Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 8017979 | Adhesion molecules in rheumatoid arthritis: role in the pathogenesis and prospects for the | 1994 May | The essential role played by cell adhesion and migration in the generation of chronic synovitis is now beyond doubt. Some of the beneficial effects of currently used drugs may be related to their ability to interfere with these mechanisms. The complexity of the process, however, means that there are many potential targets for therapeutic intervention and therefore further studies of the basic mechanisms are necessary to identify those which are most important. | |
| 7505481 | Changes in levels of IgM RF and alpha 2 PAG correlate with increased disease activity in r | 1993 | In this prospective study of 24 pregnant patients with rheumatoid arthritis, quiescent disease activity in 21 patients (88%) during gestation was followed by more active disease in the puerperium in 19 patients (79%). Increased disease activity was reflected in a deterioration in manual dexterity and this was found to correlate with a post-partum rise in IgM rheumatoid factor (IgM RF) (r = 0.86) and a post-partum decline in pregnancy associated alpha-2 glycoprotein (PAG) (r = 0.44). The increase in IgM RF also correlated with increased disease activity measured by a visual analogue scale (r = 0.44). Changes in IgA RF were not observed. These results suggest that PAG and IgM RF could contribute to the modulation and pathogenesis of rheumatoid arthritis during pregnancy. | |
| 7836028 | Rheumatoid nodules and cyclosporin A treatment. | 1994 | The authors describe the appearance of rheumatoid nodules during cyclosporin A (CsA) therapy for RA. Their course was evaluated by sonography that revealed an increase in number and size of rheumatoid nodules. The relationship between CsA treatment and the onset of nodulosis is not clear and further studies are needed to assess the role of CsA treatment in the extra-articular manifestations of rheumatoid arthritis such as rheumatoid nodules. | |
| 8070161 | Increased levels of sCD23 in rheumatoid arthritis are related to disease status. | 1994 May | The low affinity receptor for IgE (Fc epsilon RII, CD23) is involved in many aspects of T and B cell regulation. In the current study, serum levels of sCD23 were measured in monozygotic (MZ) twins discordant for rheumatoid arthritis (RA) to examine whether an increased level of sCD23 in RA is, at least in part, genetically determined. Paired analysis showed significantly elevated sCD23 levels in affected twins when compared with their unaffected co-twins (p < 0.01). There was no significant difference in sCD23 in the unaffected twins compared with normal controls. Higher levels of sCD23 were found in males compared to females in both affected and unaffected twins. Soluble CD23 showed a significant increase with age in RA affected twins (p = 0.013), but no association with disease duration (p = 0.87). There was no significant variation in sCD23 level with HLA-DR phenotype. We conclude that elevations in serum sCD23 in patients with RA are primarily disease related. | |
| 8012262 | Hybrid total knee arthroplasties in rheumatoid arthritis. | 1993 Summer | One hundred and sixty-eight total knee arthroplasties (TKA) with cementless femoral components, cemented tibial and patellar components were performed in 98 patients with rheumatoid arthritis (RA) between 1989 and 1992. At 1-4 years followup the hybrid TKA in RA provided satisfactory results when compared to the cemented TKA. There were no signs of loosening about the cementless femoral component. The results indicate that the hybrid TKA is comparable to a fully cemented knee even in the patients with severe RA at one to four years followup. | |
| 7955401 | Laboratory diagnosis and monitoring in chronic systemic autoimmune diseases. | 1994 Nov | The testing done in the diagnostic immunology laboratory contributes to the management of patients with systemic autoimmune diseases. In these diseases the interaction between environmental factors and a genetically dysregulated immune system produces a continually variable level of disease activity. Improved techniques now allow the clinical scientist to assess the integrity of a patient's immune system and to ascertain qualitative or quantitative disturbances in its activation and expression. Cellular and humoral immunity may become independently activated or dysfunctional in certain disease processes, although the generation of amplifying proteins may result in the full clinical expression of immunity and autoimmune inflammation. Autoimmune diseases can, in part, be characterized according to the activation pattern of gene expression encoding the amplifying and proinflammatory cytokines. Modern therapy is increasingly aimed at determining ways to influence discrete elements of the immune apparatus; therefore, it is important to identify and characterize the patterns of expression of the immune system mediators serially in chronic autoimmune disease states. Newer diagnostic procedures stemming from observations in basic and clinical research are expanding the useful database on patients, but they must be carefully evaluated to prove their applicability and efficacy. Because blood samples are the best available specimens for testing, one must consider all the possible sampling problems and pitfalls of using results from peripheral blood to judge changes in function of the lymphoid system. | |
| 8348275 | Factors predicting death, survival and functional outcome in a prospective study of early | 1993 Aug | Sixty-four survivors from a prospective study of early rheumatoid disease were assessed again at a mean of 15.2 years from presentation and their status compared with 29 patients who had died. Eleven of the dead and only two of the survivors had been treated with steroids. There was a small increase in mortality due to the disease itself but only one death was directly caused by it. As might be expected, those who died were older. In the first year of disease, they had lower haemoglobin levels, a lower body mass, higher sedimentation rates and higher levels of blood urea. One-fifth at entry to the study and two-fifths by the time of death, had poor functional capacity. Of 64 survivors, six had poor functional capacity at entry and nine after 15 years. Discriminant analysis was performed to identify the most powerful combination of early features predicting a poor functional outcome. A combination including early erosive change, seropositivity, poor grip strength and cervical subluxation predicted the outcome correctly in 73% of survivors. Almost 60% of survivors remained with or improved to normal function at 15 years suggesting that morbidity is not as bad as has been suggested in the past. | |
| 9282608 | Cervical spine involvement in rheumatoid arthritis: prevalence and relationship with overa | 1996 Jul | Rheumatoid arthritis (RA) affects the cervical spine in 20-90% of patients in Western countries. We report the prevalence of cervical spine involvement in RA and its relationship with duration of disease, seropositivity, hand joint erosions and symptoms and signs suggestive of cervical spine involvement. 100 patients with RA criteria were included. Apart from clinical history and examination, study included X-rays of the cervical spine in AP, open mouth and lateral views and posteroanterior view of hands and rheumatoid factor estimation. All X-rays were read by a radiologist who was unaware of the clinical details. Cervical spine involvement was seen in 65% of patients. The commonest abnormality was erosions of the odontoid process (47%), followed by atlanto-axial dislocation and apophyseal joint involvement (24%). Only 5% of patients had abnormalities of spinous processes or vertebral bodies. Patients with abnormal cervical spine radiographs had higher prevalence of rheumatoid factor and erosions on hand radiographs. Severity of cervical spine changes was related to duration of disease (> 5 years). No correlation was seen between symptoms and radiological abnormalities except when neurological deficit was present. Patients with seropositivity, erosive disease and disease duration greater than five years should be screened for cervical spine disease. | |
| 7932429 | Henoch-Schönlein purpura in rheumatoid arthritis. | 1994 Jun | This is the first report of Henoch-Schönlein purpura associated with permanent joint damage due to rheumatoid arthritis, which was observed in 3 of the 10 adults we treated for Henoch-Schönlein purpura since 1974. Each of 3 women had been admitted with palpable purpura of the lower extremities. The diagnosis was based on various findings including arthralgia, stiffness, and/or swelling of the joints, and on the results of radiographic, immunofluorescence and other studies. Renal biopsy revealed slight mesangial proliferation in 2 of the patients. The nephropathy did not deteriorate following discharge. However, bilateral swelling of the wrists with destructive joint changes was subsequently observed on radiographs in all patients. Since 2 patients showed positivity for human leukocyte antigen DR4, this antigen may have been a genetic factor in the joint disease in these patients. | |
| 8574615 | The history of rheumatoid factor. | 1995 Jul | The events that led to identification of rheumatoid factor are narrated, and the respective contributions of the researchers who worked to achieve this goal are clarified. Changes that have occurred over time in concepts concerning the clinical significance and pathophysiologic role of rheumatoid factor are briefly summarized. | |
| 8163982 | Porous-coated total hip arthroplasty in rheumatoid arthritis. | 1994 Feb | Thirty-five porous-coated total hip arthroplasties were implanted in 25 patients with juvenile-onset or adult-onset rheumatoid arthritis and prospectively followed for a mean of 4.5 years (range, 3-6.5 years). Using the Harris hip rating, the mean hip score at the final follow-up evaluation was 91, and 86% of the hips had a good or excellent result. Thirty-one hips had no hip or thigh pain, while four had occasional slight pain. After surgery, 10 patients were employed and the remainder were ambulatory. There were no early or late deep infections. There was one reoperation for recurrent dislocation of the hip, but the components were not removed. Radiographic evaluation of the acetabular component showed that only one component had a complete radiolucent line in all three zones. Three femoral components had nonprogressive subsidence. At this intermediate-term follow-up period, porous-coated total hip arthroplasty is a promising technique that is likely to be successful in young patients with rheumatoid arthritis. | |
| 1305735 | [Comparison of treatment outcome in patients with rheumatoid arthritis treated with TFX- P | 1992 Dec 7 | Thirty five patients with rheumatoid arthritis were given TFX Polfa, initially everyday in the intramuscular injections in the dose of 10 mg TFX protein for 60 days, followed by 1 injection of 10 mg TFX protein a week for 10 months. Other 30 patients with rheumatoid arthritis treated with gold salts were used for comparison. Several clinical and laboratory tests were performed before the treatment and after 1 year. A one-year therapy significantly improved all clinical parameters in both groups. A significant increase in hemoglobin and erythrocyte count was noted in patients treated with TFX. A significant decrease in the markers of inflammation was seen. A percentage of both early and delayed E rosettes increased highly significantly. The obtained results suggest that TFX Polfa is efficient in these cases of the rheumatoid arthritis which cannot be treated with gold salts. | |
| 8478878 | Development of a disease activity score based on judgment in clinical practice by rheumato | 1993 Mar | In a prospective study of up to 3 years' duration of 113 patients with early rheumatoid arthritis a disease activity score (DAS) was developed based on the clinical judgment of 6 rheumatologists. The patients were divided in groups with high and low disease activity according to explicit rules. By various statistical methods, including discriminant analysis and multiple regression analysis, a DAS could be defined. This DAS is a continuous measure consisting of the variables Ritchie articular index, number of swollen joints, erythrocyte sedimentation rate and general health measured on a visual analog scale. | |
| 8230007 | Factors predicting outcome of rheumatoid arthritis: results of a followup study. | 1993 Aug | OBJECTIVE: To determine prognostic factors in rheumatoid arthritis (RA). METHODS: One hundred thirty-two women with definite RA were followed yearly from an early phase of the disease (symptoms < 5 years) for a mean duration of 6 years. The prognostic value of the first available clinical and laboratory variables and assessments of functional ability was related to several outcome measures (physician's opinion of disease severity, disease activity, radiological abnormalities, functional ability and number of prescribed 2nd-line drugs) by single predictor analysis and by logistic regression. RESULTS: The variables most predictive for one or more of the outcome measures were number of swollen joints, Ritchie score, health assessment questionnaire score, radiographical abnormalities, positive IgM rheumatoid factor (RF), positive IgG-RF, HLA-DR4, and an elevated percentage serum agalactosyl IgG. The accuracy of predicting outcome was calculated from several combinations of these variables, and varied between 70 and 80%. The accuracy based on a combination of the commonly available variables (number of swollen joints, IgM-RF and the erosion score), closely approximated the maximal accuracy that could be achieved. CONCLUSION: The outcome of RA can be predicted by a combination of variables that are commonly available in the clinical setting. | |
| 7686834 | A cartilage-derived inhibitor of neovascularization and metalloproteinases. | 1993 Mar | It is now recognized that persistent neovascularization is a characteristic feature of a number of serious diseases including rheumatoid arthritis. In this case, deregulated capillary growth is a prominent event in the development of the rheumatoid synovial pannus. Cartilage is a normally avascular tissue and it has been suggested that a decrease or depletion of inhibitors of angiogenesis might be responsible, at least in part, for the vulnerability of cartilage to synovial attack. Our laboratory has recently purified and characterized a potent inhibitor of angiogenesis in vivo and in vitro from cartilage and from the conditioned media of chondrocytes. Importantly, this protein is also an inhibitor of mammalian collagenase. | |
| 1348199 | Sulphasalazine therapy in rheumatoid arthritis: qualitative changes in lymphocytes and cor | 1992 Apr | Clinical and immunological parameters in 14 patients with rheumatoid arthritis (RA) receiving sulphasalazine (SASP) were evaluated, to determine whether their clinical response was reflected by any quantitative changes in their peripheral blood lymphocytes after 12 weeks. Whilst disease activity markers fell significantly, no such changes were noted in the percentage or absolute numbers of lymphocytes or their subsets. The lymphocytes of a further 21 patients before and after receiving SASP for 12 weeks were then studied qualitatively. The suppression mediated by in vitro SASP on ex vivo PHA stimulated lymphocytes showed a decrease at 12 weeks. This change was more marked and reached statistical significance only in those patients who showed a good clinical response. It is postulated that this may in some way be related to expression of activation markers and concomitant SASP binding. | |
| 7631037 | Joint counts and physical measures. | 1995 May | The joint examination is the major source of information to determine clinical status of rheumatoid arthritis in the clinic or in a clinical trial. Quantitative methods may evaluate tenderness, pain on motion, swelling, deformity, and limitation of motion. Use of self-report, simplified, reduced, and binary (normal/abnormal) evaluations are presented in this article with emphasis on using binary evaluations in clinical settings. The uses of grip strength, button test, and walk time are also discussed. | |
| 8878373 | Disease course and prognosis in rheumatoid arthritis: an interdisciplinary prospective lon | 1996 Sep | A three-year follow-up of individuals with rheumatoid arthritis was performed. The overall aim was to examine the change in functional status and psychological well-being. Possible determinants of prognosis with regard to future functional disability, pain and wellbeing, were explored by both univariate and multiple regression analyses. Functional disability, pain and well-being were fairly stable over the 3-year period. Progress of RA disease was most strongly related to initial function and age and only to a minor extent to the psychological well-being. | |
| 8358987 | Increased levels of urinary collagen crosslinks in females with rheumatoid arthritis. | 1993 Jun | Bone loss is a feature of RA, but the exact mechanisms involved are not clear. The collagen crosslinks deoxypyridinoline (DPYR) and pyridinoline (PYR) are specific indices of 'mature' collagen breakdown and reflect increased bone turnover. The aims of the study were to examine crosslink levels in RA and their association with disease activity and the effect of steroids. Urinary crosslinks corrected for creatinine were measured on morning fasting samples by HPLC in 70 postmenopausal women with rheumatoid arthritis (RA) aged 45-65 and compared with 169 postmenopausal healthy age-matched controls from the population. Mean levels of PYR were significantly higher in RA cases than in controls (52.4 versus 37.5 nmols/mmolCr) although mean levels of DPYR did not differ significantly. A weak correlation was found with ESR and PYR (r = 0.35) but not with other markers of disease activity. Thirteen of the RA cases were current steroid users and their levels of DPYR and PYR even with low doses, were significantly elevated above those of non-users, ex-users and controls. The finding of raised urinary PYR but not the bone specific DPYR in nonsteroid using RA cases suggests that the increased collagen breakdown does not primarily come from bone but from other sources such as cartilage and synovium. The large increases in collagen excretion in low dose steroid users, may reflect the higher risk of osteoporosis in this group. | |
| 8064719 | Serum keratan sulfate levels in rheumatoid arthritis: inverse correlation with radiographi | 1994 May | OBJECTIVE: To correlate the serum levels of keratan sulfate (KS) in patients with rheumatoid arthritis (RA) with different clinical and radiographic variables. METHODS: Serum KS levels were measured in 85 patients with RA and 41 age matched controls. Patients with RA were classified according to their disease activity, the presence of rheumatoid factor, the medication prescribed, and to the severity of the joint radiographic changes. RESULTS: Patients with RA had significantly (p < 0.02) higher levels of serum KS compared to the healthy controls. More significantly, there was an inverse correlation of the serum KS levels with the disease activity (p = 0.02) and the severity of the radiographic changes (p = 0.012). CONCLUSIONS: Serum KS levels appear to correlate with the severity of articular cartilage damage in RA. |