Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 8720343 | [RS3PE syndrome. A new rheumatic inflammatory syndrome in advanced age]. | 1995 Nov | RS3PE syndrome (Remitting Seronegative Symmetrical Synovitis with Pitting Edema) is a new form of arthritis in the elderly, characterized by symmetrical polysynovitis of acute onset associated with distal pitting edema. Tests for serum IgM rheumatoid factor are typically negative. RS3PE syndrome affects Caucasians aged over 60, predominantly males. It has a benign course and remits completely without residua. | |
| 9019097 | Development and evaluation of fuzzy criteria for the diagnosis of rheumatoid arthritis. | 1996 Dec | In 1987, the American Rheumatism Association issued a set of criteria for the classification of rheumatoid arthritis (RA) to provide a uniform definition of RA patients. Fuzzy set theory and fuzzy logic were used to transform this set of criteria into a diagnostic tool that offers diagnoses at different levels of confidence: a definite level, which was consistent with the original criteria definition, as well as several possible and superdefinite levels. Two fuzzy models and a reference model which provided results at a definite level only were applied to 292 clinical cases from a hospital for rheumatic diseases. At the definite level, all models yielded a sensitivity rate of 72.6% and a specificity rate of 87.0%. Sensitivity and specificity rates at the possible levels ranged from 73.3% to 85.6% and from 83.6% to 87.0%. At the superdefinite levels, sensitivity rates ranged from 39.0% to 63.7% and specificity rates from 90.4% to 95.2%. Fuzzy techniques were helpful to add flexibility to preexisting diagnostic criteria in order to obtain diagnoses at the desired level of confidence. | |
| 8523366 | Radiographic progression in rheumatoid arthritis: results of 3 comparative trials. | 1995 Sep | In 3 clinical trials the effects of 6 different disease modifying antirheumatic drugs on radiographic progression were evaluated. Despite the wide range in disease duration of patients in the different studies, a statistically significant slowing of radiographic progression was found in those patients treated with aurothioglucose, sulfasalazine, and methotrexate compared to auranofin, hydroxychloroquine, and azathioprine, respectively. These drugs might therefore be considered as disease controlling antirheumatic drugs. | |
| 8838501 | Association of the shared epitope with radiological severity of rheumatoid arthritis. | 1996 Jan | OBJECTIVE: To investigate the association between radiological severity of rheumatoid arthritis (RA) and the presence of the shared epitope. METHODS: Ninety unrelated adult Spanish patients with RA with a disease duration of at least 3 years, selected according to the American College of Rheumatology criteria, were radiologically assessed (shoulders, elbows, wrists, hands, hips, knees, and feet) and classified as having severe or nonsevere RA. DNA oligotyping was used to determine DR specificities and to detect DR4 and DR1 alleles. RESULTS: Forty-one patients (45.5%) had severe RA. Sixty-six patients (73.3%) carried the shared epitope and 18 (20%) had double expression of the shared epitope. Thirty-seven (90%) of the 41 patients with severe RA expressed the shared epitope. Logistic regression analysis showed that both single and double expression of the shared epitope were strongly related to the radiological severity of RA (odds ratio = 6.3 and 9.4, respectively). CONCLUSION: Our results show that radiological severity of RA is highly associated to the shared epitope. | |
| 8215625 | Absence of Epstein-Barr virus carrying cells in synovial membranes and subcutaneous nodule | 1993 Aug | OBJECTIVES: To determine whether the Epstein-Barr virus is present in synovial membranes and subcutaneous nodules of patients with rheumatoid arthritis. METHODS: A sensitive in situ hybridisation technique was applied to tissue sections of 11 synovial membranes and five rheumatoid nodules. RESULTS: Cells carrying the Epstein-Barr virus were not detected using EBER and BHLF1 oligonucleotides in the tissue samples investigated here. CONCLUSIONS: Although it has been suggested that the Epstein-Barr virus could play a part in the aetiology of rheumatoid arthritis, it was not detected in synovial membranes and subcutaneous lesions in this study. | |
| 8835552 | Life events, psychosocial factors, and demographic variables in early rheumatoid arthritis | 1995 Dec | OBJECTIVE: To explore how life events, psychosocial factors, and demographic variables are related to one-year changes in disability in early rheumatoid arthritis (RA). METHODS: A sample of 238 patients with RA of 48 mo duration or less was examined at baseline and after 12 mo (n = 227; 95%). Data on life events and psychosocial variables were collected by structured interviews, and functional disability was measured by the Health Assessment Questionnaire (HAQ). Analyses of variance and forward stepwise linear regression analyses were used as statistical procedures. RESULTS: Mean functional disability measured by the HAQ was relatively low at baseline and remained stable during one year. Positive life events experienced during the past year were significantly related to improved physical ability, whereas female sex was significantly related to reduction in ability. Neither age, income, education, number of network members, symptoms of mental distress, nor negative life events in the past year significantly predicted one-year changes in functional limitations. CONCLUSION: The experience of positive life events during the past year was significantly related to a reduction in disability in this prospective study of 238 patients with early RA. This finding adds to our knowledge regarding the relationship between psychosocial factors and disease progression in RA. | |
| 8011438 | Rheumatology. Patients' views of changing disability. | 1994 Apr 27 | This article explores the perceptions and expectations of patients with rheumatoid arthritis by comparing actual and perceived disability every six months over a two-year period. Initial findings show that patients are unduly pessimistic about their future and are often inaccurate in their perceptions of their illness. The author points to the importance of nurses in providing realistic and positive advice and support. | |
| 1294748 | Liver disease, erroneously attributed to methotrexate, in a patient with rheumatoid arthri | 1992 Dec | We describe a patient with rheumatoid arthritis and Felty's syndrome who developed evidence of hepatic dysfunction initially attributed to a short course of methotrexate therapy. He was subsequently found to have nodular regenerative hyperplasia. | |
| 1613730 | Excitement in synovium: the rapid evolution of understanding of rheumatoid arthritis and e | 1992 Jan | Multiple events give rise to rheumatoid arthritis (RA) and many different elements create an overall pathological effect. It is highly unlikely that a single cause for RA will be identified. A greater appreciation of the multiple events that lead to the development of RA is opening up a number of promising points of intervention which may serve as potential alternatives to the broader-based and often toxic drugs used in RA therapy today. | |
| 8255975 | The relationship between serial measures of disease activity and outcome in rheumatoid art | 1993 Sep | Disease activity was measured annually over a median period of 7 years (range 5-9) in a cohort of 127 patients with rheumatoid arthritis. The measurements were plotted, and the area under the resultant curve measured. The relationship of serial measures of disease activity (area under the curve) to outcome (measured radiologically, functionally and by global assessment) was investigated. A significant correlation was found between persistent disease activity and radiographic deterioration. Similar results were found for functional outcome, as measured by Steinbrocker grade, health assessment questionnaire score or global assessment (by analogue score). Single measures of disease activity did not predict outcome. Although imprecise, current methods of measuring disease activity in RA, if measured serially, are valuable in predicting outcome over a 5-10 year period. | |
| 8528925 | [Pain and pain perception in the elderly from the viewpoint of rheumatology]. | 1995 Sep | In rheumatology there is the problem of different terminologies and classification systems; additionally there are only few studies on differential diagnosis and course of diseases in people over 65. The analysis of pain is important for diagnosis; people often have problems in exactly describing their pains. The character of pain changes in the course of disease; therefore a continuous pain analysis is necessary. | |
| 1629821 | What factors distinguish probands from multicase rheumatoid arthritis same sex sibships fr | 1992 Feb | Thirty-two of 243 same sex sibships in which the proband had rheumatoid arthritis (RA) had at least one same sex sibling with RA ("familial" RA) and 211 did not ("sporadic" RA). The most important factors accounting for familial RA were the sibship size, and the proportion of siblings sharing both HLA haplotypes with the proband. Demographic and clinical details, autoantibodies and HLA-DR status were similar between the 2 groups, with the exceptions of regular use of artificial teardrops, and involvement of distal interphalangeal joints, which were both more prevalent in familial RA. The extrapolation of results from familial to sporadic RA appears to be justified. | |
| 7791154 | Influence of low doses of methotrexate on superoxide anion production by polymorphonuclear | 1995 Apr | OBJECTIVE: The mechanism of methotrexate (MTX) action in rheumatoid arthritis (RA) is unclear. We assessed the influence of MTX on neutrophil superoxide production evaluated by ferricytochrome c reduction. METHODS: Neutrophils were collected from MTX treated patients with RA (MTX-RA), patients with RA without medication (RA) and healthy donors, cocultured with MTX or MTX-RA serum. RESULTS: Polymorphonuclear leukocytes (PMN) from MTX-RA showed decreased superoxide production when compared with cells collected from patients with RA and controls. Control PMN superoxide production was inhibited (36%) by MTX-RA serum incubation. This reduction was accompanied by clinical improvement. MTX had no activity in the in vitro assays. CONCLUSION: MTX treatment may interfere with neutrophil superoxide production. | |
| 1551284 | An idiopathic hypereosinophilic syndrome mimicking seronegative rheumatoid arthritis: 20-y | 1992 Jan | A clinical case of idiopathic hypereosinophilic syndrome mimicking seronegative rheumatoid arthritis with a twenty year follow-up is reported. The patient showed other sign of the disease, such as pericarditis, gastroenteritis and hepatomegaly. Among the laboratory findings the elevated levels of aldolase and LDH 2, never reported previously, are stressed. | |
| 8036604 | [THe treatment of patients with chronic disease: the viewpoint of the physician and of the | 1993 | The opinions of the experts and the patients with rheumatic arthritis in relation to the disease treatment and preventive measures have been analyzed. The views of the physicians coincided more frequently than those of the patients. It is emphasized that patients benefit from group and individual training, especially from individual conversations. | |
| 8467619 | Synovial sarcoma manifesting as a single joint flare in rheumatoid arthritis. | 1993 Mar | A 69-year-old female recently diagnosed as suffering from rheumatoid arthritis presented with a general flare-up of disease including a swollen left ankle. Investigation revealed the swelling to be due to a synovial sarcoma. This unusual cause should be considered in all cases of local joint flares in rheumatoid arthritis. | |
| 1441327 | [The attitude of rheumatoid arthritis patients before treatment: social psychological rese | 1992 Feb | The authors developed a special questionnaire for examination of the attitude of patients to different procedures, methods of treatment, diet, attitude to different levels of medical services, self-treatment. An anonymous study of 125 patients with rheumatoid arthritis was carried out. Many respondents were not satisfied with organization of the treatment, in particular, the outpatient variant. The causes of inadequate treatment and ways for treatment improvement are discussed. | |
| 1731362 | Positive attitude will aid treatment. A guide to rheumatoid arthritis. | 1992 Jan | Rheumatoid arthritis is a chronic destructive disease which can result in deformity and disability. While treatment can do much to aid sufferers, support and encouragement are equally vital to instil a positive attitude. | |
| 8136891 | Connectionist expert systems as medical decision aid. | 1993 Dec | In this paper neural networks are used as associative memories to build an expert system for aiding medical diagnosis. As in expert systems using symbolic manipulation, the knowledge is introduced by a knowledge engineer using a collection of known cases. The system has an object-oriented approach to knowledge organization and the resulting network topology. Fuzzy sets are used to interpret connection values and/or excitation state of the units. The main result is that the proposed neural network allows not only finding a solution in some cases, but also suggests obtaining more clinical data if the data available is insufficient to reach a conclusion. This approach is illustrated by examples. | |
| 7979919 | Detailed immunohistologic evaluation of a methotrexate-induced nodule. | 1994 Dec | Accelerated nodulosis in patients with rheumatoid arthritis who are receiving methotrexate has become a well-recognized phenomenon, and it appears to occur in both individuals with seropositive and seronegative findings. No histologic differences permit a distinction between seronegative and seropositive nodulosis--either occurring during the natural history of rheumatoid arthritis or when "induced" by methotrexate. We examined such a nodule in a man with seronegative rheumatoid arthritis. Results of immunofluorescence examination were not contributory, but studies of the inflammatory cell populations within the nodule showed 5% of the cells to be lymphocytes with a CD4/CD8 ratio of 25:1. Of the total mononuclear cells, 85% were reactive for Leu-10 (HLA-DQ) and 95% were reactive for HLA-DR, and about 75% of the macrophages were reactive for CD4+. The strong expression of CD4, in conjunction with macrophage markers, and the high T-helper/suppression ratio are of note. We discuss the implications of these findings and the role that they play in the pathogenesis of methotrexate-induced nodules. |