Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2605781 | Fragmented fibronectin and other synovial fluid proteins in chronic arthritis: their relat | 1989 Sep 29 | Fibronectin, an opsonic glycoprotein has been shown to exist in fragmented forms in serum and synovial fluid. Some fragments in synovial fluid appear to be polyethylene glycol (PEG) precipitable, suggesting incorporation into immune complexes (IC). PEG precipitation, SDS-PAGE and immunoblotting were used to determine whether PEG precipitable fragments are real or artefactual. Disease specificity of fragmentation and IC incorporation of fibronectin and other proteins were also studied using these techniques. PEG precipitable fragments do not appear to be artefactual, although some fibronectin fragments are cryoprecipitable. Protein fragments showed similar distributions in whole serum and synovial fluid, disease specific differences being confined to PEG precipitates. Rheumatoid arthritis (RA) synovial fluid PEG precipitates displayed the greatest array of fragmented immunoglobulins and fibronectin. No PEG precipitates contained albumin fragments. Protein fragments in IC may impair their effective removal from RA joints. Accumulated IC could lead to tissue damage via complement activation. | |
| 3251353 | The major leukocyte protein L1 as an indicator of inflammatory joint disease. | 1988 | L1 is a major protein in granulocytes and monocytes. It is released during activation of these cells, and the plasma level of L1 is therefore thought to reflect the turnover of leukocytes. Peripheral blood from 96 patients hospitalized in a rheumatological department, was analysed for L1, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). The total patient material was divided into groups depending on diagnosis: 47 patients with rheumatoid arthritis, 27 patients with arthritis of different etiologies, 15 patients with non-inflammatory diseases and 7 patients with arteritis. Correlation analysis were made between the different laboratory parameters. A high positive correlation was found between L1 and CRP in all the groups, and with a correlation coefficient of the total patient material of 0.68 (p less than 0.001). The correlation coefficient between L1 and ESR was 0.54 (p less than 0.001) in the total patient material, and between CRP and ESR it was 0.66 (p less than 0.001). The results indicate that the L1 protein could be a new laboratory marker of inflammation in rheumatic diseases. | |
| 3293626 | The detection of measles specific immunoglobulin M antibodies using biotinylated antigens. | 1988 Jun | The methods of reverse type enzymeimmunoassay (EIAs) with biotinylated antigens were used to determine IgM antibodies to measles virus in human sera. These antigens, either purified measles virus antigen or lysate type measles-vero antigen with lysate vero control antigen, were used in the two separate IgM-tests. Paired sera from 15 measles patients as well as 456 sera from patients with viral infections other than measles, with mycoplasma pneumoniae infections, from rheumatoid arthritis patients and blood donors, were assayed in a dilution of 1:200. Both the test systems detected all the 30 serum specimens from the measles patients as measles IgM positive, but the sera of all the other groups proved to be measles IgM negative. These tests developed for measles specific IgM antibodies, avoiding the interference of IgM-class rheumatoid factor, offer valuable tools for routine virus serology. | |
| 2260997 | Clinical and pathologic studies of twenty-six patients with penetrating foreign body injur | 1990 Dec | Foreign body synovitis has been neglected in the rheumatology literature. We describe 26 patients in whom arthritis, bursitis, or tenosynovitis appeared within 1 day to 7 years after an initial injury by a penetrating foreign body. Twenty-two patients presented with acute synovitis, which was followed by chronic or recurrent inflammation mimicking septic arthritis, osteomyelitis, monarticular juvenile rheumatoid arthritis, bone tumor, or apatite deposition disease. Foreign bodies were not seen in 5 inflammatory synovial fluids studied, but were seen in the synovium or periarticular tissues of 17 patients. Excisional biopsy was required in most patients for precise diagnosis and treatment. | |
| 1711425 | Diversity of the immune response to bovine type II and XI collagens in rats. | 1991 Jan | Immunisation of rats with native type II or type XI collagen produced an inflammatory arthritis in certain strains of rats. Antibodies to the native and denatured whole molecules, to the individual alpha chains and to the cyanogen bromide derived peptides of these chains were studied. Inter- and intra-strain variation in the specificity of the antibodies produced was seen and there were also changes with time, especially with the rats immunised with type XI collagen. Both collagen type-specific and cross-reacting antibodies were produced following immunisation with either type II or type XI collagen. Although no specific pattern of antibodies was unique to the presence or absence of arthritis in all rats, antibodies that bound to the CB-11 peptide or antibodies that bound to the CB-9,7 peptide of type II collagen occurred at the time of onset of arthritis in type II or type XI immunised, arthritic rats. Antibodies to these peptides occur in many patients with rheumatoid arthritis (RA) who also have antibodies to type II collagen. Therefore these findings suggest that epitopes on these peptides may be important in the continued production of antibodies to these collagens in patients with RA and that these antibodies may indeed be pathogenic. | |
| 1765982 | Rheumatic manifestations in populations at risk for HIV infection: the added effect of HIV | 1991 Oct | We assessed the frequency and variability of rheumatologic manifestations in 2 populations with similar risk factors for human immunodeficiency virus (HIV) infection, of which only one was affected. We studied 2 populations at risk for HIV infection (homosexual and intravenous drug users). Group A: 89 individuals carried the virus; and Group B: 80 individuals were HIV negative. In Group A (HIV+) 66.1% had rheumatic manifestations including arthralgias, Reiter's syndrome, arthritis, enthesitis, psoriatic arthritis, Sjögren's syndrome, myopathy, septic arthritis, and lupus-like illness. In contrast, in Group B (HIV-) only 2 had arthralgias, 2 Reiter's syndrome, and 1 rheumatoid arthritis. In summary, rheumatic complaints are common in patients with HIV, and HIV positivity confers an increased susceptibility in populations with similar risk factors for HIV infection. | |
| 1671848 | A diallelic RFLP of the CD3-epsilon chain of the clonotypic T-lymphocyte receptor is not a | 1991 Feb | A diallelic restriction fragment length polymorphism of the CD3-epsilon (epsilon) gene, which encodes for an invariant component of the human T-lymphocyte receptor, is observed when using genomic DNA TaqI digests probed with a CD3-epsilon chain cDNA probe. This combination shows two alleles of 9.1 kb and 8.4 kb with a frequency of 0.66 and 0.34, respectively, in the Spanish population. None of these alleles is associated with susceptibility to juvenile rheumatoid arthritis (JRA) or insulin-dependent diabetes mellitus (IDDM). | |
| 1782984 | Steady state pharmacokinetics of piroxicam in children with rheumatic diseases. | 1991 | Ten children with rheumatoid arthritis, aged 7-16 y and weighing 20-63 kg, were treated with piroxicam mean dose 0.4 mg.kg-1 once daily for 2 weeks. On Day 15, blood was sampled from 2-120 h after the last dose. The Cmax for piroxicam ranged from 3.6 to 9.8 (mean 6.6) mg.l-1 and its half-life by log linear computation was 22 to 40 (mean 32.6) h. The volumes of distribution and the total body clearance were estimated as the ratio of actual volumes of distribution and actual clearances to availability. The volumes of distribution (V/F) were 0.12 to 0.25 (mean 0.16) l.kg-1, and the total body clearances (CL/F) were 2.1 to 5.0 (mean 3.4) ml.kg-1.h-1. Thus, piroxicam clearance in these patients was higher and its half-life was shorter than those previously reported in young adults, yet V appeared similar. | |
| 2043444 | Hematologic disorders in rheumatic disease. | 1991 Feb | The 1990 literature relating to hematologic disorders in rheumatic disease is reviewed. Two main subject areas of general interest are identified. The anemia of chronic disease has been reviewed and shown to be associated with a variety of medical conditions. Generalized reticuloendothelial hyperplasia associated with heavy-chain disease is a poorly recognized complication associated with rheumatoid arthritis and may be mistaken for underlying sepsis in these patients. | |
| 2023179 | Hemorrhagic subcutaneous bursitis. | 1991 Jan | Hemarthrosis is a well recognized complication of a number of conditions. Hemorrhagic subcutaneous bursitis is less understood. We encountered a patient with a myeloproliferative disease who developed hemorrhagic olecranon bursitis. Upon reviewing other patients with subcutaneous bursitis, we found that hemorrhagic bursitis also occurs in the setting of traumatic or idiopathic bursitis, rheumatoid arthritis, gout, and septic bursitis. | |
| 2684502 | Diclofenac. | 1989 Oct | Diclofenac is the newest NSAID to be introduced to the United States. Extensive worldwide clinical studies with diclofenac have demonstrated its efficacy in the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Its overall safety and efficacy is comparable to other available NSAIDs. The potential advantage of diclofenac is its short serum half-life but long synovial fluid concentration which enables twice daily dosing. | |
| 3759639 | Transmural pyloric perforation associated with naproxen administration in a dog. | 1986 Sep 15 | Naproxen, a nonsteroidal anti-inflammatory drug developed for use in man for relief of pain and discomfort associated with rheumatoid arthritis, was believed responsible for a transmural pyloric perforation in a dog. The perforation was repaired surgically. | |
| 2643047 | Yersinia antigens in synovial-fluid cells from patients with reactive arthritis. | 1989 Jan 26 | We examined synovial-fluid cells from 15 patients with reactive arthritis after yersinia infection for the presence of yersinia antigens. Extensive bacterial cultures of the synovial fluid were negative. All the samples were studied by immunofluorescence with use of a rabbit antiserum to Yersinia enterocolitica O:3 and a monoclonal antibody to Y. enterocolitica O:3 lipopolysaccharide. Synovial-fluid cells from 41 patients with other rheumatic diseases served as controls. Synovial-fluid cells from 10 patients with reactive arthritis after yersinia infection stained positively on immunofluorescence; rabbit antiserum and the monoclonal antibody yielded similar results. In most patients the percentage of positive cells ranged from 1 to 10 percent, but in one patient nearly all the cells in the sample stained strongly. Most of the positively stained cells were polymorphonuclear leukocytes, but yersinia antigens were also found in mononuclear phagocytes. All the control samples were negative. Synovial-fluid cell deposits from nine patients were also studied by Western blotting with use of the same antibodies. The results were positive in six of the nine cell deposits from patients with reactive arthritis and in none of the 10 cell deposits from control patients with rheumatoid arthritis. We conclude that in patients with reactive arthritis after yersinia infection, microbial antigens can be found in synovial-fluid cells from the affected joints. | |
| 3207378 | Constrictive pericarditis complicating dermatomyositis. | 1988 Nov | Chronic constrictive pericarditis may complicate both rheumatoid arthritis and systemic lupus erythematosus. To our knowledge, however, this is the first time it has been described in a patient with dermatomyositis. This association should be kept in mind as constrictive pericarditis should be considered in the differential diagnosis of liver cirrhosis and Budd-Chiari syndrome in rheumatic diseases. | |
| 3579468 | [Severe, refractory neonatal inflammatory syndrome as the manifestation of a systemic mult | 1987 Feb | A neonate presented with an inflammatory syndrome with multisystemic manifestations. There was no remission until age 6 years, despite anti-inflammatory treatments. Neonatal onset and neuromeningeal manifestations identified a peculiar rare inflammatory syndrome, whose relationship with juvenile rheumatoid arthritis is discussed. In the case reported, renal, abdominal, deep lymphatic and cranial involvements were present: these have not been previously reported. | |
| 3493052 | The spectrum of rheumatic diseases in Saudi Arabia. | 1987 Feb | The spectrum of rheumatic diseases seen in Saudi Arabia appeared to be broadly similar to that seen in the West although interesting differences were noted. Rheumatoid arthritis was the predominant inflammatory joint disease, but was less severe. Ankylosing spondylitis is probably rare among the Saudis. Brucellosis was an important cause of acute back pain. Osteoarthritis was characterized by frequent involvement of the knee while the hip was rarely involved. Environmental factors may be responsible for this disease pattern. Regional pain syndromes, associated with obesity, bad posture, and poor physical fitness were also frequent problems. | |
| 3794236 | Rupture of extensor digitorum communis after distal ulnar styloidectomy. | 1986 Nov | Attrition ruptures of tendons in the hand, other than those caused by rheumatoid arthritis, are rare. We report a case in which high styloidectomy of the distal ulna caused the rupture of the extensor digitorum communis tendon to the long finger. This complication can be avoided by resection of the smallest segment of the distal ulna that is compatible with relief of the problem. Soft tissue closure over the resected end of the ulna should also be carried out. | |
| 3722779 | Mycobacterium chelonei tenosynovitis of the hand: a case report. | 1986 Jul | We report an unusual organism, Mycobacterium chelonei, which causes digital tenosynovitis. Atypical mycobacterial infections of the hand are uncommon. The diagnosis should be suspected when there is persistent swelling or tenosynovitis, inconsistent with other inflammatory processes such as rheumatoid arthritis. Synovial biopsy specimen and appropriate cultures are necessary to confirm the diagnosis. | |
| 3213267 | Recurrent rupture of a popliteal cyst in a patient with chronic tophaceous gout. | 1988 May | Popliteal cysts which rupture to mimic a deep vein thrombosis (DTV) can be seen in rheumatoid arthritis and other inflammatory arthritides. Gout with cystal synovitis and ruptured popliteal cyst has only been sporadically reported and nowhere has this occurred more than once. | |
| 3693846 | Intraosseous ganglion of the distal ulna. | 1987 Nov | A patient with wrist pain and cystic changes of the ulnar head is presented. This x-ray finding has not previously been reported in patients without rheumatoid arthritis. At the time of operation a tear of the triangular fibrocartilage was present. |