Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 597801 | Central nervous system vasculitis in rheumatoid arthritis. | 1977 Nov | The history of a patient with rheumatoid arthritis and necrotizing vasculitis affecting only the central nervous system is reported. Clinical and pathological involvement by this process was present in both cerebral hemispheres, the pons and spinal cord. Review of the literature revealed that cerebral vasculitis in rheumatoid arthritis has been reported rarely and spinal cord vasculitis not at all. | |
| 240190 | Prostaglandin synthetase activity from human rheumatoid synovial tissue and its inhibition | 1975 Jun | 1. Prostaglandin synthetase activity was found in a microsomal fraction from human rheumatoid synovia. 2. The microsomes produced PGE2 and a small amount of PGF2 when incubated with arachidonic acid. 3. The pH optimum of the enzyme from this source was similar to that found with microsomal preparations from rabbit renal medullae and bovine seminal vesicles. 4. The enzyme was inhibited in vitro by the non-steroidal anti-inflammatory drugs flurbiprofen, indomethacin and aspirin in the same rank order of potency as prostaglandin synthetase from other tissues. | |
| 4063641 | Technetium-labelled liposome imaging for deep-seated infection. | 1985 Jan | Negatively charged phospholipid liposomes were labelled with technetium 99m and used as a radioisotopic tracer to detect focal inflammatory lesions in deep-seated sepsis and rheumatoid arthritis. Patients received an intravenous injection of the radiolabelled liposome preparation and were submitted to scintigraphy on the following day. Both the human volunteer and patients showed uptake in liver and spleen but no radioactivity was observed associated with the intestines. Radioactive uptake was visualised in infected prosthetic joints, tubo-ovarian abscess and osteomyelitis. In a patient with active rheumatoid arthritis radioactive uptake was confined to clinically affected joints. The preliminary findings suggest potential for technetium labelled liposomes as a diagnostic tracer. | |
| 6351827 | Aplastic anemia in association with gold therapy for rheumatoid arthritis. | 1983 Apr | Over a ten year period five patients developed aplastic anemia in association with gold therapy for rheumatoid arthritis. None of these patients was suitable for bone marrow transplantation due to the lack of a compatible sibling. Four patients with severe aplastic anemia died, despite intensive haemopoietic support and trials of gold chelating agents. Survival ranged from 22 to 103 days (mean 55 days) with death in each case being due to a combination of bleeding and infection. The remaining patient with moderate aplasia survived, recovering over a period of two to three years. | |
| 6636709 | [Cytochemical study of leukocyte cationic proteins in rheumatoid arthritis patients]. | 1983 | The markers of granulocyte order non-ferment cation proteins (CP) have pronounced bactericide, vascular-permeable and anticoagulant effect. In connection with the participation of leukocyte ferment and non-ferment systems in the formation of immune inflammations, the cytochemical studies on CP in neutrophil polymorphonuclears in rheumatoid arthritis (RA) are of certain importance. A cytochemical method in confirming CP was applied upon smears of peripheral blood of 54 patients with RA and 90 healthy subjects. The results were presented in a mean cytochemical coefficient according to Astaldi and Verga. A significant reduction of CP was established in the leukocytes of patients with RA regardless of the form - sero-negative or sero-positive. Most likely, immune conditioned changes in leukocyte metabolism were present in both forms which no doubt had an effect on their participation in the protective reactions of organism. | |
| 157607 | Muscle spindles in rheumatoid arthritis. An ultrastructural study. | 1979 May 31 | Ultrastructural features of muscle spindles were studied in biopsy material from 100 patients suffering from classical rheumatoid arthritis. Thickening of the outer capsule, increased amount of extracellular ground substance within the inner capsule, and marked thickening of the basement membrane of capillary blood vessels supplying the muscle spindles were observed. Chronic inflammatory cells and macrophages were present within the spindles. Changes affecting the intrafusal muscle fibres were also seen. They were manifest as atrophy and degeneration of the intrafusal muscle fibres, absence of the specialised junctional complexes, and of the intercellular bridges, microladders and satellite cells. It is suggested that the changes affecting the intrafusal muscle fibres are probably secondary. Damage to the myelinated nerves was present, while the sensory and motor nerve endings were well preserved. | |
| 1174381 | [Infulence of pyrasanone on the index of articular radioisotope (tc99m) uptake in rheumato | 1975 Sep 1 | Objective and instrumental appraisal of the therapeutic effect of a new inflammatory molecule (pyrasanone) via radio-isotope and clinical assessment is reported. A highly significant decrease in articular uptake of radiotechnetium was observed when pyrasanone was administered for a short period to 6 subjects with classic or definite rheumatoid arthritis. Clinical assessment after prolonged aministration in 40 patients with various rheumatic diseases with pathogenetice inflammation showed a marked anc clinically important anti-inflammatory (and hence analgesic) effct; tolerance was good and there were no side-effects. | |
| 4366303 | Comparison of effects of long-term corticotrophin and corticosteroid treatment on response | 1974 Jun 8 | The development of the highly sensitive cytochemical bioassay for ACTH has permitted the measurement of plasma ACTH levels during the insulin hypoglycaemia test (I.H.T.) in patients treated with corticosteroids and corticotrophin. The ACTH, corticosteroid, and growth hormone (GH) responses in the I.H.T. were measured in three groups of 12 rheumatoid arthritis patients. One group was receiving long-term corticotrophin treatment, the second was undergoing long-term corticosteroid treatment, and the third had never received systemic hormone therapy. The increments in plasma ACTH, corticosteroids, and GH were diminished in the corticosteroid-treated group, as were increments in plasma GH and ACTH in the corticotrophin-treated group; but in this group the corticosteroid increment was normal. Examination of the area under the curve of the ACTH response showed that the total amount of ACTH secreted was normal though the rate of secretion was reduced. In the corticosteroid-treated group both rate and total secretion were diminished. | |
| 6981702 | In situ localization of lymphocyte subsets in synovial membranes of patients with rheumato | 1982 May | Immunological analysis of the mononuclear infiltrates in 12 rheumatoid synovial membranes was performed by means of modified peroxidase antiperoxidase technique using a panel of monoclonal antibodies, directed against T cell differentiation antigens and HLA-DR (Ia-like) antigens. Helper/inducer T lymphocytes (OKT4 +, Leu3a+) were found in large numbers in nodular lymphoplasmocellular infiltrates, whereas the number of cytotoxic/suppressor T lymphocytes (OKT8 +m Leu2a+) was very low, resulting in a high T4/T8 or Leu3a/Leu2a ratio (6á14:1). In diffusely localized lymphoplasmocellular infiltrates this ratio was only slightly increased as compared with the peripheral blood of patients with rheumatoid arthritis (2á4:1). Moreover, most of these T lymphocytes appeared to have Ia-like antigens and seemed to have contact with HLA-DR+, sometimes weakly OKT6+ dendritic nonlymphoid cells. The results showed a constant basic localization pattern of T lymphocyte subsets and suggest that interactions between dendritic nonlymphoid cells, T lymphocyte subsets and B lymphocytes determine the ultimate architecture of the inflammatory infiltrates in the rheumatoid synovial membrane. | |
| 6980556 | DNA synthesis-potentiating activity on mouse thymocytes of synovial fluid of rheumatoid ar | 1982 May | DNA synthesis-potentiating activity in synovial fluids of rheumatoid arthritis (RA) patients was studied in vitro by using phytohemagglutinin-stimulated mouse thymocytes. The activity was present only in fluids obtained during the active RA phase, and no activity was noted in fluids obtained during the inactive RA phase or in fluids of osteoarthritis deformans patients. | |
| 3861001 | Secondary Sjögren's syndrome and chromosome six markers. | 1985 May | Patients with Sjögren's syndrome (SS) in association with either Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE) or Sclerodactyly were tested for HLA-A, B and Dr antigens and the phenotypes of the 4th component of complement (CA). Significant associations were identified between HLA-Bw62, Dr4, C4B2.9, C4A8 and females with SS-RA. The MHC antigen frequencies noted for secondary Sjögren's syndrome differed from those reported for their respective primary diseases and the implications of these observations are discussed. | |
| 6789388 | [Immunohistochemical detection of tissue-bound rheumatoid factors (author's transl)]. | 1980 | Different immunoglobulin classes, complement factors, complement fixation and rheumatoid-factor activity in rheumatoid synovial membranes of 16 patients were studied. After pepsin digestion of tissue sections, greatly increased numbers of plasma cells were able to bind human gamma globulin. In addition we found after the pepsin digestion more IgG and less IgM in the tissues. The results gave evidence of intracellular blocking of rheumatoid factor activity, due to IgG-IgG rheumatoid factor complexes or self associated rheumatoid factors. Additional evidence of such plasma cell complexes was obtained by observing an in vitro fixation of the complement. With the same methods we studied 3 patients whose synovial membranes had been surgically removed not later than 6 months after the onset of evident symptoms and who developed rheumatoid arthritis within an observation period of 2 years. As a result we found a small production of predominantly M and G immunoglobulins. The rheumatoid factors were also found in a small degree. Rheumatoid factor activity can be revealed only in a little number of plasma cells by pepsin digestion of tissues. In the serum we can't find more rheumatoid factor activity after pepsin digestion in the latex test. The immunofluorescence for detection of rheumatoid factors in tissues is a practicable method and important for the differential diagnosis of joint diseases. | |
| 7073345 | Cartilage specific collagen activates macrophages and the alternative pathway of complemen | 1982 Apr | We studied the effect of human interstitial collagen types I, II, and III on serum-free cultured mouse macrophages and on the complement classical and alternative pathways in human and guinea-pig serum. Type II collagen produced a dose-dependent consumption and conversion of C3 and factor B both in the homologous and in the heterologous system. This effect on the alternative pathway was reproduced in genetically C4-deficient guinea-pig serum and could be triggered by native, triple helical type II molecules, by their component alpha chains, and the CNBr peptide mixture. Addition of type II collagen to the mouse macrophage cultures induced not only a dose- and time-dependent secretion of lysosomal enzymes, but also the generation of a supernatant factor cytotoxic for mouse mastocytoma P 815 cells. Collagen of types I and III were conspicuously less active or inactive in all assays. The studies demonstrate properties of the collagen specific for cartilage which, on a molecular level, suggest its direct, local participation in the production and perpetuation of rheumatoid arthritis. | |
| 787745 | [Experiences in the treatment of rheumatoid arthritis with 90-yttrium-silicate (author's t | 1976 Oct 1 | In 29 patients suffering from rheumatoid arthritis 90-Yttrium-silicate was instillated 48 times into the knee. An improvement was seen in 41 cases. The success lasted in 3 of 10 so far observed cases more than one year. No side effects were seen. Less than 1 p.c. of the instillated substance was leaving the joint. | |
| 3915885 | Clinical evaluation of tenoxicam in osteoarthrosis, rheumatoid arthritis and ankylosing sp | 1985 | A series of double-blind, parallel, clinical trials was carried out to assess the analgesic and anti-inflammatory effects of tenoxicam and to compare the efficacy and tolerance of this compound with those of piroxicam in patients suffering from osteoarthrosis, rheumatoid arthritis and ankylosing spondylitis. In equivalent once-daily dosage (20 mg), tenoxicam was found to be at least as effective as piroxicam in combating the symptoms of the above arthritic disorders and, even in relatively high dosages of 30 and 40 mg exhibited excellent tolerance, producing fewer adverse reactions than piroxicam. It is concluded that tenoxicam represents a valuable addition to the spectrum of anti-inflammatory agents. | |
| 1954 | [Modification of the adjuvans arthritis by carrageenin, compound 48/80, histamine- and ser | 1975 | 1. Injections of carrageenin (1,25 mg/kg i.v.) from the 1st to the 3rd day and then each 2nd or 3rd day inhibited paw swelling in adjuvant arthritis of the rat during the time of treatment. Injections from the 11th to the 15th day were ineffective. The level of plasma kininogen was slightly decreased but the total complement serum level was significantly lowered. 2,5 and 3 mg carrageenin/kg respectively were toxic after repeated injections. After a single administration the levels of plasma kininogen and of total serum complement were decreased by 50% although paw swelling was not affected. 2. Pentosane polysulfoester (25 mg/kg i.v.) did not influence paw swelling despite daily administration from the 1st to the 17th day. Heparin (10 000 IE/kg i.v.) was likewise ineffective. 3. Single or repeated injections of compound 48/80 (0,125-0,5 mg/kg i.v.; 1-5 mg/kg i.p.; 3-6 mg/kg s.c.), reserpine (0,2 mg/kg i.p.), cyproheptadine (5 mg/kg i.v.), bromolysergic acid diethylamide (2 x 2 mg/kg i.v.) or metiamide (10 mg/kg i.v.) were without effect on paw swelling. Neither did compound 48/80 effect the complement serum level. 4. Daily administration of chloropromazine (4-10 mg/kg p.o.) or of promethazine (10-15 mg/kg s.c. or p.o.) inhibited paw swelling in the first phase of adjuvant arthritis but not in the second one. 5. The soybean trypsin inhibitor (15 mg/kg i.v.) inhibited paw swelling significantly up to the 4th day, the Kunitz inhibitor (25 000 E/kg i.v.) was ineffective. 6. The content of prostaglandin E of the inflamed paws was increased threefold in both phases of arthritis. The results are discussed with regard to the putative role of mediators of inflammation (histamine, serotonin, kinins, prostaglandins, lysosomal enzymes, lymphokines, complement). | |
| 394275 | Diclofenac sodium (Voltarol) and indomethacin: a multicentre comparative study in rheumato | 1979 | A five-centre double-blind crossover trial of two two-week periods using diclofenac and indomethacin showed that both drug groups (51 patients) with rheumatoid arthritis responded similarly in relation to pain scores and morning stiffness. It was noted that the response was better in inpatients than in outpatients, despite differences in disease severity. In the osteoarthritis trial (58 patients) it was shown that neither drug significantly reduced resting pain, although both drugs were significantly better in reducing pain on movement; however, patient preference was for diclofenac. Three patients treated with indomethacin withdrew owing to side-effects, compared with one on diclofenac. A slight but significant decrease in haemoglobin levels was observed in both treatment groups with osteoarthritis, but this did not appear to be symptom-related. | |
| 1180028 | A biochemical analysis of subchondral bone of the medial tibial condyle in the normal stat | 1975 Sep | A chemical analysis has been carried out on specimens from the subchondral weightbearing area of the medial tibial condyle from 22 normal individuals, 14 individuals with osteoarthritis and 12 individuals with rheumatoid arthritis. In the normal group there was a decrease in density with advancing age. Over the age of 50 there was no significant difference between the groups. The content of collagen, calcium, phosphorus and magnesium in each bone specimen was calculated. When expressed in per cent of dry fat free bone there was no significant difference between the three groups. When calculations were made on the basis of content per volume tissue wet bone some differences were found. There was a tendency for a higher content of collagen in rheumatoid bone than in normal and osteoarthritic bone. The content of calcium was significantly higher in rheumatoid arthritis than in osteoarthritis; the same result was found in the analysis of phosphorus. In the normal group there was a decrease in phosphorus content with advancing age, this was also seen in the magnesium analysis. | |
| 7102289 | Endoprosthetic arthroplasty of the ankle joint. A clinical and radiological follow-up. | 1982 Aug | Eighteen ICLH ankle arthroplasties in 16 patients were followed up 15 to 52 months postoperatively (mean 36 months) by a review of the records, and clinical and radiological examinations. Five arthroplasties were performed for osteoarthrosis, 13 for rheumatoid arthritis. The overall clinical result was rated excellent in 2, good in 8, fair in 6, and poor in 2 joints. In osteoarthritic joints the results were somewhat poorer, no patient obtaining a rating of excellent but 2 of good, 2 of fair, and one of poor. Radiolucent zones greater than 2 millimeters were seen around the tibial component in 7 cases. Loosening defined as radiographic signs of movement between the prosthetic components and bone was present in 4 cases. The high occurrence of obvious loosening and large radiolucent zones indicates that mechanical problems will be encountered frequently in the future. From the results of this study it is concluded that ankle arthroplasty has a definite place in the treatment of severe arthritis in rheumatoid patients. | |
| 780222 | The by-pass operation for arthritis at the first carpometacarpal joint. | 1976 Jun | The By-Pass operation provides a less destructive alternative to arthroplasty or arthrodesis for fixation of the first carpometacarpal joint. |