Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6124670 | Mechanism of reduced amyloid-A-degrading activity in serum of patients with secondary amyl | 1982 Jul 31 | Human serum contains amyloid-A-degrading (AADP) activity. This activity is reduced in amyloidosis associated with rheumatoid arthritis. Since AADP co-migrates with albumin on agarose-gel electrophoresis, the relationship between these serum factors was studied in patients with amyloidosis and patients with amyloidosis and patients with altered albumin synthesis and/or distribution. AADP activity correlated positively with albumin levels in patients with rheumatoid arthritis complicated by amyloidosis. A weaker association was noted between serum activity and prealbumin levels. The AADP activity in patients with rheumatoid arthritis without signs of amyloidosis and patients with liver cirrhosis was also positively associated with serum albumin level. During the acute-phase reaction after surgery serum AADP activity fell in parallel with serum albumin level. Purified albumin preparations displayed AADP activity. The results show that serum albumin level reflects AADP activity. It is suggested that the development of hypoalbuminaemia in patients with amyloidosis may give rise to a vicious circle which leads to an accelerated reduction in AADP activity and accelerated amyloidogenesis. | |
| 6603852 | Isolation of an interleukin-1-like factor from human joint effusions. | 1983 Aug | Interleukin-1 (IL-1) is a macrophage derived mediator whose properties suggest that it could play a role in the pathology of arthritis. To test this hypothesis, joint fluids from patients with serveral different arthritides were tested. Small amounts of IL-1-like activity were recovered from many of these joint fluids after affinity chromatography over a column of rabbit anti-human IL-1. Positive fluids were obtained from patients with rheumatoid arthritis, psoriatic arthritis, Reiter's syndrome, osteoarthritis, gout, and traumatic arthritis. Upon gel filtration, the joint derived factor displayed a molecular weight distribution similar to that of IL-1 derived from human monocytes stimulated in vitro. These results suggest that IL-1 is present in joint effusions and, therefore, might contribute to joint destruction. | |
| 6681135 | Methotrexate levels, a guide to therapy? | 1983 Apr | Methotrexate (MTX) is being used with increasing frequency in the treatment of inflammatory arthritis. Seventy-one patients have been treated with MTX with only five ceasing treatment because of toxicity. From a study of the serum levels of this drug, we believe that 10 mg intramuscularly once per week should be an optimum method of treating arthritis. The measurement of a 24 hour serum level of MTX, which normally is less than 0.01 mumole/litre after 10 mg I.M., should aid in identifying those patients more at risk of developing toxicity. | |
| 4018339 | [Superficial pemphigus during the treatment of rheumatoid polyarthritis with D-penicillami | 1985 | The authors report a new case of induced pemphigus: a 64-year-old man has had rheumatoid arthritis for 10 years. When he developed his pemphigus, he had been taking D-penicillamine and piroxicam for about 8 months. He needed high doses of prednisolone associated with azathioprine to clear his eruption. The case had a fatal outcome. | |
| 271890 | Drug prescribing in rheumatoid arthritis in Otago. | 1977 Aug 10 | The drug therapy prescribed for a group of 50 patients with rheumatoid arthritis in Otago prior to specialist referral was examined. Thirty-two patients were receiving some first-line anti-inflammatory drugs and six were receiving no therapy at the time of their first hospital clinic visit. Salicylates had been prescribed first in only 16 of the 50 patients while this drug had been withdrawn because of side effects in about one-third of the patients who had been treated with it prior to specialist referral. Seven patients had received phenylbutazone and six corticosteroids as the first treatment for their rheumatoid arthritis. About one-third of the patients were receiving more than one anti-inflammatory drug at the time of their initial clinic visit. | |
| 6529283 | The surgical treatment of the rheumatoid wrist. Current perspectives. | 1984 | The authors stress the prevalence and severity of wrist involvement in rheumatoid disease. Improved knowledge of aetiopathogenesis and deformities had led to identification of the importance of the distal consequences on the digital joints of decentralization of the wrist. Synovectomy retains an important place at the onset of the disease. This may be completed by stabilization procedures (tendon transfer and partial arthrodesis). At the advanced stage of the disease, arthroplasty is currently overtaking arthrodesis. Interposition arthroplasty, with its rare indications, is now well developed. Although the solution of the future, arthroplasties lack sufficient follow up in terms of their results. The Swanson implant offers limited mobility but ensures freedom from pain and a good wrist axis. The ideal treatment of the rheumatoid wrist is oriented towards early conservative surgery and later, at an advanced stage, towards arthroplasty, the ideal technique of which remains to be discovered. | |
| 6395873 | [Plasma beta-2-microglobulin in rheumatoid arthritis]. | 1984 Sep 30 | The beta 2 microglobulin (beta 2m) is a low molecular weight protein, recognized on the cellular membranes of numerous nucleated cells and strictly correlated to the antigens of Major Histocompatibility Complex. Many authors have demonstrated an increase of the plasmatic beta 2m in different inflammatory diseases and, particularly in rheumatic ones, as Rheumatoid Arthritis (RA), Reiter's syndrome, Ankylosing Spondylitis, Systemic lupus erythematosus. We have also investigated the behaviour of the plasmatic beta 2m in 52 RA patients and in 17 healthy subjects. The beta 2m was measured in serum, by radioimmunoassay. We have demonstrated that the plasmatic beta 2m has moderately increased in the serum of RA patients, even if there is not a significant difference when compared to the normal subjects. | |
| 6481720 | Studies on the metabolism of D-penicillamine and its interaction with probenecid in cystin | 1984 Aug | Four patients with recurrent cystine stones and 5 with rheumatoid arthritis (RA) were studied. After a single dose of D-penicillamine to cystinuric patients, cystine excretion decreased considerably. Cysteine-penicillamine mixed disulfide (CSSP) and penicillamine disulfide (PSSP) metabolites appeared within 1-2 h (CSSP/PSSP approximately equal to 4.8-8.6). In RA, cystine excretion remained negligible (CSSP/PSSP approximately equal to 1.4-2.9). With daily D-penicillamine in RA (CSSP/PSSP ratios were usually greater than 7 in those with favorable clinical response. CSSP/PSSP ratios may help to predict prognosis and adjust penicillamine dosage. Coadministration of probenecid is contraindicated in hyperuricemic cystinuric patients because of increased cystine and decreased CSSP and PSSP excretion. | |
| 6719064 | A comparative study of radiographic changes in knee joints in chondrocalcinosis, osteoarth | 1984 | Knee joint radiographs from 45 patients with articular chondrocalcinosis (CC), 23 with osteoarthrosis (OA) and 19 with rheumatoid arthritis (RA) were compared. The incidence of conventional radiographic features of osteoarthrosis, osteophytes, joint space narrowing subchondral cysts, subchondral sclerosis, and varus or valgus deformity was equal in CC and OA joints. But distinctive changes in the patello-femoral area were found in half of the CC joints. Twenty knees evidenced flattening of the anterior parts of the femoral condyles, 13 showed a large erosion on the anterior surface of the femoral shaft just above the condyles and in 10 cases these changes were coincidental. OA and RA joints never showed femoral shaft erosion, but 2 OA and 1 RA joint showed condylar flattening. The 23 CC joints with erosion or flattening showed less femorotibial osteoarthrosis than the 22 CC joints without these changes. | |
| 9336625 | Radiolunate arthrodesis. Factor of stability for the rheumatoid wrist. | 1983 | Spontaneous radiolunate arthrodesis found in nearly 13% of rheumatoid wrists confer on this joint a durable physiologic orientation with reduced but sufficient mobility. Twelve cases of this type of fusion were studied radiologically and clinically with an average follow-up of 5 years. The authors advise surgical arthrodesis as a supplementary procedure with synovectomy every time there is instability of the carpal articulation with ulnar disalignment. Seven cases are reported, 4 of which are presented in detail. The operative technic and indications are discussed briefly. | |
| 7406675 | Hand grip function in patients with rheumatoid arthritis. | 1980 Aug | A new electronic dynanometer was developed and used to determine hand grip function in patients with rheumatoid arthritis. Triplicate pressure-time recordings of grip for each hand were used to calculate maximum grip strength, time required to reach 95% maximum grip strength (t95), total work and maximum power output. Measurements were done on 30 women aged 32 to 74 years (mean, 53 years) who had rheumatoid arthritis and 20 healthy women aged 37 to 69 years (mean, 50 years). The values obtained for patients and healthy women showed that the dominant hand was stronger than the nondominant hand in all women. However, all tests in patients with arthritis indicated decreased function and strength, the relative decrease being greater for nondominant hands compared with dominant hands. This new approach to measurement of hand grip function may provide better discrimination in the quantitative assessment of morning stiffness and response to changes in drug therapy. The time required to achieve 95% of maximum grip strength and maximum power outputs in particular appear to be more sensitive indicators of function than the standard maximum grip strength measurement. | |
| 6977877 | Histocompatibility antigens and rheumatic diseases. | 1982 Mar 20 | Great advances have been made during the last 10 years in the field of immunogenetics as applied to the rheumatic diseases. The association of particular rheumatic diseases with the gene products of the major histocompatibility system provides convincing evidence of a genetic basis for disease susceptibility and has enabled identification of genetic heterogeneity within disease groups. This review briefly discusses the biology of HLA system and its relevance for rheumatology today. | |
| 6813479 | Interim results of a multicenter open study with auranofin in Japan. | 1982 Jul | We report the results of 47 of 116 rheumatoid patients, who took auranofin (AF) for more than 6 months. After 8-12 weeks of treatment with AF 3 mg bid, a remarkable improvement was observed especially in numbers of tender and swollen joints and duration of morning stiffness. The mean activity index before AF was 70.1% and the index decreased linearly for 6 months to 53.5%. AF was particularly effective in patients with high rheumatoid activity, as well as in those of short duration of disease and Stages I and II. Radiographic examination showed a possible prevention by AF of progression of bone destruction in the joints. A total of 86 side effects were reported in 50 cases: 36 gastrointestinal; 34 mucocutaneous and 16 others. Most side effects cleared during the treatment and no serious side effects were reported. Drug administration was discontinued in only 11 cases (9.5%). Blood gold level reached a plateau after 9 weeks (mean level was 0.67 micrograms/ml). Urinary excretion rate was parallel with the blood gold level. | |
| 441639 | Rehabilitation of the rheumatoid shoulder. | 1979 | In the treatment of the rheumatoid shoulder physiotherapy allows the use of positions relieving the joint of discomfort and preventing deformities. Isometric contractions prevent muscular atrophy. An individual programme of gentle, progressive assisted mobilization permits the total rapid recovery of painful stiffness in simple synovitis and partial recovery of painful stiffness in simple synovitis and partial recovery in the more advanced arthritic lesions. Occupational therapy techniques are proposed to complete the effect of physiotherapy at a means of adapting the patient to the difficulties encountered in daily living. | |
| 241595 | Simultaneous pharmacokinetics of alclofenace in plasma and synovial fluid in patients with | 1975 | The simultaneous pharmacokinetics of alclofenac in the plasma and synovial fluid of 10 patients with rheumatoid arthritis were studied after a single 1 g. oral dose. A gas-liquid chromatographic method was used for assaying alclofenac in both plasma and synovial fluid. Alclofenac readily appears in the plasma and synovial fluid. | |
| 7325192 | Handedness and hand joint changes in rheumatoid arthritis. | 1981 Nov | This study investigates the relationship of hand use to the deforming hand joint changes of rheumatoid arthritis. Measurements of metacarpophalangeal lateral mobility, loss of metacarpophalangeal hyperextension, thumb metacarpophalangeal range of motion, and lateral pinch strength were statistically compared across dominant and nondominant hands of 51 adult subjects who had definite or classical rheumatoid arthritis. Incidence of boutonniere and swan neck deformities and distal radioulna laxity was also recorded. Results of a multivariate analysis of variance of the difference scores between dominant and nondominant measures were not significant. The authors concluded that the relationship of hand use to joint destruction is not yet clearly defined and further study is needed. Implications for treatment principles of joint protection are presented. | |
| 114640 | Sequential observations of in vitro responses of lymphocytes to phytohemagglutinin in pati | 1979 | Forty-seven patients receiving gold therapy for rheumatoid arthritis were observed sequentially at 6-monthly intervals. When the disease was in remission, and remained so, the in vitro responses of lymphocytes to phylohemagglutinin stimulation tended to be normal. Improvement in the disease were associated with improvement in lymphocyte response and deterioration associated with depression of response. Our observations suggest that these changes are a reflection of disease activity and their relationship to gold therapy is indirect. | |
| 825054 | IgG subclass composition of rheumatoid arthritic sera and joint fluids. | 1976 Jun | The IgG subclass composition of 24 matched pairs of synovial fluids and sera, from 24 patients with rheumatoid arthritis, was determined. The subclass composition of rheumatoid synovial fluid IgG was found to be qualitatively the same as that of the corresponding serum, differing only in certain quantitative aspects. A 7-8% increase in IgG1 level found in the sera of rheumatoid arthritis patients relative to that in the sera of normal individuals was accompanied by 6-8, 0-7, and 0-3% decreases in IgG2, IgG3, and IgG4, respectively. | |
| 6486240 | Allied health team management of rheumatoid arthritis patients. | 1984 Sep | The use of a coordinated team of allied health professionals (AHPs) to treat patients with rheumatoid arthritis assigned to experimental groups (EG) and comparison groups (CG) was assessed. The EG patients were evaluated regularly by each AHP team member, whereas CG patients were seen by AHPs only upon referral. Of the 10 EG and 13 CG patients who remained in the study for 2 years, the EG patients initially exhibited somewhat greater disease activity than CG (as reflected by erythrocyte sedimentation rate and duration of morning stiffness). After 2 years, EG patients demonstrated less disease activity than at the outset, whereas CG patients either showed little change in these parameters or deteriorated during the study. Grip strength, which was initially similar in the two groups, improved in EG patients but decreased in CG patients, so that after 2 years a significant difference was noted between the two groups (p less than .05). Tendency to lose hand range of motion was also greater in CG than in EG patients. Some EG patients showed improvement in finger flexion deformities during the study. Furthermore, EG patients showed a greater tendency to acquire positive attitudes regarding themselves and family relationships. These results suggest that ongoing "team care" may be more efficacious than episodic use of AHPs in management of patients with mild rheumatoid arthritis. | |
| 6611159 | Rheumatoid arthritis and small airways function. Effects of disease activity, smoking, and | 1984 Jul | The sensitive pulmonary function tests of change in maximum expiratory flow (delta Vmax 50) and volume of isoflow were used to determine the effects of rheumatoid arthritis (RA), smoking, and alpha 1-antitrypsin deficiency phenotypes on peripheral airways. Patients were prospectively divided into 4 groups: 14 smokers with RA, 12 nonsmokers with RA, 11 smokers without RA, and 13 nonsmokers without RA. delta Vmax 50 was the most discriminating variable and demonstrated significant small airway obstructive disease in the first 3 groups, with an additive effect in the group of smokers with RA. An increased incidence of the alpha 1-antitrypsin-deficient MS phenotype was seen in the RA smoker group, and this phenotype was associated with severe pulmonary disease. |