Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2452199 | Antigenic specificities of human monoclonal and polyclonal IgM rheumatoid factors. The C g | 1988 May 1 | The binding site specificity of 12 monoclonal and 11 polyclonal IgM rheumatoid factors (RF) isolated from human plasma or serum has been studied. All IgM RF bound best to sites on IgG and intact Fc. The monoclonal IgM RF did not bind at all to fragments lacking the C gamma 2 or C gamma 3 domains. In contrast, low level binding to the pFc' fragment, composed of the C gamma 3 domain, was seen with seven IgM RF, mainly from patients with rheumatoid arthritis (RA). IgG1 binding appeared to be a requisite specificity of all human IgM RF. IgM RF binding to IgG3 subclass was common among the monoclonal IgM RF. Most RA polyclonal IgM RF but only 2 of the monoclonal IgM RF possessed the IgG1, 2 and 4 binding pattern. Monoclonal IgM RF which bound best to histidine-modified IgG also bound well to IgG3. The 7-kDa fragment D of staphylococcal protein A inhibited the IgG binding of most monoclonal and to a lesser degree polyclonal IgM RF. Thus, the results indicate that the C gamma 2-C gamma 3 interface region of IgG contains the predominant determinants for monoclonal and polyclonal IgM RF. For some monoclonal IgM RF the binding site, even though at the interface of the C gamma 2 and C gamma 3 domains, is not the staphylococcal protein A site. Furthermore, polyclonal IgM RF possess specificities not encountered among the monoclonal IgM RF. These specificities may have special | |
| 3672014 | [Monocytic arthritis. Study of their clinical significance apropos of 43 cases]. | 1987 Jul | The clinical significance of synovial monocytosis (greater than 50 p. cent) of inflammatory fluids (greater than 1,000 elements per mm3) was studied retrospectively in 43 patients. An accurate diagnosis was made 35 times: rheumatoid polyarthritis (13 cases), lupus disease (1 case), Gougerot-Sjögren syndrome (1 case), isolated infantile monoarthritis (1 case), sarcoidosis (1 case), seronegative spondylo-arthropathy (3 cases), microcrystalline arthritis (5 cases) arthritis revealing a blood disease (2 cases), idiopathic "lymphocytic" arthritis (3 cases), eosinophilic pseudo-allergenic arthritis (2 cases), aseptic osteonecrosis of the medial condyle (1 case), femoro-patellar arthrosis (1 case). Among the 8 other patient for whom no diagnosis was made, 6 had a spontaneously resolving acute affection, evoking the possibility of a viral etiology. | |
| 1855814 | [Induction of autoreactive T-cells by bacterial stress proteins in HLA-DR4 donors]. | 1991 Apr | From the peripheral blood of HLA-DR4+ healthy donors or patients with rheumatoid arthritis autoreactive T-cell lines were obtained after stimulation with bacterial heat-shock protein. All lines obtained express an alpha/beta-T-cell receptor and they are predominantly CD4+. The determination of the fine specificity of those autoreactive T cells showed, that either amino-acid position #71 or #86 of the HLA-DR beta 1 chain was critical for recognition by the antigen receptor. | |
| 2000057 | Nodular regenerative hyperplasia of the liver: the importance of combined macroscopic and | 1991 Mar 18 | A 40-year-old man with rheumatoid arthritis, splenomegaly and mild thrombocytopenia presented with gross ascites and a history of excess alcohol consumption. Oesophageal varices were documented endoscopically. Alcoholic cirrhosis was suspected and laparoscopy revealed a macronodular liver surface. Liver biopsy disclosed subtle microscopic structural variations which together with the laparoscopic findings were consistent with the diagnosis of nodular regenerative hyperplasia. The importance in diagnosis of macroscopic appearance combined with histological findings is emphasised. Clinically significant portal hypertension may be present at a histologically early stage of this condition. | |
| 2069633 | Arthroscopic surgery of the hip joint. | 1991 | Hip arthroscopic examination of 196 joints was performed in 104 patients treated during the past 4 years. Of these, 11 joints were treated by arthroscopic surgery. We have developed a technique using a two-directional approach that facilitates a global view of joint areas and allows simpler performance of surgical procedures. Removal of loose bodies, joint debridement in osteoarthritis, and synovectomy in rheumatoid arthritis are good indications for arthroscopic surgery of the hip joint. Short-term follow-up was satisfactory, and a reduction of pain was obtained in all patients. Although the joint space of the hip is narrower and the operative technique is more difficult to perform than in the knee, we believe that arthroscopic surgery of the hip is a suitable method in selected cases. | |
| 1900544 | Anaesthetic management for atlanto axial subluxation. | 1991 Jan | A number of disease processes including congenital anomalies, malunited odontoid fractures, rheumatoid arthritis and tuberculosis can result in atlanto axial subluxation. The patient population presenting for surgery is therefore varied in age and general condition, ranging from fit young men to steroid dependent frail arthritic patients. The degree of instability and the spinal cord compression are also variable. Gauging these parameters has an important bearing on the anaesthetic management. We present management of six patients with atlanto axial subluxation in our institution. | |
| 2390952 | Acetylsalicylic acid or paracetamol? | 1990 May | Paracetamol, a widely used non-narcotic analgesic, has the same analgesic, and antipyretic efficacy as acetylsalicylic acid (ASA). In contrast to ASA, paracetamol has traditionally been claimed to have little or no anti-inflammatory effect. There is, however, increasing support for the view that paracetamol has anti-inflammatory activity and reduces pain and swelling in inflammatory conditions other than rheumatoid arthritis. Overall, paracetamol seems to be equally effective as ASA. Since ASA has a greater potential for adverse effects, paracetamol is increasingly preferred to ASA, particularly in children. | |
| 2313814 | Intravesical dimethyl sulfoxide instillations in the treatment of secondary amyloidosis of | 1990 Apr | A-22-year-old woman with long-standing rheumatoid arthritis and secondary amyloidosis of the bladder had recurrent profuse macroscopic hematuria. She was treated with intravesical dimethyl sulfoxide instillation every 2 weeks for 1 year. She remained asymptomatic during the treatment and at 6 months. Progressive disappearance of amyloid from the superficial mucosa of the bladder was demonstrated in sequential histological examinations. | |
| 2337447 | Superoxide dismutase-like activity of 1,2,3-triazole derivatives. | 1990 Jan | This paper reports the synthesis of some sulfurated 1,2,3-triazole derivatives and the biological evaluation, for the superoxide dismutase-like activity, of these new compounds together with several 1,2,3-triazoles previously described by us. All the compounds possess a SOD-like activity and some of them showed an activity equivalent to or higher than those of penicillamine or thiopronin, which are well known therapeutic drugs in the treatment of rheumatoid arthritis. | |
| 2790402 | The effect of CPH 82 on the growth of human lymphocytes in vitro. Definition of cytobiolog | 1989 Oct | A drug composed of two semisynthetic podophylline derivatives, CPH 82, has recently been launched for the treatment of severe rheumatoid arthritis. The present in vitro study of PHA-stimulated human T-lymphocytes showed that CPH 82 arrested cell division in a metaphase-like configuration. The cell cycle effects of CPH 82 were indistinguishable from the cell cycle effects of the classical microtubule depolymerizers, Colcemid (a colchicine derivative) and podophyllotoxin. A CPH 82 concentration of 1 microgram/ml, which is close to therapeutic serum concentrations, had an almost maximal effect on cell division. It is suggested that at least part of the anti-inflammatory effect of CPH 82 is due to a colchicine-like activity on, for example, proliferating lymphocytes. | |
| 2756180 | [The intravertebral vacuum phenomenon or gaseous dissection of the vertebral body]. | 1989 Jun | The intravertebral vacuum phenomenon is rather uncommon. It is determined by the collapse of the body of the vertebra with successive aspiration ex vacuo of gas (nitrogen) from the surrounding tissues, which collects under the endplates, causing them to appear disconnected. To date, the one who has reported the highest number of cases is Maldague, with sixty examples. Our report concerns four cases seen during the past five years. According to the most widely accepted pathogenetic theory, this phenomenon represents, together with vertebral collapse and increased bone density, a pathognomonic sign of ischemic osteonecrosis of the vertebrae, similar to osteonecrosis of the head of the thigh bone and, like this, favored by many different factors, such as old age, repeated traumas, alcoholism, rheumatoid arthritis, arteriosclerosis and corticosteroid therapy. | |
| 3241034 | Limited wrist fusions. | 1988 Sep | Seventeen patients had wrist fusions done for diseases other than rheumatoid arthritis of the wrist and carpal bones. Arthrodesis was done at the radiocarpal joint in five wrists and at the midcarpal joint in 12. There were 12 men and five women. Ages at the time of operation averaged 42 years. Follow-up ranged from 6 months to 5 years and 5 months, and with an average of 1 year and 10 months. Overall postoperative results were excellent in five wrists, good in seven, fair in two, and poor in three. Wrists with the midcarpal fusion fared better than those wrists with the radiocarpal fusion. Complications included one pseudoarthrosis and one rupture of the flexor pollicis longus tendon. In one of the 17 wrists new osteoarthritic changes surrounding the arthrodesed joints occurred. | |
| 3418067 | Arthrodesis of small joint of the hand: a rapid and effective technique. | 1988 Jul | Seventy-six patients underwent 103 arthrodeses of digital joints of the hand to treat deformity, pain, or instability. Each fusion was done by means of a surgical technique that allowed for proper positioning with minimal shortening. No bone graft was used. Only one joint failed to fuse. Bony union was present in 10 weeks or less in 86% of the digits. External immobilization was not used in one third of the joints, primarily low-demand patients with rheumatoid arthritis. There were two superficial pin tract infections that healed after pin removal and a course of oral antibiotics. This surgical technique proved to be technically simple and allowed for easily adjusted positioning of each joint without multiple osteotomies or excess shortening. | |
| 2908220 | The enhancing effect of cyclosporine A and sulfasalazine on the prevention of rejection in | 1988 Jul | Sulfasalazine (SASP) has been used for many years as a disease-modifying agent in inflammatory bowel disease and in rheumatoid arthritis. However, its mode of action is not entirely clear. Evidence has been accumulated which indicates that its efficacy is due to an immunomodulatory effect. In the present communication, we report that SASP has an immunomodulatory capacity in an experimental rat cardiac allograft model. A combination of 100 mg/kg per day of SASP given orally until rejection and 10 mg/kg per day of cyclosporine A (CyA) given orally for 10 days resulted in a significantly increased graft survival time as compared to that in animals given CyA alone. | |
| 20144094 | Studies on the sicca syndrome in patients with rheumatoid arthritis. | 1987 | Secretion from the parotid and the lacrimal glands has been studied in two similar groups of 48 subjects, one consisting of RA patients, the other a control group. Sialometry and sialography has been performed as regards the parotid glands; the secretion of the lacrimal glands has been measured with Schirmer's test I and the occurrence of conjunctival and corneal epithelial defects stainable with Rose-Bengal has been studied. It has been shown that lacrimal and parotid secretion was significantly reduced in the RA group as compared with the control group; that epithelial defects typical for KCS occurred significantly more often in the RA group; that parenchymal changes, sialodochiectasias, existed in the RA group but that sialodochiectasias were completely absent in the control group; that there was no significant co-variation in the RA group between lacrimal and salivary secretion or lacrimal secretion and sialodochiectasias; that criteria for Sjögren's syndrome were fulfilled by 15 subjects in the RA group. The results of the study indicate that Sjögren's syndrome is to be regarded as part of the RA complex. | |
| 3021535 | Gold sodium thiomalate activates latent human leukocyte collagenase. | 1986 Nov 10 | Gold sodium thiomalate, a drug used widely in the therapy of rheumatoid arthritis, was found to be an activator of latent human polymorphonuclear leukocyte collagenase. The activation was demonstrated by two distinct and independent collagenase assays: by recording with a spectrophotometer at 227 nm the enzyme-induced increase in ultraviolet difference absorbance of native type I collagen connected to the cleavage of collagen at 37 degrees C [(1986) Eur. J. Biochem. 156, 1-4] and by SDS-polyacrylamide gel electrophoresis analysis of formation of specific products of collagen resulting from collagenase cleavage at 25 degrees C. Activation of latent collagenase by gold sodium thiomalate appeared to be of the same magnitude as by the known activator phenylmercuric chloride. | |
| 3767467 | Spontaneous pneumomediastinum in adult dermatomyositis. | 1986 Sep | Spontaneous pneumomediastinum has not been reported in adult polymyositis or dermatomyositis, either in conjunction with spontaneous pneumothorax or in isolation. Spontaneous pneumothorax has been rarely reported as a complication of rheumatoid arthritis, systemic lupus erythematosus, scleroderma, and childhood dermatomyositis. It is associated with active, progressive pulmonary involvement and a poor prognosis. We describe an adult with dermatomyositis and spontaneous pneumomediastinum with a favourable outcome. | |
| 3518330 | Socket loosening after hip arthroplasty. Radiographic observations in 241 cases up to 15 y | 1986 Apr | Serial radiographs of 241 consecutive, noninfected low friction arthroplasties performed between 1968 and 1972 were evaluated with respect to socket migration and the presence of radiolucencies, progressive or not. The number of intact sockets in 207 cases of arthrosis decreased slowly and, depending on their classification, approached 95-88 per cent about 10 years postoperatively. Contrary to previous reports, we could not observe any increase in the rate of loosening with time; half of the hips were observed for more than 10 years, and only a few cases of socket loosening were found beyond this point. In rheumatoid arthritis the number of intact sockets was significantly fewer--23 of 34--after about 10 years of service. | |
| 3956909 | Utilization of health services in a defined Swedish population. | 1986 Mar | With the aid of a data registration system and person-specific information, utilization behaviour has been studied in a defined Swedish population. Information from three registers was linked together in order to produce the current results: a medical information system in primary care, a population register, and a register of property. The higher health care consumption for females is shown to occur independently of diagnosis, even if diseases of the genitourinary system, psychoneurosis and rheumatoid arthritis were more common among females. The consultation rate was inversely related to the distance to the surgery from the patient's residence. There was less demand for primary health care during the summer months, July and August. For the rest of the year there were no differences. | |
| 1795732 | Sporotrichosis presenting as pyoderma gangrenosum. | 1991 Dec | A 56-year-old female with an eight-year history of corticosteroid therapy for rheumatoid arthritis presented with large, deep, painful ulcers on the left buttock and thigh. The lesions appeared typical of pyoderma gangrenosum. Nine separate cultures of the exudate grew Sporothrix schenckii. During the course of iodide therapy, the patient expired due to Escherichia coli pneumonia. This is the third case report of sporotrichosis presenting as pyoderma gangrenosum and the first report from China. Sporotrichosis presenting as pyoderma gangrenosum is a special form of this disease. It develops quickly and must be treated promptly. Only two cases have been reported in the world literature. This is the first case reported from China. |