Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3059699 | [Differential diagnosis of inflammation-induced arterial vascular diseases]. | 1988 Sep 15 | The clarification of non-arteriosclerotic inflammatory vascular diseases is based on angiological, angiographical, immunological and immunohistological methods and parameters. As causes of the arterial occlusive disease of younger patients are taken into consideration the obliterating endangiitis and Takayasu's aortoarteriitis. To the clinical manifestations of the giant cell arteriitis belong the temporal arteriitis and the rheumatic polymyalgia. Hypersensitivity and panangiitides are to be delimited from the group of the pathergic granulomatoses. The secondary Raynaud's syndrome on the basis of a digital arteriitis is of differential-diagnostic and prognostic importance in collagenoses and rheumatoid arthritis. | |
| 3134142 | Glycosaminoglycan excretion in connective tissue diseases. | 1988 Apr | Abnormal glycosaminoglycan metabolism has been widely studied in cases of mucopolysaccharidoses (MPSD) with increased acid glycosaminoglycan (aGAG) excretion. A disorder in aGAG metabolism can be confirmed in several diseases with known etiology. We have carried out a comparative study on the urinary aGAG output in systemic connective tissue diseases and in childhood cases of MPSD. In children suffering from rheumatoid arthritis or scleroderma, the urinary aGAG output did not surpass 80% of the value excreted in MPSD; furthermore, 20 to 30% was uronic acid. In the case of osteogenesis imperfecta the remarkably high amount of excreted aGAG contained over 60% uronic acid. | |
| 2954756 | Caries experience of disabled school-age children. | 1987 Jun | A group of 415 disabled school-age children representing 10 different disabling conditions (hereafter called diagnostic groups) were examined and DMFT registered. Parents were interviewed about problems and habits relevant to dental health. The purpose was to study the relationship between different background variables and DMFT. It was assumed that the DMFT might have been influenced by both various predisposing conditions and factors of everyday life. Therefore two indices were made. A multiple classification analysis (MCA) was used to assess the relative importance of different background variables. Age, mother's education, everyday life factors and diagnosis were the variables showing the strongest association with DMFT. Children with juvenile rheumatoid arthritis, epilepsy and cystic fibrosis had a higher DMFT than the other diagnostic groups. | |
| 20144098 | The prevalence of rheumatoid arthritis in occupational groups. | 1987 | Distributed on 66 large occupational groups the prevalence of classical, definite, probable and possible RA (according to ARA criteria) was determined in the general population. A total of 39, 418 persons were investigated in a sample survey of five geographical areas in Sweden-this being the total populations over the age of seven. The distance between the different areas is 150-650 km. Occupational groups with high prevalence of RA were: Males: Food and dairy workers, butchers, fishermen, agricultural workers, building foremen, machine and engine repairers, bakers, foremen, washers and ironers, textile workers, industry and factory workers. Females: Cleaning workers, doctors and nurses, nurse assistants, textile workers, shop assistants, bank, post and telegraph personnel and wives. From the present series it seems as if outdoor occupations with relatively heavy work have the highest prevalence of RA. Environmental factors apparently account for differences in prevalences of RA. | |
| 2374891 | [Sicca syndrome in amyloidosis]. | 1990 Jul 10 | We report on two patients with rheumatoid arthritis and sicca syndrome due to secondary amyloidosis (A-amyloid) with involvement of the kidneys and gut. At autopsy, generalized amyloidosis was found with deposits in the salivary and lacrimal glands. Two other patients developed sicca syndrome due to primary systemic L-amyloidosis with Bence-Jones paraproteinuria, renal insufficiency and amyloid cardiomyopathy; both died of cardiac failure. Although sicca syndrome with amyloidosis has been described only occasionally, it is possible that this association is more frequent. These observations suggest that not only Sjögren's syndrome but also amyloidosis should be considered as a possible cause of sicca syndrome. | |
| 1367963 | Major histocompatibility complex binding peptides: a target for therapeutic development. | 1991 Dec | Peptides that bind with high affinity to major histocompatibility complex molecules could represent useful tools in treating class II-associated autoimmune diseases such as rheumatoid arthritis, type 1 diabetes and multiple sclerosis. Although the concept has been validated in experiments with both purified receptor systems in vitro and cellular systems in vivo, many challenging problems need to be resolved before efficacious therapeutic agents are obtained. | |
| 3280663 | A case study of pyoderma gangrenosum. | 1988 Mar | Pyoderma gangrenosum is a rare neutrophilic dermatosis seen initially as painful pustules or bullae on the skin that rapidly ulcerate and have a characteristic raised, purplish areola surrounding them. It is often associated with inflammatory bowel disease and less commonly with other systemic diseases, such as myelofibrosis, rheumatoid arthritis, and chronic active hepatitis. Pyoderma gangrenosum involving the hand is a rare entity, with only two previous cases reported in the literature. This article describes a patient with myelofibrosis in whom pyoderma gangrenosum of the hand developed after she underwent splenectomy. | |
| 20144097 | Observations on the symptoms and signs of "early" rheumatoid arthritis in a prospective st | 1987 | The authors have made a detailed study of 202 cases recognized as early RA. All of them were referred to the Institute for thorough examination and were afterwards followed up for two to six years. The observation of the course of the disease revealed four groups: 1. Cases where development of bone erosions proved the diagnosis of RA, 2. Cases in whom all previous symptoms and signs disappeared, 3. Cases in whom diagnosis could not be established after follow-up, 4. Cases in whom other diseases were manifest. The first two groups were analysed retrospectively to find the characteristic features in the early stages of RA. | |
| 1986675 | Methotrexate-induced asthma. | 1991 Jan | A patient with rheumatoid arthritis developed pulmonary symptoms and function test abnormalities consistent with asthma during methotrexate therapy. Assessments of airway responsiveness to methacholine during therapy revealed airway hyperreactivity that reverted to normal when the methotrexate was stopped. An extension of the methotrexate dosage interval from 7 to 10 days resulted in an abolition of the asthma, which remained in remission despite a return to a weekly cycle after a 3-month period of 10-day cycles. | |
| 2272072 | [Osteocalcin]. | 1990 Dec 14 | Osteocalcin, non-collagenous vitamin K dependent bone protein is as a biochemical indicator of osteoblastic activity and metabolic turnover in bone, valuable in the diagnosis of several diseases and in investigations of the dynamics of osseous changes (processes) during treatment of osteopathies. Elevated osteocalcin levels are normal in childhood and adolescence. In the diurnal rhythm the peak is recorded in the early hours. Pathologically elevated values are associated with primary hyperparathyroidism, Paget's disease, chronic renal failure, acromegaly and some malignities. A rise in women during the early postmenopausal period signalizes an enhanced metabolic turnover of bone in those women who are candidates of postmenopausal osteoporosis. Low levels are as a rule recorded in advanced age, in nanism, hypoparathyroidism, type 1 diabetes, rheumatoid arthritis, vitamin D deficiency, vitamin K deficiency, hypercorticalism and glucocorticoid treatment. | |
| 2224406 | Does primary fibromyalgia exist? | 1990 Oct | Twenty-one of 25 consecutive primary fibromyalgia or fibrositis patients, identified during a 5-year period in a tertiary care day-ward for pain syndromes, were re-examined. Fifteen fulfilled criteria for fibromyalgia but unexpectedly, all cases had either psychiatric disturbance or thyroid dysfunction. Of the four patients not seen at follow-up, two had developed neurological diseases, another rheumatoid arthritis and one other hypothyroidism. Thus, after 5 years no patient fulfilled the criteria for primary fibromyalgia. Women occupied as manual workers were over-represented. Most patients reported beneficial effects of physiotherapy. None of the patients has been able to return to full time work. | |
| 2339657 | [Secondary bladder amyloidosis. A rare cause of hematuria]. | 1990 Jan | Secondary vesical amyloidosis is an uncommon pathology and few cases are described in the literature. A suddenly appearing hematuria resistant to treatment in a patient with a diagnosis of systemic amyloidosis is usually the initial sign that guides us to its diagnosis. We present a case of vesical amyloidosis in a patient with systemic amyloidosis secondary to a Rheumatoid Arthritis of length evolution, and which was diagnosed as a result of a pattern of massive incoercible hematuria. | |
| 2692700 | Ocular myasthenia gravis after D-penicillamine administration. | 1989 Dec | A 68-year-old black woman who was put on D-penicillamine therapy (250-500 mg per day, total dose 15 g) for rheumatoid arthritis developed ocular myasthenia gravis. Two weeks after she discontinued D-penicillamine her signs and symptoms cleared with no other treatment. Review of previous cases and possible immunological mechanisms are discussed. | |
| 2872857 | Sulphasalazine in ankylosing spondylitis. | 1986 May | In recent years sulphasalazine has gained acceptance as an effective agent for the treatment of rheumatoid arthritis. Ankylosing spondylitis is a disease where remission inducing drugs so far have been lacking. In this double blind trial sulphasalazine was compared with placebo in 37 patients with ankylosing spondylitis. Evaluation after three months' treatment showed reduction of inflammatory activity and improvement of clinical variables. The side effects were mild. The results suggest that sulphasalazine is a potentially effective and safe drug in the treatment of ankylosing spondylitis. | |
| 3276541 | Degradation of cartilage proteoglycans by myeloid leukemia cells. | 1988 Feb | Polymorphonuclear leukocytes contain proteases that are capable of degrading articular cartilage matrix in disease states such as rheumatoid arthritis and osteoarthritis. In this study, the HL-60 human promyelocytic leukemia cell line was examined for ability to degrade cartilage proteoglycans. The HL-60 cells contained proteoglycan-degrading enzymes, which may contribute to the joint inflammation sometimes seen in acute leukemia. However, the protease activity was much less than in mature neutrophils and was not enhanced by the induction of myeloid maturation with dimethyl sulfoxide or retinoic acid. The diminished enzyme activity of induced HL-60 cells compared to normal neutrophils is another functional deficiency of these cells. | |
| 1712601 | Computer localization of some Gm markers on the surface of the Fc region of human immunogl | 1991 Jul | The surface localization of some Gm markers on the Fc fragment of IgG has been identified from previously published amino acid sequences associated with known Gm markers using the atomic coordinates described by Deisenhofer, INSIGHT software and a Digital VAX 11/785 computer, which together permit a study of the three-dimensional structure of the Fc fragment. The G1m(x)-associated amino acid residue 431, the G3m(s)- and G3m(u)-associated residue 435 and the nG4m (a)- and (b)-associated residue 309 are all localized in the interface between the CH2 and CH3 domains. Furthermore, it is postulated that the G1m(a)-associated residue 356 (Asp, Glu) influences the interface formation through an ion pair interaction to Lys 439. Finally, G3m(b) and G3m(g) are associated with the interface via residues 435 and 436. The data explain why sera from patients with rheumatoid arthritis are useful tools for the detection of some Gm markers and support the view that rheumatoid factors from these patients are internal images of microbial Fc-binding proteins. | |
| 3499678 | [Antibodies reacting with the antigens of the human immunodeficiency virus in systemic lup | 1987 | A study was made of the level of anti-HTLV-111 using an enzyme immunoassay (Emzygnost-anti-HTLV-111) in 75 donors and 143 patients with various diseases including SLE (57), rheumatoid arthritis (9), Sjögren's disease (3), Bekhterev's disease (2), polymyositis (2), dilatation cardiomyopathy (30), and acute lymphocytic leukemia (40). Anti-HTLV-111 were detected in 26 SLE patients and in one patient with polymyositis. A study of positive sera using immunoblotting showed no interaction with virus antigens. A conclusion was made that the detection of anti-HTLV-111 in systemic rheumatoid diseases was a false-positive result. | |
| 1651835 | [Associations between the renal tubular acidosis of primary Sjogren syndrome and the infec | 1991 Mar | To explore the possible etiological associations between the infection of Epstein-Barr Virus (EBV) and the occurrence of renal tubular acidosis (RTA) of primary Sjogren's syndrome (SS), renal biopsies from both primary SS with clinical or subclinical RTA and controls were detected by using a monoclonal antibody against EBV early antigen P138 and a 32P-labelled EBV Bam W probe. As a result, cytoplasmic fluorescence staining of epithelial cells with the monoclonal antibody as described above was noted in all the seven renal biopsies from primary SS, and one out of two renal samples among them contained EBV DNA detectable by dot blot hybridization with Bam W probe. Whereas five control renal biopsies were all negative on the same methods of detection. Our study suggested that EBV has been of a lytic fate leading to active replication in the kidneys of patients with RTA of primary SS. Therefore, EBV may play an important role in the renal damage, especially resulting in RTA, of primary SS. | |
| 2359080 | Bronchiolitis obliterans organizing pneumonia and Sjögren's syndrome. | 1990 May | A 52-year-old man developed a systemic illness with fever, malaise, cough, dry eyes and mouth. Investigation revealed bronchiolitis obliterans organizing pneumonia associated with retinal vasculitis, hepatic and renal involvement, lymphocytic sialoadenitis and symptoms of the sicca complex. High dose steroid treatment resulted in resolution of his symptoms and prolonged remission. | |
| 2369015 | [Histologic aspects of the minor salivary glands in lupus erythematosus]. | 1990 | Minor salivary glands from 10 patients with LE, 5 patients with LE and keratoconjunctivitis sicca and 5 patients with primary Sjögren's syndrome were subjected to histological examination, immunoglobulin detection and lymphocyte typing. There was no clear-cut difference between the last two groups. The 10 LE patients had a moderate lymphocytic infiltrate (stage 1 or 2 according to Chisholm's classification with a predominance of T lymphocytes and a CD4/CD8 ratio greater than 1. Exsudative vasculitis with endothelial swelling and lymphocytes within the capillary walls was always present. These vasculitic lesions in LE distinguish it from the initial periductal involvement seen in primary Sjögren's syndrome. |