Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6523082 | Posterior atlanto-axial dislocation in rheumatoid arthritis. | 1984 | Seven patients with rheumatoid arthritis and posterior atlanto-axial dislocation are presented. The patients were elderly women who had suffered with the disease a long time. In all cases earlier cervical radiographs were available, excluding any predisposing congenital anomaly. Fracture and arthritic destruction of the dens, of parts of the body of the axis, or of the anterior arch of the atlas proved to be predisposing factors of the lesion. | |
| 3974686 | A comparison of the treatment of rheumatoid arthritis in health maintenance organizations | 1985 Apr 11 | This study compares the use of health care services (hospital and ambulatory) by patients with rheumatoid arthritis who were under the care of rheumatologists in prepaid and fee-for-service arrangements. Participating physicians from a random sample of half the rheumatologists in northern California maintained a log of all their patients with well-established diagnoses of rheumatoid arthritis. We interviewed 822 of their patients, using a structured, validated phone survey to obtain information about health care use. Patients in prepaid plans had about the same number and type of hospitalizations and the same rate of surgery as those receiving fee-for-service care. However, fee-for-service patients made more ambulatory visits. We conclude that the use of expensive services (hospital admissions and surgery) for the care of patients with rheumatoid arthritis is not different in fee-for-service and prepaid settings. | |
| 7221787 | Immunological assessment of patients with rheumatoid arthritis--evaluation of the effects | 1981 May 2 | Some humoral and cellular immune functions were evaluated in a group of 10 patients with rheumatoid arthritis before and after 3 months of treatment with the beta-blocking agent propranolol. Humoral parameters measured were serum immunoglobulins including IgE, auto-antibodies, C-reactive protein, total haemolytic complement activity and the complement components C3 and C4. Cellular functions assessed were polymorphonuclear leucocyte chemotaxis, phagocytosis and postphagocytic nitroblue tetrazolium reduction, hexose monophosphate shunt activity and myeloperoxidase-mediated iodination of ingested protein; lymphocyte transformation to the mitogens phytohaemagglutinin and concanavalin A was also investigated. No alteration of humoral factors and neutrophil functions was observed following propranolol administration (40 mg 3 times a day), but lymphocyte transformation was significantly increased. Improved lymphocyte function did not correlate with clinical improvement. | |
| 6970578 | Characterization of the immunocompetent cells of rheumatoid synovium from tissue sections | 1981 Jan | T lymphocytes positively identified by alphanaphthyl acetate esterase (ANAE) (70%) were localized in perivascular "cuffs" in rheumatoid synovia. ANAE-negative lymphocytes (B lymphocytes) were primarily within the reactive lymphoid centers, whereas intracellular Ig-expressing plasma cells were outside the centers. Lysozyme of diffuse ANAE expressing mononuclear phagocytes (5-15%) were diffusely dispersed, but were seldom found in the lymphoid centers. There were few granulocytes (10%). On elution, plasma cells and lymphocytes were lost. Most granulocytes and mononuclear phagocytes in the eluate were immunoglobulin-positive. The in situ architecture is compatible with active immunologic inflammation and T-dependent immunoglobulin synthesis. | |
| 2860075 | Biochemical and clinical changes occurring during the treatment of rheumatoid arthritis wi | 1985 | Groups of 15 patients with active rheumatoid arthritis have been treated with sulphasalazine, (salazosulfapyridine INN), zinc sulfate, captopril or methyl cysteine, and assessed by seven clinical measurements and six laboratory methods on eight occasions during a 24-week treatment period. The results have been compared with equivalent data derived from the use of antiinflammatory agents (e.g. aspirin) and drugs of accepted 'antirheumatoid activity' (e.g. D-penicillamine). Improvements in mean data provide the basis of a human screening system for the detection of antirheumatoid drug activity. Results suggest that sulphasalazine and captopril have this type of activity whereas zinc sulfate and methyl cysteine do not. | |
| 6958210 | Systemic lupus erythematosus during penicillamine therapy for rheumatoid arthritis. | 1982 Nov | Six patients with rheumatoid arthritis developed a syndrome resembling lupus erythematosus while being treated with penicillamine. All patients had previous mucocutaneous reactions to chrysotherapy. Manifestations included pleurisy in five of six patients, rashes in three, nephritis in two, and neurologic disturbances in two; lupus erythematosus cells were found in five patients, antinuclear antibodies in all six, antideoxyribonucleic acid in three, positive Coombs' test results for three patients, and low C4 complement in five of the six. Symptoms were slow to resolve after penicillamine treatment was discontinued, and four of the patients needed corticosteroid therapy. A higher frequency than expected of HLA A 11 in three patients and B 15 in five patients was seen. | |
| 3258 | Salicylates and renal function in rheumatoid arthritis. | 1976 Mar 13 | The effect of salicylate treatment on the kidney, particularly medullary function, was investigated. In a retrospective analysis patients with rheumatoid arthritis (RA) treated with high doses of salicylates were shown to have inferior urinary concentrating power and increased excretion of N-acetyl-beta-D-glucosaminidase (NAG) when compared with patients who had not received salicylate treatment. A prospective study of renal funcition in healthy people and patients with RA starting salicylate in therapeutic doses showed that while epithelial cell excretion was only transiently raised in both groups the excretion of NAG was increased in all cases at three days and this increase was sustained at 10 days, all values being much higher in the patients than in the healthy subjects. Thus salicylate treatment does cause renal tubular damage but this damage results in only minimal impairment of function and does not constitute a reason for withholding salicylate treatment. | |
| 21637 | Effect of glucocorticoids on the hexose monophosphate pathway in human rheumatoid synovial | 1977 Oct | Human rheumatoid synovial lining cells have up to four times the capacity to oxidize glucose 6-phosphate, the first step of the hexose monophosphate pathway, as do the nonrheumatoid cells. The reducing equivalents produced by this system have many significant metabolic effects. Exposure of these cells by 10(-5) M prednisolone in vitro, or to 6 mg/day in vivo, causes some depression of this activity in the rheumatoid synovial lining cells; less than this dose of steroid, or the administration of nonsteroidal drugs in vivo, has little or no effect. The depression of activity produced by 6 mg/day does not bring this activity down to the value found in nonrheumatoid synoviocytes. | |
| 1184642 | Rheumatoid wrist deformities and their relation to ulnar drift. | 1975 Oct | With a new technique of roentgenography to reveal more accurately the degree of ulnar drift and radial deviation in hands of patients with rheumatoid arthritis, it was shown that the radial deviation was less marked than would be ascertained with conventional roentgenograms. Therefore radial deviation probably does not constitute a cause for ulnar drift. The study led to clinical implications as regards the position of splinting (with the wrist in ulnar deviation) and as regards operations to correct deformities of the wrist due to rheumatoid arthritis. | |
| 7404586 | Dependence of EMG-reaction times of the rectus femoris on position changes of the hip join | 1980 Jun | EMG-reaction times (EMG-RTs) of the rectus femoris in midposition (M) and internally rotated position (IR) of the right hip joint were examined in nine control subjects and nine patients who had lost most of the capsule of a hip joint after total hip joint replacement procedure. In both groups EMG-RTs of the rectus femoris were faster at IR than at M. The difference of EMG-RTs between M and IR was essentially the same in the two groups. It is assumed that information from proprioceptors in the joint capsule may not play an important role in postural dependence of EMG-RTs of the muscle. | |
| 4029960 | Haptoglobin groups and rheumatoid arthritis. | 1985 | Haptoglobin types were determined in 200 patients with rheumatoid arthritis (RA) subdivided according to sex and familial occurrence of polyarthritis. A highly significant excess of the Hp2 gene was found among patients with a family history of polyarthritis, more pronounced among males. The possible association between Hp2 and predisposition for increased immune reactivity is discussed. | |
| 6941466 | HLA-D antigen frequencies in Sjögren's syndrome. Differences between the primary and seco | 1981 | HLA-A, B, C and D typing was performed in 19 patients with primary Sjögren's syndrome (primary SS) and in 15 patients with rheumatoid arthritis (RA) and secondary Sjögren's syndrome (RA-SS). In the primary SS group, the frequency of HLA-Dw2 was increased (p less than 0.01; "corrected" p greater than 0.05) while the frequency of Dw3 was non-significantly increased. In the RA-SS patients, the frequency of HLA-Dw4 was increased to 84.6% (relative risk = 22.8; p less than 0.001) and the frequency of Dw2 was non-significantly decreased. An increased frequency of Dw2 in primary SS has not been reported before. To investigate if this observation was due to chance, a new series of 16 patients with primary SS were HLA typed. In this new group, the frequencies of both Dw2 and Dw3 were significantly increased, while the frequency of Dw4 was significantly decreased. In the whole group of primary SS patients, the frequencies of Dw2 were 56.3% (relative risk = 3.7; p less than 0.001). Dw3:50.0% (relative risk = 2.8; p less than 0.01) and Dw4: 6.3% (relative risk = 0.28; p less than 0.05). We conclude that genetic factors associated with the HLA-system are involved in the development of Sjögren's syndrome and that these genetic factors are different in primary and secondary Sjögren's syndrome. In primary Sjögren's syndrome, the association with both Dw2 and Dw3 might suggest a further heterogeneity of the syndrome. | |
| 6201143 | Increased DNA and/or RNA content of synovial fluid cells in rheumatoid arthritis: a flow-c | 1984 Apr | Flow-cytometry studies of DNA and RNA content were carried out in acridine orange-stained synovial fluid lymphocytes from 11 patients presenting with classical or definite rheumatoid arthritis. Monoclonal antibodies were used to detect specific T cell surface antigens (OKT3, OKT4, OKT8) and antigens associated with lymphocyte activation (OKIa 1, OKT10). T3 positive cell percentages were comparable to those of normal blood, although T4/T8 ratios were decreased in 4 out of 5 cases, and HLA-DR positive cells increased. Six out of 11 patients showed percentages of dividing cells varying from 2.2 to 7.2% as compared with less than 1% in the other patients and in normal blood. Nondividing cells were characterised by an increase in their RNA content compared with normal blood. A greater increase of RNA content was observed in patients with lower percentages of dividing cells, suggesting a G1/S block. Changes in cellular DNA and/or RNA contents provide a valuable parameter of lymphocyte activation, not necessarily linked to the expression of differentiation antigens by activated cells. | |
| 7010517 | [Clinical applications of enzyme-immunoassay of rheumatoid factor]. | 1980 Oct | The authors describe a method of enzymo-immunological estimation of rheumatoid factor. This estimation, of non-competitive type, includes 3 stages : the rheumatoid factor is first extracted from the serum by fixation on the aggregated IgG linked to cellulose powder; then its presence is revealed by fixation of an oxidase IgG glucose conjugate on the solid phase; finally, the enzyme activity linked to the solid phase is measured. This activity is directly related to the concentration of rheumatoid factor present. The estimation, carried out on 2 050 patients including 114 with rheumatoid arthritis, is well correlated with technic of the Rose-Waaler reaction. Furthermore, the greater sensitivity, the better reproducibility and the quantitative character of this method might improve the supervision of patients with rheumatoid arthritis. | |
| 6894842 | Arthrographic study of the rheumatoid knee. Part 1. Synovial proliferation. | 1981 Aug | The improved method of double-contrast arthrography for the knee joint, which can give extensive information on the intra-articular components, was undertaken in 131 knee joints with classical rheumatoid arthritis. Synovial proliferation was classified by its localisation into 6 types: nonproliferated (NP); localised, subdivided into suprapatellar pouch (SPP), proper articular (PA), and posterior (POST); panarticular (PAN); and burned out type (BO). These types are intimately related to the radiological stage and pathological changes of the articular cartilage and menisci. By following the dynamic changes of synovial proliferation by arthrography the clinical course of the rheumatoid knee joint may be predicted. While in the NP and SPP types destruction of the joint is minimal, it is relatively rapid and severe in the PA and PAN types. Thus the proliferation in the joint proper has a stronger influence on joint destruction than does the suprapatellar pouch. From these results synovectomy to resect proliferated synovial tissues of the joint proper completely, and to resect those of the suprapatellar pouch only superficially in the early stage, was undertaken in 21 rheumatoid arthritic joints, giving excellent results in 80.9%. The advantages of this method are discussed. | |
| 7066034 | Different molecular forms of fibronectin in rheumatoid synovial fluid. | 1982 Jan | The concentration of fibronectin in rheumatoid synovial fluid was found to be 2-3 times higher than in the corresponding plasma. Normal plasma revealed a homogeneous precipitate by cross- immunoelectrophoresis using antifibronectin, while rheumatoid plasma and rheumatoid synovial fluid exhibited a heterogeneous precipitate. The heterogeneous precipitate in rheumatoid plasma was found to be a complex between fibronectin and fibrinogen as evidenced by cross-immunoelectrophoresis. Synovial fluid fibronectin demonstrated a lower molecular weight by gelfiltration on Sepharose CL6B than did normal plasma fibronectin. We suggest that the presence of degraded fibronectin in rheumatoid synovial fluid may be the result of either the degradation of fibrin-fibronectin complexes or the destruction of matrix fibronectin from the synovial tissue. | |
| 6384507 | Thymopoietin pentapeptide (thymopentin, TP-5) in the treatment of rheumatoid arthritis. A | 1984 Aug | Thymopentin (TP-5), the active side of thymopoietin, was shown to affect immunoregulation. The effect of this drug in the treatment of rheumatoid arthritis (RA) was evaluated. Three trials were performed: a six month double-blind trial comparing TP-5 administered subcutaneously to placebo at 3 different dosages, an open longterm study in which the same dosage of the drug was administered subcutaneously, and a shortterm (3 weeks) double-blind trial in which the drug was given intravenously at a high dosage (100 mg/day). In none of these 3 studies were statistically significant improvements registered in the TP-5 treated patients, although there were important improvements in individual patients. Serious side effects were not encountered, but the majority of patients did not improve or were withdrawn because of ineffectiveness. The beneficial effect of TP-5 on the clinical evolution of RA, reported elsewhere, could not be confirmed by these studies. | |
| 4030819 | Total condylar knee replacement. A study of factors influencing range of motion as late as | 1985 Sep | The factors influencing the range of motion of the knee after total condylar knee replacement were analyzed in fifty-five consecutive patients who had seventy-one replacements and a minimum follow-up of two years. Statistically significant improvement in flexion occurred between the first postoperative evaluation in the hospital, the evaluation at discharge, and the evaluations at three months and one year after replacement. Postoperative range of motion was not influenced by the patient's gender, by the extent of the disease (monoarticular in comparison with polyarticular), or by treatment with a unilateral or bilateral procedure. The knees of patients with rheumatoid arthritis gained extension at the expense of flexion. The average flexion arcs of the knees with rheumatoid arthritis and of those with osteoarthritis were the same two years after operation as they had been preoperatively. Knees with preoperative flexion of more than 100 degrees had lost flexion at follow-up, whereas those with preoperative flexion of less than 100 degrees had gained flexion. Significant improvement in extension occurred only before discharge. For the patients whose preoperative flexion contracture was 10 degrees or more, virtually all improvement in the contracture occurred at the time of surgery. Patients who had a simultaneous bilateral total knee replacement did as well as those with a single knee replacement.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 6398152 | Placebo therapy in rheumatoid arthritis. | 1983 Jan | Few studies have attempted to describe the effect of placebo therapy on chronic pain. In this study pain was assessed daily, for 25 days, in 23 patients with rheumatoid arthritis. Patients received placebo during the last 9 days of the study. Pain scores during the first 16 days acted as a baseline from which each patient's response to placebo could be determined. Patients completed Form B of the Eysenck Personality Inventory on entry into the study, a pre-treatment expectation rating scale and a post-treatment assessment scale. Five patients were excluded from analysis because of trends in their baseline pain scores. Of the remaining patients, nine responded positively to placebo and five responded negatively. Four patients reported no significant change in pain and were found to be more introverted than both the negative (p less than 0.05) and positive placebo responders. Consequently, the degree of extraversion might prove a useful predictor of therapeutic response. No significant relationship was found between the patients expectation of therapy and the observed response which suggests that therapeutic outcome is not pre-determined. However, the patients assessment of therapeutic effect was closely related to the observed response (p less than 0.05). Neuroticism was greater in patients with side-effects than those without (p less than 0.05) and might be utilized as a means of detecting those patients most likely to complain of unrelated symptoms while on a new therapy. The different placebo responses observed draws attention to the difficulties in making therapeutic judgements in clinical practice and of assessing efficacy in drug trials. | |
| 3876900 | Induction of DNA-antibodies by d-penicillamine. | 1985 Jul | As no critical evaluation of native-DNA antibodies due to d-penicillamine (dP) has been made, we have examined this using highly purified DNA fractions obtained by benzoylated-naphthoylated-DEAE-cellulose chromatography. The nDNA, dsDNA, and ds/ss DNA binding was determined in 10 normals, 24 rheumatoid arthritis (RA) patients never on dP, 17 RA patients on dP and in serial sera from 15 of the latter before, during, and after cessation of dP. The results indicate that dP does induce both dsDNA and ssDNA antibodies which persist for many months after its cessation. |