Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3001587 | [Value and limitations of scintigraphy of the hand in rheumatoid arthritis]. | 1985 Nov 30 | 99mTc-polyphosphate joint imaging of the hand has been performed in 18 patients, with evidence of inflammatory joint disease, but without any significant radiographic lesions, which might be related to rheumatoid arthritis. The hand scans were compared to clinical and radiographic data. An year after, the same subjects were re-examined, with both the radionuclide imaging and radiography. Scintigraphy has been shown to be significantly more sensitive for detecting inflammatory joint disease than x-ray, especially in the early stage of rheumatoid arthritis. Although radionuclide imaging is non specific (activity is increased also in osteoarthritis, trauma, metabolic bone disease, infarction, etc.). Radiography is highly specific but relatively non sensitive. | |
| 6238454 | Suppressor cell responses in patients with rheumatoid arthritis: the effect of thymosin. | 1984 | Peripheral blood lymphocytes (PBL) from patients with rheumatoid arthritis (RA) and age and sex-matched normal controls were compared in a Concanavalin A (Con A)-induced suppressor cell assay. Suppression induced by pre-incubation with Con A was significantly greater in PBL from RA patients than in PBL from normal controls. Preincubation with thymosin fraction 5, in the absence of Con A, also induced greater suppressor cell activity in PBL from normal controls. Preincubation with Con A and thymosin, simultaneously, induced suppression similar to that seen with Con A alone. These results suggest the presence of an immunoregulatory defect in RA, characterized by an excess of both Con A and thymosin-inducible suppressor cells, that may play a role in disease pathogenesis. The implications of these observations for immunotherapy of rheumatoid arthritis with thymosin are discussed. | |
| 168488 | Predominantly T-cell infiltrate in rheumatoid synovial membranes. | 1975 Sep 11 | Lymphocytes infiltrating synovial membranes were characterized in eight patients with proliferative rheumatoid synovitis. Surface immunoglobulins were studied with use of immunofluorescence, and the C3 receptor was detected by adherence of red cells coated with antibody and complement - both are B-cell markers. Spontaneous rosette formation with sheep erythrocytes was used as a T-cell marker. To obtain viable lymphocytes in suspension, the villous synovium of five of these patients was digested with collagenase and deoxyribonuclease. Populations enriched in lymphocytes could be obtained by velocity sedimentation. Whereas only 9 to 35 per cent of lymphocytes bore surface immunoglobulins, the majority (70 to 85 per cent) formed sheep-erythrocyte rosettes. Cells bearing the C3 receptor constituted a distinct minority of synovial lymphocytes in frozen-tissue sections, and were found in follicle-like accumulations. These data indicate that the predominant infiltrating lymphocyte in proliferative rheumatoid synovitis is a T cell. | |
| 921348 | Transferrin iron uptake by human synovium. | 1977 Oct | 55Fe-labelled transferrin was injected into the synovial fluid before synovectomy in 6 patients with rheumatoid arthritis. The results show that transferrin iron is taken up by synovial macrophages. | |
| 843114 | Radiographic changes in early rheumatoid disease. | 1977 Feb | We have studied the radiological features in 94 patients with early rheumatoid disease followed prospectively for 5 years. The changes appeared very early and occurred in up to 71-3% of patients. Erosive changes occurred in the feet much more commonly than in the hands and considerably earlier. Erosive changes were present before there was joint-space loss. Frequent x-ray examination of feet and hands in the first 2 years after presentation is required if we are to identify patients at risk for serious joint damage. | |
| 365195 | Antilymphocyte antibodies in rheumatoid arthritis. | 1978 May 31 | The presence of cold and non-cold reacting antilymphocyte antibodies of IgG class, active against allogeneic T lymphocytes deprived of Fcgamma receptor bearing cells, was investigated by indirect immunofluorescence (IF) and by microlymphocytotoxicity in 50 patients with Rheumatoid Arthritis (RA). 6/50 rheumatoid sera have shown the presence of anti-T-lymphocyte antibodies against 8/50 positivities found when the whole lymphocyte population was employed as the target in IF test. The positive sera were also examined by microlymphocytotoxicity test and the correlation with the number of lymphoid cells in peripheral blood was studied. In only one case (RA + Sjögren's syndrome) a positive IF test, in vitro cytotoxicity and in vivo lymphopenia were observed. In the other IF positive cases neither lymphopenia in vivo nor lymphocytotoxicity of the sera were observed; these results can be due to either the presence of cold or not complement fixing antilymphocyte antibodies. | |
| 6731007 | Radiographic measurements of the cranio-vertebral region. Designed for evaluation of abnor | 1984 | A new method of measuring vertical dislocation of the C1 and C2 vertebra in rheumatoid arthritis is presented based on the distance from the lower end plate of C2 to the palato -occipital or McGregor 's line. In a normal material the distance was found to be 34 mm or more in men and 29 mm or more in women. A value below these limits should be regarded as vertical dislocation. In the same normal material the value according to the McGregor method was found to be 9 mm or less in both sexes. In a combined material consisting of healthy individuals and patients with rheumatoid arthritis a good correlation between the two measurement methods was found. The new method has the advantage of giving a measurable value also in cases with advanced dislocations and an undiscernible dens and of giving a correct value in cases with erosions and destruction of the dens. | |
| 444313 | Immune complexes in rheumatoid arthritis sera and synovial fluids: a comparison of three m | 1979 May | Sera and synovial fluids from 88 patients with rheumatoid arthritis were examined for circulating immune complexes by three assays: monoclonal rheumatoid factor radioimmunoassay, C1q binding assay, and Raji cell radioassay. Paired samples were available for 82 patients. Immune complexes were detected with high frequency in the synovial fluid by each assay (75% by the monoclonal rheumatoid factor radioimmunoassay, 95% by the C1q binding assay, and 61% by the Raji cell readioassay). In rheumatoid arthritis sera, immune complexes were detected with high frequency by the C1q binding assay (85%) and the monoclonal rheumatoid factor radioimmunoassay (70%) but infrequently by the Raji cell radioassay (26%). The presence of immune complexes in serum was most frequently accompanied by the presence of complexes in fluid, regardless of the method of detection; moreover, the levels of immune complexes in synovial fluid were generally higher than in paired serum. Further, the levels of immune complexes as measured by the C1q binding assay correlated with certain parameters of clinical activity, while the monoclonal rheumatoid factor radioimmunoassay and Raji cell radioassay correlated with extraarticular features (excluding nodules) of rheumatoid arthritis. | |
| 6704285 | Does the addition of ketotifen to non-steroidal anti-inflammatory drugs confer any additio | 1984 Feb | Ketotifen (benzocycloheptathiophene) was evaluated in a double-blind study of patients with active rheumatoid arthritis. Sixty patients were randomly allocated to receive active or matching placebo drug and reviewed 6 weekly for 24 weeks. Conventional NSAIDs were continued throughout. Disease activity was assessed clinically and biochemically at weeks 0, 12 and 24. Nineteen patients remained on active drug for 24 weeks and 11 on placebo. Significant improvement in articular index was seen in both groups but no objective improvement was noted in either group. No undue toxicity was encountered in either group. Use of a drug considered to have selective LTC4 and LTD4 antagonism in combination with conventional cyclo-oxygenase inhibitors did not confer any additional benefit in rheumatoid arthritis. | |
| 1137443 | Empyema in rheumatoid arthritis. | 1975 Apr | Case notes of the last 67 patients to present at the Brompton Hospital with nontuberculous empyemas, and without malignant disease, have been examined. Three cases of empyema in association with rheumatoid arthritis (RA) were found, and these cases are reported. Previous literature concerning this association is reviewed. It is concluded that two types of empyema may occur in patients with RA. Some develop in association with nodular pleuropulmonary disease and the formation of pyopneumothoraces; in other cases large, recurrent, primary empyemas build up in the presence of active rheumatoid disease alone. As with rheumatoid pleural effusions, middle-aged men seem to be particularly susceptible. | |
| 7250327 | Incorporation of 14C-thymidine by cultures of erythrocytes from rheumatoid arthritis patie | 1981 May 15 | Cultures of washed erythrocytes from rheumatoid arthritis patients and normal subjects were found to incorporated 14C-thymidine, suggesting the presence of an L-form. The extent of the incorporation by erythrocytes from rheumatoid patients was more variable than that by erythrocytes from normal subjects, and correlated negatively with IgG measurements and white cell counts performed on the patients' bloods, although not with the clinical activity of the patients. | |
| 3970037 | Rheumatoid arthritis and cancer studies based on linking nationwide registries in Finland. | 1985 Jan 21 | Two separate registries that cover the whole population of Finland have been linked in order to study the occurrence of cancer in patients with rheumatoid arthritis. The two registries involved were the Social Insurance Institution's Population Register, which collects information on medication for certain chronic diseases since 1967 including rheumatoid arthritis, and the Finnish Cancer Registry, which has data on all cancer patients in Finland since 1953. The 213,911 person-years' follow-up of 46,101 individuals with rheumatoid arthritis revealed 1,202 cases of cancer. The relative risk of cancer was 1.15 in males and 1.01 in females. The observed number of cases significantly exceeded that expected in Hodgkin's disease, non-Hodgkin's lymphomas, multiple myeloma, and leukemia. In general, the incidence of epithelial tumors was as expected. These findings were further supported by studying the occurrence of subsequent new primary cancers among patients with rheumatoid arthritis and cancer. | |
| 7079112 | Compression testing of foamed plastics and rubbers for use as orthotic show insoles. | 1982 Apr | Thirty-one materials have been tested in compression in order to generate the stress (force per unit of cross-sectional area) versus strain (deformation) behaviour, for the purpose of assessing the suitability of various foamed plastics and rubbers as shoe insole materials. It was found that the materials could be classified into three distinct categories (very stiff, moderately deformable and very deformable) according to the shape of the characteristic stress versus strain curve. The moderately deformable group has been selected as the most promising for clinical application. | |
| 7423109 | [Superoxide dismutase and rheumatoid arthritis. Study of a series of 6 cases]. | 1980 Jul | The authors present a short series (6 cases) of serum positive rheumatoid arthritis, treated by I.M. injections (5 cases) or intra-articular injections (one case) of dismutase superoxide of bovine origin. The treatment was stopped in one case for local intolerance. Four cases treated for four months by the intramuscular route, were uninfluenced by the treatment, nor was the patient treated by the intra-articular route. The laboratory parameters (E.S.E., Rose Waaler reaction) were not modified. On the other hand, the lymphocyte fragility in culture was improved. The good tolerance of this compound in the laboratory will permit further trials in higher dosage. | |
| 1166328 | Psychiatric illness associated with systemic lupus erythematosus. | 1975 Oct | Estimates of the frequency of mental changes associated with systemic lupus erythematosus (SLE) range from 3% to 65%. Variations in classifying and reporting symptoms account for much of the difficulty in determining the true incidence. Other problems in study design also make it difficult to compare results of various studies, although it appears that psychiatric illness associated with SLE falls into two categories: organic and functional disorders. The former occur in 22% to 29% of patients having SLE and rheumatoid arthritis and are associated with a poorer prognosis and higher mortality. The latter occur in 18% to 35% of SLE patients and slightly less in patients with rheumatoid arthritis. Several possible causes for mental changes of SLE have been proposed. The case of a patient with SLE having an acute psychotic episode illustrates the possible roles of premorbid personality, mental and environmental stress, and steroid therapy in precipitating psychiatric illness in SLE. | |
| 1115448 | UCLA Conference. Diagnosis and treatment of erosive rheumatoid arthritis and other forms o | 1975 Feb | Single or multiple destruction of joints arises from many causes, ranging from the acute destructive process (usually monarticular) in septic joint disease to the chronic, slowly evolving destruction of cartilage and adjacent bone that occurs in osteoarthritis. Medical treatment of a few of these conditions (including rheumatoid arthritis) is reasonably satisfactory if it is initiated early. On the other hand, surgical procedures are indicated if physical and X-ray examination of the involved joints discloses the presence of a significant destructive process involving both articular cartilage and bone. Several very satisfactory such operative techniques, including synovectomy (in the relatively early phases) and prosthetic joint replacement, have been recently developed. These are especially favorable in destructive disease of the hip, knee, or small joints of the hand. The various differential diagnostic, radiographic medical, and surgical procedures are discussed in some detail in this conference. | |
| 6759056 | Short-term efficacy and tolerance of tiaprofenic acid ('Surgam') in rheumatoid arthritis a | 1982 | Two multi-centre, placebo-controlled, crossover trials of tiaprofenic acid were conducted to an identical design: one in 80 patients suffering from rheumatoid arthritis, the other in 60 patients suffering from osteoarthritis. After a washout period, each patient received 600 mg tiaprofenic acid daily and placebo each for 1 week. The results were similar for both trials. Tiaprofenic acid was more effective than placebo in both rheumatoid arthritis and osteoarthritis and differences in all the assessments of efficacy used were statistically significant. This significance was attained from the first day in rheumatoid arthritis and from the second day in osteoarthritis. Tiaprofenic acid was as well tolerated as placebo. Routine laboratory tests revealed no adverse effects. Possible side-effects, which were predominantly mild and related to the gastro-intestinal system, were reported by 23% patients with tiaprofenic acid and 21% patients with placebo. The 2 patients withdrawn for possible side-effects were both receiving placebo. | |
| 6148990 | A study of serum biochemistry in Behçet's syndrome. | 1984 Nov | Serum samples from 57 Turkish patients with Behçet's syndrome (BS) were analysed for C-reactive protein, histidine, total sulphydryl concentration and gamma glutamyl transpeptidase. Clinical subgroups did not exhibit biochemical differences, including BS with and without arthritis. When compared with normal controls and with patients with active rheumatoid arthritis (RA), those with BS were shown to be biochemically abnormal in a manner quantitatively similar to RA, but to a lesser degree. Gamma-glutamyl transpeptidase concentrations were found to be normal in BS. | |
| 215367 | Suprascapular axonotmesis and rheumatoid disease: report of a case treated conservatively. | 1978 Jul | Axonotmesis of the suprascapular nerve mimics rupture of the musculotendinous cuff of the shoulder. Arthrography of the shoulder joint and electromyographic studies of the shoulder muscles are essential in arriving at the proper diagnosis. Axonotmesis of the suprascapular nerve should be suspected in the patient who presents with signs of ruptured musculotendinous cuff and who has a normal arthrogram. | |
| 335680 | [Basic therapy of rheumatoid arthritis]. | 1977 Jul 15 | Apart from the conventional treatment of the rheumatoid arthritis with steroidal and non-steroidal antirheumatic remedies, physiotherapy and balneotherapy as well as orthopaedic and surgical measures the basis therapy is an important factor. It has no or only slight analgetic effect, but shall inhibit the immunological processes in the pathogenesis of the rheumatoid arthritis. To the basis therapy belong the antimalarial remedies, the gold salts, the cytostatic remedies as immunosuppressive drugs and the D-penicillamine. Their possible and different modes of action are described, their clinical applications are explained and it is referred to their side-effects and contraindications. In these cases also the value of the individual preparations in the complex plan of treatment of rheumatoid arthritis are evaluated. |