Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6453592 | T gamma lymphocytes of peripheral blood and synovial fluid in rheumatoid arthritis: quanti | 1981 May | The distribution of T gamma lymphocytes in the peripheral blood of one group of rheumatoid patients and in the synovial fluid in a second group was determined. The results were compared to those found for peripheral blood (PB) lymphocytes of normal subjects and for synovial fluid lymphocytes of osteoarthrosis and meniscitis patients. Besides recording percentage and absolute number, we also used cytofluorographic analysis to determine individual capacity of PB T gamma cells to bind heat-aggregated IgG (agg-IgG). The following results were found: 1) there is no significant difference between the percentage and absolute number of PB T gamma lymphocytes of rheumatoid arthritis (RA) patients and those of controls, 2) individual RA PB T gamma cells had a greater number and/or avidity of Fc receptor for IgG than those cells of controls, and 3) the percentage of RA T gamma lymphocytes in synovial fluid, revealed by IgG-EA ox rosetting, is significantly lower than that found in control patients. The factors that may determine a similar lymphocyte picture in RA are discussed. | |
| 7125938 | [Changes in the cover layer of the synovial membrane in the early stage of rheumatoid syno | 1982 | In the early stage of rheumatoid synovitis, changes in synoviocytes of the cover layer in the joints with clinical manifestations of arthritis differ from stereotype reactions of these cells in the advanced stage of the disease. Fibrin, IgG and C3-fraction of complement are found on the surface and in the depth of the cover layer. Light and electron microscopy revealed the features of type B synoviocytes prevalent in the cover layer in the early stage of the disease: polymorphism and rounding of the nuclei of synoviocytes, mitoses, fragmentation and degeneration of the nucleolus, loosening of the chromatin network and appearance of interchromatin granules, nuclear bodies, formation of multinucleated synoviocytes and symplasts, destruction of organelles, activation of lysosomal apparatus of the cells. These changes may be interpreted as simultaneous manifestations of cell activation and cytopathologic effect. They are likely to be due to the effect of the etiological factor and immunocomplex mechanism. The detection of dystrophically altered chrondrocytes in the cover layer confirms the opinion of simultaneous participation of the synovial and cartilage components of the joint in the rheumatoid process. | |
| 1259795 | Differentiation and characterization of autoantibodies and their antigens in Sjögren's sy | 1976 Mar | Autoantibodies in Sjögren's syndrome (SS) were identified by their precipitin reactions with tissue antigens in immunodiffusion. The source of antigens was a sonicated extract of human lymphoid cells (WiI2) grown in tissue culture. Three distinct precipitin systems were identified and referred to as precipitins SS-A and SS-B, and rheumatoid arthritis precipitin. These studies show that precipitins SS-A and SS-B are present in high frequency in sera of patients with SS without associated rheuamtoid arthritis (RA) and are absent or present in low frequency in many other connective tissue diseases. On the other hand patients with SS who also had clinical features compatible with RA (SS-RA) did not have precipitins SS-A and SS-B but had rheumatoid arthritis precipitin (RAP). The latter precipitin was also present in RA patients in a similar order of frequency as in SS-RA. All three precipitin systems were shown to be reactions betweeen immunoglobulins and cellular antigens. The origin of SS-A and SS-B antigens was demonstrated by immunofluorescence to be primarily from the nucleus but the origin of RAP in the cell has not been established. | |
| 6808785 | The CRP-range latex test. A new method for the semiquantitative determination of C-reactiv | 1982 Mar | A new CRP Range Latex Test is described which allows by testing two serum dilutions to classify the CRP content semiquantitatively into four concentration ranges (0 - 1 mg/dl, 1 - 4 mg/dl, 4 - 16 mg/dl and 16 - 64 mg/dl). Sera of 30 patients with rheumatic diseases and of 30 control persons without inflammatory or degenerative diseases were investigated in the CRP Range Latex Test and by radial immunodiffusion. The results were compared. A good agreement between the two methods could be demonstrated. | |
| 6981842 | Yersinia enterocolitica biotype I. Diarrhoea and episodes of HLA B27 related ocular and rh | 1982 | Yersinia enterocolitica biotype I were isolated from faeces of 16% of 56 consecutive patients with diarrhoea or gastrointestinal symptoms and 2.8% of 109 healthy controls (p less than 0.01). Similar Yersinia biotypes were isolated from 4% of samples from 86 rheumatoid arthritis patients and 4.5% of samples from 140 ankylosing spondylitis patients examined regularly over an 8-month period. These results suggest that Yersinia enterocolitica biotype I are regular but infrequent inhabitants of the human gastrointestinal tract in south-east England. The increased isolation rate of these microorganisms from patients with enteric disease and from patients with exacerbations of HLA B27-related arthritic and ocular inflammatory disease justifies further investigations. | |
| 1173778 | [Steroid saving effect of naproxen]. | 1975 Feb | Since for various reasons the Lansbury Index appeared inadequate to define the therapeutic efficacy of antirheumatic compounds, we chose to investigate in our trials the prednisolone saving effect in patients with rheumatoid arthritis. Our investigations with the new antirheumatic substance d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen) in most cases showed a prednisolone saving effect of 5 mg/day with a naproxen dose of 750 mg daily. In cases where a daily dose of 10 mg of prednisolone was necessary, a saving of 7.5 mg up to 10 mg was registered. But there were also failures and lesser saving effects. The steroid saving effect differs from one individual to another. In an additional study naproxen in a daily dose of 500 mg was compared with other antirheumatic agents (indometacin, azapropazon, and nifluminic acid) in patients not requiring steroids. The results were not uniform. In some cases naproxen was more effective, in other cases the substances mentioned were better. In these series joint function and subjective changes only were evaluated. Apart from a few cases of gastrointestinal side effects the drug was well tolerated. | |
| 712192 | Rheumatoid factor interference with the latex agglutination test for fibrin degradation pr | 1978 Oct | The latex agglutination test for FDP is widely employed clinically to aid in the diagnosis of DIC and other conditions. Of sera containing RF, 93% demonstrated positive FDP latex agglutination tests. Reducing agents in all instances destroyed the RF agglutinating capability. Futhermore, 86% of sera positive for FDP and RF became FDP-negative following reduction. Therefore RF was responsible for false-positive FDP latex agglutination tests in the majority of patients. Reduction of patient sera is a rapid, simple method to distinguish a positive FDP test from a false-positive due to RF. | |
| 3876078 | Calcium absorption in rheumatoid arthritis. | 1985 Sep | Calcium absorption, assessed by a double isotope method, was found to be impaired in postmenopausal women with rheumatoid arthritis of recent onset (mean 14.2 months) compared with controls. Circulating levels of 1,25-dihydroxyvitamin D (calcitriol) were higher than in controls, suggesting a primary malabsorption of calcium in these patients. The reduction in calcium absorption correlated with several measures of disease activity, suggesting that the disease process was responsible for the intestinal defect, but an effect from non-steroidal anti-inflammatory agents cannot be excluded. A primary reduction in calcium absorption may increase the risk of osteoporosis in women with rheumatoid arthritis. | |
| 6523078 | The reliability of Swedish mortality statistics for rheumatoid arthritis. | 1984 | The reliability of Swedish mortality statistics for rheumatoid arthritis (RA) was investigated. All Swedish RA death certificates for the years 1971 and 1975 were collected. 1224 such death certificates were identified. Physicians' causal statements were compared with the corresponding National Central Bureau of Statistics' (NCBS) registration. The NCBS was found to have registered a twofold RA mortality increase for men, from PMR 0.044 to 0.112, and a threefold increase for women, from 0.180 to 0.577, whereas physicians had reported a slight decrease for men, from 0.057 to 0.043 and practically no change at all for women, from 0.213 to 0.216. The proportions of inadequately completed certificates were 34% in 1971 and 31% in 1975, and the proportions of altered certificates were 16% and 32% respectively. The diverging agreement between physicians and the NCBS was due mainly to an increased tendency on the part of the NCBS to favour RA in the registration, and not to physicians' formal errors on the certificate forms. | |
| 7332376 | The prevalence of Raynaud's syndrome in rheumatoid arthritis. | 1981 Dec | To test the validity of the putative association between Raynaud's syndrome and rheumatoid arthritis (RA) 277 patients with rheumatic disorders were questioned about cold-induced colour reactions in the extremities. The time to recover digital temperature after brief immersion in ice water was used to confirm the presence of Raynaud's syndrome. The prevalence of Raynaud's syndrome in the 148 patients with RA and the 59 patients with osteoarthritis was 2.7% and 5.1% respectively. It is concluded that Raynaud's syndrome is not a frequent accompaniment of RA, and it is suggested that in view of the close association between Raynaud's syndrome and certain other disorders, such as mixed connective tissue disease and scleroderma, when patients present with polysynovitis and Raynaud's syndrome special consideration should be given to these conditions. | |
| 6992720 | Search for viruses in rheumatoid macrophage-rich synovial cell populations. | 1980 Apr | The adherent cells remaining after short-term culture of synovial fluid and synovial membrane cells from rheumatoid and non-rheumatoid patients were examined for the presence of a productive virus infection and for various viral antigens. Labelling was carried out with 3H-thymidine and 3H-uridine followed by sucrose density gradient centrifugation of the culture supernatant. Only in 1 case was there incorporation of 3H-uridine into material of density 1 . 21 g/cm3. Viral antigens were tested for by indirect immunofluorescence with antisera to rubella virus, the retroviruses RD-114 and simian sarcoma associated virus, early adenovirus type 2 antigens, late adenovirus type 2 antigens, SV-40 T antigen, and in 1 case measles virus. No cell showed immunofluorescence with any antiserum except the early adenovirus type 2 antiserum, which stained the cytoplasm of about half the synovial cell cultures, some from rheumatoid and some from non-rheumatoid patients. | |
| 3890439 | Rheumatoid pleural effusion. A transmission and scanning electron microscopic evaluation. | 1985 May | The pathognomonic triad of a rheumatoid pleural effusion (round multinucleated inflammatory giant cells, large elongated cells and a background of granular material) has only rarely been reported, with only one case examined by electron microscopy. This paper present an additional case with emphasis on its ultrastructural features and immunochemical characteristics. Our data support an origin of the components of the effusions in the pleural rheumatoid nodules. | |
| 7244549 | [Semiquantitative determination of destruction dynamics at the joints of hands and feet in | 1981 May | The article discusses briefly the problem of classifying the degree of severity in rheumatoid arthritis. The selection of the X-ray film criteria which are best representative of the destruction dynamics, is explained. Two measurement methods are described which can be used to visualise and to measure the dynamics of the destructive processes. The destruction dynamics can be visualised graphically in a co-ordinate system or as a quotient series via calculatory or planimetric evaluation - at a later stage, this can be done photometrically. It is stated that both methods, namely, the one using the standardised evaluation foil and the one utilising the special transparent foil, can yield information on the extent and progress of joint destructions. | |
| 443882 | IgA rheumatoid factor in the sera and saliva of patients with rheumatoid arthritis and Sjà | 1979 Apr | With a sensitive radioimmunoassay we have found elevated IgA rheumatoid factor (IgA-RF) levels in the sera of patients with rheumatoid arthritis, Sjögren's syndrome, and systemic lupus erythematosus. The IgA--RF showed a pattern of reaction with human IgG subclasses and animal gammaglobulins similar to that of IgM-RF from the same patients. Rheumatoid factors of both classes were shown to be present in saliva of patients with rheumatoid arthritis and Sjögren's syndrome. | |
| 786171 | Pyoderma Gangrenosum and rheumatoid arthritis. | 1975 Aug | Two patients had pyoderma gangrenosum and rheumatoid arthritis. Biopsy specimens of the cutaneous ulcers in the patients showed a necrotizing vasculitis. Complement (C3) and immunoglobulins were not detected in the skin lesions. There was no important impairment of cell-mediated immunity observed. | |
| 6729648 | Calcified bodies in a giant Baker's cyst. A case report. | 1984 Jun 16 | A patient with long-standing rheumatoid arthritis developed a giant Baker's cyst which contained calcified loose bodies. The subject is discussed and the literature reviewed. | |
| 509838 | The clinical spectrum of psoriatic arthritis. | 1979 Sep | Epidemiologic, clinical, radiologic and serologic evidence suggests that psoriatic arthritis is a specific entity and not the coincidental occurrence of 2 common diseases, psoriasis and rheumatoid arthritis. Psoriatic arthritis may be defined as psoriasis associated with inflammatory arthritis (peripheral arthritis or spondylitis or both) and usually a negative serologic test for rheumatoid factor. Clinical characteristics of the disease include: almost equal distribution between males and females; peripheral arthritis involving only a few small joints in asymmetical fashion; involvement of distal interphalangeal joints; sausage digits; arthritis mutilans; ankylosing spondylitis; goutlike onset; and higher frequency of nail involvement than occurs in uncomplicated psoriasis. The rash may present with arthritis, or, equally, may precede or succeed joint involvement. With regard to pain and disability, the prognosis in psoriatic arthritis is better than in rheumatoid arthritis. | |
| 7065729 | Lung mucociliary clearance in rheumatoid disease. | 1982 Feb | Lung mucociliary clearance rates were measured in 11 patients with rheumatoid disease and found to be unaltered when compared with those of a group of matched control subjects. The results are discussed in relation to the increased incidence of respiratory infection in patients with rheumatoid disease and also to the recently reported finding of increased airways obstruction in these patients. | |
| 1093503 | Cyclophosphamide therapy for rheumatoid arthritis. | 1975 Jun | Cyclophosphamide in high doses was given for six months to 19 patients with rheumatoid arthritis. A second group of patients with rheumatoid arthritis whose conditions were stable on low-dose prednisone received in addition either cyclophosphamide or placebo for six months. Measurements of joint function and joint inflammation were used to estimate disease activity. Joint inflammation progressively decreased and joint function improved in the high-dose group. The low-dose cyclophosphamide-plus-prednisone group had a similar response that was different from the prednisone-plus-placebo group. Cyclophosphamide toxicity was common in the high-dose group and minimal in the low-dose-plus-prednisone group. Cyclophosphamide therapy improved the arthritis of these patients. The results were almost as good in the low-dose-plus-prednisone group, and the toxicity was much less. | |
| 770085 | Azapropazone - its place in the management of rheumatoid conditions. | 1976 | The authors review the trials carried out on azapropazone in rheumatoid arthritis and other rheumatoid conditions. They comment that in terms of efficacy azapropazone would appear to be a useful non-steroidal anti-inflammatory analgesic which compares favourably with other established antirheumatic agents against which it has been tested. Its main advantages are its low incidence of side-effects and the fact that in the majority of the trials reported azapropazone treatment was preferred by patients to that with other agents. |