Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2736827 | Sjögren's syndrome and tear function parameters. | 1989 Mar | In a group of patients with keratoconjunctivitis sicca associated with Sjögren's syndrome, the Schirmer values were lower in the Sjögren group of patients in comparison with a comparable group in which KCS was not associated with any systemic disease and these differences reached almost statistical significance. But a significant decrease in tear fluid lactoferrin concentration and tear film break-up time was demonstrated. The combination of the tear fluid lactoferrin concentration, the Schirmer I test values and the tear film break-up time provides a basis for differential diagnosis that is of some value clinically. None of these parameters in itself appeared to be of any clinical value to differentiate between KCS patients who were or were not associated with Sjögren' syndrome. | |
| 3291100 | Xerostomia due to Sjögren's syndrome. Diagnostic criteria, treatment and outlines for a c | 1988 | The initial evaluation of 25 patients suspected of suffering from Sjögren's syndrome (SS) disclosed that sialopenia and glandular atrophy without focal sialo-adenitis was the second most common cause, after SS itself, of patient complaints. This emphasizes the importance of conclusive diagnostic criteria to prevent overdiagnosis and to form a sound basis for management of xerostomia patients. We found that at the time of diagnostic evaluation, the dental status of our SS patients did not differ from that of the normal Finnish population. This suggests that SS patients can greatly benefit from adequate dental care, assuming that attention is paid to early diagnosis and management. Accordingly, the diagnostic and therapeutic approach needs to be multidisciplinary. We present our current programme for oral and dental care of xerostomia patients and the results of an open trial with Sulfarlem (trithioparamethoxyphenylpropene) which was found not to be the drug of choice in the treatment of dry mouth associated with SS. | |
| 3671240 | Bilateral submandibular gland lymphoma in Sjögren's syndrome. | 1987 Feb | Salivary gland lymphoma is associated with Sjögren's syndrome. A case of bilateral submandibular gland and sublingual gland lymphoma, arising in Sjögren's syndrome, is presented. A lymphoma involving more than one salivary gland may occur in Sjögren's syndrome, and there is an increased risk of developing an extrasalivary lymphoma. | |
| 3441866 | [A positive effect of combined therapy (plasmapheresis in combination with pulse therapy) | 1987 | The authors provided evidence of a positive effect of combined therapy (plasmapheresis in combination with pulse-therapy) on a course of cryoglobulinemic glomerulonephritis and ulcerative-necrotic vasculitis in patients with Sjögren's disease (SD). It was shown that plasmapheresis with double plasma filtration considerably decreased the cryoglobulin level in the blood whereas the level of alpha 2-globulins, C-P, RF and CIC did not change 16 hrs after the sessions of plasmapheresis. These indices significantly decreased after pulse-therapy with high doses of 6-methylprednisolone and cyclophosphamide following plasmapheresis. Combined therapy resulted in a complete epithelization of leg ulcers, regression of the symptoms of renal failure. Clinical improvement correlated with a decrease in indices of the inflammatory and immunological activity and with an increase in the cutaneous blood flow. Combined therapy can be an effective therapeutic method of SD complicated by cryoglobulinemic glomerulonephritis and ulcerative-necrotic vasculitis. | |
| 3473652 | Labial salivary gland immunopathology in Sjögren's syndrome. | 1986 | The cellular composition of the salivary gland infiltrates in primary Sjögren's syndrome and the presence of lymphokines were evaluated using the Avidin-Biotin-Peroxidase technique in 10 biopsies from patients with Sjögren's syndrome. The 10 specimens were stained with monoclonal antibodies (MoAb) against T-lymphocytes (Leu-4), Monocytes/Macrophages (M phi) (Leu-M3 and OKM1), Natural Killer cells (NK) (Leu-11 and Leu-7), class II MHC antigens (anti HLA-DR and OKIa1, anti Leu-10), Interleukin-2 (anti IL-2), IL-2 Receptor (anti IL-2 receptor) and Interferon gamma (IFN-gamma) (supernatant fluid from hybridoma cell line producing MoAb to IFN-gamma). The predominant cell was the T-helper/inducer lymphocyte. T-helper/T-suppressor ratio ranged from 1/1 to 10/1. Only few M phi were observed while NK cells were rare. More than 50% (50-100%) of the infiltrating cells were HLA-DR positive while epithelial cells were positive from 40-90% in all but two cases in which the positivity was 10%. The infiltrating cells were also positive for Leu-10 antigen (40-95%) in contrast to the epithelial cells. Both infiltrating and epithelial cells were reacting with anti IL-2 MoAb in high percentages (50-100%), while none of the infiltrating cells expressed IL-2 receptor. Finally, 40-100% of the infiltrating cells were IFN-gamma positive. Our data indicate that the salivary gland lesion in Sjögren's syndrome, is the result of an immune process in which T-lymphocytes predominate producing lymphokines, while the epithelial cells by expressing class II MHC molecules, occupy an important part of the picture. | |
| 3229028 | Antibacterial antibody pattern in seronegative spondyloarthropathies (SNSA). | 1988 Oct | The occurrence of some anti-bacterial antibodies was studied in sera from 31 healthy donors (HD) and 101 patients with different rheumatic diseases. The cases investigated included 7 Psoriatic Arthritis (PA), 35 Rheumatoid Arthritis (RA), 17 Undifferentiated Seronegative Spondyloarthritis (U-SNSA), 13 Behçet's syndrome, 18 Enteric Arthropathies (EA), 7 Ankylosing Spondylitis (AS) and 4 Reiter's syndrome. A complement fixation test was carried out to detect the presence and to evaluate the titer of the specific antibodies against the relative bacterial antigens. The antigens used were prepared for the complement fixation test by Virion Laboratories: Yersinia Enterocolitica 0:3 type (YEC), Yersinia Pseudotuberculosis (YPT), Campylobacter Jejuni (CJ) and Campylobacter Intestinalis (CI), Chlamydia Trachomatis (CT). The results indicate a statistically significant difference between the HD group and the seronegative polyarthritis one (PA, U-SNSA, Behçet, EA, AS, Reiter as a whole) as far as antibody production against YEC, CI and YPT is concerned. On the contrary, a significant difference between the HD group and RA patients for specific anti bacterial antibodies was only found against CT. Further detailed analysis of the behavior of the antibody pattern in any disease groups was carried out to identify a possible specific and featured antibody profile for some given rheumatic disorder. | |
| 2701092 | Objective measures of swallowing in patients with primary Sjogren's syndrome. | 1989 | Primary Sjogren's syndrome (SS) is an autoimmune disorder primarily affecting salivary and lacrimal glands. Durational measures of the oral phase of swallowing were obtained on 34 patients with primary SS and 34 age-matched controls from analyses of ultrasound scans. Two conditions were examined: a basal (BA) swallow (only endogeneous secretions present in the subjects' mouths) and a 10 ml water bolus (WB) swallow. The patients with SS produced swallowing durations significantly longer (p less than 0.05) than those of the controls for each of the two conditions. Moreover, unlike normals, over 40% of the patients with SS produced WB swallows that were longer than their BA swallows. For further analyses, patients with SS were classified into two groups based on the difference in duration between their BA and WB swallows. These two groups differed from each other on clinical evaluations of oral motor function and presenting complaints. No significant differences were found between these two groups for salivary function or immunologic profile. These findings support the hypothesis that dysphagia can result from conditions leading to salivary gland dysfunction and document the need for the assessment of swallowing function in patients with Sjogren's syndrome. | |
| 3827337 | SLE-like and sicca symptoms in late component (C9) complement deficiency. | 1987 Feb | Hereditary deficiencies in early and late complement components are well known to predispose to SLE-like syndromes or recurrent infection. Hitherto reported C9 deficient cases have usually been healthy subjects, however, and it is not considered that C9 deficiency is associated with any specific disease. We describe a completely C9 deficient patient with possible Sjögren's syndrome and discuss the relationship. | |
| 1848394 | Detection of Epstein-Barr virus DNA by in situ hybridization and polymerase chain reaction | 1991 Mar | PURPOSE: To determine whether Epstein-Barr virus (EBV) could be involved in the pathogenesis of Sjögren's syndrome (SS). PATIENTS AND METHODS: In situ hybridization using the BamH1-W fragment of EBV DNA was performed using labial salivary gland biopsy specimens from 14 patients with SS (eight with primary SS and six with secondary SS) and 39 control subjects. Furthermore, labial salivary gland biopsy specimens from 12 patients with SS (seven with primary SS and five with secondary SS) and 24 control subjects were submitted to the polymerase chain reaction to detect EBV DNA. RESULTS: In situ hybridization detected EBV DNA in epithelial cells of labial salivary gland biopsy specimens from four of eight (50%) patients with primary SS, zero of six patients with secondary SS, and three of 39 (8%) control subjects. The difference between patients with primary SS and control subjects was statistically significant (p less than 0.02). The polymerase chain reaction detected EBV DNA in six of seven (86%) patients with primary SS, three of five (60%) patients with secondary SS, and seven of 24 (29%) control subjects. The difference between patients with primary SS and control subjects was statistically significant (p less than 0.01). CONCLUSION: Both newly developed techniques showed that the presence of EBV DNA was significantly increased in patients with primary SS in comparison with control subjects. In all the positive SS patients who underwent in situ hybridization, epithelial cells of the labial salivary gland were the target of EBV infection. Our results suggest that this virus may play a role in the pathogenesis of SS. We cannot yet determine whether EBV is directly responsible for the destruction of the gland, or if its presence is a secondary event following gland injury. | |
| 2701789 | [Lupus erythematosus. 4. Investigation of the oral cavity: a) The antibody picture in stud | 1989 Nov | The AA. in this note IV report the most recent acquisitions about hematology, serology and immunopathologic findings; describe the association and the overlap between oral lesions in Lupus Erythematosus and other diseases. Finally analysed the importance of establishing the diagnosis of oral manifestations of Lupus Erythematosus. | |
| 3499274 | Evaluation of lip salivary gland biopsy in 21 patients with primary Sjögren's syndrome. | 1987 Nov | Lip salivary gland biopsy was performed in 21 (20 female) patients, age 26 to 74 years, with primary Sjögren's syndrome. The procedure helped identify a patient group with many autoimmune phenomena, including hypergammaglobulinemia, autoantibodies, autoimmune thyroiditis, vasculitis, and immunocytoma. A marked association with the HLA-DR3 antigen was noted. It is concluded that lip salivary gland biopsy is a simple and safe procedure that makes possible the identification among non-RA patients with sicca symptoms those who have autoimmune disturbance. This patient group deserves close medical supervision in order to detect autoimmune disease that requires treatment, such as autoimmune thyroiditis and lymphoma. | |
| 2429064 | Immunohistochemical investigations on the epimyoepithelial islands in lymphoepithelial les | 1986 Oct | The histogenetic origin of cells in the epimyoepithelial islands occurring in patients with Sjoegren's syndrome has been investigated by using different monoclonal antibodies. The majority of cells in these islands reacted with broad specificity antibodies against keratins. The same cells are stained by a monoclonal antibody CKB1 which detects myoepithelial (basket) cells and basal cells (around the ducts) in normal salivary gland tissue, but which does not stain ductal epithelial cells. Conversely, the cells are not stained by the antibody CK5 which stains ductal epithelial cells in normal salivary gland tissue. The relation of the epimyoepithelial islands to the myoepithelial/basal cell system is thus demonstrated. Certain implications for practical use in surgical pathology are discussed. | |
| 3769241 | Familial Sjögren's syndrome in the Japanese: immunogenetic and serological studies. | 1986 Jul | Serological abnormalities and HLA haplotypes were studied in a Japanese family of two patients with Sjögren's syndrome (SS) associated with other autoimmune diseases. In contrast to the reports in the U.S.A. and Europe, we found a significant excess of HLA-DRw53 antigen in the family members. Two family members, mother and niece of the probands, had suffered from other connective tissue diseases. Although none of the siblings of probands had manifestations of connective tissue diseases, two siblings had several autoantibodies. No consistent segregation, however, was found between the HLA haplotypes and the serological abnormalities in the relatives. Therefore, HLA alone can not explain the familial clustering of autoimmune diseases including SS and of autoantibodies. | |
| 3495874 | Oral problems in patients with Sjögren's syndrome. | 1986 | Minor salivary gland biopsies are important in confirming the diagnosis of Sjögren's syndrome (SS) and in understanding its pathogenesis. Biopsies should be obtained through clinically intact mucosa and contain at least 4 evaluable lobules. Immunohistologic studies using monoclonal antibodies demonstrated that the majority of infiltrating lymphocytes are T cells (CD3+) of the helper/inducer (CD4+) subset. Transmission electron microscopy (EM) and scanning EM emphasize the presence of high endothelial venules in SS biopsis and do not reveal immune complexes at the basement membranes. Taken together, these results suggest that T cell mediated immune mechanisms are responsible for salivary gland destruction. Patients with SS present specific therapeutic problems. First, their decreased saliva production predisposes them to increased oral infections and periodontal disease. These causes of increased oral pain must be distinguished from flares of the underlying disease including vasculitis and from medication side effects. Difficulty in eating solid foods may contribute to poor nutrition and to stress in social situations. In certain patients, dental restorations and prosthetic implants may improve cosmetic appearance and oral function. | |
| 1782314 | [Primary Sjogren's syndrome in men: evolution to acute lymphoblastic leukemia]. | 1991 Dec | A clinical case of a 55-year-old man with syndrome of primary Sjögren, seronegative, normoglobulinemic and normocomplementary with 7 years of evolution, which developed acute lymphoblastic leukemia, having suffered recurrent lympho-adenopathy and paresthetic meralgia as previous clinical signs, is presented. Clinical, serological and immunologic characteristics of this syndrome are reviewed, highlighting its rare appearance among men. While appearance of malignant lymphoproliferation disorders is well known, evolution to acute or chronic myeloid leukemia is very rare and so far, an acute lymphoblastic leukemia as the one presented in this study has never been described. | |
| 2061745 | Importance of detection of SS-A/Ro autoantibody in screening immunofluorescence tests for | 1991 | SS-A/Ro autoantibodies are related to Sjögren's syndrome and to several clinical subsets of lupus erythematosus. The most widely used laboratory procedure for ANA screening is the indirect immunofluorescence test (IF-ANA); the laboratory detection of anti-SS-A/Ro requires implementation and adherence to several technical and quality assurance recommendations. Using appropriate substrate cells containing the SS-A/Ro antigen, many so-called "ANA-negative" lupus erythematosus patients will demonstrate a positive IF-ANA. | |
| 1690297 | Autoantibodies to keratin in Sjögren's syndrome. | 1990 Jan | In order to determine which components of the salivary duct cells are recognized by the antisalivary duct antibodies, sera of patients with Sjögren's syndrome were screened for immunoreactivity to keratin by using an ELISA test and a Western blot analysis. The autoantibodies which reacted with keratin were demonstrated in 8 of 9 definite cases of Sjögren's syndrome and in 3 of 6 probable cases, and they reacted with different keratin peptides in each case. The results suggest that the antisalivary duct antibodies include antibodies against keratin, which exists ubiquitously as a cytoskeleton in the salivary gland epithelial cells. Detection of antikeratin antibody might be a useful aid for diagnosis of Sjögren's syndrome. | |
| 3067867 | Immunogenetics of SLE and primary Sjögren's syndrome. | 1988 Dec | SLE is a syndrome defined by clinical criteria and by the presence of autoantibodies reactive with nucleic acids and proteins concerned with transcription and translation. Breeding experiments in mice have illustrated the enormous genetic heterogeneity of this syndrome, of which the final common pathway is a widespread immune complex disease. The causes of SLE in humans are likely to be equally multifactorial. Family studies have demonstrated that genetic factors exist, but each factor appears to be a relatively weak disease-susceptibility gene. The major exceptions to this are the very rare complete deficiencies of classical pathway complement components, which are almost invariably accompanied by the development of SLE. Observations of these patients have led to the formulation of hypotheses relating complement and its receptor, CR1, to the defective removal of immune complexes from the circulation. | |
| 3180551 | Polymorphonuclear cell functions in patients with primary Sjögren's syndrome. | 1988 Jul | Polymorphonuclear (PMN) cell functions were evaluated in twenty-two patients with primary Sjögren's syndrome (SS) and 45 healthy controls. Adherence, phagocytosis, chemiluminescence and bactericidal ability were not significantly reduced in Sjögren's syndrome patients. Chemotaxis and chemokinesis were markedly reduced in SS patients and the results of the former test correlated well with those of the latter. These observations suggest that the decrease in PMN cell mobility is attributable both to a primary cell abnormality and a serum inhibitory effect. | |
| 3559203 | Detection of activated terminal complement (C5b-9) in cerebrospinal fluid from patients wi | 1987 Apr 1 | We have examined cerebrospinal fluid (CSF) and serum from patients with Sjogren's syndrome (SS) and systemic lupus erythematosus (SLE) for evidence of activation of the terminal pathway of complement. Fluid phase terminal complement complexes (SC5b-9), quantitated by ELISA, were detected in the CSF of 14 of 16 patients with SS and focal central nervous system (CNS) disease. Five of six SS patients without focal CNS disease but with psychiatric disease or cognitive dysfunction had detectable CSF SC5b-9, whereas two other SS patients without focal CNS or neuropsychiatric disease had no detectable CSF SC5b-9. Six of seven patients with SLE or SLE overlap syndrome with CNS involvement had CSF SC5b-9, whereas two patients with SLE without CNS involvement had no CSF SC5b-9. A subset of SS and SLE patients with CNS disease had SC5b-9 detected in CSF but not in serum. SC5b-9 was generally absent from the CSF of patients with noninflammatory CNS diseases. These findings demonstrate intrathecal activation of terminal complement in patients with CNS SS or CNS SLE, and suggest a role for terminal complement activation in the pathophysiology of CNS involvement in both SS and SLE. |