Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3360129 | Immunoprecipitation of human adrenal microsomal antigen. | 1988 Apr 11 | Human adrenal microsomes have been labelled with 125I and immunoprecipitated with sera from patients with Addison's disease. The immunoprecipitates were then analysed by SDS-PAGE and autoradiography. 13 of the 23 sera from the Addison patients studied contained antibodies which reacted with a 55 kDa adrenal microsomal protein. The same 13 sera were also positive for adrenal antibodies as judged by immunofluorescence. The 55 kDa protein was not immunoprecipitated from placenta or thyroid microsomes by Addison sera. Furthermore, patients with Graves' disease or rheumatoid arthritis did not immunoprecipitate the 55 kDa protein from adrenal microsomes. Our studies suggest therefore that Addison sera contain antibodies to a 55 kDa adrenal specific protein which may well be the antigen observed on immunofluorescence. | |
| 3136693 | Antiphospholipid antibodies. | 1988 Apr | Antiphospholipid antibodies are prevalent in systemic lupus erythematosus. These antibodies are not specific for systemic lupus erythematosus but may be found in other diseases such as rheumatoid arthritis, mixed connective tissue disease. Sjögren's syndrome, syphilis and chronic idiopathic thrombocytopenic purpura. High serum levels of anticardiolipin antibodies in systemic lupus erythematosus are associated with circulating lupus anticoagulant, false positive VDRL and the occurrence of thrombosis, thrombocytopenia and recurrent abortions. The immunological reactions of the antiphospholipid antibodies are not fully understood. Optimal treatment and length of therapy of patients with antiphospholipid antibodies remain tentative. | |
| 2461036 | Pemphigus-like eruption induced by d-penicillamine and captopril, in the same patient. | 1988 | A patient suffering from rheumatoid arthritis and hypertension is described who developed pemphigus foliaceus during simultaneous treatment with d-penicillamine and captopril. Discontinuation of the d-penicillamine afforded some improvement, but skin symptoms still persisted after 3 months. When the captopril was discontinued as well, all lesions healed within 2 weeks. Our findings suggest that both these chemically related drugs might have been responsible for the pemphigus-like eruption in this patient. | |
| 3608304 | Primary iliopsoas bursography in the diagnosis of disorders of the hip. | 1987 Aug | The iliopsoas bursa is a well-defined anatomic structure that has been involved in various diseases about the hip, including osteoarthritis, rheumatoid arthritis, pigmented villonodular synovitis, and synovial chondromatosis. Demonstration of the iliopsoas bursa using contrast material has been reported during hip arthrography and inadvertently during angiography, but no direct or primary methods of iliopsoas bursography have been reported. A technique of primary bursography under fluoroscopy is described wherein filling of the bursa with contrast material allowed the observation of movement of the iliopsoas musculotendinous unit across the front of the pelvis during motion of the hip. This technique, which was of significant benefit in determining the etiology of two cases of the snapping hip syndrome of the internal variety, is simple, easily reproducible, and has clinical application. | |
| 3467425 | Primary fibromyalgia. A clinical and laboratory study of 55 patients. | 1986 | The clinical symptoms of 55 patients with primary fibromyalgia (PF) were studied and compared with 30 patients with rheumatoid arthritis (RA). The PF patients expressed a more intense feeling of illness than did the RA patients. Stiffness occurred just as often in PF as in RA. Trigger points occurred less frequently in RA patients. Muscular fatigue appeared to be one of the most disabling symptoms in PF. Neurophysiological studies indicated that the fatigue was at least partly of central origin. Ischemic forearm exercise test gave no evidence of impaired glycogenolysis. Laboratory investigation revealed normal 25-hydroxyvitamin D, cobalamin, folate, estrogen, testosterone, and myoglobin in the PF patients. | |
| 2373536 | Gastric carcinoma presenting as polyarthritis. | 1990 Jul | A patient with carcinoma of the stomach presenting with symmetrical polyarthritis of the upper limbs is described. Rheumatoid factor and LE cell were negative, but antinuclear antibody was positive. The arthritis subsided after the tumour was excised. | |
| 2517540 | NE-58095: a diphosphonate which prevents bone erosion and preserves joint architecture in | 1989 | The rat adjuvant arthritis model, like human rheumatoid arthritis, is characterized by fulminating intra- and periarticular inflammation and bone lysis. This model was used to determine the effectiveness of a potent antiresorptive diphosphonate (NE-58095: monosodium [2-(3-pyridinyl) ethylidene] hydroxy diphosphonate) prophylactically in Lewis rats and therapeutically in Sprague-Dawley rats. Modified Freund's adjuvant (MFA) was injected into the tail of Lewis and Sprague-Dawley rats. Prophylactic treatment in Lewis rats [oral (PO): 14.8 mg/kg/day); subcutaneous (SC): 0.148 mg/kg/day] was begun on the day of MFA injection. A significant reduction in paw swelling was seen as early as day 12 after MFA injection with both oral and parenteral treatment. NE-58095 produced a reduction in paw swelling of 28, 39 and 61% on days 12, 17 and 24 respectively, as compared to the saline-treated MFA control. Bone lysis in the saline-treated MFA group was 85% of total possible incidence for 6 joint regions in the hind paws and 4 regions in the front paws at day 24. This resorption was reduced by 70% in the rats administered NE-58095 PO and SC at 24 days after MFA. In the therapeutic experiments with Sprague-Dawley rats, treatment with NE-58095 (SC: 0.148 mg/kg/day) was begun on day 14 after MFA injection, at which time significant paw swelling (greater than 0.5cc) had occurred. On day 25 (12 days of treatment), paw swelling was reduced 70% by NE-58095 treatment as compared to the saline-treated MFA controls. Histologically, the architecture of the tibio-tarsal joints in the saline-treated MFA rats was affected, in contrast to the NE-58095-treated MFA rats where the architecture of the joint was preserved. This new potent diphosphonate is not an anti-inflammatory compound by any of the classical tests and is effective both orally and parenterally. The mechanism by which this diphosphonate protects joint integrity is not clear but appears to be related to its ability to block bone resorption and the consequent inhibition of the diffusion into the joint space of calcium, chemotactic factors and cytokinas released from bone matrix, resulting in a quenching of the arthritic process. | |
| 3118179 | Effect of auranofin and other gold complexes on the activity of phospholipase C. | 1987 Sep | Auranofin (AF) is an orally active chrysotherapeutic agent used for the treatment of rheumatoid arthritis, a self-perpetuating inflammatory disease. Because of reports suggesting that AF and other gold complexes can, under certain circumstances, exacerbate rheumatoid inflammatory lesions in humans and adjuvant arthritic rats and that phospholipase C (PLC) and phospholipase A2 activities are increased in rheumatoid patients, the effects of AF and a related gold complex on in situ mammalian and purified Bacillus cereus PLC were examined. Results of our studies show that 1) AF and triethylphosphine gold chloride (TEPG), an AF analog, stimulated PLC activity in the sonicate of RAW 264.7 macrophages; 2) AF and TEPG stimulated B. cereus PLC activity in a concentration-dependent manner, but the pattern of stimulation and concentrations of drugs required to stimulate the purified enzyme differ from those seen with the macrophage PLC; 3) metals (cobalt and zinc) and sulfhydryl reagents (N-ethylmaleimide, iodoacetic acid, and glutathione), tested at the same concentrations of AF that enhanced PLC activity, had no effect on the enzyme. These data suggest that stimulation of PLC may be a generic phenomenon since two divergent PLCs are affected by gold complexes. Additionally, these studies may provide one potential explanation for rheumatoid lesion flares seen in patients and animals on chrysotherapy. | |
| 1883689 | Immunosuppressive drug therapy for rheumatic disease. | 1991 Jun | The use and complications of intravenous cyclophosphamide, azathioprine, nitrogen mustard, and cyclosporine are reviewed. Studies have failed to demonstrate superiority of intravenous versus oral cyclophosphamide in rheumatic diseases other than systemic lupus. Azathioprine is a useful immunosuppressive agent in Beçhet's disease. Further studies of cyclosporine in rheumatoid arthritis indicate that efficacy and toxicity are both dose related. | |
| 2202699 | What's in a relationship? Sarcoidosis and tuberculosis. | 1990 Jun | The relationship between the two granulomatous diseases sarcoidosis and tuberculosis is reviewed. Data from 14 published case series are presented in the form of a figure which indicates that case series collected earlier in time and with a high proportion of non-white patients show a higher prevalence of tuberculosis. This high prevalence was also found in other chronic diseases such as diabetes and rheumatoid arthritis. The more frequent presence of mycobacteria in sarcoid than in control tissue, the parallel changes in the prevalence of sarcoidosis and tuberculosis in a community and the presence of myocbacteria on culture if pursued with sufficient aggression, are consistant with a mycobacterial aetiology. Recent developments in the immunology of the two diseases are reviewed. | |
| 2189535 | The heel in systemic disease. | 1990 Apr | Heel pain is most commonly the result of mechanical abnormality in foot structure or function. Systemic disease, however, may also affect the heel, resulting in pain, deformity, or both of the rearfoot. This article discusses and reviews notable systemic conditions, exclusive of the seronegative spondyloarthropathies, which may produce subjective or objective heel findings. Specific conditions discussed are rheumatoid arthritis, crystal deposition arthropathies, osteoporosis, diffuse idiopathic skeletal hyperostosis, diabetes mellitus, hypertrophic osteoarthropathy, Paget's disease, hyperlipidemia, sarcoidosis, sickle cell anemia, and acromegaly and their effects on the heel. | |
| 2336957 | Failure of the Christiansen hip. Survival analysis of 265 cases. | 1990 Feb | Totally, 265 primary Christiansen total hip arthroplasties were followed clinically and radiographically for a median of 6 years. The operations were performed for arthrosis in 220 cases, failed fracture in 23, and rheumatoid arthritis in 13. The influence of 11 presumed determinants on the radiographic outcome was studied. In all, 96 hips were exchanged because of aseptic loosening, 35 stems were loose, and 210 sockets were definitely or probably loose at the last radiographic examination. The survivorship analyses revealed the probability of having a radiographically intact stem after 10 years as 67 percent and for the socket 0 percent. None of the 11 determinants influenced the radiographic outcome. | |
| 2333617 | [New approaches to local antirheumatic therapy]. | 1990 | Local antirheumatic therapy is viewed as an important component in the total system of the treatment of rheumatic diseases. Drug-induced synovectomy, local anti-inflammatory, antifibrotic and potential immunosuppressive therapy are analyzed. Special attention is paid to local therapy based on the use of dimethyl sulfoxide. The effects of local and general treatment are realized at least partially by means of the same mechanisms. There is possibility to improve the results of general therapy at the expense of goal-oriented local treatment without producing any influence on its tolerance. In fact, every patient with rheumatoid arthritis or other articular disease should be regarded as a potential candidate for local anti-inflammatory therapy. | |
| 2298899 | Evaluation of acute gait abnormalities in preschool children. | 1990 Jan | The charts of 60 consecutive children aged less than 5 years hospitalized for evaluation of a new onset limp or refusal to bear weight were reviewed. Only 1 of 22 patients with a normal complete blood count (CBC), erythrocyte sedimentation rate (ESR), and temperature had an infection. Of the 14 patients with a diagnosis of infection, only one had a normal CBC, ESR, and temperature. Radiographs were diagnostic in only four cases, whereas aspiration identified nine of 13 infections. Thirty-five bone scans were performed; 18 led to a definitive diagnosis including synovitis osteomyelitis, Perthes disease, juvenile rheumatoid arthritis, (JRA), fracture, soft tissue infection, and discitis. | |
| 1981437 | Response of atypical bullous pyoderma gangrenosum to oral minocycline hydrochloride and to | 1990 | An 80-year-old Caucasian female with rheumatoid arthritis and recurrent atypical bullous pyoderma gangrenosum is described. There was no evidence of any underlying myeloproliferative disorder. Rapid healing occurred in response to oral minocycline hydrochloride and topical clobetasol propionate. | |
| 2797372 | [Rotational stenosis of the vertebral artery at the atlantoaxial joint: report of three ca | 1989 Sep | Three cases of vertebral artery stenosis or occlusion at the level of the atlantoaxial joint during head rotation were reported. The vertebral artery was mechanically compressed on the side of the head opposite to the direction in which the heads was turned. One case was associated with atlantoaxial dislocation due to rheumatoid arthritis. Posterior fixations of C1 - C2 or C1 - C3 using iliac bone and wire were performed in two cases, and a neck collar was applied in another case. All of the three cases have been free from vertebrobasilar insufficiency since the treatment. The pathogenesis and treatment of vertebral artery occlusion at the atlantoaxial joint are discussed. | |
| 2791641 | Pyoderma gangrenosum and adrenocortical carcinoma. | 1989 Sep | Systemic disorders that have been associated with pyoderma gangrenosum include inflammatory bowel disease, rheumatoid arthritis, paraproteinemias, and hematologic malignancies. We report the case of a 55-year-old woman with pyoderma gangrenosum, IgA monoclonal gammopathy, and a cortisol-secreting adrenocortical carcinoma. Review of the literature revealed one previous case of pyoderma gangrenosum associated with a solid tumor; at autopsy, a carcinoid tumor and an adrenocortical adenoma were found. Our patient's rapid improvement after the carcinoma was resected and her subsequent disease-free course suggests that the two conditions were related. This case suggests that evaluation for underlying malignancy should be considered in patients with pyoderma gangrenosum. | |
| 2676084 | [Evolution of the concept of autoimmunity and its therapeutic implications]. | 1989 Apr | Autoimmunity is paradoxically a physiologic phenomenon. One finds in normal sera natural autoantibodies that are encoded by germ line genes. Autoimmunity is at the origin of common and severe diseases such as diabetes mellitus, rheumatoid arthritis, systemic lupus erythematosus and perhaps psoriasis and Crohn's disease. The disease may be due according to cases to exacerbation of physiologic autoimmunity or to appearance of autoreactive clones producing autoantibodies encoded by mutated genes. The respective role of triggering environmental factors and genetic predisposition (HLA and non HLA genes) is not determined. New immunotherapeutic methods, particularly cyclosporine, monoclonal antibodies (against T cells, CD4 and T cell receptor molecules and Ia antigens) and autoantigen-specific vaccination open new major therapeutic perspectives that presage major improvement in the prognosis of these diseases. | |
| 2730295 | Fracture of the lower extremity after total hip replacement. | 1989 | The incidence of ipsilateral fracture of the lower extremity after total hip replacement (THR) was evaluated in 1442 THRs performed between 1968 and 1983. Twenty-two fractures had occurred, of which 14 were femoral. Twelve of the femoral fractures occurred in women and two in men. The accumulated postoperative risk of femoral fracture during an observation period of 15 years was 25.3 per 1000. Short femoral stems were associated with proximal femoral fractures and long stems with more distal femoral fractures. No specific preoperative diagnosis such as arthrosis, rheumatoid arthritis, or femoral neck fracture was associated with significantly increased incidence of postoperative fractures. | |
| 2643298 | Hemobilia in a patient with multiple hepatic artery aneurysms: a case report and review of | 1989 Jan | Hepatic artery aneurysm is a rare vascular lesion that accounts for nearly 10% of hemobilia cases. Its etiology is most often atherosclerosis, trauma, or infection. Autoaggressive disorders are rarely associated with hepatic artery aneurysm as is thyroid dysfunction. Presented here is a case of hemobilia secondary to a rupture of one of multiple aneurysms of both right and left hepatic arteries in a women with a history of rheumatoid arthritis, hypothyroidism, and hypertension. Surgical intervention has been the rule in the past. Selective transcatheter embolization has gained clinical application in recent years, especially in the treatment of intrahepatic aneurysms. Its efficacy and safety are demonstrated by this case. |