Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6592003 | Blood viscosity measurements in both extensional and shear flow by a falling ball viscomet | 1984 | A falling ball viscometer is used to measure whole blood and plasma viscosities. The principle of the device is to determine the fall time of a ball contained in a disposable syringe; the periodic run of the sphere prevents blood sedimentation during the measuring cycle but does not prevent the aggregation process which takes place with a short relaxation time. The analysis of the flow field is discussed relative to previous papers. The study of the dynamics of the falling ball provides two characteristic rates of deformation for the mixed extensional and shear flow field. The Reynolds numbers are calculated using different velocities and radii. Results on blood and plasma viscosity of patients suffering from rheumatoid arthritis are given in relation with clinical and biological indexes. | |
| 7327927 | Arthroprosthesis of the ankle joint. | 1981 Apr | The authors report the results obtained with arthroprostheses of the ankle joint in twelve patients. The surgical indications were severe post-traumatic degenerative, lesions, rheumatoid arthritis and post-traumatic necrosis of the talus. The types of prosthesis used were the St. Georg-Buchholz, Smith and TPR designs. The joint was exposed in the majority of cases by an antero-medial approach. The results (at a minimum of one year and a maximum of two and a half years) were satisfactory, being excellent in eight cases, fair in three and negative in one. The one failure was partly due to the surgical exposure, which involved osteotomy of the distal third of the fibula. | |
| 353200 | DNA antibodies detected by microhemagglutination test in the diagnosis of systemic lupus e | 1978 | A method of tanned erythrocyte agglutination of wide applicability is described for the study of DNA antibodies. The practical aspects of the method have been explored in estimation of antibodies to DNA in human cases of systemic lupus erythematosus, discoid lupus erythematosus, rheumatoid arthritis, other collagenoses and not related diseases. This method was found to be of high sensitivity and specificity, detecting DNA antibodies only in sera of systemic lupus erythematosus. Results were compared with those obtained by immunofluorescence test using rat liver hepatocytes as source of nuclei. | |
| 4071423 | [Role of arthroscopy in the diagnosis of chronic monoarthritis of the knee joint]. | 1985 | The author analyzes the arthroscopy findings of 70 knee joints in 68 patients (35 men and 33 women) suffering from chronic monoarthritis of the knee joints with a disease standing from 3 months to 12 years. According to the x-ray data the overwhelming majority of the joints (54) showed stage 0-1, 15 stage II and 1 stage III of the pathological process. In accordance with the preliminary diagnoses 32 patients had synovitis of unclear genesis, 4 rheumatoid arthritis, 3 gonarthrosis deformans, 2 psoriatic arthritis, 5 patients were afflicted with Bechterew's disease, 1 with chondromatosis, and in 21 patients the diagnosis was doubtful. Arthroscopy promoted considerable improvement of the diagnosis, since rheumatoid arthritis including juvenile one was recognized in 12 patients, psoriatic arthritis in 8, reactive synovitis due to gonarthrosis in 16, Bechterew's disease in 12, Reiter's disease in 2, chondromatosis in 4, and pigmented villous-nodular synovitis in 3. The arthroscopic appearance of the disease remained unclear in 7 patients. Therefore, arthroscopy proved a highly effectual method that permits one to differentiate between reactive synovitis and genuine inflammatory diseases and to differentiate with a great probability between rheumatoid synovitis, psoriatic arthropathy and Bechterew's disease. | |
| 6159827 | Plasma levels of beta 2-microglobulin in rheumatoid arthritis. | 1980 Aug | A simple and inexpensive method is described for the determination of beta 2-microglobulin (beta 2-MG) by enzyme-amplified single radial immunodiffusion. The values obtained with this method correlate well with those determined by means of a commerical RIA kit. Using the immunodiffusion method we have measured the plasma levels of beta 2-MG in 135 patients with rheumatoid arthritis (RA) and normal serum creatinine levels. 33% of the patients had increased concentrations of beta 2 MG, but the levels were found to correlate poorly with the values of several variables generally used as indices of the degree inflammatory activity in RA. Furthermore, in contrast to earlier claims to the contrary, beta 2-MG correlated positively with age. The value of beta 2-MG in plasma as an index of inflammatory activity in RA is questioned. | |
| 826257 | Chrysotherapy. A prospective study. | 1976 Nov | A 4-year prospective clinical study of chrysotherapy was designed to reexamine old beliefs and traditions, and to test potentially new approaches to chrysotherapy. The standard weekly dosage of 50 mg was compared to that based on 1 mg/kg body weight; no significant differences were found. The rapidly absorbed aqueous thiomalate was compared to the slowly absorbed oil repository thioglucose; the latter produced significantly less side effects and an appreciably higher percentage of improvement. Almost half (43%) of nonresponders on standard regimen had a satisfactory clinical response at higher dosage levels without increase in toxicity. Some of these findings vary so much with traditional beliefs and practices that the authors urge caution in their interpretation. But generally speaking these problems are technical and do not detract from the conviction that chrysotherapy is valuable and comparatively safe in the management of rheumatoid arthritis and that it deserves more widespread application in clinical practice. | |
| 6678682 | Joint fluid leukocytosis of patient with rheumatoid arthritis Computer analysis of possibl | 1983 Mar | The relationship between joint fluid leukocytosis and some clinical and laboratory parameters (disease duration, ESR, maximal titres of rheumatoid factor and of antinuclear factors, blood leukocytosis and sex) was studied in 27 consecutive patients with seropositive rheumatoid arthritis. The concentration of leukocytes was significantly higher in the synovial fluid than in peripheral blood. Variations of joint fluid leukocytosis could, however, not be explained by disease duration, actual ESR, maximal rheumatoid factor or antinuclear factor titres, concentration of blood leukocytes, or sex. It is suggested that a possible correlation between joint fluid leukocytosis and the listed parameters of rheumatoid arthritis may be too complex for analysis by a linear multiple regression model in samples of the present size. | |
| 3972949 | The causal sequence on death certificates: errors affecting the reliability of mortality s | 1985 | Physicians' amount of diagnostic information and the adequacy of the causal sequence(s) on death certificates involving rheumatoid arthritis (RA) were investigated. Physicians' reporting was compared with the Swedish National Central Bureau of Statistics' (NCBS) registration of the causal conditions, particularly the underlying cause of death. All Swedish RA death certificates for the years 1971 and 1975 were studied. A total of 1224 such certificates were identified. The causal sequences were inadequate in 35% of the certificates, 37% in 1971 and 33% in 1975. Ten types of inadequate sequences were identified. The NCBS rejected the underlying cause of death in 56% of the inadequate sequences and in 52% of the adequate sequences. When the whole sequence leading directly to death was described by only a single diagnosis, 374 (31%) of the cases, this diagnosis was rejected by the NCBS in 54% of the certificates from 1971 and 75% from 1975. More than one diagnosis on each line of the causal-sequence-description appeared on 28% of the certificates. The total number of diagnoses on each certificate did not, however, exceed the NCBS' registration capacity (up to seven diagnoses) in more than 1.6% of the 1224 cases. Thus, the major problem in the NCBS' data collecting process was not how to sort out excessive diagnostic information, but to record properly the causal classification of the conditions, and to interpret the physicians' account of the underlying cause of death. | |
| 657609 | The cervical spine in rheumatoid arthritis. | 1978 Mar | Of 53 severely rheumatoid patients, 43% had cervical spine involvement, Six major categories were found: a) C1-C2 subluxation; b) serial subluxation; c) upward translocation of the odontoid; d) odontoid erosion; 3) apophyseal joint fusion; and f) miscellaneous findings of osteoporosis, endplate erosion, and disk space narrowing without osteophytosis. Although disease duration and activity appeared to correlate somewhat with the development of cervical spine disease, this was by no means universal. Rheumatoid cervical spine disease may be dangerous even in the absence of clinical signs and symptoms. It is therefore recommended that the cervical spine be evaluated in patients with severe rheumatoid disease before general anesthesia is scheduled irrespective of cervical spine complaints recorded in the chart. | |
| 6442055 | [Multicenter double-blind comparison of auranofin and Tauredon]. | 1984 | A multicenter double-blind comparative study with auranofin (Ridaura) and Na-auro-thiomalate (Tauredon) was carried out in order to investigate under controlled conditions whether the new oral gold compound may be an alternative to injections of gold salts. 121 patients were included in the study, data of 86 patients treated for at least one year could be analysed. The following parameters were examined at regular intervals: number of painful and swollen joints, grip strength, morning stiffness, pain and general health on the visual analogue scale, ESR; from these data the articular index and activity index (according to Lansbury, with slight modifications) were calculated. Blood samples for routine safety monitoring and serum gold levels as well as urine tests were obtained regularly. Both treatment groups showed similar improvement in the values for efficacy measurements after one year, starting within 8 to 12 weeks. Patients in the auranofin group with a disease duration of less than 2 years showed greater improvement in the values for efficacy assessment with the exception of grip strength and the number of tender joints than patients with a disease duration of 2 years or more. No such trend was seen in the Tauredon-subgroups. Numerous side effects were recorded in both groups: 89.7% of the patients on Tauredon and 68.8% of the patients on auranofin had observed one symptom during the course of one year. There was a clear distinction concerning the nature of side effects: mucocutaneous symptoms, especially rash and pruritus, were approximately twice as common with Tauredon, whereas diarrhoea was much more frequent in patients treated with auranofin.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 7051258 | [Rheumatoid arthritis with IgE type rheumatoid factors]. | 1982 May | IgE class rheumatoid factors (IgE RF) were sought by indirect immunofluorescence (IFI) in 107 cases of rheumatoid arthritis (RA). They were found at a level of 1/2 in 34 per cent of cases and 1/10 in 16 per cent of cases. From a laboratory standpoint, RA with IgE RF is characterized by the presence in a statistically larger number of cases as well as in larger amounts of agglutinating RF. There is no correlation between IgE RF levels and serum IgE levels. From the clinical standpoint, RA with IgE RF is characterized only by its more advanced state. The presence of abarticular manifestations is far from constant and is no more common than in RA without IgE RF. | |
| 3977420 | Endothelial cell cytotoxicity in inflammatory vascular diseases--the possible role of oxid | 1985 Mar | One of the proposed mechanisms of vascular damage in connective tissue disease is the direct action of a cytotoxic serum factor inducing endothelial cell damage. The nature of this serum factor is unclear, but has been suggested to be a lipoprotein. Sera from patients with (1) systemic necrotising arteritis (polyarteritis nodosa, Wegener's granulomatosis, and necrotising arteritis associated with rheumatoid synovitis), (2) systemic or joint restricted rheumatoid disease, and (3) large vessel/giant cell arteritis have been examined for cytotoxicity to human cultured endothelial cells and azide-resistant ferroxidase-like activity (indicative of the oxidised lipoprotein content). Stored sera from patients with necrotising arteritis showed a significantly enhanced tendency to develop oxidised lipoprotein, which correlated closely with human endothelial cell cytotoxicity. Fresh sera also contained this factor, but to a lesser extent. It is argued that the cytotoxic factor detected in previous clinical studies is in part an in-vitro artefact, although its accelerated development in certain patient groups might suggest an excess of pro-oxidants that have developed in vivo. | |
| 6445922 | Changes in the growth and metabolism of cells cultured from normal, sclerotic and rheumato | 1980 Jun | D-penicillamine and sodium salicylate were equally effective in suppressing the proliferation of fibroblasts from normal and scleroderma skin and rheumatoid synovial cells. The effects were concentration-dependent, beginning at around 100 microgram/ml, and proliferation was almost halted at 1600 microgram/ml. Individual cell strains of each type showed differences in drug susceptibility but there was no consistent difference between cells from normal and abnormal tissues. Acid mucopolysaccharide secretion was more clearly inhibited in scleroderma fibroblasts than in synovial cells, and penicillamine produced greater inhibition than salicylate, beginning at 10 microgram/ml and reaching almost 50% at 500 microgram/ml. Confluent cultures of scleroderma fibroblasts showed 23% less incorporation of 3H-proline into collagenase-sensitive protein in the presence of 1600 microgram/ml penicillamine, without significant effect on other protein synthesis; sodium salicylate had no effect. These data suggest that D-penicillamine may affect connective tissue metabolism in other ways than by interfering with collagen synthesis or cross-linking. | |
| 7221982 | Membrane diffusing capacity and pulmonary capillary volume in rheumatoid disease. | 1980 Nov | In some patients with rheumatoid disease gas transfer across the lungs is abnormal. We measured the membrane component of gas transfer (Dm) and pulmonary capillary volume (Vc) in 48 patients with rheumatoid arthritis and in 48 normal volunteers matched for age, sex, and smoking habits. Volunteers had normal chest radiographs and normal forced expiratory volume in one second and vital capacity. There were no significant differences between the rheumatoid and control groups for Dm. Mean Vc in rheumatoid male smokers (64.0 ml, SD 16.5) was significantly lower than in control male smokers (76.3 ml, SD 18.0 p less than 0.05). In rheumatoid female smokers mean Vc (43.4 ml, SD 13.3) was significantly lower than in rheumatoid female non-smokers (58.4 ml, SD 15.4 p less than 0.01). There was no significant difference between rheumatoid and control female non-smokers (mean Vc 58.4 ml and 60.7 ml respectively). Significant differences in Vc in terms of per cent predicted normal were found between patients receiving corticosteroids and those not receiving corticosteroids or penicillamine (p less than 0.02) and between patients with nodules and those without (p less than 0.05). Patients with persistently low transfer factor for five years had a significantly lower Vc (p less than 0.02). There was no consistent correlation between Dm and Vc and dynamic compliance or static recoil pressure. It appears that the abnormality of transfer factor in rheumatoid disease previously demonstrated is caused by reduction of Vc. It seems that involvement of pulmonary blood vessels occurs in patients with nodules and is suppressed by treatment with corticosteroids. | |
| 4089540 | Activated T lymphocytes of the synovial membrane in rheumatoid arthritis and other arthrop | 1985 Dec | Immunohistological techniques were used to identify activated T lymphocytes within the synovial membrane of patients with rheumatoid arthritis, using the monoclonal antibody (MoAb) RFT2, which identifies a 40-k dalton molecule preferentially expressed by T blasts or activated cells. Using this reagent together with a monoclonal 'cocktail' that stains all T cells, cell counts on consecutive sections of rheumatoid synovium revealed that up to 50% T lymphocytes were RFT2+ (range 9.3-50.2%, mean 25.4). Subsequent analysis using combination immunofluorescence demonstrated that over 90% of these activated cells were of the T4+ subset. Furthermore all these cells appeared to be Leu8-, suggesting that the activated population were exclusively 'true helpers' and not suppressor inducers. Studies indicated that 50% of the RFT2+ cells were positive with anti-Tac MoAb. Comparisons with tissues from other arthropathies demonstrated that this relatively high proportion of RFT2+ cells was a feature restricted to rheumatoid arthritis, although biopsies from patients with psoriatic arthritis and ankylosing spondylitis also contained activated cells. Biopsies of Reiter's syndrome, osteo-arthritis, and pigmented villonodular synovitis contained no activated cells, nor were any seen in sections of normal synovium. The presence in rheumatoid synovial membrane of activated T cells which are only of the T4+, Leu8- subset adds weight to the suggestion that local immunoregulatory dysfunction contributes to the chronic inflammation of rheumatoid arthritis. | |
| 6687527 | Rheumatoid meningitis. A case report and review of the literature. | 1983 Mar | Focal rheumatoid inflammation of the dura and leptomeninges was found in an 89-year-old man who was neurologically asymptomatic and had clinically inactive rheumatoid disease. Previous reports of this entity have not stressed that rheumatoid meningitis can be virtually asymptomatic and can develop in persons with apparently quiescent joint disease. The presence of vasculitis of the meningeal or cerebral vessels is associated with symptoms. Intracranial rheumatoid lesions were associated with rheumatoid lesions in other organs, especially the heart and lungs. | |
| 350894 | Reference preparation to standardize results of serological tests for rheumatoid factor. | 1978 May | The variance of between-laboratory results for rheumatoid factor tests was reduced through the use of a reference serum preparation. Two separate proficiency testing surveys have shown reduction of 58 to 81% in variance with samples of differing levels and composition. Reduction of variance was seen in data from laboratories in which the same methods and reagents were used, but greater reduction in variance was seen in results from laboratories using different methods and reagents. This study demonstrates that comparability of results of rheumatoid factor tests can be significantly improved through the use of a standard reference serum preparation and that confidence in such results can therefore be increased. A serum rheumatoid factor level of approximately 50 IU/ml is equivalent to a titer of 160 in the Singer-Plotz latex test, which has traditionally been accepted as evidence of rheumatoid arthritis. | |
| 779796 | Controlled trial of cyclophosphamide in rheumatoid arthritis. | 1976 May | Twenty-four patients with severe progressive rheumatoid arthritis were randomly assigned to cyclophosphamide or placebo in a double-blind crossover trial. Eleven patients who completed 9 months on cyclophosphamide (average dose: 1.8 mg/kg/day) demonstrated significant decrease in painful joints, swollen joints, and morning stiffness and increase in grip strength when compared to 11 patients on placebo. After crossover, significant improvement was observed in patients switched to cyclophosphamide, and deterioration within 2 months was observed in most patients changed from drug to placebo. Serum immunoglobulins and rheumatoid factor titers decreased with cyclophosphamide but antibody response to Vi antigen was unaffected. Primary delayed immune response to 2,4-dinitrochlorobenzene was markedly depressed. Adverse effects were troublesome--hemorrhagic cystitis affected 4 patients and amenorrhea occurred in 3. Despite striking beneficial effect, cyclophosphamide should be prescribed cautiously and only in severe resistant cases of rheumatoid arthritis. | |
| 6844368 | Maintenance therapy of rheumatoid arthritis and of osteoarthrosis with proglumetacin. | 1983 | Maintenance therapy with proglumetacin was studied in an open investigation in 25 patients with classical or definite rheumatoid arthritis and in 34 patients with osteoarthrosis. Proglumetacin (150 mg) was administered twice daily, at meals, and therapy was continued without interruption for 12 months. Patients with rheumatoid arthritis showed a progressive improvement in objective parameters (erythrocyte sedimentation rate, haemoglobin) and in semi-objective parameters (pain, articular tenderness, number of painful joints, morning stiffness, grip strength, Ritchie articular index). Patients with osteoarthrosis also showed a progressive improvement in objective parameters (movement angles of the affected joints) and in subjective parameters (pain, mobility, response to therapy). During the study, 4 patients reported occasional nausea (3 with vomiting), and 3 reported episodes of slight headache. These symptoms did not require interruption of treatment. Haematology, blood chemistry and urinalysis were not adversely affected by the treatment. Five drop-outs were recorded in the rheumatoid arthritis group: 2 because patients failed to report, 2 because of severe relapses which required a radical change in the therapeutic programme and 1 for incorrect enrollment. Fourteen drop-outs were recorded in the osteoarthrosis group: 6 because the patients failed to report, 4 because of orthopaedic surgery and 4 because it was necessary to change the therapeutic programme. No drop-out was due to an intolerance to proglumetacin. It is concluded that proglumetacin appears to have the effectiveness of tolerability features required for a first-choice medicament for long-term maintenance treatment of patients with rheumatoid arthritis or with osteoarthrosis. | |
| 6099186 | Stabilization of the ulnar side of the rheumatoid wrist, following radiocarpal Swanson's i | 1984 Fall | A report on the use of a portion of the extensor carpi ulnaris tendon tenodesed into the distal end of the cut ulna as a technique for stabilizing the ulnar side of the rheumatoid wrist following radiocarpal Swanson's implant arthroplasty in 28 patients. |