Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6784773 | The quantitative spectrophotometric estimation of total sulfated glycosaminoglycan levels. | 1981 Apr 3 | The formation of soluble complexes between alcian blue dye and sulfated glycosaminoglycans provides the basis for the quantitative spectrophotometric estimation of the total concentration of these polysaccharides. Samples containing microgram quantities of sulfated glycosaminoglycan are mixed with a stable dye solution prepared in 15% phosphoric/2% sulfuric acids and absorbance readings at 480 nm are compared to an appropriate standard curve. The method is rapid, convenient, and reproducible. Analyses are performed under conditions in which there is no interference from the non-sulfated glycosaminoglycan hyaluronic acid, or most other anionic macromolecules. In addition, estimations are not effected by small anions or individual monosaccharides. The method has been used for the determination of the purity of commercially available preparations of hyaluronic acid and for the estimation of the sulfated glycosaminoglycan content of various biological fluids including normal human urine and the synovial fluid of individuals with rheumatoid arthritis and osteoarthritis. | |
| 2411400 | Weibel-Palade bodies as a marker for neovascularization induced by tumor and rheumatoid an | 1985 Sep | An analysis was made of ultrastructural changes in capillary endothelial cells in experimentally induced angiogenesis and in a human pathological situation known to involve increased angiogenesis. Chick chorioalloantoic membrane (CAM) showing a positive angiogenic response to low-molecular weight angiogenesis factor isolated from rat Walker sarcoma or from human rheumatoid joint was compared with untreated CAM. Serotonin-treated CAM provided an additional control in that serotonin has the capacity to stimulate endothelial cell growth in vitro but did not induce angiogenesis on the CAM. Human rheumatoid joints were studied using normal healthy human joints as controls. The number of Weibel-Palade (W-P) bodies per unit of cytoplasmic area were higher in tumor angiogenesis factor-treated CAMs (not significant) and rheumatoid angiogenesis factor-treated CAMs (P less than 0.008) than in untreated controls. These differences were more pronounced if W-P body volumetric density was analyzed (P in both cases less than 0.008). Serotonin-treated control CAMs did not show higher numbers of W-P body or greater WPV than untreated controls. Numbers of W-P body and W-P body volumetric density were higher (P less than 0.008) in rheumatoid joints than normal joints. Median values for W-P body number were 16-fold higher and, for W-P body volumetric density, they were up to 30-fold higher in rheumatoid joints. | |
| 7436187 | Work disability in rheumatoid arthritis: effects of disease, social, and work factors. | 1980 Oct | We explore here the relative contribution of selected disease, social, and work-related factors to disability status in a population of persons with rheumatoid arthritis. Our study differs from previous studies in that it is limited to one diagnostic entity, yet at the same time evaluates a broad range of social and work-related factors in disability. One hundred-eighty persons with rheumatoid arthritis sampled from 19 socially diverse practice settings were given a structured survey about their medical and work histories and social backgrounds. We found significant effects of stage and duration of illness on continued employment but no positive effect of selected therapies. Social and work factors combined had a far larger effect on work disability than all disease factors. Among work factors, control over the pace and activities of work and self-employment status had the greatest effect on continued employment, suggesting that time control issues are crucial to the maintenance of one's job after onset of this illness. | |
| 3878876 | Relationship of HLA-DR4 to defective cellular immunity in rheumatoid arthritis using PPD, | 1985 Oct | The disordered cellular immunity of rheumatoid arthritis (RA) was studied in vitro by assessing the stimulatory effect of tuberculin PPD, a mycoplasma product with major histocompatility complex restricted properties in mice (MAS) and concanavalin A (Con A) on RA and control cells of known tissue type. PPD provided the best discrimination between RA and controls (RA responses 34% of latter). The only significant association with HLA-DR type was that patients with RA who exhibited poor responsiveness to MAS had a significantly increased frequency of HLA-DR4. | |
| 7161778 | Whole body retention of diphosphonate in rheumatoid arthritis. | 1982 Nov | The skeletal metabolism of patients with rheumatoid arthritis (RA) osteoarthritis (OA) and ankylosing spondylitis (AS) has been assessed by 24-h whole body retention of 99mTc diphosphonate (WBR). Values for RA and AS patients were significantly elevated but those of OA patients were not when compared to age and sex matched controls (27.0 +/- 8.6 vs 20.5 +/- 1.8%; 24.8 +/- 5.4 vs 19.4 +/- 1.5% greater than and 21.4 +/- 4.1 vs 21.2 +/- 1.4%, respectively). The WBR of patients taking steroids was greatly elevated and RA inpatients had higher values than outpatients, but the increased WBR could not be correlated with disease activity. The increased WBR in RA may represent an indirect effect possibly related to immobility. | |
| 6391077 | Total hip replacement with spongious bone graft for acetabular protrusion in patients with | 1984 Oct | Total hip replacement (THR) with the use of autogenous spongious bone graft reinforcement to the medial acetabular wall proved a successful surgical procedure in patients with rheumatoid arthritis and acetabular protrusion. In 25/26 THR followed for an average of 2 (1-4) years, the bone grafts healed in place radiographically and no further protrusion occurred. A non-progressive radiolucent zone of 3 mm at the bone-cement interface occurred around one acetabular cup. Recurrent dislocations occurred in one hip, which eventually turned out to have a loose acetabular cup. One hip with a firmly seated cup was converted to a resection arthroplasty 4 months after the primary operation because of deep infection. | |
| 6366225 | Generalized vasculopathy and finger blood flow abnormalities in rheumatoid arthritis. | 1984 Feb | Resting blood flow, spontaneous variations of resting blood flow and postischemic peak flow of the fingers, measured by venous occlusion plethysmography, were reduced in patients with rheumatoid arthritis (n = 39) as compared to normals (n = 18). Resting blood flow and postischemic peak flow were reduced only in patients without skin vessel wall immune complex (IC) deposits, whereas spontaneous variations of resting blood flow were found to be reduced in patients with IC deposits. However, after inducing sympathicolysis, postischemic peak flow was reduced in both groups. These findings were consistent with the presence of organic lesions of the finger arteries in both groups associated with additional functional vasospasm in patients without complex deposits, that in the other group may have been counteracted by the presence of IC deposits. | |
| 6623021 | Comparison between serum alpha 2-pregnancy-associated globulin and activity of rheumatoid | 1983 | A possible association between alpha 2-pregnancy-associated globulin (alpha 2-PAG) and activity of rheumatoid arthritis (RA) during pregnancy was investigated. In a prospective study, the correlation between disease activity and serum alpha 2-PAG levels during and after pregnancy was evaluated in 11 women with RA. For comparison, 12 women with ankylosing spondylitis (AS) and 14 healthy women were also studied. No correlation between improvement of disease activity and serum alpha 2-PAG levels could be detected in pregnant RA or AS patients. In contrast, a positive association between total disease activity score and serum alpha 2-PAG levels was found in pregnant RA and AS patients. | |
| 1243035 | The effects of suprofen in rats with Mycobacterium butyricum-induced arthritis. | 1975 Oct | The activity of alpha-methyl-4-(2-thienylcarbonyl)benzeneacetic acid (suprofen) was studied in rats with established Mycobacterium butyricum-induced arthritis. The arthritic response was evaluated by measuring the diameter changes of the hind paws and tibiotarsal joints, using a new apparatus. Treatment once daily by gavage during 14 days revealed activity at the dose of 1.25 mg/kg and above. The lowest ED50 was 6.2 mg/kg. In comparison with simultaneously studied reference compounds, this corresponded approximately to the activity of phenylbutazone. In the higher dose range, 10 to 40 mg/kg, the reduction of external arthritic symptoms was associated with marked reversal of multiple bone deformations. A treatment schedule with 4 administrations of 2.5 mg/kg/day was significantly more effective than a single daily administration of 10 mg/kg and comparable to that of 10 mg/kg once daily. Mixing of suprofen with the diet, to give the low daily dose of 1.28 mg/kg confirmed the high activity expected from the maintenance of a practically constant compound level in the treated rats. In a comparative study involving suprofen, acetyl-salicylic acid, indometacin, phenylbutazone and tolmetin, all administered over 14 days with the diet in a dose range up to toxic dose levels, dose-related anti-inflammatory and toxic effects were obtained. The potency order and ED50's of the compounds were: indometacin (0.31 mg/kg) greater than suprofen (1.48) greater than tolmetin (18.0) = phenylbutazone (18.2) greater than acetyl-salicylic acid (440). Suprofen had by far the largest safety margin (48), followed by phenylbutazone (20), tolmetin (16), indometacin (8) and acetyl-salicylic acid (2). In conclusion, three major symptoms of adjuvant arthritis: joint inflammation, impaired growth and bone erosion, were markedly reduced by different doses of suprofen, which revealed to be a safe compound when compared to several reference compounds. | |
| 6744704 | Total wrist arthroplasty. A clinical review. | 1984 Jul | Since 1974, a cementable, semi-constrained total wrist prosthesis has been implanted in patients with advanced destruction of the carpus usually secondary to rheumatoid arthritis. The single most common problem observed after surgery in the first one hundred cases was that of ulnar deformity. Since 1977, 25 total wrist arthroplasties have been performed in 22 patients (3 bilateral cases). A modification of the original prosthesis was employed in these. The newer designs allow for the precise reduplication of the instant center of motion of the normal wrist. Additionally, in the last six patients operated on, methylmethacrylate cement was not used to secure the metacarpal component because a secure press-fit was possible in each case. To date, postoperative results have disclosed no cases of radial ulnar imbalance. No cases of dislocation, infection, or loosening have occurred. No difference in the degree of postoperative pain relief has been observed between those cases in which cement was employed to secure the prosthetic components and those cases in which cement was used only to secure the radial component. | |
| 6607158 | Other NSAIDs of choice for rheumatoid arthritis. | 1984 Jan | Aspirin is an effective antiinflammatory and analgesic agent. Pain relief is achieved with relatively modest doses, far below those necessary for inflammation control. The patient reacts to the need for pain relief and will take fewer aspirin than prescribed because the lower dosage is better tolerated and less expensive. This often obviates the wanted effects. This pain-inflammation gap does not exist for most nonsteroidal antiinflammatory drugs (NSAIDs), in which analgesic and antiinflammatory doses approximate each other. The range of toxic effects from aspirin is larger than that for nonsteroidal drugs. Gastric erosions and bleeding are far more prevalent with aspirin. Other organ systems are involved more by aspirin than by other drugs, and, in osteoarthritis, aspirin actually may militate against recovery by interfering with glycosaminoglycan synthesis. | |
| 4029762 | [Carpal instabilities]. | 1985 Jul | The ligaments of the wrist and the bony configuration--beside muscles and tendons--are responsible for stability in the wrist joint, which is impaired in certain pathological conditions: unstable fractures of the scaphoid, scapholunate dissociations, perilunate fracture-dislocations, malunited Colles' fractures, Kienböcks disease, rheumatoid arthritis and posttraumatic laxity of ligaments. The differentiation between dorsal and palmar instability is made by radiological examination and measuring of the scapholunate, capitolunate and radiolunate angles. The understanding of normal anatomy and (post-)traumatic conditions is facilitated by the concept of dynamic action of the ligaments and the bones of the wrist as articular and extraarticular slings. | |
| 7316342 | D-penicillamine and the ocular myasthenic syndrome. | 1981 Oct | D-penicillamine is a potent drug used to treat rheumatoid arthritis, Wilson's disease and cystinuria. D-penicillamine has recently been found to cause myasthenia gravis in certain susceptible patients. We present a typical case of one patient who developed myasthenia while taking D-penicillamine. The withdrawal of D-penicillamine and the institution of short-term anticholinesterase therapy resulted in the resolution of this disease. The literature is reviewed and attention is focused on the point that all patients who developed myasthenia while undergoing D-penicillamine therapy had ocular symptoms. | |
| 681409 | Arthroplasty of the knee. | 1978 Aug | Arthrodesis of the knee is a simple and safe operation that ensures stability and freedom from pain. But it is achieved at the expense of movement and occasionally of social acceptability. If arthroplasty is to be recommended, the advantages of arthrodesis must be retained, with the added bonus of a functional arc of movement. | |
| 3898296 | Some observations on various dose regimens of thymopentin treatment in rheumatoid arthriti | 1985 | Eight patients suffering from active rheumatoid arthritis were treated with thymopentin, 50 mg, administered as fractionated intravenous infusion over 10 min 3 times weekly for 3-20 weeks. Seven patients experienced clear-cut amelioration of symptoms and signs after just 2-4 weeks of treatment, and this improvement lasted for 6-8 weeks after thymopentin had been discontinued. Comparable positive results were observed in 2 patients who later continued thymopentin therapy by subcutaneous administration. Several subcutaneous dose regimens were tried; the optimal response appears to be achieved with 100-150 mg three times weekly and 150-200 mg twice a week, respectively. Because the subcutaneous therapeutic approach is more attractive to the patient-and also more practical for the physician-it should be investigated further. | |
| 7282103 | [Zinc levels in blood and urine of rheumatoid arthritis patients after four months treatme | 1980 Nov | In 10 female patients with classical rheumatoid arthritis D-penicillamine was administered in a daily dose of 150-150 mg for 4 months. The only additional antiphlogistic treatment was indomethacin (100-150 mg daily). At the beginning and during the trial blood (total) levels of zinc with n-activation analysis and the excretion with urine were determined using n-activationanaysis and atom absorption. By spectrometry following results were obtained: an increase of zinc excretion. By spectrometry following results were obtained: in increase of zinc excretion in urine until day 21; after 2 and 4 months decreased above levels at the original value before beginning of treatment. Blood levels of zinc decreased distinctly until the 2nd week, increase at the 3rd week and return to the original value of the controls before D-penicillamine therapy at the 2nd and 4th months. | |
| 770083 | A comparative study of azapropazone and indomethacin in the treatment of rheumatoid arthri | 1976 | A double-blind crossover trial in 50 patients with rheumatoid arthritis was carried out to compare the clinical effectiveness of 800 mg. azapropazone per day with 100 mg. indomethacin per day. Blood plasma concentrations of azapropazone were also studied in 10 patients. Patients received both drugs for a 3-week period, the order of treatment being determined at random. Although there were no marked differences in any of the objective measurements, patients assessments of response to and preference for each drug treatment period suggested that azapropazone produced significant improvement compared to that with indomethacin. Plasma levels of azapropazone remained remarkably constant for each patient. Side-effects with both drugs were mild and transient, and there were no marked variations from normal in any of the laboratory parameters measured. | |
| 6607352 | Case-control studies. | 1983 Nov | This paper will provide an overview of the case-control study including the definition, types of study design, advantages and disadvantages, potential types and sources of bias, selection of controls, statistical measures of association, and criteria for suggesting inferences about causation. Measures of association for HLA-B27 and ankylosing spondylitis (AS) and HLA-DR4 and rheumatoid arthritis (RA) are calculated from previously published data. Case-control studies are useful for identifying etiologic associations in uncommon diseases. | |
| 122655 | Effect of penicillamine on the kidney. | 1977 | Twenty patients with rheumatoid arthritis developing proteinuria when being treated with penicillamine have been studied. In 5 the proteinuria was mild and resolved rapidly. Eleven of the remaining patients have undergone renal biopsy. One was found to have amyloidosis, and in the other 10 there was evidence of an immune complex type of injury, manifested by a granular immunoglobulin deposition within glomerular capillary walls associated with subepithelial deposits, found on electron microscopy. The proteinuria associated with this was mild (mean 2.6 g per 24 h) and occurred on average some eight months after commencing therapy (range 6 weeks to 60 months). | |
| 7015541 | Indomethacin or sulindac at night in rheumatoid arthritis. | 1981 Jun 13 | The effects of indomethacin and sulindac in relieving troublesome morning stiffness and nighttime pain were tested in a double-blind cross-over trial. Thirteen of the 17 patients who completed the trial preferred indomethacin which was found to be superior to sulindac in all the parameters tested. Sulindac did, however, have some beneficial effect and can be used as an alternative to indomethacin when this drug cannot be used as the agent of first choice. |