Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7068729 | The geometric knee replacement in polyarthritis. | 1982 | The British Orthopaedic Association assessment questionnaire for knee replacements was adapted to allow comparison of the severity of underlying polyarthritis with the benefits of geometric knee replacement in a retrospective study of 150 knees between six months and six years after operation. Total or partial relief of pain was achieved in 81 per cent of the operation, and changes in mobility occurred in fewer patients. Late sepsis remained a serious complication of nine per cent of the operations and one patient died from septicaemia. Late sepsis was associated with previous synovectomy or osteotomy. Retropatellar pain rarely interfered with the mobility of the patient. There was no association of operations that failed with a high erythrocyte sedimentation rate, a high platelet count, a low haemoglobin level or with a strongly positive rheumatoid factor but pain in the contralateral knee was associated with a diminished functional capacity. | |
| 4144722 | Haematology and biochemistry of ankylosing spondylitis. | 1973 Apr 28 | Forty men with ankylosing spondylitis have been reviewed clinically, radiologically, haematologically, and biochemically, and the results of the last two compared with a male group of rheumatoid patients and a control group. In the patients with ankylosing spondylitis the haemoglobin levels were much higher and the E.S.R. significantly lower than in the rheumatoid group, and the E.S.R. in the patients with ankylosing spondylitis was unrelated to disease activity as evidenced by pain. The alkaline phosphatase level was raised in 19 cases and in most was derived from bone. Though 10 patients had abnormal globulin levels, the albumin levels were normal, as was renal function in all cases. | |
| 6440909 | Chrysiasis following gold therapy for rheumatoid arthritis: ultrastructural analysis with | 1984 Dec | Chrysiasis is a rare, permanent, pigmentation of the skin caused by the parenteral administration of gold preparations followed by subsequent exposure to ultraviolet light. We report a case of chrysiasis following gold therapy for rheumatoid arthritis, wherein ultrastructural analysis combined with x-ray energy spectroscopy afforded precise identification and localization of the gold pigment in skin biopsy specimens. | |
| 766142 | The effect of low doses of prednisolone compared with placebo on function and on the hypot | 1976 Feb | A double-blind trial of prednisolone in patients with rheumatoid arthritis using doses of zero, 3 mg and 5 mg is reported. Patients on a dose of 3 mg derived little sustained benefit but subjects on the higher dose showed some improvement which did not last more than two years. Mild suppression of the hypothalamo-pituitary-adrenal axis occurred in both steroid-treated groups. | |
| 6962718 | Antimalarials in rheumatic diseases. | 1982 Dec | The use of antimalarials in rheumatoid arthritis (RA) and systemic lupus erythematosis (SLE) has declined over recent years due to concern over retinal toxicity and the impression that this class of drugs is relatively ineffective in rheumatic diseases. Recent reviews suggest that this position should be changed. Firstly, there is now good evidence for the efficacy of these drugs in RA and secondly strict control of the daily dosage and careful ophthalmological surveillance can almost eliminate the risk of serious retinal toxicity. | |
| 7327092 | [Myasthenia syndrome during chloroquine treatment (author's transl)]. | 1981 Dec 25 | Myasthenic reaction with partial neuromuscular block in the electromyogram and increased antibodies against acetylcholine-receptor protein developed during chloroquine administration over two months in a 52-year-old man known for eight years ot have rheumatoid arthritis. When the drug was discontinued and pyridostigmine administration begun, myasthenia improved within six weeks and had completely disappeared after three months. During the same period abnormal neuromuscular transmission regressed. Also, the significantly increased antibodies against acetylcholine-receptor protein became normal. It remains undecided whether this was a drug-induced myasthenia gravis or only a latent myasthenia manifested by the drug. | |
| 315207 | Rheumatic disease in Jamaica. | 1979 Aug | The relative prevalence and clinical pattern of the major rheumatic diseases in the patient population of a teaching hospital in Jamaica were studied over the 3-year period 1974--7. The prevalence of systemic lupus erythematosus approached that of rheumatoid arthritis (RA). All grades of severity of RA were seen, and there was an unusually high proportion of females with RA. Rheumatic fever and exacerbations were relatively common, and in the absence of carditis differentiation from infective polyarthritis, especially gonococcal, was occasionally difficult. | |
| 7020614 | Inflammatory synovial tissue mononuclear cells release leucocyte migration inhibition fact | 1981 Aug | The presence of leucocyte migration inhibition factor (LIF) in supernatants from apparently antigen- and mitogen-free cultures of mononuclear cells (MNC) was studied. MNC were eluted from inflamed synovial tissue or isolated from blood. Untreated supernatants, supernatants in which any LIF had been inactivated, and culture medium were compared in their ability to affect the migration of homologous polymorphonuclear leucocytes. LIF was released by synovial tissue MNC from all of the 9 patients studied, consisting of 5 patients with rheumatoid arthritis, 2 with psoriatic arthropathy, and 2 with juvenile rheumatoid arthritis. Blood MNC of the patients and of 8 healthy blood donors did not release LIF. When synovial tissue MNC supernatants from 2 patients were examined, LIF activity increased as time of incubation was extended. In at least 2 synovial tissue MNC supernatants in which LIF had been inactivated a migration enhancement activity was revealed. | |
| 7331552 | [DNA metabolism of synovial cells in chronic polyarthritis after intra-articular administr | 1981 Nov | In 8 patients with rheumatoid arthritis the influence of intra-articular (i.a.) injections of prednisolone-21 -acetate on the DNA metabolism of synovial fluid cells was examined. Two hours after an i.a. injection of 25 mg prednisolone acetate a significant decrease of the sedimentation of nucleoids was found. After a 60 minute incubation the sedimentation of nucleoids became normal. An inhibition of DNA repair by 25 mg prednisolone acetate could not be demonstrated. | |
| 115476 | [Studies on cellular protein synthesis in synovial fluid following intraarticular gold adm | 1978 | Na-aurothiomalate was applied intraarticularly in the conentration range between 2 and 40 mg to joints of patients with rheumatoid arthritis. Between 2 and 20 mg a constant inhibition of 3H-aminoacids incorporation in proteins was observed. At a dosage of 40 mg of this gold salt a strong inhibition could be detected. In the low concentration range an additional degradation of structurally changed proteins could be the cause of the lower incorporation rate of 3H-aminoacids. From 40 mg on a real inhibition of protein synthesis seems to occur. | |
| 7278416 | The Sickness Impact Profile: development and final revision of a health status measure. | 1981 Aug | The final development of the Sickness Impact Profile (SIP), a behaviorally based measure of health status, is presented. A large field trial on a random sample of prepaid group practice enrollees and smaller trials on samples of patients with hyperthyroidism, rheumatoid arthritis and hip replacements were undertaken to assess reliability and validity of the SIP and provide data for category and item analyses. Test-retest reliability (r = 0.92) and internal consistency (r - 0.94) were high. Convergent and discriminant validity was evaluated using the multitrait--multimethod technique. Clinical validity was assessed by determining the relationship between clinical measures of disease and the SIP scores. The relationship between the SIP and criterion measures were moderate to high and in the direction hypothesized. A technique for describing and assessing similarities and differences among groups was developed using profile and pattern analysis. The final SIP contains 136 items in 12 categories. Overall, category, and dimension scores may be calculated. | |
| 6189175 | Serum beta 2-microglobulin, sialic acid, and C-reactive protein in systemic lupus erythema | 1982 | Serum beta 2-microglobulin (beta 2m), sialic acid and C-reactive protein (CRP) were studied in 58 patients with systemic lupus erythematosus (SLE) on 186 occasions. Serum beta 2m was significantly higher in SLE patients than in control subjects. Increased serum beta 2m levels were seen in 68% of the patients with only extrarenal manifestations of SLE, in 75% of the patients with renal manifestations but normal glomerular filtration rate, and in 100% of the patients with renal failure. Serum beta 2m levels in 12 SLE patients with associated Sjögren's syndrome were similar to those in patients without that syndrome. Serum sialic acid was also significantly increased in the SLE patients. Sixty-one (33%) of the 186 sera were positive for CRP (greater than or equal to 5 mg/l). The CRP elevation was not accompanied by recognized intercurrent infection or other superimposed cause of tissue injury and inflammation in 37 instances (61%). Under such conditions CRP was only moderately increased. | |
| 6392329 | Comparison of nonspecific reactivity in indirect and reverse immunoassays for measles and | 1984 Nov | Serum specimens collected from patients convalescing from acute measles or mumps infections, other viral infections, or rheumatoid arthritis and from blood donors were tested in indirect and reverse assays for measles and mumps immunoglobulin M (IgM) antibodies. All the samples from patients convalescing from acute mumps and measles infections gave positive IgM results in both tests. However, 6% of sera from patients recovering from other viral infections, 68.4% of sera from patients with rheumatoid arthritis, and 5.6% of sera from normal blood donors gave false-positive results by the indirect measles IgM enzyme immunoassay (EIA). By the indirect mumps IgM EIA, 9% of sera from other viral infections, 70.1% of sera from patients with rheumatoid arthritis, and 5.6% of sera from normal blood donors gave false-positive reactions. The reverse test system for measles IgM gave false-positive results in 1.5% of sera from the group with other viral infections, and the reverse mumps EIA gave false-positive results in 0.9% of the patients. Other sera groups did not react in either measles or mumps reverse IgM assays. The results indicated that although nonspecific reactions are frequent in indirect IgM tests for viral antibodies, such reactions are rarely encountered when reverse IgM EIA tests are employed. | |
| 991507 | Semiconstrained total elbow arthroplasty. | 1976 Nov | Diminution of elbow function may be both embarrassing and severely disabling, especially in patients with multiple arthritic joints. Over the past century, multiple techniques of soft tissue reconstruction of the elbow have been advocated. In general, they do not compare well with total elbow arthroplasty. Arthrolysis has often resulted in little improvement of elbow motion and interposition arthroplasty to instability. Synovectomy may however offer satisfactory relief of disability for the rheumatoid elbow provided that initially there is little evidence of joint destruction. The major problem with rigidly linked total elbow arthroplasty has been a high incidence of prosthetic loosening. Biomechanical analysis has shown that high moments tend to disrupt the osseousmethacrylate junction in the humoral medulary canal. Development of a semi-constrained total elbow prosthesis transfers the developed stress to the collateral soft tissues and reduces prosthetic loosening to approximately 3 per cent. This is about one-tenth of the incidence of loosening of the hinge type arthroplasty. This reduction in prosthetic loosening has been coupled with excellent gains in flexion and estension. However, improvement in forearm rotation has not been predictable, especially in elbows exhibiting preoperative fusion or fibrous ankylosis. Though the semi-counstrained total elbow has only been generally available for 3 years, a review of these results justifies its continued use for elbow reconstruction. | |
| 1105749 | The origin of rheumatoid arthritis. | 1975 | The origin of rheumatoid arthritis (RA) is in our opinion a bacterial infection. The infection gives rise to changes in the macrophages, with release of enzymes, etc., and secondarily abnormal immune processes occur. In favor of this opinion is, among other things, the similarity with rheumatic fever, which is caused by streptococci group A, as well as experience gained in connection with experimentally provoked arthritis. In experimental arthritis, produced by streptococci group B (Svartz), there appears in rats the same type of joint disease as in human RA and, besides, a rheumatoid factor (RF)-like macroglobulin, which cannot be distinguished by available methods from human RF macroglobulin. A 7 S hemagglutinating RF (RF II) was also produced in animals, as well as some other immunoglobulins. The RF II has a much weaker hemagglutinating capacity than the usual RF macroglobulin which for comparison could be termed RF I. The streptococci B used in our investigations were mostly isolated from the nasopharynx of RA patients. | |
| 4590669 | Treatment of rheumatoid arthritis with fenoprofen: comparison with aspirin. | 1974 Feb 2 | Fenoprofen, a compound with analgesic, anti-inflammatory, and antipyretic properties in animals, has been compared with placebo in a double-blind cross-over trial in 60 patients with rheumatoid arthritis. There was a statistically highly significant reduction in pain, duration of morning stiffness, analgesic requirements, and articular index, with increase in grip strength. There was no significant reduction in joint size or temperature. In a subsequent double-blind group-comparative study fenoprofen proved to be as effective as aspirin in relieving the symptoms of rheumatoid arthritis, with strikingly fewer side effects. Almost half of the patients taking aspirin were unable to tolerate the drug in adequate dosage for six months. The remainder were able to take on average only 4 g daily, and at this dose almost half still complained of tinnitus and deafness.Fenoprofen is likely to be useful for patients who cannot tolerate aspirin and other more toxic anti-inflammatory drugs or whose disease is not of sufficient severity to justify their use. | |
| 6420270 | [Width of the normal tendon sheath in the 2d to 5th fingers in oblique exposures]. | 1984 Jan | Oblique views of the fingers, using a low kilovolt technique, show a portion of the tendon sheaths which can be regarded as representative of the entire sheath. Because of the varying obliquity of each finger, this proportion differs in the fingers. With increasing age the projected portion of the sheath becomes smaller because it is covered by increasing bone formation in the insertion of the tendon sheath. Normal values have been obtained for adults according to their decades; from these, quite minor degrees of tendon sheath thickening can be determined. In camptodactyly of the fifth finger, which is not uncommon, the tendon sheath may be widened in the absence of a tenosynovitis. | |
| 7222939 | [Tuber angle of the calcaneus (Boehler's angle) observation of a variant (author's transl) | 1980 Dec | 1) The tuber angle (Lusted and Keats: Boehler's angle) is described with regard to its size and its importance in accident surgery and orthopaedics. 2) The author describes his own observation in the case of a patient with a tuber angle enlarged to double the normal size (variant); attention is drawn to early signs of wear. 3) The author suggests to utilize Boehler's angle on a larger scale, and also recommends to determine the rate of incidence of variations and their importance. | |
| 6929437 | Serum copper and zinc in rheumatoid arthritis and osteoarthritis. | 1980 Jan 23 | Serum copper, zinc and caeruloplasmin levels were measured in 49 patients with active rheumatoid arthritis, in 33 patients with osteoarthritis and a group of blood donor controls. Serum copper and caeruloplasmin levels in the osteoarthritic patients were significantly higher and serum zinc levels significantly lower than in the blood donor controls. Although these differences could not be accounted for on the basis of age or drug administration neither did they correlate with a radiological grading of disease severity. Copper and caeruloplasmin levels were raised in the rheumatoid group as compared to both osteoarthritic and control groups. These were strong correlations between serum copper, caeruloplasmin, ESR and alpha 1 globulin levels in the rheumatoid patients. Although caeruloplasmin-bound copper accounted for most of the elevation in serum copper levels in the rheumatoid group, the calculated non-caeruloplasmin bound copper level was also elevated in rheumatoid, as compared to osteoarthritic patients. Serum zinc levels in the rheumatoid group were lower than in the control group but not significantly different to those in the osteoarthritic group. | |
| 695664 | [Measles antibodies in systemic lupus erythematosus (author's transl)]. | 1978 Oct 13 | 30 patients with systemic lupus erythematosus (SLE), 19 patients with rheumatoid arthritis (RA) and 34 controls were investigated with regard to measles antibodies (AB). The titres were compared with clinical and immunological parameters. As previously reported by several authors we found increased measles AB titres more frequently (kappa 2-test, p less than 0.05) in patients with SLE than in those with RA and controls. No significant correlation was found between immunoglobulins, antinuclear antibodies, CH50 or rheumatoid factor, and an elevation of the measles AB titre. A trend was noted, however, towards a positive correlation between measles antibodies and IgM. An elevated measles AB titre in SLE can be explained on the basis of several mechanisms. However, hyperimmunoglobulinaemia with non-specific, secondary AB elevation can be ruled out as a cause of elevated measles AB titre according to our results. |