Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2060159 | Increased bronchial responsiveness in primary Sjögren's syndrome. A sign of tracheobronch | 1991 Mar | Thirty-six patients with primary Sjögren's syndrome (pSS) and 60 healthy volunteers underwent provocative bronchial testing with aerosolized dosed methacholine. On the average, pulmonary functions tests performed before bronchial testing were normal. However, 18/36 patients (50%) had bronchial hyper-responsiveness (BH), an incidence higher that that found in our control population (6.6%). No difference between BH and normally responsive patients was found in the duration of disease, immunological abnormalities or symptoms, and only the FEF50 was significantly lower in the BH group. It is therefore hypothesized that in pSS bronchial hyper-responsiveness may be due to lymphocytic inflammation and an alteration in secretion secondary to gland damage. | |
| 2198166 | Increased bronchial responsiveness in primary and secondary Sjögren's syndrome. | 1990 May | We examined one group of 33 patients with primary Sjögren's syndrome, one group of 17 patients with secondary Sjögren's syndrome, i.e. associated with other connective tissue diseases, and one group of 14 patients with connective tissue diseases but without Sjögren's syndrome. In each patient we obtained chest radiographs and measured lung volumes, carbon monoxide diffusing capacity and airway responsiveness to methacholine. We observed no difference in chest radiograph abnormalities, in lung volumes and in carbon monoxide diffusing capacity among the three groups. However, we found a slight but significant increase of bronchial responsiveness in patients with primary and secondary Sjögren's syndrome compared with patients with connective tissue disorders but without Sjögren's syndrome. Thus PD20FEV1 methacholine was 1.07 mg (1.2) (geometric mean and GSEM) in primary Sjögren's syndrome, 0.91 mg (1.4) in secondary Sjögren's syndrome (NS), and 2.24 mg (1.09) in patients with connective tissue diseases but without Sjögren's syndrome (t = 2.59 and t = 2.8, both p less than 0.05, vs primary and secondary Sjögren's syndrome, respectively). These results show that some patients with Sjögren's syndrome have mild bronchial hyperresponsiveness, which may be related to the specific airway abnormalities of this disease. | |
| 2736826 | Clinical ophthalmological tests for the diagnosis of keratoconjunctivitis sicca. | 1989 Mar | According to the Copenhagen criteria for Sjögren's syndrome, the diagnosis of keratoconjunctivitis sicca requires the performance of 3 objective ocular tests of which 2 should give pathological results. The tests presently in use are: Break-up time, Schirmer-1-test and Rose-Bengal score. A list of clinical ophthalmological tests has been established in order to enable various SS-study groups to compare results. The list has 3 groups, each containing tests evaluating mainly one characteristic function of the lacrimal system: Tear production, tear quality and ocular surface condition. The tests of the list have been evaluated in 10 1 degree SS-patients and in 10 incipient SS patients. The diagnostic sensitivity and the accuracy of various combinations of the 3 tests have been evaluated. It is suggested that SS-study groups should select one of the marked (*) tests from each group on the list, and that KCS should be defined present, when 2 of the selected 3 tests show pathologically changed results. (table; see text). | |
| 3511018 | Sjogren's syndrome in an adolescent. | 1986 Jan | Sjogren's syndrome is a chronic autoimmune disorder characterized by keratoconjunctivitis sicca, xerostomia, and recurrent enlargement of the salivary glands. Most commonly noted in adults, it rarely affects adolescents. We describe a 15-year-old adolescent with recurrent parotid enlargement as an initial manifestation of this disease. | |
| 2076121 | [Sjögren's syndrome]. | 1990 Oct | We carry out an updated review of Sjögren's syndrome on occasion of the presentation of three new clinical cases whose oral manifestations led the patients to first seek help. Each patient was subjected to clinical exploration, together with complementary evaluations, aimed at establishing an early and precise diagnosis of the syndrome. We consider it important to adopt a series of standardized diagnostic criteria and revise treatment to maintain the orodental conditions as favorable as possible. | |
| 3729577 | Angioimmunoblastic lymphadenopathy with dysproteinaemia (AILD) and sicca syndrome. | 1986 Jun | We report a case of AILD and sicca syndrome. The patient had presented with renal insufficiency, lymphadenopathy, hepatosplenomegaly, polyclonal hypergammaglobulinaemia, dryness of the eyes and mouth. Lip biopsy specimens showed an unusual cellular infiltrate similar to his kidney lesions. Data from the eight previously reported cases support the hypothesis that the association is a distinct pathological entity differing from pseudolymphoma and malignant lymphoma, which occur in the course of Sjögren's syndrome. The recognition of AILD is important because lymphoproliferation may lead to death after a few months. | |
| 3365531 | Prevalence of primary Sjögren's syndrome in an elderly population. | 1988 Apr | Sixty-two elderly apparently healthy volunteers, inmates of a public nursing home, were examined for evidence of primary Sjögren's syndrome (pSS). Evaluation included a specific questionnaire for subjective xerophthalmia and xerostomia, slit-lamp eye examination after rose Bengal staining. Schirmer's I test, stimulated parotid flow measurement, testing of sera for autoantibodies and labial minor salivary gland biopsy. A greater than or equal to 2+ lip biopsy score on Tarpley's scale was a sine qua non for the diagnosis of Sjögren's syndrome. Labial salivary gland (LSG) biopsy revealed fibrosis and/or fatty infiltration in the majority of the individuals, related to ageing. However, four people had a lip biopsy score of greater than or equal to 2+, which, supplemented by other objective criteria, classified three of them as having pSS. Another four had an LSG biopsy score of 1+, and although they fulfilled other objective criteria, they could not be characterized as pSS. All these individuals were completely asymptomatic, and none of them had anti-Ro(SSA) or anti-La(SSB) autoantibodies. The present study suggests that pSS in elderly people in elderly people is subclinical, benign and relatively common. | |
| 3260689 | [The autoantibody profile in Sjögren's syndrome]. | 1988 | The serological profiles of 54 patients clinically diagnosed as pSS and 92 RA patients with or without sSS were retrospectively evaluated and correlated with different SS subgroups, degree of minor salivary gland biopsy lymphocytic infiltrates, and the presence of glandular and extraglandular manifestations. Anti-Ro, anti-La and RF correlated with the development of pSS, while in RA, ANA and anti-Ro were associated with the presence of sSS, and anti-La were practically absent. In pSS patients the incidence of anti Ro and anti-La as well as the titers of ANA and RF correlated with a degree of salivary lymphocytic infiltrates (1+ to 3+). In class 4+ a substantial decrease in autoantibodies was noted. In pSS patients anti-Ro and anti-La correlated with earlier disease onset and longer disease duration, recurrent parotid gland enlargement (RPGE) and extraglandular manifestations, particularly splenomegaly and/or lymphadenopathy and vasculitis. Anti-Ro correlated with positive Schirmer's test, ANA with decreased parotid flow rate and extraglandular manifestations, whereas RF correlated with RPGE and subjective xerostomia. In RA patients autoantibodies were mainly found in the presence of xerophthalmia. ANA correlated with positive Schirmer's test, Rose-Bengal staining and subjective xerophthalmia, the latter also correlated with anti-Ro. This study reemphasized the diagnostic importance of autoantibodies for SS. | |
| 3677784 | Lacrimal gland, cornea, and tear film in the NZB/NZW F1 hybrid mouse. | 1987 Oct | The NZB/NZW F1 hybrid mouse has been reported to contract a disease similar to Sjögren's syndrome in man. We studied lacrimal gland morphology, corneal morphology, and tear osmolarity in this mouse as a function of age. Lacrimal glands of hybrid mice contained abnormal periductal infiltrates of lymphocytes and plasma cells. Maximum infiltration of the lacrimal gland occurred in the 29-week-old female hybrid mouse and was estimated to involve 12% of the gland, but was insufficient to alter tear osmolarity relative to DBA and Balb/c control mice. Nevertheless, both NZB/NZW F1 hybrid mice and DBA and Balb/c control mice had tear osmolarity and corneal surface morphology similar to that reported for keratoconjunctivitis sicca in man. Although the NZB/NZW F1 hybrid mouse may provide a valuable model for the study of lacrimal gland infiltration, since its tear osmolarity and ocular surface remain normal for a mouse, its usefulness as a model for ocular surface disease in human keratoconjunctivitis sicca may be more limited than previously thought. | |
| 2883940 | Sulphasalazine and regression of rheumatoid nodules. | 1987 Mar | The regression of small rheumatoid nodules was noted in four patients after starting sulphasalazine therapy. This coincided with an improvement in synovitis and also falls in erythrocyte sedimentation rate (ESR) and C reactive protein (CRP). The relation between the nodule regression and the sulphasalazine therapy is discussed. | |
| 1869118 | [Neurologic complications of primary Sjogren's syndrome]. | 1991 Mar 1 | Primary Sjogren's syndrome has a wide clinical spectrum, ranging from an exocrinopathy to a systemic process and even extending to B-lymphocyte neoplasia. We describe a patient with this syndrome who developed central nervous system involvement manifested by involuntary dystonic movements of the mouth and larynx. We believe that the neurological involvement in this patient is part of his basic disease. Further studies are required to define more accurately the frequency, severity and spectrum of the neurological manifestations associated with primary Sjogren's syndrome. | |
| 3263241 | Immunological patterns in monoarticular juvenile rheumatoid arthritis. | 1988 Jul | Seven pediatric patients with monoarticular arthritis, three of whom had a recent onset form and the remaining four a disease of longer duration, were examined for possible modifications of their immunological parameters. The diagnosis of JRA was made on all these patients according to the ARA criteria after a follow-up of at least two years. Humoral and cellular abnormalities of the immune system were searched for in peripheral blood, synovial fluid and synovial membrane. No evidence for complement consumption and for increased levels of immune-complexes was found in the sera and in the synovial fluids of these patients, who were all seronegative. Some patients had antinuclear antibodies in their sera and synovial fluids. With regard to the lymphocyte distribution, whereas only some patients had an increased number of circulating B cells, the majority had a decreased CD4+/CD8+ ratio in the synovial fluid compared to the ratio found in the peripheral blood. A massive infiltration of CD4+ cells and macrophages and the presence of a substantial number of OKT9+ cells was found in the synovial membranes. | |
| 3473636 | Confirmatory tests for the dry eye of Sjögren's syndrome. | 1986 | The diagnosis of moderate degrees of tear depletion is difficult using conventional tests such as the Schirmer test, clinical evidence and even a confirmatory test such as the lysozyme test. We have refined the lysozyme test using quantitative techniques and calibrated standards. We found this satisfactory on a population basis, but not on an individual basis. We developed an ELISA test for assaying five tear proteins 'lysozyme, lactoferrin, ceruloplasmin, IgA and IgG' which gives a much more accurate assessment of dryness on an individual patient level. | |
| 3238365 | Acquired transient autoimmune reactions in Lyme arthritis: correlation between rheumatoid | 1988 | Lyme spirochaetal disease (LSD) is a complex multisystem disorder which has been recognized as a separate entity due to its close geographic clustering of affected patients. The study aimed at evaluating the clinical and immunological features of LSD with chronic symptoms of meningoradiculitis, carditis and pauciarticular arthritis. Six patients with LSD and erosive arthritis who developed an increase of serum IgM rheumatoid factor (RF) which correlated with the inflammatory activity of the disease are described in detail. Besides raised IgG antibody titers to Borrelia burgdorferi (B. burgd.) antigen measured by ELISA technique, circulating immune complexes, antinuclear antibodies (ANA) and RF measured by laser nephelometric immunoassay were detected. Increased ANA and RF antibody rates suggest that LSD may closely be linked with transient autoimmune phenomena. Thus, in some cases, B. burgd. antigens might be able to produce a strong polyclonal B-cell stimulation, hence leading to an unspecific autoimmune reaction. But the question remains if transient unspecific autoimmune reactions actually take part in the pathogenesis of LSD. | |
| 2645874 | A double-blind placebo-controlled study of auranofin in patients with psoriatic arthritis. | 1989 Feb | Two hundred thirty-eight patients with psoriatic arthritis were entered into a 6-month, multicenter, double-blind trial comparing auranofin and placebo. Polyarthritis (greater than 5 tender joints) was present in 90% of the patients, and 94% were seronegative. Auranofin treatment was statistically superior to placebo treatment, according to physician's global assessment and functional scores. A trend in favor of auranofin treatment was seen for each of the other disease parameters studied. Psoriasis worsened in 6 auranofin-treated patients and in 3 placebo-treated patients. The incidence and nature of other side effects were similar to those observed in similar trials of patients with rheumatoid arthritis. Our observations suggest that the use of auranofin in the treatment of psoriatic arthritis is safe, although its therapeutic advantage over treatment with nonsteroidal antiinflammatory drugs alone is modest. | |
| 2962720 | Digital foot deformities in the arthritic patient. | 1988 Jan | Relieving pain and preventing deformity in the rheumatoid foot are best accomplished early in the disease course. Although the treatment of digital deformities may not differ significantly in the rheumatoid versus the nonrheumatoid patient, early and more aggressive management is most important in the rheumatoid patient. The digital deformities associated with inflammatory arthritis are progressive as long as the disease is active. Therefore, it becomes necessary to treat these patients both medically and mechanically to slow the progression of the digital deformities. In determining whether medical, surgical, or biomechanical treatment options are appropriate, the physician must examine multiple considerations. These include disease activity, presence or absence of symptoms, degree of deformity and resultant potential for complications, shoe intolerance, and level of activity. Changing attitudes have dictated that little benefit is gained from withholding treatment until the disease is so-called burnt out. It is in the patient's best interest to maintain function whenever possible to allow for increased productivity. The psychosocial ramifications of this approach are obvious. | |
| 1912231 | [The R3SPE syndrome. Presentation of 3 clinical cases]. | 1991 May | The R3SPE syndrome represents a new disorder included in the inflammatory rheumatisms of old age, being related to rheumatoid arthritis. It differs from the latter in some clinical and evolutive peculiarities. Its etiology and pathogenesis are unknown. The best treatment, purely symptomatic, consists of the association of aspirin and synthetic antimalarial drugs. Low-dose corticosteroids are very effective in initial stages. We report three patients and their clinical, evolutive and therapeutic features. | |
| 2023196 | Palindromic rheumatism: a response to chloroquine. | 1991 Jan | We reviewed 71 patients with palindromic rheumatism. The average length of followup was 3.6 years. Fifty-one patients received antimalarial therapy. Forty-one of the 51 patients experienced marked improvement with 77.5% reduction in frequency and 63% reduction in duration of attacks. Sixteen out of the 71 patients developed persistent arthritis in the form of rheumatoid arthritis (12 patients), systemic lupus erythematosus (2 patients), Crohn's disease (1 patient) and asymmetric seronegative arthropathy (1 patient). Chloroquine therapy, therefore, seems effective in relieving palindromic rheumatism. | |
| 2379046 | What do rheumatologists do? A pilot audit study. | 1990 Aug | Four consultant rheumatologists from different health districts compared their out-patient and in-patient workloads for 3 months. Data collection proved simple and valuable to each local unit. Inflammatory joint disease (particularly severe rheumatoid arthritis) dominated the workload in all centres. Large differences in the number of new referrals with osteoarthritis, soft tissue diseases and polymyalgia rheumatica were observed. Differences were also apparent in the organization of clinics, provision of follow-up appointments for different diagnostic groups, and usage of steroid injections. Although there may be a variety of explanations for these similarities and differences, the data emphasize the need for further audit of rheumatology practice in the UK. | |
| 3445028 | [Autoimmune pathology and esthetic surgery. Apropos of a case]. | 1987 Nov | The authors report the case of a 46-year old woman who, 7 years after bilateral implantation of a silicone breast prosthesis, presented with a seropositive rheumatoid arthritis involving the shoulders, wrists, metacarpophalangeal and interphalangeal joints of both hands, as well as the knees and ankles. Six months after the onset of the arthritis, she developed a Raynaud's syndrome and a lacrymal and salivary dry syndrome with unilateral axillary lymphadenopathy. No regression followed the removal of the breast prostheses, one of which was found broken. |