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PMID	Title	PublicationDate	abstract
322669	Skin basement membrane immunofluorescence in rheumatoid arthritis: lack of diagnostic corr	1977 Mar	Thirty-nine patients with rheumatoid arthritis were studied for the presence of skin basement membrane immunofluorescence. Punch biopsies from normal sun-exposed skin of the forearm were negative for basement membrane immunofluorescence in all cases, except one which was read as questionable. No correlation with serum antinuclear antibody or lupus erythematosus cells was observed. Skin immunofluorescence studies are helpful in differential diagnosis when patients with a clinical picture of rheumatoid arthritis present with serum antinuclear antibodies and lupus erythematosus cells. Positive basement membrane immunofluorescence is strong evidence of systemic lupus erythematosus.
1100304	Correlation of plateau serum salicylate level with rate of salicylate metabolism.	1975 Sep	The range of plateau serum salicylate concentrations was 4.4 to 33 mg/100 ml in patients with rheumatoid arthritis after they were treated with 50 mg/kg of aspirin daily for 5 days. Individual plateau serum levels correlated better with urinary excretion rates of the metabolite, salicylurate (whose maximum production is capacity-limited), than with total urinary excretion of salicylates. These observations suggest that large intersubject variations in plateau serum salicylate levels are determined, at least in part, by similar differences in the maximum rates of capacity-limited metabolic reactions. For optimal therapeutic responses, individualization of aspirin dosage by following serum salicylate levels is recommended.
6124215	Pyogenic arthritis due to bacteroides complicating rheumatoid arthritis.	1982 Jun	Two cases of anaerobic, pyogenic arthritis complicating rheumatoid disease due to bacteroides are described. The relative well-being of the patients and indolence of the affected joints are emphasised, and the effective role of metronidazole in the treatment of septic arthritis due to bacteroides is discussed.
7373617	Analysis of treatment terminations with gold and antimalarial compounds in rheumatoid arth	1980 Mar	Life table analysis was used to determine the incidence of treatment termination in rheumatoid arthritis patients after initial therapeutic courses of gold (93) and antimalarial compounds (101). Patients treated with antimalarial compounds tended to terminate treatment sooner than those receiving gold. The most common reasons for discontinuing antimalarial therapy were lack of initial benefit and loss of response to the drug. Clinical and laboratory characteristics of patients at onset of therapy did not influence failure rates to a great extent.
1214430	[Cure of scleromalacia perforans manifesting in the course of rheumatoid arthritis with d-	1975 Sep	A new treatment of a case of scleromalacia perforans, complicating rheumatoid arthritis is reported. To save the eye fascia lata was transplanted, preoperatively prednisolone and d-penicillamine was started, and this therapy was continued for one year thereafter. The effect was favorable, as pains vanished, and the grafted fascia remained whole. Cure of scleritis of the other eye hitherto unresponsive to local treatment was attained. Advantages of the combination of both immunosuppressive and surgical therapy is emphasized.
7415586	[Prostaglandins E2 and F2 alpha concentrations in the synovial fluid in rheumatoid and tra	1980 May	Prostaglandin E2 (PGE2) and F2 alpha (PGF2 alpha) concentrations in synovial fluid samples from 15 patients with various knee joint disorders were measured by radioimmunoassay. High concentrations of PGE2 wee found in all the samples obtained from patients with knee effusions due to various inflammatory processes as compared to the very low PGE2 levels in patients with osteoarthritis or traumatic effusions. The highest PGE2 levels were measured in knee joint effusions from patients with severe forms of rheumatoid arthritis. Two patients suffering from rheumatoid arthritis commenced with indomethacin (150 mg/day) after the first synovial fluid sample collection only. Some weeks later in a new sample a partial reduction of PGE2 concentration was found. The results of our investigations ar discussed with regard to possible correlations between prostaglandins and inflammation on the one hand and bone resorption associated with various pathological disorders on the other hand.
384237	Cytogenetic studies in patients treated with penicillamine.	1979 Aug	Cytogenetic studies were performed on bone-marrow cells from 11 patients with rheumatoid arthritis treated with penicillamine. One of the patients was studied while developing a granulocytopenia and thrombocytopenia. The findings show that penicillamine had no chromosome-damaging effect as estimated by the micronucleus test and by the number of structural chromosomal aberrations.
3978366	The nature of arthritis pain.	1985 Feb	A modified version of the McGill Pain Questionnaire in visual analogue format was used to evaluate the sensory, affective and evaluative intensities of pain experienced by 40 patients with rheumatoid arthritis and 20 patients with degenerative arthritis. The affective component of the pain was found to be more intense than the sensory component in all patients indicating the importance of emotional factors in the pain experience. The sensory aspects of the pain were more complex than the affective ones reflecting the varied sources and combinations of somatic pathology. There were no significant differences found in the overall pain experience between rheumatoid and degenerative arthritis. No differences were noted in the evaluative category of pain. Overall pain intensity increased with disease duration in both rheumatoid and degenerative arthritis. The relationship of affective and sensory components of the pain experience did not alter with duration of disease.
6692606	Total knee arthroplasty in rheumatoid arthritis.	1984 Jan	The results of total knee arthroplasty (TKA) have improved steadily during the past decade due to refinements in design, fixation, and surgical technique. A review of the evolution of prosthetic design and of the clinical performance of the concept of cruciate-sparing knee arthroplasty provides both direction for improvement and cause for optimism. The results of 798 TKAs performed in one institution were reviewed to validate the principles and concepts of prosthetic design and surgical technique. During the years reviewed the incidence of good and excellent results rose from 67% to 92%, while revision rates declined. Failures resulting in revision were due to loosening in 1.3% of the knees, patellofemoral pain in 1.8%, and infection in 0.4%. Patients with rheumatoid arthritis (RA) achieve results similar to those of patients with osteoarthritis with regard to range of motion and pain relief; the polyarticular nature of RA results in some decrease in functional outcome, primarily related to disease in other joints. In the relatively short follow-up evaluation, the failure rate is acceptably low, and radiolucent lines, indicative of potential later failure, appear to be diminishing in frequency and extent. The improving success rate in each successive series of TKAs reviewed in this paper provides grounds for optimism regarding the future of TKA, and important lessons can be derived from the failures.
6380898	Monoclonal antibody investigation in rheumatoid arthritis: presence of a T cell subpopulat	1984 Jun	Using a double marking technique of peripheral blood lymphocyte (PBL) from 23 patients suffering from rheumatoid arthritis (RA) and 12 normal healthy subjects (NHS), the authors were able to demonstrate that there was no alteration in the OKT8 + ve population of RA patients, when compared with NHS. On the contrary, an increased percentage of the subpopulation of lymphocytes OKT4 + ve was detected. Finally, the presence of a subpopulation of T cells carrying both the receptors for monoclonal antibodies OKT4 and OKT8 has been detected.
277165	Renal papillary necrosis associated with indomethacin and phenylbutazone treated rheumatoi	1978 Apr	A case of renal papillary necrosis is reported in a 55-year-old man with rheumatoid arthritis. He consumed 1.1 kg indomethacin and 5.5 kg phenylbutazone over the seven years prior to presentation.
7222718	[Comparison of the efficacy of diflunisal and acetylsalicylic acid in rheumatoid arthritis	1981 Feb 15	Diflunisal, a new difluorophenyl derivative of salicylic acid was compared with acetylsalicylic acid in 16 patients with rheumatoid arthritis in a double-blind study during 8 weeks. All patients who had taken Diflunisal and showed a good therapeutic response were treated with Diflunisal over additional 24 weeks. Diflunisal showed a statistically significant better efficacy than acetylsalicylic acid in all subjective and objective parameters. Above all the grip strength improved greatly in the Diflunisal group. In the patients who were included in the following 24 week study with Diflunisal the successful treatment could be continued through the whole study period. Day-pain and morning stiffness showed statistically significant improvement. Side effects appeared during the double-blind study only in the acetylsalicylic acid group. The results of the study showed Diflunisal in an average dosage of 500 to 1000 mg per day to be a useful drug in the treatment of rheumatoid arthritis not least due to the negligible side effects.
1267667	[The treatment of chronic knee joint synovitis with radioactive isotops (author's transl)]	1976 Feb 26	On the basis of 77 cases report is given on the treatment of chronic synovitis of the knee in rheumatoid arthritis with radioactive isotopes. Gold 198 and Yttrium90 have been applicated. During an observation period up to 6 years a follow-up on 46 knee joints has been carried out. Very good and good results could be achieved in 50% of these cases.
7042371	High dose intravenous methylprednisolone "pulse" therapy in patients with rheumatoid disea	1982	Twenty seven patients with acute rheumatoid disease who had not previously received systemic corticosteroid therapy were given a pulse(s) of high dose methylprednisolone sodium succinate (MPS) intravenously. Of the 27 patients 22 received 1 g MPS once and 5 were given the drug on three consecutive days. Plasma "MP" (total MPS plus hydrolysed methylprednisolone) and cortisol levels were measured at various intervals post infusion. Clinical assessments were made before and at 2 week intervals after each infusion for 12 weeks. Patients showed objective improvement for up to 12 weeks post infusion. Maximum "MP" levels ranging between 16 and 72 mumol/l were obtained after single infusions. In a majority of the patients "MP" concentrations in plasma were reduced to values between 0.12-3.4 mumol/l in 24 h, 0.06 to 0.13 mumol/l in 48 h. Plasma cortisol levels were incompletely suppressed for a few days in all patients, but the drug was removed from plasma and normal adrenal function restored within a fortnight after steroid infusion at the latest.
4010427	Rheumatoid arthritis of the cricoarytenoid joints: a case of laryngeal obstruction due to	1985 Jul	A 63-year-old female with severe rheumatoid arthritis and respiratory obstruction with stridor due to cricoarytenoid (c.a.) arthritis is described. Low voltage radiography of the neck revealed erosive changes in the c.a. joints. At laryngoscopy the arytenoids were fixed in adduction, and there were signs of active arthritis. Corticosteroid therapy was instituted with remarkable effect on the obstruction. After the active arthritis had subsided, there remained limited arytenoid mobility with a glottic chink of about 5 mm, but no laryngeal symptoms.
1087014	Rheumatic diseases. 2. Therapeutic considerations.	1976 Dec	In the management of rheumatic diseases, the use of corticosteroids should be reserved for active arthritis. Phenylbutazone (Butazolidin) is probably the drug of choice for acute gout and is also effective in ankylosing spondylitis, Reiter's syndrome, and psoriatic arthritis. Indomethacin (Indocin) also is useful in these conditions. Ibuprofen (Motrin) is only slightly more efficacious than aspirin. Aspirin is still the preferred treatment for rheumatoid arthritis and should be tried before ibuprofen. Osteoarthritis of the cervical or lumbar spine calls for a full program of physical therapy. Experimental procedures for total replacement of joints other than hip and knee show promise.
4004359	Mapping of proteins from cultured fibroblasts of synovial and subcutaneous origin by high	1985 May	Nine different cell lines of human (A) rheumatoid and (B) normal synovial fibroblasts and of (C) normal skin fibroblasts were obtained from tissue explants and grown as monolayers. The cellular protein synthesis was studied by high resolution two-dimensional polyacrylamide gel electrophoresis. Between the fourth and 10th passage of the cells in culture apparently no consistent differences were found which could be ascribed to the origin of the cells, to the rheumatoid state of the synovial tissue, or to the increasing age of the cultured fibroblasts.
282445	The place of levamisole in the armamentarium for rheumatoid arthritis.	1978	Levamisole is a welcome addition to the list of penicillamine-like drugs. Many patients fail to respond to these drugs or develop adverse reactions requiring withdrawal of treatment. Levamisole will be a useful alternative for these patients.
831733	Rheumatoid pericardial effusion with heart block treated by pericardiectomy and implantati	1977 Jan	A patient with long-standing seropositive erosive rheumatoid arthritis developed a pericardial effusion with chronic cardiac tamponade. He had evidence of conducting system disease and developed heart block. He was successfully treated by pericardiectomy and implantation of a demand pacemaker.
1124961	Rheumatoid plantar synovial cysts.	1975 Feb	A patient is described with rheumatoid arthritis and a painful synovial cyst, which originated from a metatarsophalangeal joint and presented as a swelling on the plantar surface of the foot. The cyst was successfully excised.