Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 739494 | A systematic survey of the HLA B27 prevalence in inflammatory rheumatic diseases. | 1978 Winter | HLA B27 has been tested systematically in 246 patients attending a rheumatology clinic for chronic inflammatory arthritis or spondylitis. Patients were allocated to nine groups: typical ankylosing spondylitis, ankylosing spondylitis with moderate involvement without peripheral arthritis, ankylosing spondylitis with moderate involvement and with peripheral arthritis, juvenile chronic arthritis, Reiter's syndrome, Yersinia arthritis, arthropathies of inflammatory bowel disease, psoriatic arthritis, seronegative and seropositive rheumatoid arthritis. Except for seropositive rheumatoid arthritis, a significant association with HLA B27 antigen was found in all groups. In the seronegative rheumatoid arthritis group HLA B27 was present in 40% of the cases in contrast to 5.6% of the seropositive rheumatoid arthritis cases. These data confirm that a wide range of the so called "seronegative arthropathies" are associated with HLA B27 and suggest that sex and HLA B27 antigen are important factors in the manifestation of rheumatic disease. Women had less severe spondylitic changes but more peripheral arthritis of the small joints. Ankylosing spondylitis in its various forms had a comparable sex distribution despite relatively mild disease in females. The mean age of onset in the HLA B27 associated diseases was found to be significantly lower than in the seropositive rheumatoid arthritis group. | |
| 4077266 | Diagnostic significance of pleural fluid lactate concentrations. | 1985 Nov | Lactate concentrations in the pleural fluid and plasma of 57 patients with pleural effusions were measured by an enzymatic method. The mean pleural fluid lactate concentrations were significantly higher in patients with empyemas and rheumatoid arthritis than in patients with tuberculosis, cancer, non-specific pleural effusions and congestive heart failure. Pleural fluid lactate concentrations correlated significantly with pleural fluid lactate dehydrogenase activities and inversely with pleural fluid glucose concentrations. An elevated pleural fluid lactate concentration is not diagnostic for empyema, as most patients with rheumatoid arthritis and some with tuberculosis and cancer also show high values. | |
| 6824822 | Gold and pulmonary function in rheumatoid arthritis. | 1983 Feb | The effect of gold therapy on pulmonary function in rheumatoid arthritis has been studied prospectively in a group of 14 patients and retrospectively in 96 patients. There was no evidence that gold had any adverse effect on pulmonary function. | |
| 6411922 | Liver dysfunction associated with gold therapy for rheumatoid arthritis. | 1983 Jun | Hepatic toxicity is rarely associated with gold therapy. Three patients with rheumatoid arthritis who developed jaundice during the course of chrysotherapy are described. Jaundice occurred both early and late in the course of therapy. differing grades of severity of dysfunction were encountered. Liver biopsy revealed intrahepatic cholestasis. Significance of jaundice occurring during gold therapy is discussed. | |
| 7230155 | Free-radical oxidation (peroxidation) products in serum and synovial fluid in rheumatoid a | 1981 Mar | Free-radical oxidation (peroxidation) products were measured in (a) 65 synovial effusions and (b) 30 sera from normal subjects and 58 sera from patients with rheumatoid arthritis (RA). Free-radical oxidation products were detectable in 90% of synovial fluids, their concentration being higher in "inflammatory" than in "degenerative" joint disease. Free-radical oxidation products in serum were significantly elevated in patients with RA compared to normal controls; the levels declined after treatment with a variety of antiinflammatory agents. | |
| 6414389 | Fatal bronchiolitis obliterans associated with chrysotherapy. | 1983 Oct | We describe a patient who developed fatal bronchiolitis obliterans following gold therapy and review the relationship between rheumatoid arthritis and bronchiolitis. | |
| 7377862 | Lack of hidden complement fixing IgM rheumatoid factor in adult seronegative rheumatoid ar | 1980 Feb | IgM rheumatoid factors capable of complement fixation and activation are commonly present in the sera of adults with rheumatoid arthritis. Hidden complement fixing IgM rheumatoid factor has been demonstrated in the majority of patients with juvenile RA and hidden agglutinating IgM rheumatoid factors have been demonstrated in the serum of adults with seronegative rheumatoid arthritis. We studied 27 adults with seronegative rheumatoid arthritis and were unable to demonstrate hidden complement fixing IgM rheumatoid factor in their sera. | |
| 6718285 | Resistant rheumatoid arthritis. What to do when conservative therapy doesn't work. | 1984 May | A significant number of patients with rheumatoid arthritis fail to obtain satisfactory disease suppression with conservative therapy. What other means of treatment are available? In what order should they be introduced? What are the potential side effects? The authors address these questions in the following review of management of resistant rheumatoid arthritis. | |
| 7042368 | Double-blind cross-over study of indoprofen versus ibuprofen and placebo in rheumatoid art | 1981 | Thirty patients with classical or definite rheumatoid arthritis were given indoprofen 800 mg/day, ibuprofen 1200 mg/day or placebo in a double-blind cross-over trial, for three consecutive 10-day periods. The two drugs were both superior to placeto, intoprofen on more parameters than ibuprofen. Indoprofen was on the whole better than ibuprofen and the difference was statistically significant on pain, grip strength, morning stiffness, patients' preference and investigators' opinion of the therapeutic effect. Both drugs were well tolerated clinically. | |
| 901030 | Comparative study of tibial (single) and tibiofemoral (double) osteotomy for osteoarthrosi | 1977 Aug | Osteotomies on 101 knees in 79 patients were assessed either prospectively or retrospectively. High tibial osteotomy was performed in 54 knees (27 with rheumatoid arthritis (RA) and 27 with osteoarthrosis (OA)) and double (tibiofemoral) osteotomy in 47 knees (25 RA and 22 OA), and were assessed prospectively in 46 and retrospectively in 55. Using a subjective assessment, 65% showed some improvement--70% of the single and 60% of the double osteotomies. Of the four groups (OA single or double, RA single or double), OA knees having a single osteotomy improved most frequently (74%), and OA knees having a double osteotomy least frequently (50%). Significant improvements in pain score and angular deformity were recorded. The mean range of movement of the operated knee was significantly reduced, and was particularly evident in those knees having a double osteotomy. We conclude that double osteotomies tend to have a higher incidence of complications, including impaired movement, and are not more efficient in relieving pain than single osteotomies in either OA or RA. | |
| 3980927 | Distal radioulnar joint arthroplasty: the hemiresection-interposition technique. | 1985 Mar | The hemiresection-interposition technique for distal radioulnar joint arthroplasty was developed from anatomic studies that indicated the importance of preserving the functional elements of the ulnocarpal ligament complex. The technique has been previously described. My experience with 38 patients who were followed for an average of 2 1/2 years shows that the procedure is most valuable for patients with rheumatoid arthritis (85% had stable, painless pronation averaging 84 degrees and supination of 77 degrees, while 15% had mild pain and pronation of 70 degrees and supination of 75 degrees). It is also valuable for patients with degenerative or trauma-induced arthritis (100% had painless rotation-pronation averaging 80 degrees and supination of 80 degrees). A modified procedure is useful for patients with ulnocarpal impingement syndrome where the Milch shortening osteotomy may not succeed because of radioulnar incongruity. | |
| 6230446 | Factors involved in cartilage injury. | 1983 Dec | The cellular and humoral mechanisms whereby the synovial membrane can bring about the degradation of the cartilage in the rheumatoid joint are discussed. | |
| 2419931 | Metal ions and oxygen radical reactions in human inflammatory joint disease. | 1985 Dec 17 | Activated phagocytic cells produce superoxide (O2-) and hydrogen peroxide (H2O2); their production is important in bacterial killing by neutrophils and has been implicated in tissue damage by activated phagocytes. H2O2 and O2- are poorly reactive in aqueous solution and their damaging actions may be related to formation of more reactive species from them. One such species is hydroxyl radical (OH.), formed from H2O2 in the presence of iron- or copper-ion catalysts. A major determinant of the cytotoxicity of O2- and H2O2 is thus the availability and location of metal-ion catalysts of OH. formation. Hydroxyl radical is an initiator of lipid peroxidation. Iron promoters of OH. production present in vivo include ferritin, and loosely bound iron complexes detectable by the 'bleomycin assay'. The chelating agent Desferal (desferrioxamine B methanesulphonate) prevents iron-dependent formation of OH. and protects against phagocyte-dependent tissue injury in several animal models of human disease. The use of Desferal for human treatment should be approached with caution, because preliminary results upon human rheumatoid patients have revealed side effects. It is proposed that OH. radical is a major damaging agent in the inflamed rheumatoid joint and that its formation is facilitated by the release of iron from transferrin, which can be achieved at the low pH present in the micro-environment created by adherent activated phagocytic cells. It is further proposed that one function of lactoferrin is to protect against iron-dependent radical reactions rather than to act as a catalyst of OH. production. | |
| 1080877 | [Presence of cryoprecipitates in the serum of patients with rheumatoid arthritis]. | 1975 Jul | Serum samples from 140 controls (C) and from 72 patients suffering from defined rheumatoid polyarthritis (RP) were tested for cryoglobulins (CG). CG were found in 19.7 percent of C and 55 percent of RP : a highly significant difference (p less than or equal to 0.001). In the controls there was no correlation between the CG and age or sex. The RP with cryoglobulins seemed to have more inflammation, but systemic manifestations were not any more frequent than in the cryonegative RP. In the RP a correlation was noted between the presence of CG and the following parameters : increase in the sedimentation rate, rise in serum immunoglobulins, IgA and IgC, presence of antinuclear factors, and drop in the C4 fraction of complement. There was no correlation with the presence of the rheumatoid factor in the serum. In 33 cryoprecipitates in the RP, 7 contained IgG, 1 IgM, 22 IgM-IgG -- of which 11 contained C1q and 16 rheumatoid factor -- and 3 contained IgA-IgM-IgG -- of which 1 contained C1q and 2 rheumatoid factor. Some of the biochemical data support the hypothesis that likens these cryoglobulins to immune complexes. | |
| 1103113 | Feprazone compared with indomethacin in the management of rheumatoid arthritis. | 1975 Jul | A double-blind cross-over trial of feprazone 450 mg daily and indomethacin 75 mg daily was carried out in fourteen patients with rheumatoid arthritis. The analgesic and anti-inflammatory activity was indistinguishable from that of indomethacin under the conditions of the trial. Seven patients expressed a preference for feprazone and four for indomethacin. Feprazone appeared to be well tolerated and free from serious side-effects. These results suggest that feprazone will be a useful drug in the management of rheumatoid arthritis. | |
| 394280 | Diclofenac (Voltarol) in rheumatoid arthritis: a report of a double-blind trial. | 1979 | A double-blind trial compared diclofenac with placebo in 44 outpatients. On from each group dropped out with dyspepsia, and one (placebo group) with ineffective treatment. Twenty completers received diclofenac. Dosage was one tablet (25 mg diclofenac) three times daily during the first week. In the second (final) week, most patients had four or six tablets. Diclofenac had significantly greater effect on pain, grip, morning stiffness, joint tenderness and swelling, and in comparison to previous treatments, even though the placebo group required significantly more rescue anaglesic. A few patients in each group had slight dyspepsia. One in the active and six in the placebo group complained of minor central nervous system symptoms. There were no serious side-effects. Haematological, biochemical and urinary analyses showed no clinically important changes. It is concluded that, in the short term, diclofenac (Voltarol) is effective in relieving the symptoms of inflammatory polyarthritis. It is well tolerated as placebo medication, and had no detrimental haematological or biochemical effects. | |
| 120350 | New knowledge of the connective tissue diseases I. | 1979 Oct | This paper examines the extent to which understanding of six of the principle disorders of connective tissue: the glycosaminoglycan storage diseases, ankylosing spondylitis, rheumatoid arthritis, systemic lupus erythematosus, chondrocalcinosis, and osteoarthrosis, has progressed during the past ten years. The paper recalls the pioneer observations of PAUL KLEMPERER on the systemic diseases of collagen, and introduces a series of reviews in which advances in present understanding of some of the connective tissue diseases will be examined in greater detail. | |
| 3925019 | Interference of IgM rheumatoid factor with nephelometric C-reactive protein determinations | 1985 Jun 12 | Different nephelometric assay systems for quantitation of C-reactive protein (CRP) were compared with radial immunodiffusion (RID) and tested for their susceptibility to interference by serum IgM rheumatoid factor (RF). In 3 nephelometric assays, RF was found to elevate CRP values. Sera with high RF content from patients with rheumatoid arthritis gave significantly higher CRP values by nephelometric assay than by RID; the addition of purified RF to RF-negative sera increased CRP values markedly; and removal of RF from sera corrected falsely elevated CRP values. This interference by RF is explained by the action of human RF as a (secondary) antibody reacting with complexed mammalian IgG anti-human CRP in the assay. In this way the nephelometric signal is enhanced to give falsely elevated CRP values. In contrast, the gel diffusion RID method does not suffer from this non-specific interference. | |
| 919561 | [Morphology of articular cartilage in fab2-induced arthritis of the knee-joint in the rabb | 1977 Nov 11 | An arthritis closely resembling rheumatoid arthritis in man can be produced by the intra-articular injection of Fab2 into the knee joint of rabbits. This experimental model was used for the examination of ultrastructural alterations in articular cartilage. The lesion starts at the surface and advances gradually to the deeper zones of the cartilage. Morphologically, the lesion is characterized by progressive necrobiosis of the chondrocytes, as well as by a continually increasing thickening of the collagen fibres. It is suggested that the initial damage to the cartilage is not brought about by the pannus tissue, but is caused by a direct reaction to the pathologically-altered synovial fluid in response to inflammation. | |
| 7362681 | A sensitive radioimmunoassay for quantitation of IgM rheumatoid factor. | 1980 Mar | A solid-phase radioimmunoassay capable of detecting nanogram quantities of human IgM rheumatoid factor (RF) in biologic fluids has been developed. Binding curves for monoclonal IgM RF and polyclonal IgM rheumatoid factors were similar under the conditions utilized for the assay. Human IgG did not interfere with the detection of IgM RF by this method. Small quantities (less than or equal to 0.2%) of nonspecific binding by nonRF IgM to the human IgG coated tubes utilized in the assay were corrected for by assaying samples in parallel bovine serum albumin coated control tubes. As expected, patients with seropositive rheumatoid arthritis (RA) had significantly higher concentrations of IgM RF than seronegative RA patients (mean +/- 1 SD = 652 +/- 553 microgram/ml versus 11.3 +/- 13.3 microgram/ml, P less than 0.001). In contrast, all normal control sera assayed to date contained less than 0.1 microgram/ml of IgM RF. The capacity of the assay to detect nanogram quantities of IgM RF should permit investigation of the cellular mechanisms underlying RF production. |