RABC

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Biomarkers name	Biomarker Type	Source database	Information	Details
NFE2L2	gene	CTD	Gene Symbol=NFE2L2; Gene ID=4780; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Azathioprine\|Chlorambucil\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Dinoprostone\|Edaravone\|Enalapril\|glyphosate\|Gold\|Hydrocortisone\|Indomethacin\|Leflunomide\|Maneb\|Meloxicam\|Methotrexate\|Methylprednisolone\|Nitrites\|ochratoxin A\|Oxygen\|Ozone\|Penicillamine\|Pesticides\|Plant Extracts\|Prednisolone\|Reactive Oxygen Species\|Resveratrol\|Sulfasalazine\|Tacrolimus\|tamibarotene\|Thalidomide\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|Vorinostat; Inference Score=66.22; Reference Count=395	details
TXNRD1	gene	CTD	Gene Symbol=TXNRD1; Gene ID=7296; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Aspirin\|Auranofin\|Aurothioglucose\|Azathioprine\|Chlorambucil\|Curcumin\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Diclofenac\|Gold\|Gold Compounds\|Gold Sodium Thiomalate\|Leflunomide\|Maneb\|Methotrexate\|ochratoxin A\|Organogold Compounds\|Oxygen\|Ozone\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|valdecoxib; Inference Score=66.01; Reference Count=215	details
NFKBIA	gene	CTD	Gene Symbol=NFKBIA; Gene ID=4792; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Arsenic Trioxide\|Aspirin\|Auranofin\|Chloroquine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Dinoprostone\|Edaravone\|Enalapril\|Freund's Adjuvant\|Gold Compounds\|GW 506033X\|Hydrocortisone\|Hydroxychloroquine\|Indomethacin\|Leflunomide\|Maneb\|ochratoxin A\|Oxygen\|Ozone\|Phenylbutazone\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Sulfasalazine\|Sulindac\|Tacrolimus\|Thalidomide\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|Vorinostat; Inference Score=66; Reference Count=160	details
BBC3	gene	CTD	Gene Symbol=BBC3; Gene ID=27113; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Aspirin\|Chlorambucil\|Chloroquine\|Curcumin\|Cyclophosphamide\|deoxynivalenol\|Dexamethasone\|entinostat\|Indomethacin\|Maneb\|Methotrexate\|ochratoxin A\|Oxygen\|Ozone\|Penicillamine\|Plant Extracts\|Resveratrol\|Sulindac\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|valdecoxib\|Vorinostat; Inference Score=65.94; Reference Count=362	details
IL17A	gene	CTD	Gene Symbol=IL17A; Gene ID=3605; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antigens\|Arsenic Trioxide\|Aspirin\|Chloroquine\|Cyclophosphamide\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Freund's Adjuvant\|Indomethacin\|Leflunomide\|Levamisole\|Methotrexate\|ochratoxin A\|Ozone\|Plant Extracts\|Prednisolone\|Resveratrol\|Sulfasalazine\|tamibarotene\|Tobacco Smoke Pollution\|tofacitinib\|triptolide; Inference Score=65.46; Reference Count=240	details
PCNA	gene	CTD	Gene Symbol=PCNA; Gene ID=5111; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Arsenic Trioxide\|Aspirin\|Azathioprine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|entinostat\|Famotidine\|Freund's Adjuvant\|glyphosate\|Hydrocortisone\|Indomethacin\|Leflunomide\|Maneb\|Meloxicam\|Methotrexate\|ochratoxin A\|Oxygen\|Ozone\|Piroxicam\|Plant Extracts\|Resveratrol\|Sulfasalazine\|Sulindac\|Tacrolimus\|tamibarotene\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin; Inference Score=65.1; Reference Count=223	details
MYC	gene	CTD	Gene Symbol=MYC; Gene ID=4609; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Arsenic Trioxide\|Aspartame\|Aspirin\|Chlorambucil\|Curcumin\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Dinoprostone\|glyphosate\|Indomethacin\|Leflunomide\|mancozeb\|Maneb\|Methotrexate\|ochratoxin A\|Oxygen\|Ozone\|Pesticides\|Piroxicam\|Plant Extracts\|Quinacrine\|Reactive Oxygen Species\|Resveratrol\|Sulindac\|Tacrolimus\|tamibarotene\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|Vorinostat; Inference Score=64.88; Reference Count=192	details
DUSP1	gene	CTD	Gene Symbol=DUSP1; Gene ID=1843; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Aspirin\|Azathioprine\|Curcumin\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Dinoprostone\|glyphosate\|Gold\|Hydrocortisone\|Indomethacin\|Leflunomide\|Methotrexate\|Oxygen\|Ozone\|Penicillamine\|Piroxicam\|Plant Extracts\|Resveratrol\|Thalidomide\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|valdecoxib; Inference Score=64.38; Reference Count=365	details
FOS	gene	CTD	Gene Symbol=FOS; Gene ID=2353; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Arsenic Trioxide\|Aspirin\|Azathioprine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Dinoprostone\|entinostat\|Famotidine\|Flurbiprofen\|Freund's Adjuvant\|glyphosate\|Gold\|Gold Compounds\|GW 506033X\|Indomethacin\|Leflunomide\|Levamisole\|Maneb\|Methotrexate\|Nabumetone\|ochratoxin A\|Oxygen\|Ozone\|Pesticides\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Sulindac\|Tacrolimus\|Thalidomide\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin; Inference Score=64.08; Reference Count=228	details
ISG15	gene	CTD	Gene Symbol=ISG15; Gene ID=9636; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Azathioprine\|Chloroquine\|chloroquine diphosphate\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Diclofenac\|entinostat\|Freund's Adjuvant\|Gold Sodium Thiomalate\|Indomethacin\|Meloxicam\|Methotrexate\|Methylprednisolone\|Piroxicam\|Prednisolone\|tamibarotene\|tofacitinib\|Tretinoin\|Vorinostat; Inference Score=64.08; Reference Count=228	details
MKI67	gene	CTD	Gene Symbol=MKI67; Gene ID=4288; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Arsenic Trioxide\|Aspirin\|Azathioprine\|Chloroquine\|Curcumin\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|entinostat\|glyphosate\|Gold\|Indomethacin\|Leflunomide\|Methotrexate\|ochratoxin A\|Oxygen\|Ozone\|Piroxicam\|Plant Extracts\|Resveratrol\|Thalidomide\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|Vorinostat; Inference Score=63.87; Reference Count=223	details
IL1A	gene	CTD	Gene Symbol=IL1A; Gene ID=3552; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Aspirin\|Azathioprine\|Chloroquine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Dinoprostone\|Enalapril\|entinostat\|Gold\|Gold Compounds\|Hydrocortisone\|Indomethacin\|Methotrexate\|Naproxen\|ochratoxin A\|Oxygen\|Ozone\|Plant Extracts\|Quinacrine\|Resveratrol\|Sulfasalazine\|Sulindac\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=63.73; Reference Count=245	details
CXCL10	gene	CTD	Gene Symbol=CXCL10; Gene ID=3627; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Adjuvants, Immunologic\|Air Pollutants\|Arsenic Trioxide\|Chloroquine\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Dinoprostone\|entinostat\|Gold\|Hydrocortisone\|Hydroxychloroquine\|Indomethacin\|Maneb\|Meloxicam\|Methotrexate\|Naproxen\|Oxygen\|Ozone\|Plant Extracts\|Resveratrol\|Tacrolimus\|tamibarotene\|Thalidomide\|Tobacco Smoke Pollution\|tofacitinib\|Tretinoin; Inference Score=63.72; Reference Count=216	details
MMP9	gene	CTD	Gene Symbol=MMP9; Gene ID=4318; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Angiotensin-Converting Enzyme Inhibitors\|Antirheumatic Agents\|Arsenic Trioxide\|Aspirin\|Chloroquine\|Curcumin\|Cyclosporine\|Dexamethasone\|Dinoprostone\|Edaravone\|entinostat\|Famotidine\|Flurbiprofen\|Freund's Adjuvant\|glyphosate\|Gold\|Gold Compounds\|Hydrocortisone\|Indomethacin\|Methotrexate\|Minocycline\|ochratoxin A\|Oxygen\|Ozone\|Plant Extracts\|Prednisolone\|Reactive Oxygen Species\|Resveratrol\|Sulfasalazine\|Thalidomide\|thymoquinone\|Tobacco Smoke Pollution\|tofacitinib\|Tretinoin\|triptolide\|Vorinostat; Inference Score=63.53; Reference Count=249	details
SOD1	gene	CTD	Gene Symbol=SOD1; Gene ID=6647; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Arsenic Trioxide\|Auranofin\|bucillamine\|Chloroquine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Edaravone\|Enalapril\|glyphosate\|Gold\|Indomethacin\|mancozeb\|Maneb\|Methotrexate\|Nitrites\|ochratoxin A\|Oxygen\|Ozone\|Penicillamine\|Pesticides\|Phenylbutazone\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Sulfasalazine\|Sulindac\|Thalidomide\|thymoquinone\|Tiopronin\|Tobacco Smoke Pollution\|Tretinoin; Inference Score=63.22; Reference Count=387	details
OAS1	gene	CTD	Gene Symbol=OAS1; Gene ID=4938; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Aspirin\|Azathioprine\|chloroquine diphosphate\|Cyclosporine\|Dexamethasone\|Diclofenac\|Gold Sodium Thiomalate\|Leflunomide\|Methotrexate\|Methylprednisolone\|Ozone\|Plant Extracts\|Prednisolone\|tamibarotene\|Tobacco Smoke Pollution\|tofacitinib\|Tretinoin; Inference Score=62.75; Reference Count=205	details
CASP8	gene	CTD	Gene Symbol=CASP8; Gene ID=841; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Arsenic Trioxide\|Aspirin\|Auranofin\|Chlorambucil\|Chloroquine\|chloroquine diphosphate\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Dinoprostone\|Edaravone\|entinostat\|Freund's Adjuvant\|Gold\|Indomethacin\|mancozeb\|Maneb\|Methotrexate\|Minocycline\|ochratoxin A\|Oxygen\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Sulindac\|Tacrolimus\|Thalidomide\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|Vorinostat; Inference Score=62.68; Reference Count=239	details
SLC7A11	gene	CTD	Gene Symbol=SLC7A11; Gene ID=23657; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Azathioprine\|chloroquine diphosphate\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Diclofenac\|entinostat\|Gold Sodium Thiomalate\|Indomethacin\|Leflunomide\|Methotrexate\|Methylprednisolone\|ochratoxin A\|Oxygen\|Ozone\|Piroxicam\|Prednisolone\|Reactive Oxygen Species\|Sulfasalazine\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=62.68; Reference Count=226	details
TNFSF10	gene	CTD	Gene Symbol=TNFSF10; Gene ID=8743; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Arsenic Trioxide\|Aspirin\|chloroquine diphosphate\|Curcumin\|Cyclosporine\|Dexamethasone\|entinostat\|glyphosate\|Indomethacin\|Leflunomide\|Methotrexate\|Naproxen\|Oxygen\|Ozone\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Sulindac\|tamibarotene\|Thalidomide\|Tobacco Smoke Pollution\|tofacitinib\|Tretinoin\|triptolide\|Vorinostat; Inference Score=62.64; Reference Count=195	details
XBP1	gene	CTD	Gene Symbol=XBP1; Gene ID=7494; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Arsenic Trioxide\|Curcumin\|Cyclosporine\|deoxynivalenol\|Diclofenac\|entinostat\|Freund's Adjuvant\|Hydroxychloroquine\|Indomethacin\|Leflunomide\|Methotrexate\|Minocycline\|ochratoxin A\|Oxygen\|Ozone\|Penicillamine\|Reactive Oxygen Species\|Resveratrol\|Sulfasalazine\|Sulindac\|Tacrolimus\|tamibarotene\|Tobacco Smoke Pollution\|Tretinoin; Inference Score=62.59; Reference Count=373	details