | |
| 2291988 | Improvement of pneumonia and arthritis in Felty's syndrome by treatment with granulocyte-m | 1990 Dec | A 63-year old man with Felty's syndrome and pneumonia of unknown origin was treated with GM-CSF. Granulocyte counts increased and arthritis-related symptoms improved under GM-CSF. Pneumonia was treated effectively with antibiotics only during or after GM-CSF application. This suggests, that antibiotic-resistant infections can be treated effectively in patients with Felty's syndrome when granulocyte counts are raised by GM-CSF. | |
| 2754526 | [A diagnostic and etiologic studies of Sjögren's syndrome--II. On the relationship betwee | 1989 Mar | The histopathological findings of the salivary glands in Sjögren's syndrome and of the thyroid gland in chronic thyroiditis have similarity in lymphocytic infiltration of the stroma and decrease or disappearance of parenchyma. In order to investigate the pathogenesis of Sjögren's syndrome, the author performed serological and histopathological examination of the thyroid gland in 89 confirmed cases of Sjögren's syndrome and 26 suspected cases, a total of 115 subjects and the following results were obtained. 1) Thyroidal microsomal and thyroglobulin antibodies were detected in 34.5% and 21.4% of 89 confirmed Sjögren's syndrome. 2) The positivity rate of the antithyroid antibodies increased in the more severe histopathological changes of the thyroid gland and thyroidal microsomal antibody, in particular, reflected the absence or presence of lymphocytic infiltration of the stroma. 3) The correlation between histopathological findings of the thyroid gland and titers of antithyroid antibodies was insignificant. 4) The correlation between histopathological grading of thyroid gland and of salivary glands was insignificant. 5) Approximately 30% of confirmed cases of Sjögren's syndrome presented chronic thyroiditis as a complication, therefore, it was suggested that both Sjögren's syndrome and chronic thyroiditis might have a common etiology. | |
| 2845007 | Subacute sensory neuronopathy associated with Sjögren's sicca syndrome. | 1988 Jul | Sensory subacute neuropathies associated with sicca syndrome without any systemic involvement have been reported rarely. A sixth case is described with what appears to be the first report of muscle and nerve biopsy findings. The histological studies revealed axonal degeneration without vasculitis in the sural nerve, and a slight denervation process and a discrete myositis in the gastrocnemius muscle, reflecting a subtle systemic disorder. The clinical course of a long-standing subacute sensory neuropathy, the biopsy-documented axonal degeneration, and the neurophysiological findings suggest involvement of the dorsal root ganglia. | |
| 2396222 | [The regional circulation of the parotid gland in Sjögren's disease]. | 1990 | Morphological methods, rheography and coagulography were used to study regional circulation in the parotid salivary gland (PSG) in 20 patients with the primary dry syndrome (Sjögren's disease). It has been established that in the presence of immune inflammation with the predominance of traits characteristic of delayed-type hypersensitivity, the vascular bed of the PSG undergoes transformation (changes in the tone, elasticity of vessels, blood flow rate, dystonia of resistive and atonia of capacitance microvessels, lymphostasis, and so forth). The changes in regional circulation are not infrequently coupled with a high concentration of fibrinogen and low fibrinolytic activity of the blood tending towards hypercoagulation. | |
| 2584458 | Annular erythema associated with primary Sjögren syndrome: analysis of T cell subsets in | 1989 Dec | Immunohistochemical analysis was performed on the annular erythema associated with Sjögren syndrome. This type of annular erythema is characterized by a doughnutlike appearance with an elevated border and central pallor; it is distinct from subacute cutaneous lupus erythematosus. Histologically this erythema is characterized by coat sleeve-like infiltration of lymphocytes around blood vessels and by nuclear debris in the connective tissue. Vasculitis or epidermal changes suggestive of lupus erythematosus were not observed in any of the cases, although immunoglobulin or complement deposition along the basement membrane zone and focal liquefaction degeneration of the basal layer in involved skin were seen in some cases. Major dermal infiltrates consisted primarily of CD4+ and 4B4+ lymphocytes. |