Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7869305 | Relationship of education level to treatment received for rheumatoid arthritis. | 1994 Nov | OBJECTIVE: To determine whether treatment received for rheumatoid arthritis (RA) is systematically different among individuals with different levels of formal education. METHODS: Using 4,455 patient-years of observational data from the University of California, San Francisco (UCSF) RA panel, we estimated the relationship between patients' education level and treatment received for RA. We define RA treatment broadly in terms of both the use of specific medications and use of health services. Independent variables include spouse's education level, as well as demographic, clinical, and socioeconomic characteristics, which are potential cofounders of this relationship due to associations with education level or RA treatment. RESULTS: Patients with RA with higher levels of formal education are more likely to be hospitalized or to undergo surgery for RA, even after differences in demographic, clinical, and socioeconomic characteristics are taken into account. In contrast, the use of specific medications was not systematically different among individuals with different education levels. CONCLUSION: The association of education level with use of health services may partially explain the association of education with RA outcomes. Further studies are needed to test this hypothesis formally. | |
| 8670339 | Progression of rheumatoid arthritis following bone marrow transplantation. A case report w | 1996 Jul | The progression of rheumatoid arthritis (RA) is documented in a patient receiving a sex-mismatched, allogeneic bone marrow transplant (BMT) for gold-induced marrow aplasia. DNA typing confirmed a high probability of a full donor engraftment (complete chimerism). Although the RA was in complete remission 2 years post-BMT, clinical, laboratory, histologic, and radiologic evidence of the recurrence of synovitis from 3-13 years post-BMT is presented. Implications of these observations for theories of the pathogenesis of RA and the future of immunotherapies are discussed. | |
| 8146771 | [An evaluation of the effect of the sauna on the clinical, laboratory and psychological in | 1993 | The direct effect of sauna procedures was assessed in 196 patients with rheumatoid arthritis (RA) in minimal or moderate activity stage. Three temperature and humidity regimens were tested. The optimal conditions occurred at 80 +/- 5 degrees C and relative air humidity 10-20%. Sauna produced a positive effect on locomotor system, psychoemotional status, alleviated pain. Clinico-biochemical and immunological indices of the peripheral blood underwent insignificant transient shifts. | |
| 7940336 | [The mechanism of the action of laser therapy in rheumatoid arthritis]. | 1994 | 48 patients with rheumatoid arthritis (RA) were exposed to He-Ne laser radiation. Due to the course of the above laser therapy the patients displayed reduced levels of E and F2 alpha prostaglandins, a trend to a decrease of lipid peroxidation products, glycosaminoglycans and collagen-peptidase activity. This evidences for suppression of the inflammation and destruction in the connective tissue. Catalase activity in red cells enhanced. The authors point to high efficacy of low-intensity He-Ne laser in moderate rheumatoid inflammation. | |
| 8779786 | [Clinical and immunological effects of leukapheresis therapy using cotton-wool filter for | 1996 Jun | Remarkable clinical effectiveness of leukapheresis (LP) using a cotton-wool filter as a therapy for patients with rheumatoid arthritis (RA) was previously reported. To study the mechanism and indications for this therapy, 14 patients with RA were treated with this filter 6 times at 2 weeks intervals. The effects on clinical symptoms and subpopulations of peripheral blood mononuclear cells were evaluated on day 0, 3, 7, 14, 42 and 84. The Ritchie articular index, swollen joint counts, Lansbury index and health assessment questionnaire (HAQ), all showed improvements within the first week and the improvements were still observed 3 month later. Improvements in tender joint counts and visual analog pain scale (VAPS) were also observed on day 84. Eight patients showed remarkable improvements (responders) and 6 showed no apparent improvement (non-responders) according to the ACR core set criteria. Responders showed several characteristic features compared to non-responders as follows: the duration of RA was significantly shorter, the anatomical stage was earlier, the positive rate of susceptible HLA-DR4 haplotype associated with Japanese RA (DRB1*0405) was lower, and the proportion of CD4 + Leu8 + lymphocytes and the ratio of CD4+ cells to CD8+ cells (CD+/CD8 ratio) in the peripheral blood were higher throughout the treatment period and increased further even after the course of therapy. The proportion of CD4 + Leu8 + cells was inversely correlated with HAQ and VAPS, suggested that it is critically involved in the mechanism of this therapy. Blood leukocyte analysis at inlet and outlet of the filter showed increase of CD4 +, CD4 + Leu8 + cell percentages and CD4/CD8 ratio. These results suggested that patients with a shorter disease duration, less destruction of the joint, and without susceptible genes were more responsive to this therapy and that the mechanism of clinical improvement of RA by LP with cotton-wool involves immunological modification, such as immunosuppression by CD4 + Leu8 + lymphocytes. | |
| 8284904 | [Extra-articular manifestations of rheumatoid arthritis]. | 1993 Nov | The author gives an account of the incidence of extraarticular organ manifestations of rheumatoid arthritis. These manifestations cause deterioration of the prognosis of the disease and are evidence of the systemic character of rheumatoid arthritis, which cannot be conceived as an articular disease. | |
| 1404120 | The relation of extraarticular tenderness to inflammatory joint disease and personality in | 1992 Jun | We measured the pain tenderness threshold at 16 fibrositic tender points in 44 consecutive patients with rheumatoid arthritis (RA) attending the outpatient rheumatology clinic of a university hospital. Pressure threshold measurements were transformed to z units to equalize the weights of the values at different anatomic sites and were then summed. This pain tenderness score correlated with the joint score index (p less than 0.02, r = -0.363), signifying a low pain threshold in the patients with a high joint score index. In contrast to this, the pain tenderness score was not explained by either personality factors or the generalized disease activity measuring variables (erythrocyte sedimentation rate, C-reactive protein). Our results show that the fibrositic point tenderness is real in RA, and that the tenderness is augmented near the active joints. The pain tenderness score of patients with RA is not affected by the subject's personality but may relate to sensitization of the pain fibers in arthritic joints. | |
| 1455811 | [The combined action of an ultrahigh-frequency electrical field bitemporally and decimeter | 1992 Jul | The thymus of rheumatoid arthritis (RA) patients was exposed to combined action of bitemporal UHF electric field and decimeter waves to study immunomodulating effect of the combination. Biochemical, immunological and endocrinological findings during the patients follow-up gave evidence for conclusion on activation of the hypothalamic-hypophyseal-thymic axis. A response was achieved in RA seronegative variant with concomitant synovitis. This may be due to genetic factors. | |
| 8209450 | [Changes in the central and intracardiac hemodynamics of patients with rheumatoid arthriti | 1993 Apr | It was found that rheumatoid arthritis patients with clinical signs of cardiac involvement showed significant changes of the central and intracardiac hemodynamics that were characterized by suppression of the contractile and pumping function of the left ventricle as compared with patients showing no heart involvement. The authors describe in detail special treatment of RA patients with cardiac involvement. | |
| 7823315 | Assessment of rheumatoid arthritis--a clinician's viewpoint. | 1994 Oct | There are many measures that can be used for the short and longterm monitoring of patients with rheumatoid arthritis (RA). An important requirement for such assessments is the development of new pharmacologic therapies. It is important to assess the need for and the outcome of therapy. In recent years, it has been realized that subjective assessments have many advantages over objective ones. However, in the majority of cases subjective measures and objective measures parallel each other closely. The measurement of acute phase protein, in particular C-reactive protein (CRP), is helpful as an indicator of successful therapy. From data regarding axial osteoporosis, CRP has been shown to be a convenient marker indicating persistent active disease that will produce catabolic effects. Dual energy X-ray absorption scans have also been shown to be promising in objectively measuring change in the hand for patients with inflammatory arthritis. In patients presenting early with RA, it is necessary to have accurate indicators. In this respect, genetic predictors have a particular value. The most important aspect of the assessment of RA is subjective impressions. Therefore, a functional questionnaire such as the health assessment questionnaire combined with the objective measure of choice, CRP levels, are the assessments of choice. | |
| 8358763 | [Basic indicators of energy metabolism in patients with rheumatoid arthritis evaluated by | 1993 Jun 20 | The objective of the investigation was to examine basic parameters of the energy metabolism (energy expenditure at rest (REE), the respiratory quotient (RQ) and evaluate their relationship with age, basic parameters of the activity of the disease, serum positivity, basal therapy and corticoid therapy in patients with rheumatoid arthritis. The investigation comprised 26 patients with rheumatoid arthritis selected at random, incl. 12 serum positive ones. The mean age af the patients was 62.2 +/- 11.0 years, BMI 26.65 +/- 4.35, the mean duration of the disease was 11.8 +/- 9.9 years (range 1-36 years). A total of 12 patients had basal therapy, 12 patients took glucocorticoids regularly. The examination comprised a record of the case-history, clinical examination (Thompson's articular index), REE was evaluated by indirect calorimetry. The assessed REE value was compared with the expected value calculated according to Harris-Benedict's empirical formula (BMR) and expressed in per cent of the calculated value (REE%). The respiratory quotient (RQ) was calculated from the assessed CO2 and O2 consumption. The authors found a close correlation between REE and REE% (r = 0.606, p < 0.01) but no correlation between BMR and REE% (r = 0.115). The above parameters did not differ in serum positive and serum negative patients with RA treated with corticoids and those without corticotherapy, only in patients with basal therapy there are statistically significantly higher REE values (6456.7 +/- 790.5 kJ/24 h vs. 5396.4 +/- 826.7 kJ/24 h, p < 0.01) and REE% (110.6% +/- 99.2%, p < 0.05), as compared with subjects without basal therapy.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 1294360 | Lack of association of the alpha-1-antitrypsin PIZ allele with rheumatoid arthritis or wit | 1992 May | PIZ allele frequencies were defined by PCR amplification and hybridization using a PIZ SSO (sequence specific oligonucleotide) probe. The groups studied included 64 normal controls, 104 subjects with rheumatoid arthritis (RA) without any extra-articular features, 29 of whom had severe arthritis and 31 of whom had mild RA. The extra-articular subsets include 41 with RA-bronchiectasis (RA-BR), 21 with bronchiectasis without RA (BR), and 23 with RA and pulmonary fibrosis (RA-PF). Fifteen RA subjects with obstructive airways disease (RA-OAD) were compared to 25 RA patients with normal lung function tests. Using Fishers' exact test and chi-squared statistical analysis with Yates correction, no statistically significant associations were found between PIZ and any of the groups studied. Thus in this population there is no evidence that PIZ either increases susceptibility to rheumatoid arthritis or affects the risk of pulmonary complications or the severity of arthritis in subjects with rheumatoid arthritis. | |
| 1357891 | Rheumatoid arthritis: an association with pemphigus foliaceous. | 1992 Aug | We have observed a high incidence of pemphigus foliaceous, in the absence of therapy with penicillamine, within a small population of patients with rheumatoid arthritis. We suggest that penicillamine as well as inducing autoimmune disease might exacerbate subclinical pemphigus foliaceous in this group, accounting for those few patients whose skin disease fails to resolve following drug withdrawal. Pemphigus and rheumatoid arthritis have both been associated with HLA DR4, which was present in all three of our patients who were tested. | |
| 8693204 | [The mode of onset of rheumatoid arthritis and seasonal variations]. | 1995 | The aim of the study was to establish age and sex distribution, seasonal variations, and mode, of onset in a sample of patients with rheumatoid arthritis. One hundred eighty nine patients (146 women and 43 men), whose age ranged from 18 to 77 yrs. (mean age 49.1, SD 12.93) were included in the survey. In majority of patients the disease started between 31-50 years, whereas in the age group from 21-30 it occurred more frequent in women, and in the age group from 51-60 in men. The onset of rheumatoid arthritis was in almost equal proportions acute or insidious, regardless sex. No difference was found concerning onset of the disease and seasonal variations. However there was a statistically significant correlation between mode of the onset and seasonal variations (P < 0.05). Rheumatoid arthritis started abruptly more often in springtime, and more insidiously in autumn, whereas in summer and winter there was an equal number of patients with acute or insidious onset of the disease. | |
| 8368090 | [Functional assessment of the autonomic nervous system in rheumatoid arthritis]. | 1993 Jun | Sympathetic and parasympathetic nervous system evaluation was performed in 21 patients with rheumatoid arthritis. Every patient had autonomic nervous system (ANS) dysfunction, the parasympathetic involvement being the most frequent. ANS dysfunction may explain some manifestations and may well be the expression of a larger neuropathic involvement with pathogenic implications. | |
| 1582078 | The HLA association with rheumatoid arthritis. | 1992 May | Rheumatoid arthritis (RA) is primarily associated with HLA-DR4 in a wide range of ethnic groups. DNA analysis of HLA-DRB1 sequences shows that a limited set of alleles are positively associated with the disease. Third hypervariable region sequences QRRAA, QKRAA and RRRAA are found in up to 85% of RA patients and may constitute the basic unit of association. Risk estimates for alleles and hypervariable regions differ between ethnic groups and subsets of patients. Severe RA and Felty's syndrome are significantly associated with DR4 Dw4 and, to a lesser extent, with DR4 Dw14. In patients the latter allele is almost exclusively found in combination with Dw4, suggesting that complementation is occurring. Critical substitutions in the peptide binding groove correlate with the presence of RA, suggesting that the disease may be driven by the presentation of specifically bound peptide and/or may be influenced by differential selection of the T cell repertoire. | |
| 8478865 | Choosing a core set of disease activity measures for rheumatoid arthritis clinical trials. | 1993 Mar | Rheumatoid arthritis (RA) clinical trials often include at least 10 measures of disease activity (e.g., tender and swollen joint counts, erythrocyte sedimentation rate, patient pain, grip strength, etc.), and each trial contains different measures. Using dissimilar disease activity (outcome) measures to assess therapies makes it impossible to judge therapies against a common standard. Furthermore, multiple statistical testing is performed, and outcome measures are often used which are insensitive to change. Ultimately, to compare different RA therapies, the same outcomes should be measured in all trials. In the first stage of an effort to develop a core set of outcome measures to be used in all RA trials, we present an approach to the selection of the measures. This approach is based on a critical evaluation of whether commonly used outcome measures have construct, face, content, criterion, and discriminant validity. In addition, our approach includes testing whether these measures are redundant. Also, selected evidence on the validity of currently used outcome measures is reviewed. | |
| 9245109 | [Rheumatoid arthritis in a patient with osteopoikilosis]. | 1996 | 57-years old woman with spotted bones was reported, with concomitant rheumatoid arthritis. It was great concern because of low incidence of osteopoikilia and diagnosis obstacles concerning coexistence of this two pathologies. | |
| 8546949 | Rheumatology. Sharing care in an outpatient clinic. | 1995 Nov 1 | Patients with rheumatoid arthritis require a multidisciplinary approach to their care that allows them as much control over their condition as possible. This article describes how a clinic led by a clinical nurse specialist and an occupational therapist has set out to achieve these aims. | |
| 1588748 | [Psychosomatic medicine in rheumatoid arthritis]. | 1992 Mar | Recent studies have shown that neuropeptides, such as substance P, are responsible for arthritis. We therefore studied opioid peptides (beta-endorphin, Methionine-enkephalin, Leucine-enkephalin) in order to confirm our belief that mental status may have some influence on the activity of rheumatoid arthritis (RA). We examined opioid peptides, lymphocyte subsets, psycologic test (Cornell Medical Index-Health questionnaire (CMI), the Face scale) and clinical data in patients with RA. Plasma Leu-enk, % Leu2a+ Leu15- cells,% Leu3a+ Leu8- cells and % Leu11+ Leu7- cells were higher in patients with a larger number of psycologic complaints in CMI. Plasma Leu-enk concentration was higher while % Leu11+ Leu7- cells was lower in proportion to the degree of neurosis, as indicated by the descrimitive chart of CMI. Plasma Met-enk concentration, % Leu2a+ Leu15- cells, and Lansbury's index were significantly higher in the group of patients whose facial expression was more severe. These findings suggest that mentala status have some relationship with the plasma level of opioid peptides (enkephalins) and immunologic functions, and that it may exert indirect effects on RA. |