Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1711963 | Tenoxicam. An update of its pharmacology and therapeutic efficacy in rheumatic diseases. | 1991 Apr | Tenoxicam administered orally, rectally or parenterally is an effective analgesic and anti-inflammatory agent for the symptomatic treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and various rheumatic conditions such as tendinitis, bursitis, sciatica, back pain and gouty arthritis. In clinical trials its efficacy is at least equivalent to that of other NSAIDs and it is at least as well tolerated as piroxicam and probably better tolerated than diclofenac, indomethacin and ketoprofen. Compared with many other NSAIDs, tenoxicam offers certain advantages in that it is conveniently administered once daily and dosage adjustment is not required in the elderly or in patients with renal or hepatic impairment. | |
| 2680345 | Changes in hyaluronan concentration in tissues and body fluids in disease states. | 1989 | Proteins which specifically bind hyaluronan have been used to develop sensitive immunoassay-like analytical techniques. These assays have made it possible to analyse hyaluronan concentrations in nanogram amounts in tissues and body fluids. The normal adult human circulating level of hyaluronan varies between 10 and 100 micrograms/l. Increased levels of serum hyaluronan (greater than 1 mg/l) have been found in inflammatory rheumatic diseases such as rheumatoid arthritis, scleroderma and psoriatic arthritis. Even higher levels occur in serum from patients with cirrhotic liver diseases and in patients with malignant mesothelioma. Elevated serum hyaluronan levels are a sign either of increased production and/or outflow from the tissues or of decreased elimination of the polysaccharide in the liver endothelial cells or in other parts of the reticuloendothelial system or through the kidneys. The serum concentration is also influenced by increased age and by the degree of physical activity. Important information on pathological processes has been gained by analysing the hyaluronan concentration in other body fluids such as urine, perfusion fluid from the intestine and bronchoalveolar lavage fluid. In the future these analyses should also be useful in clinical work. | |
| 3292677 | [Incidence and location of synovitis in the metatarso-phalangeal joints of the fore and hi | 1988 Mar | Arthritis of the metatarso-phalangeal joints resembling rheumatoid arthritis was produced by immunization of rabbits with heat-killed Escherichia coli 0: 14. In all of fifteen rabbits immunized for 4 months, hyperplasia of synovial lining cells was observed: 108/240 joints, synovial edema in 15 rabbits: 126/240, lymphoid cell infiltration in 12: 110/240 and fibrinoid deposition in 15: 115/240. Inflammatory findings were induced in each of 14 rabbits immunized for 10 months, 14 rabbits: 113/224 joints, 14: 97/224, 12: 66/224, 14: 88/224 respectively. The lymphfollicle was noted in 7 joints of only one rabbit after 10 months immunization. Lymphoid cell infiltration of the perichondral synovium was observed in 13 joints of 11 rabbits after 4 month immunization and in 33 joints of 10 rabbits after 10 months immunization. The incidence of the inflammatory findings in the volar synovium was significantly higher than that in the dorsal one (p less than 0.01). | |
| 3333342 | Management of fibromyalgia, a distinct rheumatologic syndrome. | 1987 Oct | The pathophysiology and management of fibromyalgia, a unique nonarticular rheumatologic syndrome characterized by diffuse musculoskeletal aches and pains, stiffness, discrete tender points at typical soft-tissue sites, and a characteristic sleep disturbance, are reviewed. The prevalence and incidence of fibromyalgia are not known, but it is one of the most common conditions seen by rheumatologists (after degenerative joint disease and rheumatoid arthritis). It was previously thought to involve inflammation of fibrous intermuscular septa and is sometimes referred to in the literature as fibrositis. It is not primarily psychogenic, but psychological factors may contribute. The tender points are the key to diagnosis. Fibromyalgia may be classed as primary (when no underlying disease is present) or secondary (when an associated condition exists). The pathophysiology of fibromyalgia is unknown but appears to involve complex interactions of central neurotransmitters with a relationship to pain perception, mood, and sleep. Treatment is empiric; nondrug treatment involving education, relaxation, and increased physical activity is essential. Few controlled trials of drug therapy have been conducted. Analgesics, anti-inflammatory drugs, phenothiazines, tricyclic antidepressants, and the tricyclic muscle relaxant cyclobenzaprine have been used; low doses of amitriptyline or cyclobenzaprine provide increased control of pain and mood.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 1788702 | [Vital findings in capillary microscopy in collagen diseases]. | 1991 | Microangiopathic changes in capillary architecture associated with collagen diseases can be visualized by vital capillary microscopy. In our study of 100 patients with collagen disease we found typical capillaroscopic images in 64%. Differentiation in subclasses showed the highest diagnostic value of this method in systemic sclerosis (77%) and rheumatoid arthritis (68%). It was lower in patients with Sharp- and CREST-syndrome (55%) and very low in systemic lupus erythematosus (33%). In summary, vital capillary microscopy is a valid method in non-invasive diagnostic of collagen diseases. | |
| 2075352 | [Determination of lymphocyte receptors to Klebsiella in ankylosing spondylitis]. | 1990 Oct | The authors give the results of determining receptors to Klebsiella antigens on the surface of the peripheral blood lymphocytes in ankylosing spondyloarthritis (AS). They examined 21 patients with AS, 20 patients with rheumatoid arthritis (RA) and 20 healthy individuals. Determination of the receptors was done in the reaction of indirect rosette formation. An ultrasonic disintegrate of Klebsiella culture isolated from a patient with AS was used as an antigen. Favourable results were obtained in 10 patients with AS and in none of the cases in the group of patients with RA and in healthy individuals. A higher specificity of the reaction of antigen binding lymphocytes was shown. | |
| 2135453 | [Health knowledge in patients with rheumatic diseases]. | 1990 | An inquiry was made on a group of 188 rheumatic patients chosen by random in three rheumatologic out-patient services. The inquiry showed a very poor knowledge of the disease and its functional prognosis, great differences in the patient's opinion on the value of his personal engagement in the treatment and rehabilitation, as well as many other parameters that influence the patient's positive behaviour in health matters. Evaluating the data from the inquiry, the authors found the highest level of health-education in patients with rheumatoid arthritis and ankylosing spondylitis, whereas those with degenerative and extraarticular rheumatism had lesser knowledge. The authors conclude from this study, that much more attention has to be paid in future to health-education of rheumatic patients. | |
| 2101031 | [Aspirin in the preventive treatment of cataract]. | 1990 Jan | In the patients with rheumatoid arthritis treated for a long time with aspirin, the percent of cataract is very low. Three action ways of aspirin were formulated in hindering the appearance of cataract: 1) acetylation of the lens proteins; 2) decrease of glycemia and 3) decrease of triptophen amount in the blood plasma. The lab experiments plead for these hypotheses. For preventing cataract, the persons with high risk of cataract and with incipient signs of opacity are recommended a daily and long treatment with 1/2 buffered and effervescent aspirin tablet, or 1 tablet at two days, under careful ophthalmologic surveillance. | |
| 2509697 | Pure red cell aplasia in mixed connective tissue disease. | 1989 Oct | We describe a patient with mixed connective tissue disease (MCTD), who developed pure red cell aplasia which responded favorably during treatment with corticosteroids. Pure red cell aplasia has been described in a few patients with rheumatoid arthritis and systemic lupus erythematosus, but, to our knowledge, this is the first report of an association between it and MCTD. | |
| 2591126 | Altered lymphocyte proliferation by low dosage laser irradiation. | 1989 Sep | The effect of gallium-aluminum-arsenide laser irradiation on the proliferation of human lymphocytes in culture in response to mitogenic stimulation by phytohemagglutinin was investigated. Mitogenic proliferation was inhibited by the laser irradiation at a low energy fluence and enhanced at a high energy fluence. The results indicate that low-watt laser irradiation can interfere with the immune response in vitro, and similar interference could occur in patients with rheumatoid arthritis subjected to laser therapy, if an appropriate dosage is chosen. | |
| 2478361 | Affinity electrophoresis for diagnosis of cancer and inflammatory conditions. | 1989 Aug | Affinity electrophoresis, with concanavalin A and Lens culinaris agglutinin as ligands, was applied to study the microheterogeneity of serum proteins, with special emphasis on alpha 1-fetoprotein and alpha 1-acid glycoprotein, two proteins of potential clinical value. A total of 602 samples of serum from patients with various neoplastic and inflammatory conditions were evaluated. Affinity electrophoresis provided useful information for differential diagnosis of cancers of various origins including hepatomas, metastatic liver cancers and yolk sac tumors. The method also proved indispensable for the detection of intercurrent infection in patients with rheumatoid arthritis, systemic lupus erythematosus and scaled burns. | |
| 2636421 | Primary fibromyalgia syndrome--a variant of depressive disorder? | 1989 | Primary fibromyalgia syndrome (PFS) is a form of connective tissue rheumatism, characterized by diffuse chronic pain in periarticular tissue, for which no organic cause can be identified. The present study examined the personal and family history, clinical and psychodynamic features of 40 PFS patients, and compared them to a matched control group of patients suffering from rheumatoid arthritis. Depression, either in the past or at present, was seen significantly more often among PFS patients that among controls. Dependence and passivity, idealization of family relationships, obsessive-compulsive personality, maladaptive response to loss, and prepain ergomania were the psychodynamic features characteristic of PFS patients. It is suggested that PFS is a well-defined disorder, in which specific premorbid, familial, and psychodynamic characteristics result in a depressive disorder which takes the form of a physical symptom: pain. | |
| 2491260 | Interleukin 6 and plasma cell neoplasias. | 1989 | Interleukin 6, an essential factor for B cells to differentiate to immunoglobulin-producing cells has been demonstrated to be involved in abnormal polyclonal plasmacytosis in cardiac myxoma. Castleman's disease, rheumatoid arthritis and AIDS. Furthermore, IL-6 was found to be a potent growth factor for both plasmacytoma and myeloma. The involvement of IL-6 in plasma cell abnormalities was further demonstrated by the generation of a lethal plasma cell growth in IL-6 transgenic mice. Continuous IL-6 gene expression could be considered to play an essential role in both polyclonal plasmacytosis and the generation of plasma cell neoplasias. | |
| 3385898 | Scleroderma after silicone augmentation mammoplasty. | 1988 Jul 8 | Scleroderma was diagnosed in five patients two to 21 years after silicone augmentation mammoplasty. Four patients had features of typical scleroderma and one patient had the clinical features of eosinophilic fasciitis. These five patients represent 4.4% of 113 new female patients with scleroderma who were seen during a period of seven years. In contrast, only one (0.3%) of 286 new patients with rheumatoid arthritis who were seen during the same interval had had a breast implant. This difference was statistically significant and suggests a relationship between silicone augmentation mammoplasty and scleroderma. Due to the long period of latency observed, the full impact of this association may not yet be apparent. | |
| 3395421 | Retrotendinous calcification of the infrapatellar tendon: unusual cause of anterior knee p | 1988 | Bilateral anterior knee pain is a common presentation to the orthopaedist. Correct diagnosis is based on careful history and physical examination aided by proper radiographs. Erroneous diagnosis may lead to improper treatment. This report describes a case of bilateral anterior knee pain syndrome of 3 years' duration. The teenaged patient was believed to be suffering from seronegative rheumatoid arthritis. Her pain persisted despite numerous antirheumatoid medications as well as a single injection of steroids into each infrapatellar tendon. The management of her case by means of arthroscopic surgical intervention is described. | |
| 3298922 | Adverse reactions with oral and parenteral gold preparations. | 1987 May | Auranofin (triethylphosphine gold), an oral gold preparation, has recently been made available, and along with injectable gold preparations, is of therapeutic value for rheumatoid arthritis. Serious gold toxicity is uncommon, and drug-related deaths rare. Many potential adverse reactions are similar, including dermatitis, stomatitis, thrombocytopenia, leucopenia, and proteinuria, generally with increased incidence in the injectable gold-treated patients. Oral gold is associated with benign lower gastrointestinal side effects, including diarrhoea, loose stools and abdominal cramps that are often dose-related and resolve spontaneously. The incidence of severe reactions such as thrombocytopenia, aplastic anaemia and exfoliative dermatitis is lower with oral gold than injectable preparations, and contributes to a superior risk-benefit ratio. The treatment of gold toxicity depends on the type and extent of organ involvement. | |
| 3585190 | [Pyoderma gangrenosum. 14 personal observations and review of the literature]. | 1987 | Fourteen cases of pyoderma gangrenosum are reported. Twelve were associated with various diseases: ulcerative colitis, Crohn disease, colic tumor, rheumatoid arthritis, chronic myeloid leukemia, agammaglobulinemia, respiratory infections (2 cases) and post surgical intervention. In 2 cases pyoderma gangrenosum appeared to be primary. The clinical characteristics of the affection make it a very particular type of ulcer: pustular onset, frequent localization to other than leg, rapid eccentric spread, frequent associated morbidity (mainly digestive and hematologic). The pathogenesis is still unknown and the treatment is not well codified. | |
| 2947217 | [Lipoid nephrosis of toxic origin. 2 cases]. | 1986 Nov 8 | Classically, the histological lesion observed in a drug-or heavy metal-induced nephrotic syndrome is membranous glomerulonephritis. We report two cases of "toxic" nephrotic syndrome with unusual histological features. One was secondary to mercury intoxication and the other, to D-penicillamine in a patient with rheumatoid arthritis. In both cases, renal biopsy revealed minimal glomerular changes. The proteinuria rapidly disappeared after exposure to the toxic agent was discontinued. Genetic factors and a disregulation of the immune system with lymphokine production may be responsible for these renal changes. This study demonstrates that renal biopsy is necessary in this clinical setting. | |
| 3489860 | [Posterior uveitis in systemic diseases. A pathologic and epidemiologic study]. | 1986 Aug | In the course of 2943 autopsies, during which the eyes were also removed, investigations were carried out concerning inflammatory lesions of the posterior uveal tract. Posterior uveitis was found in 202 cases (6.9%) of subjects whose mean age was 74.5 years. In 98% of the cases this was a non-granulomatous inflammation. The frequency of the associated systemic diseases in the cases of uveitis was compared with the frequency of such diseases in an accurately chosen control group. The results of our investigation showed that diabetes mellitus and inflammatory diseases, particularly rheumatoid arthritis, myocarditis, endocarditis and hepatitis are more frequently found in patients with uveitis. | |
| 3941866 | Osteoid osteoma of the hip stimulating an early onset of osteoarthritis. | 1986 Feb | Thirty-six patients with osteoid osteomas in the hip were retrospectively studied, including 30 with intraarticular nidi and six with extracapsular nidi. Osteoarthritis developed in 50% of those patients with intraarticular lesions; none of the patients with extracapsular lesions had joint changes. Rheumatologic studies were conducted with eight of the patients with osteoarthritis. The cause of the degenerative joint disease is open to speculation. However, as five of the eight patients had major histocompatibility (HLA) markers for rheumatoid arthritis, the presence of this HLA factor may indicate the patients at risk for inflammatory changes in the joint. |