Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6607353 | Cohort studies. | 1983 Nov | Cohort studies generally provide more definitive evidence regarding causality than do other types of observational epidemiologic studies, but the high cost usually associated with them limits their use to special situations. Retrospective cohort studies and combined cohort/case-control studies are suggested as modifications of the traditional prospective cohort study which retain certain of their advantages but which are considerably less expensive. | |
| 147816 | [Band-like osteoporosis (author's transl)]. | 1978 Mar | Atrophy of the skeleton due to inactivity may have two types of radiological change: diffuse decalcification and band-like porosis in the zones involved by previous growth. The type of decalcification is evidently determined by the vascular anatomy of the bones. This results in localised differences which are independent of age, the type of trauma or the duration of immobilisation. | |
| 482842 | [Biosynthesis of PGE2 and PGF2 alpha in normal and pathological human synovial fluid]. | 1979 Apr | The biosynthesis capacity of PGE2 and PGF2 alpha in normal and pathological (rheumatoid arthritis and osteo-arthrosis) synovialis was studied using the radio-immunological method, simultaneously on homogenized tissues and the microsome fraction, with or without addition of exogenous arachidonic acid. Among the results obtained, the most significant concern rheumatoid polyarthritis: a net increase in PGF2 alpha and especially in PGE2, more pronounced in the homogenized emulsion than in the microsomial fraction. Exogenous arachidonic acid increases the biosynthesis capacity of the PG. The prospective interest of this model is underlined: the possible introduction in the incubation medium of various drugs, making it possible to study the various factors taking part in the biosynthesis of PG (phospholipase A2 and prostaglandin-synthetase). | |
| 675118 | [Fc-gamma-receptor cells and rheumatoid arthritis]. | 1978 May | Certain blood lymphocytes of patients suffering from rhumatoid arthritis (RA) and or control subjects, can be detected using a rosette technique in the presence of erythrocyte antibody compounds (EA). The EA rosettes demonstrate the presence of cells having a receptor for the Fc fragment of the IgG's (Fc-receptor). A significant increase in highly active EA rosettes during RA was demonstrated using six EA compounds differing according to the type of erythrocyte and the quantity of sensitizing antibody. These highly active EA rosettes correspond to the case in which few antiserum molecules cover the erythrocytes. Their high level in RA may correspond to an increased number of Fc-receptor cells or to a stronger linkage of EA compounds. The cells forming EA rosettes are responsible for the resulting cell antibody cytotoxicity that seems to change little during rhumatoid disease. However, the very special behavior of Fc-receptor lymphocytes incubated in vitro suggests that the IgG receptors are modulated by the immune compounds present during RA. | |
| 6986646 | [Roentgenological diagnosis and differential diagnosis of injuries of the upper cervical v | 1980 Feb | Accurate differentiation of traumatic, inflammatory and congenital changes in the upper cervical vertebral column requires specific knowledge of the complex anatomic conditions in this segment of the spine, as well as of its embryological specialities and its regional pathology. This article deals with the analysis of the most important traumas of the upper cervical vertebral column and the relevant differential diagnosis. | |
| 6458880 | Appearance of anti-HLA-DR-reactive cells in normal and rheumatoid synovial tissue. | 1981 Aug | The reactivity of rabbit anti-HLA-DR antigen antibodies with cells in normal and rheumatoid synovial tissue was investigated by indirect immunofluorescence on frozen sections of tissue. The antibodies reacted with a significant proportion of the synovial lining cells of both normal and rheumatoid synovial tissue, with endothelial cells, and with a number of, most probably, migratory cells. After dispersion of cells from rheumatoid synovial tissue by digestion with collagenase and DNase, adherent cells of both a macrophage-like and a dendritic appearance reacted with the anti-HLA-DR antigen antibodies. The adherent cells were also found to be potent stimulators in the allogeneic MLR. In addition, it was found that a high percentage of T lymphocytes from both peripheral blood and synovial tissue of rheumatoid patients bound anti-HLA-DR antibodies. The present data suggest a role for synovial lining cells in HLA-D-locus-dependent events of importance in the pathogenesis of rheumatoid arthritis and other joint diseases and point to the need for further investigations on T lymphocytes derived from the site of inflammation in the study of rheumatoid arthritis. | |
| 717036 | Lymphatics filled at knee arthrography. | 1978 | A review of 587 knee arthrographies revealed filling of lymph vessels in 12 cases. They occurred in connection with arthritis (4 rheumatoid), osteoarthritis, ruptured meniscus, ruptured popliteal cyst and after operation. Lymphatic filling was not related to the leakage of contrast through a ruptured popliteal cyst or to inadvertent extra-articular injection. Filling of lymphatics is more likely to occur in examinations with a positive contrast medium when a larger amount of medium is used. | |
| 871301 | Hand flexor tenosynovitis in rheumatoid arthritis. Prevalence, distribution, and associate | 1977 May | Tenosynovitis of one or more flexor tendons of the hand (mean 3.1 tendons per patient) was noted in 55% of 100 patients with rheumatoid arthritis (RA) examined periodically during a mean period of 5 years. The third flexor tendon was involved most frequently (71% of patients), followed by the second (62%), fourth (53%), fifth (27%), and first (13%). Patients with flexor tendonitis (FT) had a significantly higher prevalence of rheumatoid nodules (56% vs 33%), carpal tunnel syndrome (47% vs 13%), wrist extensor tenosynovitis (47% vs 9%), and elbow epicondylitis (22% vs 7%) than patients without FT. Dupuytren's contracture, DeQuervain's tenovaginitis, flexor carpi radialis and ulnaris tendonitis, and Achilles tendonitis were found exclusively in patients with FT. A control group of 50 non-RA patients with FT had statistically fewer diseased tendons per patient (mean 1.5) and a different digital distribution, the thumb being affected more frequently (P less than 0.05) than in RA patients. | |
| 83590 | [beta2-Microglobulin in synovial fluid (author's transl)]. | 1978 Sep | In a series of patients with rheumatoid arthritis we found higher levels of synovial beta2-microglobulin (5,2 +/- 3 mg/l) than in gouty arthritis (2,4 +/- 0,6) or osteoarthritis (1,2 +/- 0,3 mg/l). The ratio of synovial/plasma beta2-microglobulin was always superior to unity (2,3 +/- 0,7) in the R.A. patients whereas it is always inferior to unity in the other groups. The correlation between plasma or synovial beta2-microglobulin and synovial lymphocyte count was highly significant in all cases in RA patients plasma and synovial beta2-microglobulin are significantly related to the degree of joint involvement as expressed by the joint count. | |
| 6099172 | Etiology and management of adduction contracture of the thumb. | 1984 Fall | The most common etiological factors producing adduction contracture of the thumb are presented. Development of contracture in congenital deformities, rheumatoid arthritis and osteoarthritis, cerebral palsy, burns, after snakebite, and as a consequence of trauma are each described. | |
| 488789 | Assessment of past results and current practice in the treatment of rheumatoid metacarpoph | 1979 Jun | A new design of prosthetic finger joint for the rheumatoid patient, and the technique for its insertion is described, which has now been in use for five years. The technique includes the soft tissue correction of the ulnar deviation. Results are reported for all the cases performed in one year giving a two year follow up, assessing flexion strength, pinch strength and the degree of recurrence of ulnar drift associated with loss of pinch strength. | |
| 6386232 | N-terminal procollagen peptide and beta 2-microglobulin in synovial fluids from inflammato | 1984 Aug 31 | The concentrations of NH2-terminal procollagen peptide were determined radioimmunologically in synovial fluids from inflammatory and non-inflammatory joint diseases. The mean concentrations +/- SD were 1.39 +/- 0.77 and 1.13 +/- 0.63 mg/l and, hence, did not reveal significant differences. Compared with serum, peptide levels in synovial fluids are 10(3) times higher. No statistical correlation was found between procollagen peptide levels and the concentrations of beta 2-microglobulin, a suggested parameter of disease activity, and other established indicators (total protein, total and differential cell count) of inflammatory activity. | |
| 1225213 | [Study of the sensitivity of Halprowia (microorganisms of the OLT group) isolated in joint | 1975 Jun | Sensitivity to antibiotics and sodium sulfapiridasin of the microorganisms of group OLT, i. e. Halprowia and Chlamidia isolated from the joint fluid and synovial of the affected joints in patients with rheumatoid or non-specific infectious arthritis and Raiter syndrome was studied in ovo. The data provided determination of the spectrum of their sensitivity to various drugs. The antibiotics of the tetracycline group, i. e. olemorphocycline, tetracycline and rondomycin were shown to have the highest inhibitory effect. Penicillin and ampicillin only delayed the death of the infected embryons. As for kanamycin and streptomycin used in the doses tested, the agents were not sensitive to them. The isolates were also resistant to sodium sulfapiridasin which once more confirmed the questionable value of this criterion for differentiation of Halprowia. | |
| 6578712 | Chemotherapy related leukemogenesis. | 1983 | Administration of aggressive chemotherapy to patients with cancer has considerably improved their outlook for effective palliation or cure. However, a hitherto unappreciated complication consisting of a secondary malignancy, in particular acute leukemia, has emerged. Prolonged therapy with alkylating agents and chemotherapy plus radiotherapy are associated with an increased risk of this complication. The disease evolves through a preleukemic phase of pancytopenia and sideroblastic refractory anemia. The median onset from the initiation of chemotherapy is about 5 years with an increasing incidence with time. Myelomonocytic, monocytic and erythroleukemia with atypical features and resistance to conventional therapy predominate. Hyploidy and aberrations involving chromosomes 5 and 7 are frequent. Alkylating agents are carcinogenic in laboratory animals. Although the pathway to leukemogenesis in humans is unknown, a multistep evolution is envisaged. This involves: 1) initiation through induction of errors in DNA, 2) promotion related to stem cell replication following chemotherapy-induced aplasia and 3) propagation related to immunosuppression. It is possible that, as in myeloproliferative disorders, an underlying tendency for leukemia is present in patients with cancer. This may be accentuated by chemotherapy, and more frequently observed due to the longer survival of such patients. The crucial role of chemotherapy in leukemogenesis is evident from data accumulated in non-malignant conditions such as rheumatoid arthritis. | |
| 414344 | Floctafenine (Idarac) in the management of rheumatoid arthritis. | 1977 Nov | A double-blind controlled cross-over trial comparing floctafenine 1.6 g daily with soluble aspirin 4.0 g daily and matching placebo, in 48 patients suffering from rheumatoid arthritis, is reported. Floctafenine and aspirin gave statistically significant reduction in morning stiffness, grip strength and better subjective assessment than the placebo. There was no difference in the relief of pain between the three treatments under the conditions of this trial where paracetamol was allowed as an additional escape analgesic. During the period of aspirin therapy there was a higher indicence of concurrent complaints, faecal occult blood loss and a reduction in haemoglobin. An open long-term study in 12 rheumatoid patients receiving floctafenine 1.6 g daily for 3--6 months showed satisfactory management of their clinical condition. There were no significant or serious side-effects or change in biochemical or haematological parameters, and patients completed their course of therapy. | |
| 6626924 | The effective management of venous ulceration. | 1983 Oct | The importance of the direct perforating veins of the lower leg in the aetiology of venous ulceration is supported by the results of a 6-year study of 77 patients with 109 ulcerated legs. Incompetent perforating veins were demonstrated by examination and Doppler ultrasound, and confirmed at operation, in 108 legs. Subfascial ligation of these veins, with stripping of incompetent saphenous veins when necessary, was followed by elastic compression stockings in 44 legs (40 per cent) in which deep vein incompetence was demonstrated by non-invasive methods and phlebography. Some 91 ulcers (84.3 per cent) remain healed (76 per cent greater than 3-year follow up). Eight patients with rheumatoid arthritis in addition to venous incompetence had a 75 per cent failure rate. If these patients are excluded, 88 (92 per cent) of 96 ulcerated legs remain healed. It is submitted that these results support the argument for the importance of perforating vein incompetence in the aetiology of venous ulceration. They also suggest that a more optimistic attitude towards treatment is justified. | |
| 6985415 | [Circulating immune complexes in a population of subjects seropositive for rheumatoid fact | 1982 | The level of immune complexes has been detected with the C1q binding test in 179 subjects positive by Latex agglutination test (titre greater than 1/20). The average of C1q binding was 5.36%, significantly higher than in 30 normal blood donors. A positive correlation was observed between the percent of C1q binding and, respectively, the titre of the latex test and the erythrocyte sedimentation rate. Of the 36 patients with rheumatoid arthritis, 16 (45.7%) showed an high level of C1q binding activity (greater than 5%), as well as 4 of the 8 patients with chronic hepatitis (50%) and 11 of the 31 patients with infectious diseases. No immune complexes were detected among the 11 healthy latex positive subjects. | |
| 1258548 | [The course of adjuvant disease in rats of the strain AF/Han-EMD-SPF]. | 1976 Jan | The development of articular and osseous lesions in AF/Han-EMD-SPF breed rats with adjuvant disease was studied by morphological methods. At the noninjected side arthritic lesions with eventual progressive joint destruction appeared about the tenth day after adjuvant injection. Nearly simultaneously an incipient tumorous osteomyelitis in the bones both of injected and non-injected side was observed. Since epitheloid granuloma were also seen in the periarticular tissue of some animals the authors believe that all lesions in adjuvant arthritis are caused by a widespread dissemination of the injected complete adjuvant. | |
| 4084037 | Total condylar knee arthroplasty. A report of 2-year follow-up on 247 cases. | 1985 | Two hundred and forty-seven consecutive total knee replacements using the Insall-Burstein standard total condylar knee system with 2 years' follow-up were studied. Of the 238 available to follow-up, two were reoperated during the period, owing to infection and traumatic loosening of a tibia component respectively. Seventy-nine patients were operated for rheumatoid arthritis and 94 for osteoarthritis. In assessment of the total therapeutic result, registration of pain, walking ability, range of motion, muscle strength, flexion deformity, valgus-varus deformities, instability, and use of walking aids were included, according to a rating system. Excellent or good results were found in 91.5%; 6.5% were fair, and 2% were poor. There were two cases of infection; one resulted in removal of the prosthesis and an arthrodesis was done. There were four suspected aseptic loosenings, three cases of transient peroneal nerve palsies, and three patients who developed reflex dystrophy. | |
| 6115866 | Rectal biopsy in the diagnosis of systemic vasculitis. | 1981 Aug | Vasculitis has been seen in rectal biopsies from 22 patients over a six year period. The most common finding was a necrotising vasculitis of small arteries, indistinguishable from that seen in polyarteritis nodosa (PAN). Sub-acute, chronic ("burnt out") and leucocytoclastic changes were also seen. Sixteen patients had vasculitis complicating rheumatoid arthritis (RA), 3 PAN and 3 overlap syndromes. Patients with RA and rectal vasculitis had a higher mortality, and a greater incidence of neuropathy than those with negative biopsies. An adequate biopsy is positive in 40% of patients with clinical vasculitis and RA but was only positive in one of a control series of 46 RA patients with no clinical vasculitis. Rectal biopsy in experienced hands is a safe, and repeatable procedure. It is useful as a "blind" biopsy site in the diagnosis of systemic vasculitis, especially that complicating RA. It can also be used for serial studies of the evolution of vasculitis. Serial sections of the entire biopsy may be required to reveal the vasculitis which is often focal in nature. |