Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6623271 | Difficult intubation in a patient with rheumatoid arthritis. A case report. | 1983 Oct 15 | A 12-year-old White girl underwent bilateral extracapsular lens extraction. She was known to be suffering from rheumatoid arthritis. The peri-operative handling and anaesthetic implications are discussed. | |
| 6746293 | Toward clinical applications of health status measures: sensitivity of scales to clinicall | 1984 Aug | While the validity and reliability of many newer health status instruments have been reported, few data are available regarding the sensitivity of these instruments to clinically discernible changes in patient status. We studied this feature of the Sickness Impact Profile (SIP) in a group of patients with rheumatoid arthritis, comparing it with more traditional measures of functional status (the American Rheumatism Association (ARA) functional classification and a patient self-rating scale). Four different approaches were devised to measure "sensitivity to clinical change." These involved comparisons of functional score changes with clinical changes in patient status which were independently agreed upon by both clinician and patient, and also comparisons with several clinical disease severity indicators. When applied to groups of patients, the SIP and the patient self-rating scale were modestly superior to the ARA scale, but neither the SIP nor the self-rating scale was clearly superior to the other. For considering individual patients, all of the scales were relatively insensitive, and predictive accuracy for clinically estimated change was low. New strategies for assessing sensitivity to small changes should be developed and applied to health status and functional scales. Attention to this characteristic should allow refinement of existing scales and may enhance their clinical usefulness. | |
| 6352553 | Microangiographic studies of experimental erosive synovitis in rats. | 1983 May | Chronic remittent erosive synovitis, which is clinically, radiologically and pathologically similar to rheumatoid arthritis in man, can be produced in rats by systemic injection of cell wall fragments isolated from Group A streptococci. Because of our desire to study the synovial microvasculature in this experimental model, we developed a reliable microangiographic technique to document these changes. This paper describes the first reported microangiographic studies of rat joints and discusses the microvascular changes that parallel the previously reported radiographic and histologic findings. As the arthritis progresses, as judged by clinical and radiographic parameters, early synovial hypervascularity associated with developing hyperplastic synovium gives way to a more obliterative hypovascular pattern associated with chronic erosions, periosteal reaction, and fibrous ankylosis. Microangiography offers an additional and helpful modality by which to investigate synovial microvascular morphology as well as the pathophysiology of joint destruction during erosive synovitis. | |
| 6723123 | Penicillamine metal chelates and their possible importance in rheumatoid arthritis--a brie | 1984 | Complexes formed between penicillamine and metal ions have in vitro effects that may have implications regarding the therapeutic action of D-penicillamine in rheumatoid arthritis. Penicillamine-copper (I) complexes suppress arthritis in animal models and suppress or inhibit mediators of inflammation such as lysosomal enzymes, prostaglandins and the oxidative metabolites of the respiratory burst; whether the inhibition of certain in vitro immunologic responses by the same complexes has any in vivo significance remains to be determined. | |
| 6138116 | Comparison between penicillamine and sulphasalazine in rheumatoid arthritis: Leeds-Birming | 1983 Oct 15 | Sulphasalazine was first formulated by Svartz in the early 1940s, specifically for use as a remission inducing drug in rheumatoid arthritis. After the publication of an unfavourable trial, however, the drug was restricted to patients with ulcerative colitis. In the late 1970s sulphasalazine was re-examined in rheumatoid arthritis and favourable results reported in "open" trials. A double blind controlled trial was therefore conducted comparing enteric coated sulphasalazine and D-penicillamine in patients with active rheumatoid arthritis. A total of 63 patients were recruited in two centres; 31 were treated with sulphasalazine and 32 received penicillamine. After 16 weeks' treatment both drugs had produced significant improvements in clinical score, pain score measured on a visual analogue scale, grip strength, Ritchie articular index, erythrocyte sedimentation rate, and serum C reactive protein concentration. Nausea was the major side effect in the sulphasalazine treated group. No potentially dangerous effects of sulphasalazine were encountered in contrast with those seen in the penicillamine group. The results suggest that sulphasalazine is an effective and safe drug capable of producing remissions in active rheumatoid arthritis. They also lend confidence to the use of preliminary "open" trials as a means of screening for remission inducing drugs in rheumatoid arthritis. | |
| 7287401 | Arthritis of rats and mice: implications for man. | 1981 Jul | Numerous attempts to implicate mycoplasmas in rheumatoid arthritis of man have resulted in complete failures or inconsistent results. The striking similarity of rheumatoid arthritis to a number of chronic mycoplasmal arthritides in animals, and new information on the pathophysiology of mycoplasmas and their complex interplay with the immunological apparatus of the host, suggest that the search for mycoplasmas in human disease should not be abandoned. Furthermore, increasing knowledge of mycoplasmal arthritis in animals emphasizes possible serious deficiencies of past studies in man. | |
| 6114214 | [Transient arthritis of the hip in childhood and Perthes disease (author's transl)]. | 1980 | The possibilities of the relationship between transient arthritis of the hip and Perthes disease have been analysed here. They pointed to the fact, that the intra-articular pressure is increased by the overproduction of the synovial fluid as a result of inflammation, and a continuously high pressure can lead to necrosis of the femoral of inflammation of the femoral capital epiphysis. Experiences are reported here, when an intertrochanteric osteotomy at the early stage of Perthes disease was performed with simultaneous fenestration of the joint capsule for decompression, and a great amount of synovial fluid was discharged under high pressure. They conclude therefore, that transient synovitis can not be regarded only as a harmless condition, but it can precede Perthes disease. | |
| 308251 | [Biorheologic study of pathological synovial fluids]. | 1978 Jun | Rheometric studies of 34 synovial fluids done using a rheometer with a cone and stage (Shirley-Ferranti type) showed that arthrotic synovial fluids had pseudoplastic characteristics (non-Newtonian) but in inflammatory rheumatisms, the characteristics index rises, the consistency decreases and the fluid tends to loose its pseudoplastic properties and to become Newtonian. Radioisotope synoviorthosis seems capable of restoring to a certain extent and in certain cases the rheometric characteristics of the pseudoplastic properties. | |
| 6455397 | HLA-DR characterization of a Chippewa Indian subpopulation with high prevalence of rheumat | 1981 Mar | The adult population (N = 227) of a Chippewa Indian reservation in central Minnesota is characterized by a high prevalence of arthropathy with 7.1% having rheumatoid arthritis (RA). In a prospective study 168 reservation residents (74%) were evaluated. Complete HLA typing identified 57 haplotypes, many of which probably arose via HLA-A/B or B/D recombination. The number of founder haplotypes appeared to be about 20. The population frequency of DR4 (including DRw9, formerly designated 4 X 7) was 67%; for RA it was 100% (p less than 0.05). Apparent DR4 homozygotes, a number of the RA patients, and family members were selected for further study in a mixed lymphocyte culture (MLC) test and with 8th International Workshop cellular and serologic reagents. In MLC with homozygous typing cells (HTC), non of the DR4+ cells typed for any known HLA-D specificity, although they reacted to all DR4 antisera on the local panel. However, 8th International Workshop DR antisera revealed patterns of reactivity with non-DRf4 reagents consistent with the MLC. A minimum of three DR4 variants, one DRw9 variant, and a specificity related to both DR4 and DR2 are required to explain both the cellular and serologic reactions. For the present, we are designating the antigens as DR4.1chip, DR4.2chip, DR4.3chip, DR9chip, and DR(2 X 4)chip. No single variant of DR4 was characteristic of the RA patients in this Amer-indian population. | |
| 6270556 | Defective EBV-specific suppressor T-cell function in rheumatoid arthritis. | 1981 Nov 19 | Several lines of evidence, including high antibody titers to Epstein-Barr virus (EBV)-associated antigens and rapid transformation of B cells into lymphoblastoid cells lines, suggest an association between EBV and rheumatoid arthritis. When lymphocytes from normal immune donors were infected with EBV in culture, they produced an exponentially increasing number of immunoglobulin-secreting cells for eight to 10 days. Thereafter, there was a marked late suppression of their response, mediated by immunoregulatory T cells; by 12 days in culture, this suppression averaged 90 per cent. Lymphocytes from 20 EBV-immune patients with rheumatoid arthritis also responded with increasing production of immunoglobulin-secreting cells, but the late suppression expected in immune donors was absent. Tests of several other T-cell functions in these patients gave normal results, suggesting a more restricted defect in suppressor-T cell function relating specifically to EBV. Since EBV persists in host B cells and thus represents a potential stimulus for immunoglobulin production, this persistence, along with a specific regulatory T-cell defect, may contribute to many of the immune abnormalities underlying rheumatoid arthritis. | |
| 1235828 | Uncommon arthropathies seen at the University Teaching Hospital-a presentation of two case | 1975 Dec | Two cases of arthritis are presented the first being a case of rheumatoid arthritis and the second a case of hypertrophic osteoarthropathy secondary to pulmonary disease. Similar conditions have probably been seen in Zambia previously but none have been recorded, as far as we are aware. | |
| 6747423 | Wrist joint arthroplasty in rheumatoid arthritis: a comparison between the Meuli and Swans | 1984 Jun | A personal series of twelve wrist arthroplasties performed on ten patients with rheumatoid arthritis of the radio-carpal joint were reviewed in retrospect. Six arthroplasties were of the Meuli metal/plastic/metal design and six were of the Swanson silastic type with an additional silastic ulnar head prosthesis. Both prostheses were successful in giving a pain free stable joint with some degree of useful movement. The Meuli appeared to give a greater range of movement than the more constrained Swanson prosthesis. Although complications were encountered it is concluded that wrist arthroplasty does have a place in the management of patients with rheumatoid arthritis of the radio-carpal joint. Our present policy is to continue with the use of the Swanson design because of the advantages of a cement free prosthesis. | |
| 7247475 | Dislocation of the manubriosternal joint in rheumatoid arthritis. | 1981 Jun | Rheumatoid arthritis (RA) is a disease characterised by joint deformity and subluxation. Although many joints may be involved, dislocation of the manubriosternal joint is extremely rare. A case of dislocation of this in a woman with RA is presented. | |
| 7208761 | Traumatic events in dreams of psychosomatic patients. | 1980 | Several examples of repetitive traumatic dreams reported by psychosomatic patients are discussed. The dreams involve injury to the body of the dreamer himself. The occurrence of dreams of this type indicates a failure in the functions of the ego concerned with the protection of the self. It may also indicate the presence in the memory systems of a latent traumatic event. Finally, it is suggested that the repetitive experience of consummated trauma contributes to the malfunctioning of the physiological systems, and therefore, to the production of illness. | |
| 871070 | Serum sulfhydryl groups in rheumatoid arthritis. | 1977 Mar | The sulfhydryl groups are chemically active parts of the protein molecule and participate in many important biochemical and metabolic processes. The present material comprised 132 patients with rheumatoid arthritis, 104 patients with other diseases and 44 controls. The patients with rheumatoid arthritis had decreased serum sulfhydryl group levels, the decrease being greater in patients with active disease. Changes in the activity of rheumatoid arthritis were correspondingly followed by changes in the serum sulfhydryl group levels. The serum sulfhydryl group levels diminished significantly with advancing age. Similarly decreased serum sulfhydryl group levels could also be observed in many other diseases. | |
| 6822675 | Serum copper: a marker of disease activity in rheumatoid arthritis. | 1983 Jan | Serum copper concentrations were measured in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), osteoarthritis (OA), and in healthy controls. Median serum copper concentrations were raised significantly in RA and AS, but not in OA. Serum copper in RA correlated significantly with a number of disease activity markers--for example erythrocyte sedimentation rate (ESR), C-reactive protein, haemoglobin concentration, morning stiffness, and grip strength. It also correlated well with the overall disease activity as assessed by a composite index. Raised serum copper was associated with severe RA as manifested by the presence of immunoglobulin M rheumatoid factor, extra-articular features, weak grip and highly active disease. High serum copper might be related to the development of the pathological lesions observed in RA and not just be a secondary response. | |
| 942275 | Serum pyridoxal in patients with rheumatoid arthritis. | 1976 Apr | Abnormalities of tryptophan metabolism have been reported in patients with rheumatoid arthritis (RA) and it has been suggested that these abnormalities are the result of disordered vitamin B6 metabolism. Fasting serum pyridoxal, assayed by an automated microbiological system, was found to be below normal in 35 out of 42 patients with RA while a similar abnormality was found in 8 out of 35 patients with osteoarthrosis (OA). Within the RA group the abnormality could not be related to the age, sex, or drug therapy of individuals but of the 8 patients with OA and a low serum pyridoxal, 7 were receiving indomethacin either alone or in conjunction with aspirin. | |
| 1082029 | Lymphocyte subpopulations in normals and patients with rheumatoid arthritis and ankylosing | 1975 Dec | Seventy-four normal persons, 48 patients with rheumatoid arthritis, and 25 patients with ankylosing spondylitis, were examined in respect to lymphocyte subpopulations in the peripheral blood. The simultaneous enumeration of T lymphocytes (E rosettes), B lymphocytes (surface immunoglobulin), as well as null cells and double marker cells was performed. No significant differences could be observed in the three examined groups in respect to the absolute or the relative lymphocyte counts, suggesting that possible immunological impairment assumed in rheumatoid arthritis and ankylosing spondylitis, is due not to reduced cell numbers, but to a possible functional disorder. | |
| 7066269 | Sterile corneal perforation after cataract surgery in Sjögren's syndrome. | 1982 Mar | Painless, sterile, noninfiltrated corneal ulceration and perforation, which may occur after recent cataract surgery in patients with rheumatoid arthritis, and Sjögren's syndrome, appears to be a distinct clinical entity. The cause is probably multifactorial. Contributing factors may be the underlying systemic disease process in rheumatoid arthritis and Sjögren's syndrome, the associated keratoconjunctivitis sicca, the surgical procedure, and the postoperative use of oral and topical corticosteroids. Two cases of this clinical entity are reported here. Preoperative recognition by cataract surgeons that corneas in patients with rheumatoid arthritis and Sjögren's syndrome have an increased risk for postoperative ulceration should prompt postoperative preventive measures. | |
| 6441247 | IgA deficiency during aurothioglucose treatment. A case report. | 1984 | A 43-year-old woman with seronegative rheumatoid arthritis developed a selective IgA deficiency during aurothioglucose treatment. No antibodies against IgA were detectable in the serum; normal numbers of IgA, IgG and IgM positive cells were demonstrated by immunofluorescence studies on a biopsy specimen from the small intestine. These data would suggest a defect in IgA secretion rather than in production by plasma cells. |