Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 450399 | Synovectomy of the knee joint. | 1979 Jan | Patients with active rheumatoid arthritis of the knee should be considered for synovectomy to arrest the disease and to preserve joint function. Careful selection of patients on the basis of the weight bearing roentgenogram is important. Surgery should not be delayed if there is evidence of progression of the disease on serial roentgenograms, or if the original films reveal early joint disease. Preservation of the suprapatellar pouch to prevent adhesions of the quadriceps mechanism greatly improves the postoperative range of motion. Long term follow-up over 10 years has demonstrated the value of synovectomy in rheumatoid arthritis of the knee. | |
| 4081663 | Utilization of hospital care among persons with rheumatoid arthritis compared with control | 1985 | The use of hospital care was assessed in a 13-year follow-up of 293 persons with rheumatoid arthritis (RA) and a healthy contrast group of 456 persons. The groups were identified in an epidemiological survey of RA made in Stockholm in 1965-67. Data on deaths, migration and use of in-patient care during the follow-up were obtained by a linkage with the Stockholm County Medical Information System. Follow-up shows that the persons in the RA group were admitted to hospital more than twice as often as the controls and had three times as many hospital days. However, only 15% of the individuals in the RA group were ever admitted with a diagnosis of rheumatoid arthritis and only 1% of the RA group's total number of hospital days were spent at specialist rheumatology departments. The amount of psychiatric care was also low. The use of hospital care in the RA group was closely correlated to the severity of the disease prior to follow-up, as measured by Steinbrocker functional grading, number of criteria for RA fulfilled and perceived severity of joint symptoms. | |
| 7137083 | A comparison of the clinical usefulness of eight tests for IgM rheumatoid factor. | 1982 Oct | The clinical usefulness of seven commercially available tests for IgM rheumatoid factor are compared using sera from 28 patients with classical rheumatoid arthritis with 126 patients from appropriate control groups. The test system which provided the greatest sensitivity and specificity for the diagnosis of rheumatoid arthritis was considered the most desirable. No attempt was made to test reproducibility. The Ortho latex slide screening test demonstrated the best balance of sensitivity and specificity with 24/28 positive in sera from patients with classical rheumatoid arthritis, and 6/127 positive in non-rheumatoid controls. Of the systems tested, the Behring latex test was least useful due to an unacceptable lack of sensitivity, with only 8/28 positive using sera from patients with classical rheumatoid arthritis. Until a more internationally standardized rheumatoid factor assay is available, the comparative results of this study may serve as a guide to clinicians and laboratory directors in selecting a clinical useful, commercially available test system. | |
| 7362719 | Rheumatoid aortic valve prolapse requiring emergency aortic valve replacement. | 1980 Feb | Rapid progression of aortic regurgitation was closely observed in a patient with severe seropositive rheumatoid arthritis. Rheumatoid changes within the aortic valve leaflets resulted in severe prolapse necessitating emergency operation. The postoperative course was satisfactory. | |
| 496455 | Septic arthritis due to Pasteurella multocida complicating rheumatoid arthritis. | 1979 Aug | A patient with rheumatoid arthritis treated with corticosteroids developed a septic arthritis of her right knee. She had been bitten on her right leg by her pet cat 2 weeks earlier. Pasteurella multocida, resistant to penicillin, was isolated from the septic joint and from the oropharynx of the cat. The arthritis was successfully treated with ampicillin. No attempt to eradicate the organism from the cat was made because of the expectation of early recolonisation. | |
| 2411231 | Antikeratin antibodies in serum and synovial fluid show specificity for rheumatoid arthrit | 1985 Jul | Tests for antikeratin antibodies (AKA) were performed on 2152 disease-associated and control sera by indirect immunofluorescence (IF) on rat oesophagus substrate. The incidence of AKA was significantly raised in rheumatoid arthritis (37%) in comparison with systemic sclerosis (8%), psoriasis (7%), ankylosing spondylitis (6%), systemic lupus erythematosus (3%), and normal controls (2%). AKA were detected in synovial fluid obtained from patients with rheumatoid arthritis (RA) (48%) but not from patients with other conditions. Further experiments on AKA-positive sera showed reactivity with stratum corneum of rabbit prepuce and lips. A specific rabbit antihuman keratin antiserum was shown, by IF and inhibition studies, to have a different specificity from that of spontaneous human AKA. AKA were associated with the presence of subcutaneous nodules in RA (p = 0.05), but not with Raynaud's phenomenon, Sjögren's syndrome, or HLA-DR4 positivity. Rheumatoid factor (RF) was not associated with AKA either in RA or in RF-positive disease controls. | |
| 4031003 | Multiple tumor incidence in patients with rheumatoid arthritis or allied disorders. | 1985 | The incidence of multiple malignant neoplasms in 55,279 patients with rheumatoid arthritis (RA) or allied disorders was studied by linking two separate nationwide data registers covering the whole Finnish population. The linking of the Social Insurance Institution's Population Register and the Finnish Cancer Registry resulted in 2106 cancer patients in whom both cancer (diagnosed in 1967-1978) and rheumatoid arthritis or allied disorders (diagnosed before cancer) were diagnosed. In 1974, the allied disorders (ankylosing spondylitis or systemic connective tissue diseases) accounted for 3.9% of all the diagnoses in the Social Insurance Institution's Population Register. The incidence of multiple neoplasms was slightly but not significantly higher in cancer patients with RA or allied disorders than in the general population or in all cancer patients taken together. The risk of leukemia was four times higher in the rheumatoid or allied disease cancer patients than in all the cancer patients. The results are consistent with previous results showing that the leukemia incidence in RA patients is higher than expected. | |
| 6356907 | Remission-inducing therapy in rheumatoid arthritis. | 1983 Oct 31 | Rheumatoid arthritis is characterized by immunologically mediated chronic inflammation of synovial structures. Remission-inducing drugs, such as gold compounds, antimalarials, and D-penicillamine, have been shown to suppress disease activity in rheumatoid arthritis while having minimal nonspecific anti-inflammatory properties. The possibility that these agents are effective because they modulate the underlying immunologic reactivity prompted an examination of the immunosuppressive properties of these drugs. The evidence indicates that immunosuppression is an action that is shared by these agents and thus supports the view that remission induction may result from suppression of the immunologic activity that underlies rheumatoid inflammation. Despite the fact that these agents can function as immunosuppressives, each appears to have a unique site of action, specifically inhibiting the function of only one of the populations of cells likely to be involved in chronic immunologically mediated inflammation. Gold compounds and anti-malarials appear to be active by virtue of their capacity to depress various functions of mononuclear phagocytes, while D-penicillamine acts by inhibiting a number of the activities of T lymphocytes. These results imply that the means by which these drugs suppress rheumatoid inflammation are fundamentally different. This suggests the conclusion that the remission-inducing drugs may be classified as T cell-active and mononuclear phagocyte-active agents. A better understanding of the pathophysiology of rheumatoid arthritis should thus be helpful in deciding which of these classes of drugs is appropriate in individual cases. | |
| 6366988 | The effect of drugs on serum histidine levels in rheumatoid arthritis. | 1983 | Groups of 15 patients with active rheumatoid arthritis were treated for 24 weeks with zinc sulphate, trien, captopril, clozic in two doses or a combination of D-penicillamine and hydroxychloroquine. Serum histidine levels were monitored along with measures of disease activity including C-reactive protein, plasma viscosity, articular index, grip strength and early morning stiffness. Zinc sulphate and trien were found to be ineffective while the other drugs all showed evidence of second-line action. Serum histidine was found to improve during successful therapy. The possible cause of low serum histidine and its response to therapy is discussed. | |
| 7084273 | Electron microscopic studies of the synovial-cartilage junction in rheumatoid arthritis. | 1982 | The synovial membrane-articular cartilage junction has been studied with electron microscopy in 20 patients with rheumatoid arthritis. Material came from specimens taken at synovectomy operations in the majority in an attempt to avoid far advanced disease. Comparisons were made with osteoarthritic tissue and with one normal control case (a meniscectomy). The process of cartilage destruction in RA appears to be multifactorial in origin. The pannus showed to distinct appearances being either cellular and usually vascular, or more fibrous in appearance. These may be two phases of the one process. There was evidence of collagenase activity in junctional cells and for deeper chondrocytes playing a role of polymorphs, a cell given considerable emphasis for cartilage destruction from biochemical studies. Nutritional factors may also be involved and the invasion of rheumatoid granulation tissue may be provoked by chemotaxis from immune complexes in the cartilage surface. The place of a substance similar to tumour angiogenic factor remains uncertain from morphological evidence. The separate phases of the reaction between synovium and cartilage means that responses to various anti-rheumatic drugs may vary widely, and this fact should be appreciated by those testing drugs experimentally. | |
| 6266161 | [Relation between serum enzymes and articular radionuclide tests in the diagnosis of osteo | 1981 | Serum enzymes and articular radionuclide tests have a restricted application in solving the current diagnostic and differential-diagnostic problems of present-day rheumatology. The enzyme tests became positive in case of a high activity of rheumatoid arthritis, not objectivizing the articular degeneration. Their correlation with radionuclide tests of the patients with osteoarthrosis and the patients with rheumatoid arthritis is not elucidated. A juxtaposition was made of the serum enzymes with the articular radionuclide quantitative indices in 88 patients with rheumatoid arthritis with various clinical-laboratory activity, 88 patients with osteoarthrosis in various X-ray stages and 22 healthy controls. A correlation dependence was established between LDH, CPK, acid phosphatase, clearance effectiveness of articular cavity and the deposition of 99mTc-pyrophosphate in knee joints of the patients with osteoarthritis and between gamm-GT, alkaline phosphatase, acid phosphatase and radionuclide articular indices of the patients with rheumatoid arthritis. Those characteristics enabled the earlier overcoming of the diagnostic difficulties in those two basic rheumatic diseases. | |
| 4590670 | Penicillamine in rheumatoid disease: a long-term study. | 1974 Feb 2 | Eighty-five patients with rheumatoid disease were treated with penicillamine, and 69 completed more than one year's treatment. The main reason for discontinuing penicillamine in the 16 patients who withdrew was adverse reaction. The number of adverse reactions, however, declined when patients were given lower maintenance doses of penicillamine. In those who tolerated the drug the results of treatment were good. To prevent side effects the drug should be introduced gradually and maintenance doses should be the lowest which produce a satisfactory response. Urine should be monitored for protein and blood for changes in platelet and white cell counts at frequent intervals throughout treatment. | |
| 6984130 | Etiology of rheumatoid arthritis. | 1982 Oct | The major thesis of the proposed hypothesis is that in the absence of microbial material synovial macrophages in rheumatoid arthritis patients continue to release interleukin 1, which perpetuates the inflammation so characteristic of the disease. Its release is suggested to result from an altered synovial macrophage glutathione metabolism brought about by the action of interleukin 1 on host copper metabolism. Three anti-rheumatic drugs are suggested to act at different points in this pathogenic chain reaction. Alclofenac on interleukin 1, gold thiolates on copper-inhibited macrophage glutathione reductase, and D-penicillamine on IgC catabolism. Drawing upon the hypothesis some suggestions are made for drug design. | |
| 189973 | Bullous pemphigoid and rheumatoid arthritis with herpes simplex in the vesicular fluid. | 1977 Jan | Six cases of bullous perphigoid in association with rheumatoid arthritis have previously been reported in the literature. In the case reported in this paper, herpes simplex virus was found in the vesicular fluid. It is the first time this has been reported to this author's knowledge; this finding may contribute to the knowledge of the ultimate etiology of pemphigoid. | |
| 3893817 | Amyloidosis and rheumatoid arthritis. | 1985 Apr | In spite of an apparent decrease in its occurrence during the last 2-3 decades, amyloidosis associated with rheumatoid arthritis is a significant cause of increased morbidity and early death in both juvenile- and adult-onset rheumatoid arthritis (RA). Like other forms of reactive amyloidosis, the amyloid fibrils associated with rheumatoid disorders are of the protein AA type, and the acute phase reactant SAA, which is complexed to high density lipoprotein in serum, is its putative precursor. Raised SAA appears to be one of the prerequisites for the development of reactive, AA amyloid. Effective treatment of the underlying disorder i.e. rheumatoid arthritis, which lowers the levels of SAA is, therefore, recommended both as a prophylactic and therapeutic measure against reactive amyloidosis. As renal disease is the most severe and life-threatening consequence of reactive amyloidosis, both hemodialysis and renal transplantation are also to be considered in such patients. | |
| 6987483 | Diclofenac and ibuprofen in rheumatoid arthritis and osteoarthritis. | 1980 Jan 12 | Forty patients with arthritis (26 rheumatoid and 14 osteoarthrosis) entered a five-week double-blind crossover trial of diclofenac and ibuprofen. Four patients failed to complete the 10-week trial. There was no statistically significant difference in parameters of disease activity for the rheumatoid arthritis patients, but patients with osteoarthrosis fared significantly better on diclofenac. There was a low incidence of side effects on both regimens. | |
| 3893606 | The diagnostic value of synovial biopsy in patients with arthritis of unknown cause. | 1985 Aug | Synovial biopsy of a knee joint was performed in 59 patients with arthritis of unknown cause. Light microscopy revealed a diagnosis in three. A cause became apparent in only a further 23 over a prolonged period of follow-up. Neither light microscopy, immunofluorescence nor electron microscopy discriminated between te principal diagnostic groups. Synovial fluid analysis was better than synovial biopsy at predicting osteoarthritis. Five men with giant effusions developed osteoarthritis and these might represent an entity. Synovial inflammatory changes were less pronounced in those with longer histories. Disease duration and activity may have more influence on synovial characteristics than the nature of the disorder. | |
| 6334465 | [Lupus biology: incidence and development in 84 rheumatoid polyarthritis patients treated | 1984 | Eighty four patients with classical rheumatoid arthritis were treated with 300-1 200 mg/day of D-Penicillamine. During follow-up, attention was paid to various clinical and biological parameters including the antinuclear factor (ANF) and anti-deoxyribonucleic acid (DNA) antibodies. Before therapy the ANF was greater than or equal to 1/50 in 22 patients (26 p. 100); it increased significantly in treated patients (p less than or equal to 0.01). In addition, positive ANF were found in 22 of the 62 patients (35.5 p. 100) who had negative ANF before D-Penicillamine therapy. There was no correlation between the appearance of ANF or the increase in ANF levels and the initial clinical and biological status, tolerance of therapy, the percentage of cases in which D-Penicillamine was effective. Anti-DNA antibodies were found in 5 patients but no clinical signs of lupus disease were observed despite treatment periods of up to 3.5 years in one case. Anti-SM antibodies were also found in one female patient. The disappearance of anti-DNA antibodies after reducing the dosage of D-Penicillamine (1 case) or withdrawal of therapy (2 cases) is an argument in favour of the inducing role of the drug. The incidence, signification and consequences of these observations are analysed and compared with previously reported results. | |
| 330058 | Membrane characteristics of adherent cells dissociated from rheumatoid synovial tissue. | 1977 Jun | Synovial tissues from rheumatoid-arthritis patients were dissociated by enzymes and the resulting cells incubated overnight in tissue-culture flasks. The adherent cell population was resuspended with EDTA-trypsin, and morphological examination showed 68--80% non-lymphoid cells, most of which had the appearance of synovial lining cells. The proportion of these cells increased during subsequent culture. Between 40 and 60% of the cells exhibited marked phagocytosis, and less than 14% of the non-lymphoid cells could form EA rosettes. Further culture diminished this Fc-receptor-bearing cell population. Indirect immunofluorescence studies with rabbit anti-human collagen sera revealed membrane staining for 30--60% of the cells; this proportion usually increased to greater than 90% after 6--14 days in culture. Omitting any changes of culture medium resulted in a marked decrease in the proportion of cells staining with anti-collagen sera, whereas the viability and phagocytic ability of the cells did not significantly alter. Subsequent cell passage was followed by an increase in the proportion of cells demonstrating membrane-associated collagen, and this effect was more pronounced when a high concentration (50%) of serum supplement was used. No clear definition could be made as to whether the membrane-associated collagen represents synthesis or phagocytosis of collagen by the cells. Faint membrane staining was also observed with non-immune rabbit serum for 4--20% of the cells after the initial overnight incubation, and this usually dropped to less than 5% during prolonged culture. Rabbit antisera to human albumin, F(ab')2 fragment of IgG or alpha2-macroglobulin also gave similar results, whereas the F(ab')2 fragment of rabbit IgG antibody to human alpha2-macroglobulin was completely negative. More than 99% of the cells commonly exhibited membrane-associated beta2-microglobulin. | |
| 473928 | Transformation of the capillary wall elements in synovial tissue in rheumatoid arthritis. | 1979 May | 1. The morphologically comprehensible starting point of rheumatoid arthritis is a permeability change of the synovial capillaries. 2. In the context of rheumatoid arthritis all three building elements of the blood capillaries undergo a transformation. 3. In the endothelial cells and the pericytes the endoplasmatic reticulum, the Golgi-apparatus, as well as the mitochondria can be multiplied (progressive transformation). The cell structures can, however, be subject to a degeneration (regressive transformation). The basement membrane as a secretion product, in contrast, undergoes exclusively quantitative changes. 4. The transformation possibilities of the capillary elements will be treated and classified on a graph under general pathological aspects. 5. As an element of the connective tissue the endothelial cell, as are lining cell and stroma cell in rheumatoid arthritis, is subject to transforming influences which, however, at the synovial capillary will be the starter of fibrin exudation into the joint cavity. |