Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6800572 | [Hydroxyapatite microcrystals in synovial mitochondria in human and experimental rheumatis | 1981 Nov 16 | This paper deals with mitochondria microcrystal deposition in some human inflammatory rheumatism and in experimental arthritis. Hydroxyapatite microcrystals were observed in Ankylosing Spondylitis (AS) and Reiter Syndrome (RS) but never in rheumatoid synovitis nor in chondrocalcinosis synovitis. In Rat and Rabbit experimental arthritis, they were always seen in mitochondria as in AS and RS and never in lysosomes. This fact suggests mitochondrial abnormalities in calcium metabolism, which may be a consequence of synovial inflammation in a susceptible host. | |
| 6827872 | Measuring functional outcomes in chronic disease: a comparison of traditional scales and a | 1983 Feb | A new "health-status" questionnaire, the Sickness Impact Profile (SIP), was examined to determine whether it offered measurement advantages over the traditional American Rheumatism Association (ARA) functional scale or patient self-ratings of function. Seventy-nine outpatients with rheumatoid arthritis (RA) administered the SIP to themselves and provided self-ratings on a 7-point functional scale. Clinicians independently rated patients on the ARA functional scale, and repeated measures were obtained over a 6-month period. Scores on the SIP or its subscales showed stronger correlations than the other scales with hematocrit, sedimentation rate, grip strength, morning stiffness, duration of RA, anatomic stage, work status, and psychiatric status. Validity of the SIP appeared to be maintained with repeated administrations, and the SIP was more reliable than either of the other scales. These findings, as well as the comprehensiveness and feasibility of the self-administered SIP, suggest that this (and perhaps similar health status instruments) may be a useful supplement to more traditional measures of chronic disease outcome. | |
| 788739 | Plasma concentration of phenylbutazone and its therapeutic effect-studies in patients with | 1976 Feb | 1 Phenylbutazone in doses of 50, 100, 200 and 300 mg/day has been given for four periods of 3 weeks to seven patients with rheumatoid arthritis. The trial was double-blind and the order of administration of doses was arranged to eliminate order and carry-over effects. 2 Before the trial and at the end of each period, the patient's responses were assessed by measurement of the duration of morning stiffness, the pain score, paracetamol tablet count, grip strength, digital joint size and articular index. 3 The plasma phenybutazone concentration was measured by gas-liquid chromatography and was also predicted by prior measurement of the phenazone half-life. 4. Compared with the pretreatment period, phenylbutazone had a significant therapeutic effect, as judged by morning stiffness, pain score and articular index, in a dose of 50 mg/day, but no statistically significant differences in effect were seen between the various doses of phenylbutazone. 5 There were no significant coorelations between the plasma concentration of phenylbutazone and any of the clinical assessments. 6 The plasma phenylbutazone concentration agreed closely with that predicted at doses of 50 and 100 mg, but at higher doses the plasma concentration was significantly lower than predicted (P less than 0.05). This may have been due to saturation of the protein binding sites at these doses. | |
| 6166963 | [Immunohistochemical detection of antigammaglobulin factors in the serum (author's transl) | 1980 | Agglutination procedures for the detection of rheuma factors are inadequate concerning IgG and IgA factors and sensitivity to IgM factors, too, is generally limited. Both these disadvantages are to a great extent overcome when rheuma factors are fluorescence-marked with anti-human-gammaglobulin respectively with monospecific antiserums and when reaction steps according to Svartz and Schlossmann are applied to a microscope slide test. This test and the results of investigations of 101 cases (different joint diseases and healthy blood--donors) are described in this paper. | |
| 1078726 | [99mTc-polyphosphate scintigraphy of joints, xeroradiography and radiography of hands]. | 1975 Jan 31 | Joint imaging with 99m-Tc-Polyphosphate was carried out in 21 patients having inflammatory or degenerative diseases of the joints of the hands. A comparison was made between 99m-TcPP, xeroradiography and radiography. In a total of 630 different joints 237 positive scans, 132 positive roentgenograms and 183 positive xeroradiograms were obtained. In the early stage of inflammatory joint disease only the scintigraphic results are positive, in the later stage 99mTcPP-imaging was less sensitive than xeroradiography and radiography. The reason for the increased concentration at the site of acute joint inflammation is probably the increased uptake in the soft tissues of the joints. The best time for scanning after the application of 99m-TcPP seemed to be at 3 hours. | |
| 7293522 | Comparison of three therapeutic regimens using nonsteroidal antirheumatic drugs in patient | 1981 Jul | Three therapeutic regimens using nonsteroidal antirheumatic drugs in the treatment of rheumatoid arthritis were compared in an open long-term cross-over trials. Voltaren 100 mg suppositories or Naprosyn 500 mg suppositories were introduced every evening at bed-time, and Naprosyn tablets were administered twice in a day, in the morning and at night. Each drug was administered for one month and every patient was treated with all three drugs in succession. The individual sequence was determined by randomization. The assessment included nine objective and subjective criteria and after the termination of the trial each patient named his preferred sequence of drugs. All three drugs proved effective. The results of our investigations showed that nonsteroidal antirheumatic drugs in the form of suppositories were more effective in the treatment of rheumatoid arthritis. They exerted a more beneficial effect on morning stiffness and on pain than tablets of the same drug. The treatment was most effective as late as in the third month of the therapy, regardless of the substance which was administered as the third drug. This confirmed our experience of the advantage of alternate administration of various nonsteroidal antirheumatic drugs. A series of subjective and objective criteria, as well as the preference expressed by the patients spoke in favour of Voltaren suppositories, which was obviously due to the fact that Naprosyn was ineffective in about 20 per cent of the patients. | |
| 631696 | [Cerebro-organic syndrome during gold therapy. Possible correlation between gold therapy i | 1978 Mar 23 | In this article the possible relationship between gold therapy of a chronic seronegative polyarthritis and the appearance of a cerebro-organic syndrome in a 56-year-old postmenopausal woman will be discussed. We take into consideration the basic illness, the biography, the hormonal situation, the simultaneous chloroquin therapy and the overdosage of the gold drug. After a careful consideration of the different diagnostical possibilities following the above mentioned factors, not only a temporal but also a causative relationship of gold therapy and cerebro-organic syndrome seems to be possible. | |
| 506488 | [Tubular nephropathy in chronic polyarthritis]. | 1979 Jul | Disc electrophoresis and N-acetyl-beta-D-glucosaminidase (NAG) of urine are sensitive indicators of renal damage. In 28 from 50 patients with definite rheumatoid arthritis, a tubular proteinuria and a high urinary NAG-excretion and in 10 other patients one of these pathological parameters were detected. A positive correlation with disease activity was noted. Both methods are able to demonstrate a rheumatoid involvement of renal function. | |
| 6996929 | A controlled trial of magnesium dithiosalicylate compared with aspirin in rheumatoid arthr | 1980 | The anti-inflammamtory effectiveness and side-effects of magnesium dithiosalicylate were compared to aspirin in a 3-month, parallel, double-blind trial in 40 patients suffering from active rheumatoid arthritis. The results showed that 3 g magnesium dithiosalicylate daily had anti-inflammatory properties similar to those of 3 g aspirin daily in rheumatoid arthritis. A statistically significant change in morning stiffness, number of tender joints, pain score and erythrocyte sedimentation rate was observed in the magnesium dithiosalicylate group. In the magnesium dithiosalicylate group, 8 patients had to be withdrawn from the trial because of serious side-effects compared to 5 in the aspirin group. Gastro-intestinal intolerance occurred as frequently in both treatment groups. Hypersensitivity to magnesium dithiosalicylate was a serious problem and the reason for withdrawal in 4 cases. The high frequency of side-effects to magnesium dithiosalicylate makes this drug unacceptable for treatment of rheumatoid arthritis at the present time. Further pharmacological studies might reveal new derivatives which are as effective but with less side-effects. The anti-inflammatory activity of magnesium dithiosalicylate resembled that observed with gold and penicillamine. The fact that all these drugs have a sulphhydril group in common is stressed. | |
| 1096603 | Clinical applications of complement measurements in rheumatic diseases. | 1975 Mar | There is now convincing evidence that the complement system is involved in the pathogenesis of at least some of the manifestations of human rheumatic diseases. Complement measurements in serum and/or pathologic fluids from patients with these disorders not only reflect this involvement but also may provide important clues regarding the activity and extent of the disease processes. Future studies should provide additional information concerning the usefulness of such measurements for predicting the outcome of specific therapeutic regimens, and perhaps also be the basis for the evolution of new and more rational forms of therapy. | |
| 7028072 | The distribution of fibronectin in the pannus in rheumatoid arthritis. | 1981 Aug | Fibronectin is an adhesive glycoprotein synthesized by mesenchymal cells. Its distribution in the rheumatoid pannus has been studied by immunofluorescence using a monospecific antiserum. All areas of the pannus contained immunoreactive fibronectin, including its junctions with synovium, ligaments, bone and cartilage. It formed a coarse extracellular meshwork which surrounded the inflammatory cells infiltrating the pannus and which codistributed with reticulin and "immature" collagen. The proliferative cellular areas of the pannus showed marked reactivity for fibronectin. Although fibronectin was present at the pannus-cartilage junction, it was not otherwise found in articular cartilage. Fibronectin in the pannus did not have any relationship to the distribution of immunoglobulins or complement. Fibronectin is a structural component of the rheumatoid pannus and may play a role in the pathogenesis of rheumatoid synovitis. | |
| 7239553 | [Cyclosporin A--effects and side effects in the treatment of rheumatoid and psoriatic arth | 1981 Mar | The treatment of rheumatoid arthritis and psoriatic arthritis with cyclosporin A is described. Cyslosporin A is a new selective immunosuppressant which acts primarily on the T lymphocytes. It has already been shown to be effective in preventing rejection following kidney transplantation as well as in preventing graft-versus-host disease. In rheumatoid and psoriatic arthritis, however, its effect was not satisfactory, although rather different in the two conditions; overall only about one third of the patients showed any marked improvement. By contrast, and for reasons which are as yet unexplained, it had a beneficial effect on the cutaneous symptoms of psoriasis. Cyclosporin A had little effect on immune parameters. Side effects--mainly kidney toxicity, gastro-intestinal reactions and hirsutism--were common but reversible. On present evidence its principal indication among rheumatological diseases would seem to be as a treatment for severe, intractable psoriatic arthritis. | |
| 6524328 | Hip fracture in rheumatoid arthritis. | 1984 Dec | All patients with rheumatoid arthritis, admitted for hip fracture to a regional hospital during a 5-year period, were studied in retrospect. Of 1092 hip fractures, 16 cervical and nine trochanteric fractures occurred in rheumatics. Four cervical fractures were stress fractures. The mean patient age was lower than in a normal hip fracture material and the female predominance more pronounced. Of 14 surviving patients with cervical fractures, three had an uncomplicated 2-year healing, while 11 developed redisplacement, non-union or segmental collapse, in eight cases necessitating hip arthroplasty. Of eight surviving patients with trochanteric fractures, serious complications developed in two: non-union in one and septicaemia in one, necessitating nail extraction 1 week after the primary operation. The complication rate was higher than in an unselected femoral neck fracture material. | |
| 190953 | Comparative study of carcinoembryonic antigen in rheumatoid synovium, tumour, and normal a | 1977 Feb | Material reacting like carcinoembryonic antigen (CEA) in the radioimmunoassay has been extracted from rheumatoid synovial membranes. This CEA activity has been compared to that found in hepatic metastases from colorectal tumours and in normal adult lung. The antigen in the rheumatoid synovium has been shown to be more sensitive to perchloric acid and to isolate with a lower weight than that derived from the tumour and lung. Immunodiffusion studies with anti-CEA indicate that the CEA-like determinants in the rheumatoid synovium have partial identity with tumour CEA and that a significant proportion of them are associated with large molecular weight material. Production of an antiserum to these CEA-like components in the rheumatoid synovium should enable further identification of their relationship to tumour CEA and might allow a better judgement of whether or not they represent the expression of neoantigens in the disease. | |
| 394281 | An open assessment of the efficacy and tolerability of diclofenac sodium (Voltarol) in pat | 1979 | The efficacy and tolerability of diclofenac was studied in an initial two-week assessment study in 24 patients with rheumatic disease. During the first week patients received 1 x 25 mg diclofenac t.d.s., with subsequent dosage adjustments according to response. Most completers showed improvement in joint pain and functional grade, and patients' rating of their condition indicated a significant improvement. Nine patients were withdrawn because of poor symptom control or side-effects, and there were a number of other minor side-effects not necessitating withdrawal. However, there were no persistent or lasting side-effects, and laboratory tests revealed no significant abnormalities. In a two-week double-blind study, diclofenac was compared with indomethacin in 43 outpatients with osteoarthritis or rheumatoid arthritis. Dosage in the first week was 1 x 25 mg tablet of either diclofenac or indomethacin (random allocation) t.d.s., with further adjustments as necessary. There were no significant differences in the effectiveness of the two drugs, and no differences in dosage requirements. Three patients were withdrawn from each treatment group. Gastrointestinal side-effects predominated in the diclofenac-treated group, with central nervous system unwanted effects more frequent in the indomethacin group. | |
| 4441121 | Scleroderma in childhood. Report of 5 cases. | 1974 Nov | Five cases of scleroderma in childhood have been reviewed. All presented with cutaneous complaints. Raynaud's phenomenon occurred in 2 and Sjögren's syndrome in one. A patient with linear scleroderma and hemiatrophy developed subcutaneous calcification 5 years after the onset of disease. Of the 5 patients reviewed, 2 have been clinically well for several years, while the disease is progressive in the remaining 3. Because of the clinical and serological overlap, confusion is possible between dermatomyositis, scleroderma, juvenile rheumatoid arthritis, and systemic lupus erythematosus, particularly when these connective tissue disorders are so uncommon in children. It appears that scleroderma in children may be less severe than in adults and that systemic involvement is less common. The presence of Raynaud's phenomenon, antinuclear factor, lupus erythematosus (LE) cells, and a raised erythrocyte sedimentation rate indicate a poor prognosis. | |
| 457743 | Carpal involvement in inflammatory (erosive) osteoarthritis. | 1979 Jun | Inflammatory or erosive osteoarthritis, in addition to the classical digital distribution, may involve the carpus. Characteristic carpal changes are restricted to the radial aspect of the wrist and consist of narrowing, eburnation, osteophytosis, and mild subluxation of the first carpometacarpal and trapezio-scaphoid joints. Radiographic findings and differential diagnosis are discussed. | |
| 204325 | Multicentric reticulohistiocytosis and malignant disease. | 1978 Feb | Multicentric reticulohistiocytosis developed in a 45-year-old woman, who had a 3 year history of untreated breast carcinoma. A review of the literature revealed that malignant disease has been associated with 27% of reported cases. It is considered that, like adult dermatomyositis, the onset of multicentric reticulohistiocytosis should stimulate detailed investigation for an underlying neoplasm. | |
| 6743470 | Clinical evaluation of two strategies for improving patient recall of prior drug therapy. | 1984 Jun | The ability to recall details of current and prior drug therapy was evaluated in two studies employing a total of 94 patients with inflammatory polyarthritis. Ten per cent of patients were unable to completely recall the names of their current anti-inflammatory drugs and eighty-three per cent of patients to completely recall the details of prior anti-inflammatory drug therapy. Prompting firstly with the proprietary names of drugs and thereafter with a pill board substantially enhanced recall particularly for prior NSAID therapy. Nineteen per cent of responses obtained with verbal prompting were inaccurate. No such problems were encountered in responses obtained using the pill board. These findings indicate that a complete and accurate drug history can only be obtained in the majority of patients using recall enhancement strategies. | |
| 6466394 | Histopathology of the rheumatoid lesion. Identification of cell types at sites of cartilag | 1984 Aug | Histochemical and ultrastructural techniques were used to examine the cartilage-pannus junction of 49 rheumatoid joints. Whereas 24 showed relatively acellular, fibrous pannus tissue, 25 demonstrated "cellular" junctions with different cell types at sites of erosion. Macrophages and fibroblasts were commonly observed as majority cell types in most specimens, but others showed mast cells, polymorphonuclear leukocytes, dendritic, or plasma cells as the predominant cell type. Some showed local accumulations of different cell types at sites along each junction. Our findings show that the cellular composition at sites of cartilage erosion varies greatly and suggest that cells are subject to turnover and interchange. |