Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 796942 | Clinical evaluation of ketoprofen (Orudis) in rheumatoid arthritis: a double-blind cross-o | 1976 | In a double-blind cross-over trial, ketoprofen was found to be as effective as indomethacin in the treatment of rheumatoid arthritis. Side-effects, particularly headache and vertigo, were less common in patients receiving ketoprofen. | |
| 720528 | A mechanism of formation of desmosome-like structures between synovial intimal cells. | 1978 Sep 15 | Desmosomes or desmosome-like structures do not occur between normal synovial cells but such structures do develop between the synovial cells in cases of traumatic arthritis, rheumatoid arthritis and villonodular synovitis. Morphological evidence is presented suggesting that such structures develop as a result of the interaction of fibrin trapped between synovial cells and the plasmamembrane of these cells. | |
| 6219934 | Diagnostic immunopathology of the kidney biopsy in rheumatic diseases. | 1983 Apr | Nephropathies found in systemic lupus erythematosus (SLE), progressive systemic sclerosis, rheumatoid arthritis, Sjögren's syndrome, and mixed connective tissue disease are discussed. Pathogenetic insights derived from the study of kidney tissue are highlighted and clinicopathologic correlations indicated. The question of whether to perform kidney biopsy in lupus patients is also addressed. | |
| 6350385 | Bullous pemphigoid and multiple autoimmune diseases. Alopecia universalis, bullous pemphig | 1983 Aug | A 57-year-old white man developed Hashimoto's thyroiditis, bullous pemphigoid, and autoimmune neutropenia during the last year of his life. In addition, he had alopecia universalis since the age of 21 and rheumatoid arthritis since the age of 38. This unique constellation of autoimmune diseases has not been reported previously. Its significance is discussed in relation to the polyglandular failure syndrome and thymoma-related autoimmune disease. | |
| 7384716 | [Lesions of the nerves of the hip involving chronic rheumatic infections (ankylosing spond | 1980 Jan | We have studied the nerves of the synovium and capsules of 6 hips with ankylosing spondylitis, 6 hips with rheumatoid arthritis and 14 cases of coxarthrosis either primary or secondary to a malformation. The nerves were studied with the usual methods of peripheral neuropathology. In the various diseases except 5 cases of coxarthrosis secondary to a malformation, the inflammatory and vascular involvements with tissue fibrosis were able to affect the nerves crossing the tissues. This nerve involvement could be the cause of articular pain. Despite the importance of the surrounding lesions, the nerves are preserved for a long time and this could explain the persistance of the pain. | |
| 6746686 | The radiolucent line beneath the tibial components of the Oxford meniscal knee. | 1984 Aug | Radiolucent lines at the bone-cement interface beneath the tibial components were assessed in 91 consecutive Oxford meniscal knee replacements in 78 patients. Of 80 knees in which radio-opaque cement was used, a radiolucent line was observed in 77, with a radiodense line in the bone immediately adjoining. Radiolucent lines developed in the majority of patients within one year after operation. In 11 knees fixed with radiolucent cement (which precluded assessment of the radiolucent line) a radiodense line was observed beneath the lucent cement in all cases. Histological examination of the interface obtained from secure tibial components showed the lucent zone to be composed of fibrocartilaginous connective tissue and the radiodense line to be a thick lamella of bone. It is suggested that the living bone under a rigid prosthesis requires a layer of relatively compliant fibrocartilaginous material at its interface to accommodate load-bearing. Attention is drawn to the importance of the radiodense line: its presence may constitute positive evidence that healing at the level of bone section is complete and that equilibrium is established; its absence at a mature interface may indicate disequilibrium and impending failure. | |
| 49177 | Granulopoietic activity in Felty's syndrome. | 1975 Apr | The levels of urinary and serum granulopoietic factor have been determined in nine patients with Felty's syndrome and compared with similar levels in patients with rheumatoid arthritis without Felty's syndrome and patients with neutropenic disorders of other causes. These studies have shown that urinary and serum levels of colony stimulating activity (CSA) in patients with Felty's syndrome are low (mean urine CSA 10.0 and serum CSA 4.0) when compared to patients with neutropenic disorders without rheumatoid arthritis (mean urinary CSA 26.8 and serum CSA 9.4). These findings suggest that Felty's syndrome may be, in part, the result of decreased production or activity of granulopoietic factors rather than due simply to increased granulocyte destruction. | |
| 2409794 | Human placenta-eluted gammaglobulins in immunomodulating treatment of rheumatoid arthritis | 1985 Jun | Thirty-one patients with severe rheumatoid arthritis were treated with intravenous perfusion of human placenta-eluted gammaglobulins. These gammaglobulins, which are IgG eluted from placental tissue, have strong immunomodulating properties in vitro. Several clinical trials were tested to find the optimal useful dosage. A 50 percent improvement was considered a good result and was obtained in 60 percent of patients with rheumatoid arthritis. The best results were obtained in patients receiving 1,500 mg daily seven days each month. Six subjects had a long remission of their disease after the end of treatment. The side effects were usually minor. In all patients, an immunostimulation of lymphocyte function was shown, even when they had no improvement. A control group of patients underwent perfusion with IgG from placental blood without any clinical or immunologic effect. It is suggested that the in vivo effects of placenta-eluted gammaglobulins might be mediated by polyspecific anti-HLA-DR antibodies. | |
| 459562 | Total joint arthroplasty. The elbow. | 1979 Aug | The first total elbow arthroplasty at the Mayo Clinic was performed in 1972, and it provided markedly superior results compared with previously performed procedures for elbow arthritis. However, a high revision rate (14%), due mainly to loosening (75%), tempered early enthusiasm for the procedure. Prospects for improved design and surgical technique based on our clinical experience and biomechanical data are encouraging. For the present, however, more limited procedures are recommended, and the total elbow arthroplasty is reserved for only a relatively few patients for whom there are no other viable surgical options. | |
| 6810460 | Does hypothyroidism predispose to gold-induced thrombocytopenia? | 1982 Jul | Two patients receiving gold therapy for rheumatoid arthritis suffered from a sudden and unpredictable fall of platelet count. Spontaneous bleeding into the soft tissues occurred in both cases, and nasal epistaxis or macroscopic haematuria complicated each case. Both patients were on long term replacement therapy with thyroxine and it is postulated that changes associated with hypothyroidism may predispose to acute thrombocytopenia due to gold. Patients who suffer from hypothyroidism may require particularly close monitoring whilst on gold therapy. | |
| 6692604 | Six- to 11-year results of total hip arthroplasty in rheumatoid arthritis. | 1984 Jan | The results of 138 total hip arthroplasties in 98 rheumatoid arthritic patients were reviewed six to 11 years (mean, 7.0 years) after operation. While 96% of the patients were clinically improved as a result of surgery, radiographic analysis suggests that, despite their low functional requirements, this group of patients experiences mechanical loosening and failure with time. Improvements in prosthetic design and cementing technique should contribute to a lowered incidence of mechanical failure in the future. In addition to improvements in technology, the failure rate can be further diminished by recognition of the systemic problems associated with rheumatoid arthritis, e.g., high incidence of infection, osteopenia, and sequelae of multiple joint involvement. In reconstruction of the acetabulum, especially in the presence of protrusio, failure to restore the anatomic position and orientation of the acetabulum predisposes to loosening and migration. | |
| 422280 | Pregnancy-associated a2-glycoprotein in rheumatoid arthritis. | 1979 | Pregnancy-associated alpha2-glycoprotein (PAG) was found to be increased in sera and synovial fluids of patients suffering from rheumatoid arthritis tested in the single radial immunodiffusion. The PAG levels in rheumatoid sera correlated well with the activity of arthritis in the patients. The purified PAG inhibited clearly the 3H-thymidine uptake of normal lymphocytes stimulated with phytohemagglutinin and also the spontaneous attachment of sheep erythrocytes to normal lymphocytes. 17 of 19 rheumatoid plasmas inhibited the 3H-thymidine uptake of normal lymphocytes and intensity of their inhibitory effects correlated with serum PAG levels. | |
| 145621 | [Dissecting popliteal cyst in rheumatoid polyarthritis: clinical and therapeutic aspects]. | 1977 Sep | The authors present a dynamic observation of a patient with advanced rheumatic polyarthritis that developed considerable hydrathrosis of the left knee and popliteal deep cyst of the Backer type. The general treatment was completed with radioisotopic synoviorthesis with Au198 that administered directly in the articulation and in the cavity of the cyst, resulting in the rupture of its wall. The symptomatology of the dissecting popliteal cyst was similar to that of thrombophlebitis. Posterior incision and drainage of the cyst collection have resulted in the disappearance of the local phenomena. | |
| 7065731 | Conversion from daily to alternate daily corticosteroids in rheumatoid arthritis. | 1982 Feb | An attempt was made to convert 24 patients on corticosteroid treatment from a daily to an alternate daily regimen. Ten patients were successfully converted, 11 failed to convert, and 3 had to be withdrawn for irrelevant reasons. A simple tetracosactrin stimulation test gave some indication of which patients were more likely to convert successfully. Success was not influenced by severity or duration of disease, nor by dose of duration of steroid therapy. Conversion did not influence various clinical and laboratory measures of undesirable steroid side effects, but the follow-up period was probably too short to judge this. The evidence of others suggests that conversion is worth attempting. | |
| 6432404 | Failure of sodium aurothiomalate and triethyl phosphine gold to cause renal tubular injury | 1983 Sep | The urinary excretion of two proteins, B-2-microglobulin (beta 2M) and N-acetyl-B-D-glucosaminidase (NAG) was measured in 25 patients with rheumatoid arthritis (RA) on nonsteroidal anti-inflammatory drugs (NSAID). Although beta 2M excretion was normal NAG excretion was raised. As NAG excretion by a group of osteoarthritis patients receiving similar doses of NSAIDs was normal, it is concluded that rheumatoid disease per se may be associated with mild renal tubular dysfunction. Twelve of the above 25 patients were then given oral triethylphosphine-gold (auranofin) 6 mg daily and urinary beta 2M and NAG were measured after 6 months' treatment. Urinary excretion of beta 2M and NAG was also measured in 13 patients with RA established on intramuscular sodium aurothiomalate (MGST) and NSAIDs. Neither auranofin nor myocrisin were found to further significantly increase beta 2M and NAG excretion. These results suggest that gold compounds are not toxic to renal tubular epithelium. | |
| 8835 | A long-term study of benorylate in patients with rheumatoid arthritis. | 1975 | The analgesic and anti-inflammatory efficacy and adverse effects of benorylate were studied over a period of 6 months in 33 patients suffering from definite or classical rheumatoid arthritis. The average dose used was 6 g daily and examinations were made before treatment and at regular intervals during treatment to assess the clinical status of the patient, tolerance to the drug and any effect on blood, liver or renal function. Benorylate had a satisfactory effect in 28 patients. Additional treatment was requried in 3 cases and treatment discontinued in 2 cases. Distinct improvement of grip strength, morning stiffness and E.S.R. in 25 cases indicates the anti-inflammatory efficacy of benorylate. There were no signs of toxicity to bone marrow, liver or kidney. Severe side effects such as stomch ulcers, gastrointestinal bleeding and severe allergic complications were not observed. Side effects such as constipation and tinnitus that occurred at the beginning of treatment were mainly of a a passing nature and disappeared without a need to change therapy. Benorylate is suitable for the treatment of recent rheumatoid arthritis of a low to moderate activity as well as for long-term treatment. | |
| 1092716 | Immunopathological changes in rheumatoid arthritis and other joint diseases. | 1975 Feb | A comparative study of the distribution of immunoglobulins G, M, and A and C3 in the synovium and inside synovial fluid leucocytes and of the relative levels of IgG, IgM, AND C3 in paired samples of serum and synovial fluid from both seropositive and seronegative patients with rheumatoid arthritis and other types of non-infective synovitis shows that although there is no distinctive immunopathological feature of rheumatoid arthritis, the incidence of immune complexes containing IgG and IgM with and without detectable C3 in the affected synovium or inside synovial fluid granulocytes is higher in rheumatoid arthritis and especially so in seropositive cases. The mean level of C3 in synovial fluid from patients with rheumatoid arthritis is lower than that from the group without rheumatoid arthritis. In contrast to previous reports, extracellular clumps of IgA could be detected in the affected synovium of a number of affected patients. Aggretated human IgG could be bound by some of the synovial biopsies and synovial fluid leucocytes from both seropositive and seronegative rheumatoid arthritis patients. Antinuclear factor and rheumatoid factor could be detected in the synovial fluid but not in the serum of several patients suggesting either selective sequestration or local synthesis of antinuclear and rheumatoid factors in the affected joints. | |
| 4859190 | A comparative study of some commercially available tests for rheumatoid factor. | 1974 May | Seven commercially available screening tests for rheumatoid factor and two quantitative tests have been compared with the standard Rose-Waaler test in a series of 477 sera from patients with various joint diseases. Markedly different results were obtained, and on the basis of our findings suggestions are made as to what we consider to be the most satisfactory currently available tests. | |
| 868493 | Arthroplasty of the knee in osteoarthritis and rheumatoid arthritis. | 1977 May | 147 cases of arthroplasty of the knee were reviewed. Three types of prostheses were used, viz., St. Georg, Geomedic and hinge (Shier and Guépar). Pain was the most common indication for the operation which produced complete or almost complete relief in 90% of the cases. In half of the joints with a mobility of less than 80 degrees preoperatively, the range of movement was increased to more than 80 degrees by the operation. Lack of extension, deformity and instability could be largely corrected. Two cases of deep infection were observed, both in patients treated with a hinge prosthesis. In one of them the complication led to amputation above the knee and in the other to arthrodesis. | |
| 6751193 | [Antiperinuclear factors in psoriasis. Correlation with other serological abnormalities in | 1982 | Antiperinuclear factors (APF), studied in 90 patients suffering from psoriasis, were found in psoriasis without arthritis, in psoriasis with psoriatic arthritis and in psoriasis with true rheumatoid arthritis (RA): respectively 57, 36 and 43 p. 100. Patients with APF did not differ from patients without APF apart form rheumatoid factors detected by indirect immunofluorescence. They were much more frequent in psoriasis with APF. These results are compared with those of RA. They lead to look for other auto-antibodies in psoriasis. |