Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7013009 | Isoxepac in rheumatoid arthritis: a double-blind comparison with aspirin. | 1981 Feb 1 | Nineteen patients with rheumatoid arthritis entered a double-blind cross-over study, comparing a new anti-inflammatory agent isoxepac, 200 mg three times daily, with aspirin 1.2 g three times daily. Eighteen patients completed 2-4 weeks treatment with each drug. The treatments were similar when assessed by measurement of joint pain, grip strength, morning stiffness, patients' global assessment and overall preference. Significantly fewer adverse effects were associated with isoxepac therapy when compared with aspirin therapy. | |
| 412248 | Effect of gold on progression of erosions in rheumatoid arthritis. Better results with ear | 1977 | The advance of radiological destruction in 57 patients with definite rheumatoid arthritis was observed for 5-6 years. In all patients gold treatment was started 2-36 months after the onset of the disease. In 18 patients gold was discontinued because of side-effects of other reasons before reaching the total dosage of 500 mg, while the remaining 39 patients received a mean dose of 2030 mg of natriumaurothiomalate. The advance of the radiological destruction was statistically significantly less marked in patients treated with the full gold therapy. The earlier the treatment was initiated, the better was the result. | |
| 1084131 | Transformation of human lymphocytes in vitro by autologous and allogeneic rheumatoid synov | 1976 Feb | To assess the possible participation of cellular immune mechanisms in the pathogenesis of rheumatoid arthritis (RA) in vitro studies of the blastogenicity of rheumatoid and non-rheumatoid synovial fluids for human peripheral blood lymphocytes were conducted. In autologous cultures it was found that 13 of 19 rheumatoid fluids induced significant lymphocyte blastogenesis, whereas only 1 of 13 nonrheumatoid fluids induced such a response. In allogeneic cultures rheumatoid fluids induce significant blastogenesis of RA lymphocytes in 18 of 23 experiments, and of non-RA lymphocytes in 8 of 18 experiments. By contrast, nonrheumatoid fluids induced significant blastogenesis of RA lymphocytes in 2 of 13 experiments, and of non-RA lymphocytes in 1 of 14 experiments. The blastogenicity of fluids was found to correlate significantly with the presence therein of immunofluorescent intracellular inclusions of immunoglobulin and complement. These studies support the concept that the presence of immune complexes in the majority of rheumatoid synovial fluids might render the latter blastogenic for human lymphocytes in vivo, thereby perpetuating rheumatoid synovitis. | |
| 6830075 | Fatal polymyositis in D-penicillamine-treated rheumatoid arthritis. | 1983 Mar | Thirteen reports of patients who developed polymyositis or dermatomyositis during treatment with D-penicillamine are reviewed and a fourteenth case is described. Twelve of the fourteen patients recovered after D-penicillamine was withdrawn; two patients died from cardiac involvement. Proximal muscle weakness was present in 13 patients and dermatomyositis in 4 patients. Dysphagia was the presenting symptom in 6 patients. Although D-penicillamine is useful in the management of rheumatoid arthritis, this drug should be used with caution and patients monitored closely for evidence of polymyositis or dermatomyositis. | |
| 7131461 | Ulnar deviation of the fingers in gout simulating rheumatoid arthritis. | 1982 Jul | Two cases of gout with marked ulnar deviation (UD) are reported. Both cases were previously diagnosed rheumatoid arthritis (RA) at referral, but gout was clinically suspected because of atypical features of RA, and subsequently confirmed by demonstration of monosodium urate crystals under the polarized microscope. No definitive evidence of associated RA was present in either case. Although UD in gout is distinctly rare, it is important to recognize this deformity in gout in order to avoid inappropriate therapy. Mechanical factors might have contributed to the hand deformities in both cases. | |
| 6810577 | [Occurrence of malignant non-Hodgkin lymphoma after long-term azathioprine therapy of chro | 1982 May | The case is presented of a female patient with rheumatoid arthritis, in whom a malignant non-Hodgkin lymphoma developed following long-term treatment with azathioprine. The possibility of an increased incidence of malignant lymphomas in immunological disorders, including rheumatoid arthritis, is discussed, as is the question of the extent to which azathioprine therapy might be involved in this. Some pathogenetic mechanisms of the development of malignant lymphomas are also considered. | |
| 6939879 | Proteinuria in D-penicillamine-treated rheumatoid arthritis. | 1981 Jan | The incidence of proteinuria in D-penicillamine-treated rheumatoid arthritis has been between 10% and 20% in the 1st year of therapy; afterward, few develop proteinuria. Incidence is related to both quantity of penicillamine administered and inherent response variability. About 1/3 of those with proteinuria may proceed to a nephrotic syndrome if therapy is continued. Light microscopy of renal biopsy tissue shows only minimal glomerular changes. Electron microscopy reveals sub-epithelial electron-dense deposits and fusion of epithelial cell processes. Immunofluorescence microscopy demonstrates granular capillary wall deposits of IgG and C3. | |
| 356240 | A comparative, double-blind trial with proquazone and naproxen in the treatment of rheumat | 1978 | In a double-blind trial lasting 6 months, 36 patients with classical or definity rheumatoid arthritis were divided into two groups, one receiving 3x300 mg proquazone/day and the other 2x250 mg naproxen plus one placebo capsule/day. Efficacy parameters were assessed and laboratory tests performed at regular intervals throughout the trial. Both drugs were well tolerated, in that no abnormal changes were found in the results of laboratory tests in either group, and that drug-related side effects, mainly gastrointestinal disturbances, occurred in just over half the cases in each group. Both drugs improved the Lansbury Index, especially grip strength, walking time, and ESR. Proquazone did significantly better than naproxen in improving ESR and nocturnal pain. More therpaeutic successes were recorded with proquazone than with naproxen in the overall assessment at the end of the trial. | |
| 1083878 | Structural requirements for arthritogenicity of peptidoglycans from Staphylococcus aureus | 1976 Jun | The comparative studies on the arthritogenicity of chemically well defined peptidoglycans (PG)2 from the cell walls of Staphylococcus aureus (FDA 209P) and Lactobacillus plantarum (ATCC 8014) showed that 1) a polymer of disaccharide-peptide with or without the presence of N-acetylglucosaminyl-ribitol-teichoic acid produced severe arthritis; 2) oligosaccharide-peptides with or without the special structure (N-acetylglucosaminyl-ribitol-teichoic acid in S. aureus, a polymer of rhamnose and glucose in L. plantarum) produced severe disease; 3) disaccharide-heptapeptide-disaccharide with or without the presence of either glucose-ribitol-teichoic acid or a polymer of rhamnose and glucose appeared to be arthritogenic but much less effective for disease production; 4) N-acetylmuramyl-heptapeptide-N-acetylmuramic acid and disaccharide-hexapeptide were non-arthritogenic; 5) none of the synthetic N-acetylmuramyl-peptides, including tetrapeptide, produced the disease. Thus it is concluded that arthritis-inducing activity is related to the peptidoglycan moiety but not to the special structure, and the most important moiety responsible for disease production may be located in a chain length of two or more disaccharide units on PG subunits. However, it is discussed that non-arthritogenicity of peptidoglycans, including synthetic compounds, may be due to a lack of adjuvanticity in rats rather than a lack of antigenic determinant(s) responsible for production of arthritis. | |
| 686866 | Studies of lymphocytes in rheumatoid arthritis. I. Uptake of 125I-heat aggregated human Ig | 1978 Aug | The uptake of 125I-heat aggregated human IgG (125I-HAGG) by monocyte-free peripheral blood lymphocytes was investigated in patients with active rheumatoid arthritis (RA), inactive RA patients with other inflammatory joint diseases (ankylosing spondylitis and Still's disease), and in normal controls. The lymphocytes of patients with RA, whether active or inactive, showed significantly raised levels of 125I-HAGG uptake when compared with normals. Patients with other inflammatory joint diseases showed normal levels of HAGG uptake. High uptake was not due to the presence of cytophilic antibodies and was not related to drug treatment, rheumatoid factor status, patient age, duration of disease, and did not correlate with disease activity. These results indicate that Fc-receptor bearing lymphocytes in patients with RA differ from those of normal subjects and patients with other inflammatory joint diseases. This difference was not due to differences in numbers of Fc-receptor bearing lymphocytes but may be due either to increased numbers of Fc-receptors on each cell or to increased avidity of such receptors for HAGG. | |
| 7051751 | Inflammatory activities of synovial fluids from rheumatoid- and osteo-arthritis to guinea | 1982 Jul | For initial study to examine the chemical pathogenesis of rheumatoid and non-rheumatoid arthritis, the nature and inflammatory activities of 12 synovial fluids from rheumatoid arthritis and 10 from osteoarthritis were studied. Both rheumatoid and non-rheumatoid synovial fluids were found to have high protein concentration, acid and neutral protease activities. When injected 0.1 ml intradermally to normal guinea pig skin, both synovial fluids induced a strong vascular permeability at 0 minutes, mild one at 60 minutes, and mild inflammation which comprised histologically moderate leukocyte infiltration around the venules, swelling of venular endothelial cells, edema, and degeneration of collagen fibrils in the deep dermis of the guinea pig skin 4 hours following the injection. However, these parameters of inflammation induced by synovial fluids from both arthritis were of same degree in intensity. The identification of chemical mediators of inflammation in the synovial fluids of both arthritis requires further study. | |
| 4042415 | Simultaneous turnover of normal and dysfunctional C1 inhibitor as a probe of in vivo activ | 1985 Jul | Simultaneous turnover of normal and dysfunctional C1-inhibitor (C1-INH) was carried out in 10 normal subjects and 13 patients with rheumatoid arthritis as a measure of the in vivo activation of C1 and the contact activatable enzymes. In the first series of experiments, dysfunctional protein We was used in simultaneous turnover studies in five normal subjects and nine patients. The fractional catabolic rate of the dysfunctional C1-INH, We, (FCR(d)) was unchanged in both groups but the fractional catabolic rate of the normal C1-INH (FCR(n)) was faster in the patients compared to the controls, in particular patients with vasculitis. The enzyme-dependent catabolism defined as FCR(n-d) X concentration of C1-INH X plasma volume, was raised in the patient group, and correlated with disease activity score (r = 0.83, P less than 0.05). Neither FCR(n) nor FCR(d) was dependent on C1-INH concentration. The latter was higher in the patients (206 mg/l compared with 155 mg/l) indicating a very high synthetic rate in the patients (280.81 micrograms/kg/h compared with 179.77 micrograms/kg). In the second series of turnovers in six patients and five normal subjects, another dysfunctional C1-INH, at, was used. The FCR of C1-INH was slower than C1-INH (We) (1.88%/h compared with 2.7%/h). Enzyme-dependent catabolism of C1-INH in these patients were raised and also correlated with disease activity score (r = 0.82, P less than 0.05). | |
| 1190699 | HL-A27 and arthritis. | 1975 Jun | In patients with recent inflammatory arthritis HL-A27 was seen in 6 out of 7 patients with ankylosing spondylitis, in 15 out of 18 patients with Reiter's disease, in 9 out of 12 patients with reactive postinfectious arthritis, in 22 out of 45 patients with rheumatoid arthritis, and in 2 out of 14 patients with other types of inflammatory arthritis. In two control series HL-A27 occurred in 46 out of 326 persons and in 3 out of 34 persons. The high frequency of HL-A27 in RA patients is in disagreement with previous results by other investigators. The explanation for this may be either that the diagnostic criteria do not apply at the early stage of the disease, or that there is a high prevalence of HL-A27 associated RA in Finland. | |
| 843291 | Evaluation of 350 sciatic blocks in rheumatoid foot surgery. | 1977 Feb 28 | Sciatic block with Mepivacaine (3-4 mg/kg) revealed successful in 91.9% of 340 rheumatoid patients with Keller/Clayton operation. In unsufficient blocks (8.1%) supplementary anesthesia by femoral nerve block, reblocking the sciatic nerve or local anesthetics secondarily gave good operating conditions. In three cases it was necessary to use additional spinal anesthesia. The concomitant sympathetic block gives an immediate cessation of sweating and a long lasting evaluation of skin temperature. | |
| 415514 | A simple method for demonstrating gel-precipitating human anti-immunoglobulin antibodies. | 1977 Dec | The use of aggregated human IgG for the detection of anti-immunoglobulin antibodies by double immunodiffusion in gel is described. Of rheumatoid arthritis sera, 54 of 56 sera having a Waaler-Rose test titre of greater than or equal to 1:16 contained antibodies to aggregated IgG, in contrast to only 2 of 52 sera from blood donors. Furthermore, after 2-mercapto-ethanol treatment anti-IgG was still demonstrated in 5 of 16 sera. | |
| 7097675 | Chick "crooked-toe" syndrome induced by polar lipid in synovial fluids from some rheumatoi | 1982 Mar | Injection into fertile chicken eggs of synovial fluids from some rheumatoid arthritis patients resulted in either embryo death or the development of the "crooked-toe" (CT) syndrome, or both, in newly hatched chicks. Synovial fluids from most RA patients (and fluids from a few non-RA individuals), however, were harmless. Dialyzing, partitioning, and gel filtration experiments indicated that the CT syndrome-inducing factor consists of 1 or more heat stable, dialyzable, polar lipids with molecular weights of about 3 to 4 x 10(3). Thin-layer chromatography revealed quantitative and qualitative differences between partially purified lipid preparations from "active" and "inactive" synovial fluids. | |
| 6975826 | HLA-DR4 in Negro and Mexican rheumatoid arthritis patients. | 1981 Sep | We tested HLA-DR antigens in 38 Caucasian, 18 Negro, 17 Mexican, and 5 Japanese patients with rheumatoid arthritis. Significantly high HLA-DR4 frequencies were observed in all races; 61% in Caucasians, 39% in Negroes, 77% in Mexicans, and 100% in Japanese. However, no clinical correlation with DR4 was found in these patients. | |
| 238484 | Rheumatoid arthritis associated with hyperviscosity syndrome and intermediate complex form | 1975 Feb | A patient with long-standing rheumatoid arthritis developed hyperviscosity syndrome that correlated with the presence of abundant intermediate complexes in plasma. The intermediate complexes were isolated, and evidence is presented that these complexes are composed predominantly of igG-rheumatoid factor. | |
| 7361025 | Intra-articular osmic acid in rheumatoid arthritis: five years' experience. | 1980 Feb | Two hundred and one patients (305 knees) with rheumatoid arthritis received intra-articular osmic acid in one or both knees. Assessment was based on pain relief, warmth, tenderness, size and presence of effusion, degree of synovial thickening and range of pain-free movement. Satisfactory results were obtained in 61% at one year gradually reducing to 22% over a five-year period. If only those knees with none or minimal joint damage were considered, then a satisfactory result was obtained in a higher percentage, 74% at one year and 38% at five years. | |
| 216133 | Detection of antibody to a new antigen induced by Epstein-Barr virus in rheumatoid arthrit | 1979 Feb | A new antigen which is different from Epstein-Barr virion antigen was detected in NC-37 cells infected with Epstein-Barr virus (EBV). A significant elevation of the titer of antibody to this new antigen was observed in the sera of the patients with rheumatoid arthritis (RA), but not in the sera of controls. From the standpoint of the etiologic role of EBV in RA, it is interesting that the antibody to the new antigen is not detected in the healthy persons in contrast to other viral antibodies. Therefore, it differs from any other viral antibodies so far reported. |