Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 518150 | Successful valve replacement for aortic incompetence in rheumatoid arthritis with vasculit | 1979 Oct | A patient with rheumatoid arthritis (RA), vasculitis, and aortic valve incompetence of the histologically nonspecific type is described. Valve replacement was undertaken, and an excellent haemodynamic result was achieved. Both arthritis and vasculitis subsequently remitted. Valve replacement can be successfully performed in RA despite active vasculitis. | |
| 478600 | Neutrophil enzyme activities in rheumatoid inflammation. | 1979 Jul | This study analyzed the neutrophils and sera of patients with rheumatoid arthritis and of normal controls. No significant differences were found in the activities of the granular enzymes beta-glucuronidase and lysozyme or the cytoplasmic enzyme lactic dehydrogenase (LDH). Normal neutrophils were found to release significant (P less than 0.05) amounts of the granular enzymes, but not of LDH in response to immunoglobulin G aggregates. There was no difference in the percent release exhibited by rheumatoid versus control neutrophils. Studies delineating the effects of rheumatoid factor sera and normal sera on aggregate-induced enzyme release revealed a significant negative correlation between the amount of rheumatoid factor in the sera and the percent release of beta-glucuronidase and lysozyme but not of LDH. These studies thus demonstrate no abnormalities in rheumatoid neutrophil or rheumatoid serum enzyme activities or in neutrophil response to immunoglobulin G aggregates. They suggest, however, that rheumatoid factor may partially inhibit the release of lysosomal enzymes, thus suppressing this important component of the rheumatoid inflammatory process. | |
| 6383233 | Laminin and vascular proliferation in rheumatoid arthritis. | 1984 Aug | Laminin is a high molecular weight basement membrane structural glycoprotein. In rheumatoid arthritis and other arthropathies immunoreactive laminin was prominent in synovial blood vessel basement membranes and acted as a marker for them. It codistributed with collagen type IV. Immunohistological reactivity to laminin showed extensive vascular proliferation in rheumatoid arthritis together with basement membrane reduplication, which was confirmed ultrastructurally. Parallel histological studies showed vascular proliferation was predominantly in the subintimal rheumatoid synovium, where it was related to connective tissue proliferation but not to the inflammatory cell infiltrate. Vascular proliferation was also seen in relation to connective tissue changes in biopsies from cases of haemophilic arthritis, osteoarthritis, and meniscal tears. We suggest connective tissue activation is non-specific reaction associated with vascular proliferation. This involves laminin and other structural proteins. It occurs in rheumatoid arthritis and other arthropathies but is distinct from inflammatory cell infiltration. | |
| 382804 | The pharmacological consequences of the binding of anti-rheumatic drugs to plasma proteins | 1979 Jun | Evidence is presented that rheumatoid arthritis is a disease resulting from abnormal protein binding and that anti-rheumatic drugs act by correcting the abnormal binding. | |
| 7308947 | [Local rheumatoid therapy. Indomethacin level in the synovia and serum after application o | 1981 Nov 26 | 9 patients with rheumatoid arthritis and one with activated gonarthrosis were treated by means of application of Amuno ointment to one knee in a dosage of 3 X 5 cm ribbon of ointment, rubbed in on an area of approximately 200 cm2, over a period of 3 days. After this interval in 8 patients the knee-joints not treated with ointment were punctured, and synovial fluid was won. In all 10 cases serum level determinations were carried out. The obtained average values in serum ranged from 114.4 - 134.3 ng/ml, the average value found in the synovial fluid was ascertained at 235.6 ng/ml. Although this report is presenting only intermediate results these may nevertheless serve as evidence for a systemic effect of Amuno ointment at the synovium. | |
| 2985424 | Etiology of rheumatoid arthritis. | 1985 Apr 15 | Definite genetic associations with immunological cooperative HLA-D(R) antigens have been demonstrated for rheumatoid arthritis (RA). Microbial etiology has not been proven, but some hope for the supporters of this view is still given by small viruses, plasmids of enteric bacteria or perhaps oncogen-like DNA-sequences. Yet, electrophoretical analysis of membrane proteins or surface glycoproteins of RA synovial cells does not show any differences compared to reference cells. Autoimmunity to several tissue elements has been demonstrated, but most of it is of secondary nature. Antigenicities of type II and III collagens are probably only contributory factors for HLA-DR4 positive individuals. Proteoglycans or minor cartilage collagens have not been extensively studied, so far. Endocrine, dietary or psychological influences might be triggering events for otherwise 'preloaded' individuals. | |
| 6663598 | Rheumatoid arthritis and granulomatous hepatitis: a new association. | 1983 Dec | There are no distinct hepatic manifestations of rheumatoid arthritis (RA). Granulomatous hepatitis has rarely been described in association with RA. We report 2 patients with RA who developed granulomatous hepatitis which appeared unrelated to drug use or other etiologies. | |
| 6607341 | Immunologic dynamics in cryapheresis for rheumatoid arthritis. | 1983 Dec | Five patients with erosive rheumatoid arthritis (RA) who had previously experienced a favorable response to lymphoplasmapheresis were treated with cryapheresis. Cryapheresis was performed 9 times in 3 weeks using a membrane filtration device that selectively removes plasma proteins with molecular weights greater than 100,000 daltons. Four of the 5 patients so treated improved clinically. The membranes selectively removed more immunoglobulins and complement components that were part of circulating immune complexes than those that were not. Plasma or albumin replacement was not necessary in these patients. Cryapheresis might be a safe and effective technology in treating patients with refractory RA. | |
| 464759 | An alternate method for posterior fixation in anterior and inferior atlanto-axial dislocat | 1979 Mar 19 | A modification of common methods is described for fixation of anterior and inferior atlanto-axial dislocation (AAD and IAD). In AAD a wire is passed around the atlas arch and knotted around the spinous process of the axis in a way that a figure 8 arrangement is achieved as seen in the lateral view. In IAD a wire is passed through holes in the occiput and knotted around the spinous process of the axis. A rectangular bone graft is inserted between the occiput and the spinous process of the axis, thus preventing further inferior dislocation. In both methods methyl methacrylate and bone grafts are as a rule added for further long-time stabilization. The methods have been used in 15 cases of AAD and in three cases of IAD. On radiologic examination with attention focused on the immediate postoperative fixation the follow-up time has been three months. The long-time results of fixation have been recorded with a follow-up time of six years. The fixation proved to be satisfactory in 14 patients with AAD and in the three patients with IAD. The clinical results were good in the 14 patients with AAD and in the three with IAD. | |
| 6339939 | Plasmapheresis therapy in rheumatoid arthritis. A controlled, double-blind, crossover tria | 1983 May 12 | Twenty-six patients with rheumatoid arthritis (average age, 57 years; average duration of disease, 11 years) who were unresponsive to antiinflammatory and slow-acting antirheumatic drug therapy were entered into a controlled, double-blind, crossover study to assess the efficacy of plasmapheresis therapy. All patients received 10 true and 10 sham aphereses as outpatients and continued to take their usual drugs. Twenty patients completed the study, and six were withdrawn--three because of poor venous access. Standard clinical and laboratory measures were assessed by personnel blinded to the therapy administered. Paired t-test analysis of seven clinical measures failed to show significant differences between the true and sham procedures (P = 0.36 to 0.96), although transient, mild improvement did occur during both cycles of apheresis, probably because of a placebo response. Significant reductions in the erythrocyte-sedimentation rate, rheumatoid factor titer, and levels of hemoglobin, IgM, and C3 occurred only with true therapy (P = 0.001, 0.01, 0.03, 0.045, and 0.005, respectively). We conclude that plasmapheresis does not have clinical benefit in chronic rheumatoid arthritis, in spite of impressive laboratory changes. | |
| 6196834 | [Treatment of rheumatoid arthritis with isoprinosine. Personal experience]. | 1983 Oct | Twenty patients with classical or proved rheumatoid arthritis were treated with Isoprinosine. 13 patients received a dose of 25 mg/kg/day and 7 received a dose of 50 mg/kg/day, continuously for 2 months and then discontinuously, 5 days every fortnight. The series being treated with 25 mg/kg/day (7 patients) have received treatment for 12 months. No side effects have been observed; the only reason for ceasing treatment was its ineffectiveness (after at least 3 months of administration). The dosage of the associated anti-inflammatory drugs did not need to be increased, but neither was it decreased. The authors conclude that Isoprinosine is largely ineffective clinically, on laboratory tests and in terms of immunology, at least with the therapeutic protocols tested here. | |
| 7424204 | [Possible involvement of the auditory system in rheumatoid arthritis]. | 1980 Mar | 32 patients with definite or classical rheumatoid artritis, aged between 22 and 60 years, were checked with respect to clinical aspects, laboratory data and pure-tone audiometry. None of them had received salicylates in former times or at the time of this study. The audiometric results in the arthritis patients did not differ from those in comparison with the results of a random sample study of clinically normal ears. Ototoxic salicylate therapy may have influenced earlier results about hearing loss in rheumatoid arthritis. | |
| 159020 | D-penicillamine and immune complex deposition. | 1979 Aug | Dense, granular immunoglobulin deposits have been identified at the epidermo-dermal junction in 4 out of 10 patients who developed toxic reactions to D-penicillamine therapy for rheumatoid arthritis. Three of 4 patients developing a lupus-like syndrome while on penicillamine had similar findings on skin biopsy. Serum immunoglobulin and complement levels decreased significantly in patients treated with penicillamine. It is suggested that, in addition to penicillamine nephropathy, other side effects of this drug may be related to widespread deposition of immune complexes. | |
| 7259330 | Cellular phagocytic studies in rheumatoid arthritis patients treated with levamisole. | 1981 Aug | A simple method is described which allows sequential monitoring of the endocytic activity of blood and synovial fluid cells from rheumatoid arthritis patients undergoing therapy with levamisole. Evidence of immediate (24 hours) and long-term (5-7 weeks) cellular phagocytic enhancement is presented. | |
| 6394759 | The renal excretion of prostaglandins and changes in plasma renin during treatment with ei | 1984 Dec | Ten patients with rheumatoid arthritis (RA) and concomitant heart failure were treated with either naproxen or sulindac in an open randomized study to study the drugs' effects on the urinary excretion of prostaglandins on the plasma renin level and on the renal function of the group. Both drugs were given for 14 days and caused a similar and marked decrease in renal excretion of the prostaglandins PGE2 and PGF2 alpha and in plasma renin in all patients. There was no significant effect on the diastolic blood pressure, the body weight or the 24-h creatinine clearance and the clinical effect on the joint symptoms was identical. We conclude that both sulindac and naproxen inhibit the renal prostaglandin synthesis in patients with RA. | |
| 745168 | [Cervical involvement in rheumatoid arthritis (author's transl)]. | 1978 Oct | The authors studied 577 records of rheumatoid arthritis examined radiologically in the Department of Radiology B of Cochin Hospital: 165 patients showed evidence of lesions of the cervical spine. The risk of cervical involvement in rheumatoid arthritis is thus not negligeable: 28%. This involvement may occur at any time during the course of the disease and presents as pain or by rare and more or less slight neurological manifestations. Radiologically emphasis must be placed upon the orientation points of straight and lateral films, and the value of lateral films with the neck in flexion. Atlanto-axial dislocation is the commonest lesion, usually measured by the distance separating the anterior arch of the atlas from the odontoid peg. However, other lesions are possible, in particular involvement of the lateral masses and erosion or destruction of the odontoid. It is astonishing to discover large dislocations (of up to 10 mm) which remain well-tolerated, with minimal clinical signs. However, it is the neurological risk of quadriplegia (even though minimal) which remains the constant worry since it may result from the slightest trauma or forced movement of the neck. Fixation, usually posterior occipital C1-C2, may be indicated. It is thus necessary to carry out a routine radiological examination of C1-C2 at reasonable intervals during the clinical surveillance of a patient with rheumatoid arthritis. | |
| 1105776 | Treatment of chronic articular effusions with 90-yttrium (90Y). | 1975 | In an open, controlled trial, radioactive 90Yttrium was injected in doses of 3-6 mCi into 40 joints with chronic effusions in patients suffering from rheumatoid arthritis and other rheumatoid diseases. The processing in a computer was carried out by the punch card method. Intra-articular administration of 90Y resulted in a significant improvement of five objective criteria. In our study we have paid particular attention to the clinical and statistical differentiation of the effects of systemic, and especially of basic therapy, from the effects of topical intra-articular therapy. At the time of the last check-up examination, 43% of the patients were free of any effusion. The treatment was well tolerated. Skin necrosis occurred in only one single case. Intra-articular treatment with radioactive 90Yttrium represents a valuable contribution to the therapeutic arsenal for the treatment of the chronic articular effusions when all other methods of treatment failed. | |
| 699237 | [Surgical treatment of rheumatoid arthritis]. | 1978 Oct | The Authors presents a review of the orthopedic surgery in patient with rheumatoid arthritis. The aims of surgical treatment in this patients are: an improvement of the function, relief of pain and improvement in appearance. In this study are presented the major types of operation currently used: synoviectomy, arthroplasty, repair of tendons, osteotomy and arthrodesis. | |
| 971870 | [Osteosyntheses in rheumatoid arthritis]. | 1976 | The wrist joint is fused by an original method consisting of a Rush pin from the third metacarpal bone high up in radius and secured against rotation by two staples between carpal bones and radius. The MP-joint of the thumb is arthrodesed by aid of a staple with compression - a special instrumentarium is used. PIP-joints were fused according to BOYES technique and the DIP-joints with compression screws. | |
| 219810 | Immunological experimental arthritis in pigs. I. Propagation dynamics of the attenuated st | 1978 | Studies on the propagation dynamics of Aujeszky's disease virus and the formation of general and local joint immunity were to provide information explaining the mechanism of experimental rheumatoid arthritis in animals. It was shown that: Aujeszky's disease virus administered intramuscularly caused viremy on 3-4th day after its application and disappeared from the blood circulation on 5-6th day, introduced into the pig ankle joint, the virus was eliminated from the articular fluid two hours after injection, but it appeared again 3-7 days later probably due to the propagation in the cells of the synovial membrane, and that first parenteral administration of the virus induced the formation of neutralizing antibodies in low titer (5-10 units); application of the virus for the second time brought about a considerable increase of antibodies titer within 40-80 units. |