Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3101709 | [Interferon-gamma in the therapy of chronic polyarthritis]. | 1986 Oct | The paper gives a survey of the studies with interferon-gamma and the actual status of the clinical trials with this substance concerning rheumatoid arthritis (RA). About 60% of the patients with RA respond to the therapy. In the initial therapy which covers a time of 2 to 6 weeks 50 micrograms (in case of side effects 20 or 10 micrograms) should be given 3 to 7 times per week by the subcutaneous route. When the disease is improved, the maintenance therapy starts. According to the patient's status, the dosage frequency and the dose have to be reduced to sustain the effect. | |
| 3553248 | Gold therapy and its indications in dermatology. A review. | 1987 Apr | Gold compounds have long been known as therapeutic agents and have been used extensively in the treatment of rheumatoid arthritis. Their mechanisms of action in vivo, however, remain unclear. In comparison to parenteral gold, the pharmacokinetics of a newly available oral compound, auranofin, differ greatly. Auranofin also appears to have specific immunomodulatory actions and to be associated with fewer and milder toxic effects. The role of chrysotherapy in dermatology has been reemphasized recently. It may be used as an adjuvant in pemphigus or other steroid-responsive diseases to help control disease activity and to taper or eliminate corticosteroid therapy more rapidly. Reports on the use of gold in dermatology are otherwise limited. They include one case of epidermolysis bullosa acquisita and psoriatic arthritis. The benefits of gold treatment have to be weighed against the risks inherent in its adverse reactions, some of which are serious and unpredictable. | |
| 3740979 | New methods in arthroscopy: preliminary investigations. | 1986 Jul | The microhysteroscope, which affords direct in vivo observation of otherwise inaccessible surfaces, can be used to great advantage in arthroscopy. Although conventional arthroscopy can distinguish between 'inflammatory' and 'reactive' (post-traumatic) synovial changes, the microendoscope offers the possibility of more precise differentiation. Synovial membranes, joint cartilage, and menisci were studied at four different magnifications, including microscopic observation of vitally stained cells. Frankly pathological synovia (e.g., rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis) were compared and distinguished from examples of less florid synovial changes. The fibrocartilaginous structure of the menisci and secondary undulations and tertiary depression of joint cartilage become visible in vivo with the microendoscope; these may well point to early damage to these structures. The authors believe that the three dimensional images at the magnifications provided by this microendoscope go some way towards bridging the gap between the conventional arthroscope, the light microscope, and the scanning electron microscope. This report presents preliminary findings with this new technique. | |
| 3284676 | Extensive hemosiderin deposition in the medial meniscus of a knee. Its possible relationsh | 1988 May | Hemosiderin deposition in the tissues of the musculoskeletal system is unusual, and deposition of these pigments in the menisci of the knee is extremely rare. Conditions that may predispose to these changes include rheumatoid arthritis, hemochromatosis, pigmented villonodular synovitis, hemophilia, and tuberculous arthritis. A 79-year-old woman developed extensive hemosiderin deposition in the medial meniscus of a knee. Hemosiderin within meniscal chondrocytes was associated with degenerative joint disease and suggested a cause and effect relationship. | |
| 3404321 | Juxtaarticular bone loss in experimental inflammatory arthritis. | 1988 | The osteopenia associated with experimental inflammatory arthritis was studied by a histomorphometric method that exphasized net changes in bone composition. Juxtaarticular trabecular bone volume and turnover were studied in the carrageenan injection model of inflammatory arthritis of the mature rabbit knee. Trabecular bone volume was studied by histomorphometry of the femoral condyles and confirmed by photodensitometry on standard macroradiographs. Osteogenesis was studied by imaging of calcein fluorochrome-labeled newly formed bone in undecalcified histological sections. A significant net loss of cancellous bone (approximately 20%) occurred over 49 days in both the medial and the lateral femoral condyle in the arthritis group compared with normal controls. Total osteogenesis was increased fourfold and it was calculated that an even greater increase in total bone resorption was responsible for the negative bone balance. There is evidence that the periarticular bone loss of human rheumatoid arthritis is also associated with increased bone turnover. Quantitative studies of the kinetics of bone remodeling in inflammatory arthritis will provide the basis for therapeutic attempts to prevent or reverse arthritis-induced bone loss. Fracture risk in inflammatory arthritis may be increased not only by osteopenia, but additionally by the presence of a large proportion of newly formed (and presumably less mineralized) bone. | |
| 1883700 | Metabolic bone disease associated with systemic disorders. | 1991 Jun | Osteoporosis occurs in patients with rheumatoid arthritis, acromegaly, anorexia nervosa, chronic liver disease, sickle cell hemoglobinopathies, and mastocytosis. Osteomalacia occurs in patients with renal tubular acidosis, and with tumors. | |
| 2003394 | Osteolysis after ceramic-on-ceramic hip arthroplasty. A case report. | 1991 Feb | A patient with rheumatoid arthritis operated on with insertion of an uncemented ceramic-on-ceramic Mittelmeier total hip developed an extensive, rapidly evolving osteolysis around the prosthetic stem, which in turn fractured spontaneously after 5 years. Aggressive bone resorption cannot be prevented by exclusion of polyethylene and bone cement from hip arthroplasty. | |
| 2348071 | Traumatic rupture of the profundus tendon proximal to the lumbrical origin. | 1990 May | Traumatic flexor tendon ruptures are rare in patients without rheumatoid arthritis. A case of closed flexor digitorum profundus tenon rupture in the palm, proximal to the lumbrical origin, is presented. Thorough patient evaluation revealed no associated tendinous or bony pathology. | |
| 2519327 | [Palindromic rheumatism]. | 1989 | 49 cases of palindromic rheumatism with a follow-up of 25 years, are reported. More than half of the patients (58%) had their first symptoms between the age of 20 and 39. The knee was the joint the most frequently affected. Five patients had later a rheumatoid arthritis, one had a psoriatic rheumatism, one a cutaneous vasculitis and one had a sero-negative spondylarthropathy. Two patients were completely cured. | |
| 27452055 | Children, Sports, and Chronic Disease. | 1990 Oct | In brief Chronic disease afflicts several million children in the United States, many of whom face the additional burden of having their physical activities unnecessarily restricted. Yet sports and exercise can alleviate symptoms as well as improve a child's psychosocial development and quality of life. Physicians should consider prescribing exercise programs for children with cystic fibrosis, congenital heart disease, juvenile rheumatoid arthritis, and asthma. They should also strongly advocate these children's right to engage in whatever levels of physical activity will allow them to reach their potential. | |
| 21234066 | Immunogenetic markers in rheumatic diseases. | 1990 Mar | Certain genetic markers in the major histocompatibility complex have been associated with increased risk of developing ankylosing spondylitis, rheumatoid arthritis, and systemic lupus erythematosus. These markers, however, do not appear in all patients with these diseases, suggesting that other gene products or environmental factors may play a role in disease expression. Current investigations using monoclonal antibody and peptide mapping techniques suggest that many gene products share similar protein sequences with known disease susceptibility genetic markers. | |
| 3417701 | Results after knee replacement with a posterior cruciate-substituting prosthesis. | 1988 Sep | From 1979 to 1984, eighty patients (119 knees) were arbitrarily selected for treatment with knee arthroplasty in which a posterior cruciate-substituting replacement was used. The average age of the forty-nine women and thirty-one men was 66.9 years (range, twenty-two to eighty-four years). Sixty-one right and fifty-eight left knees were operated on, and bilateral replacement was performed in thirty-nine of the eighty patients. The diagnosis was osteoarthritis in fifty-eight patients (eighty-eight knees), rheumatoid arthritis in fourteen patients (twenty-two knees), osteonecrosis in three patients (four knees), and traumatic arthritis secondary to a fracture of the tibia or femur in five patients (five knees). The average preoperative score on The Hospital for Special Surgery knee-rating scale was 47.5 points, and the average range of motion preoperatively was 88 degrees (range, 30 to 140 degrees). Of the 119 knees, eighty-seven had a varus alignment (maximum, 35 degrees) before knee replacement. After follow-up of two to eight years, the average score on The Hospital for Special Surgery scale was 90 points, and the average range of motion was 107 degrees. Of the 119 knees, 83 per cent were rated as excellent; 15 per cent, as good; none, as fair; and 2 per cent, as poor. Radiolucencies of one millimeter were present in 76 per cent of the knees; of two millimeters, in 7 per cent; and of three millimeters, in 3 per cent. No statistically significant correlation between radiolucencies and the clinical result was found. The results in knees of patients who had rheumatoid arthritis were not as good as those in knees of patients who had other diagnoses (F = 11.44). Our experience suggested that the posterior cruciate-substituting design provides more motion than do the cruciate-sacrificing surface-replacement designs, with no deleterious effects. The rate of infection (1.6 per cent) after these procedures, which were carried out in a standard operating theater with vertical airflow, was equivalent to that in other published series in which rooms with laminar airflow were used. Patients who had a bilateral procedure did as well as those who had a unilateral replacement, but they required approximately 3.5 more units of blood. | |
| 2043456 | Arthroscopic management of disorders of the knee. | 1991 Feb | Arthroscopy and arthroscopic surgery have gained tremendous popularity within the past several years with both physicians and the general public. Arthroscopic surgery is a dramatic aid in reducing soft tissue injury, rehabilitation time, and the costs associated with surgery when applied to the knee or other large joints of the body. Although this technique is in widespread use for many acute and sports injuries, the arthroscope and developing arthroscopic surgical techniques have significant advantages in the diagnosis and treatment of common inflammatory disorders, rheumatoid arthritis, osteoarthritis, joint synovectomy, septic arthritis, and osteochondritis dissecans. The popularity of arthroscopic management of disorders of the knee and other major joints is well deserved, as these procedures are increasingly successful and hold promise for future major advances in the treatment of joint disease. | |
| 2108450 | Leukotrienes and inflammation. | 1990 | The leukotrienes are synthesized from essential fatty acids via a 5-lipoxygenase enzyme. Most is known about the four-series leukotrienes derived from arachidonic acid. Leukotriene B4 is a potent chemotactic agent for leukocytes and it induces neutrophil-dependent increased microvascular permeability. Leukotrienes C4, D4 and E4 are bronchoconstrictors; and potent mediators of microvascular tone and permeability. The leukotrienes have been suggested to have a role in many inflammatory conditions in man in the skin (e.g. psoriasis), the lung (e.g. allergic asthma), joints (e.g. rheumatoid arthritis) and in the heart (e.g. myocardial infarction). Drugs which inhibit the generation and the actions of leukotrienes are under development and are being tested clinically as potential anti-inflammatory agents. | |
| 2685521 | The interleukin concept and the periodontal diseases. | 1989 Aug | The interleukins are hormone-like substances found at sites of inflammation such as in rheumatoid arthritis and periodontal disease. The present article analyzes a hypothetical mechanism of periodontal pathogenesis, whose etiology is still unclear despite its high prevalence. | |
| 3306332 | Dermatomyositis. | 1987 Aug | Dermatomyositis is a condition that combines an inflammatory myopathy with characteristic cutaneous disease. This disorder is closely related to polymyositis, which has all the muscular features of dermatomyositits without the presence of skin disease. Both dermatomyositits and polymyositis may occur in the presence of other collagen vascular diseases such as lupus erythematosus, scleroderma, Sjögren's syndrome, rheumatoid arthritis, and various vasculitides. Dermatomyositis seems to be characterized by an increased frequency of internal malignancy and both dermatomyositis and polymyositis are associated with morbidity and mortality. Therefore, prompt and aggressive therapy is necessary. | |
| 3315620 | Tenoxicam. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and | 1987 Sep | Tenoxicam is a new non-steroidal anti-inflammatory and analgesic agent of the oxicam class, and therefore closely related to piroxicam. It possesses a long half-life which enables it to be administered once daily. Clinical trials in patients with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout and non-articular rheumatism suggest that tenoxicam 20mg daily is an equally effective anti-inflammatory and analgesic agent compared with piroxicam 20mg daily, and that it is at least as well tolerated. Additionally, a few small studies in rheumatoid arthritis and osteoarthritis suggest that tenoxicam 20mg daily is as effective and as well tolerated as usual therapeutic dosages of diclofenac, ibuprofen, indomethacin and naproxen. Transient mild or moderate gastrointestinal symptoms, in 8% of patients at a dosage of 20mg daily, are the most frequently reported side effects. If further studies confirm the initially favourable efficacy and tolerability findings, particularly the relatively low incidence of adverse effects, tenoxicam can be considered a useful new agent for the symptomatic treatment of rheumatic and inflammatory diseases, and a worthwhile alternative to other non-steroidal anti-inflammatory drugs. | |
| 3501355 | Enzyme immunoassays for the detection of IgG and IgM anti-dsDNA antibodies: clinical signi | 1987 Jul | A solid phase Enzyme-Linked Immunosorbent Assay (ELISA) was developed for the measurement of IgG and IgM antibodies to double-stranded DNA (anti-dsDNA). This method is sensitive, specific, relatively simple and suitable for routine use. Thus, we evaluated sera from 224 Greek patients with the following autoimmune rheumatic diseases: 54 patients with classical rheumatoid arthritis (RA), 50 patients with primary Sjögren's syndrome (SS), 41 patients with systemic lupus erythematosus (SLE), 30 patients with scleroderma, 20 patients with idiopathic Raynaud's phenomenon (IRP) and 29 patients with juvenile rheumatoid arthritis (JRA). Sera from 119 age- and sex-matched healthy blood donors were tested as normal controls. The presence of both IgG and IgM anti-dsDNA highly correlated with SLE. However, IgM anti-dsDNA levels were significantly lower. Serum complement C3 and C4 levels correlated negatively with anti-dsDNA levels in the SLE group. Finally, in sequential sera from five SLE patients, the anti-dsDNA activity proved to be a relatively sensitive marker of SLE activity. | |
| 3487649 | Autoantibody profiles in juvenile arthritis. | 1986 Apr | Serologic and correlational testing was performed in a series of 65 patients diagnosed as having juvenile arthritis (JA) and in 21 age matched controls to detect the presence of antinuclear antibodies (ANA), antibodies to ssDNA, IgM and IgG rheumatoid factor (RF), immune complexes (IC) and antibodies to bovine type I and human type II collagen. ANA were found in 51% of the JA patients; the highest incidence (75%) was noted in the pauciarticular onset disease group. Low levels of anti-ssDNA antibodies were detected in 22% of the patients, all of whom had active disease. IgM RF was detected in 35% of the JA patients but only 6% of patients had IgG RF. Similarly, about one fourth of the JA patients had IC detected by the Clq assay. Antibodies to bovine type I and human type II collagen were noted in about 12% of the JA patients. | |
| 2601574 | Morphine self-administration in the rat during adjuvant-induced arthritis. | 1989 | Rats injected with Freund's adjuvant develop a syndrome resembling human rheumatoid arthritis complete with paw swelling, edema and persistent pain. At the onset of pain, arthritic rats and their pain-free littermate controls (vehicle injection) were allowed to self-administer intravenous morphine (5.0 mg/kg/injection) in a 24 hr/day schedule. Self-injected morphine appeared to provide analgesia in arthritic rats as demonstrated by a decreased sensitivity to applied tail pressure. Arthritic rats self-inject significantly less morphine than pain-free animals. Injection of indomethacin, which alleviates the pain and inflammation of the adjuvant-induced disease, reduces, at least initially, morphine self-injection in the arthritic but not pain-free animals. As the adjuvant-induced inflammation and pain dissipated, arthritic rats rapidly began to increase opioid intake. The presence of persistent pain apparently reduces the addictive properties of morphine. |