Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1014223 | [Objective control in treating arthrosis deformans of the knee joint in hospitals and unde | 1976 Oct | The aim of the present work is to study the peculiarities of upright position and walking in patients with deforming arthrosis of the knee joint and to make a conclusion as to the possibility of using biomechanical methods for an objective estimate of the efficacy of treatment in such patients. The authors examined 88 patients with deforming arthrosis of various degree of severity and marked pain syndrome. In the examination separate weighing, seismoactography, ichnography and podography were employed. Deforming arthrosis of the knee joint was found to be accompanied with significant disorders in the upright position and walking, including a decreased static stress on the affected extremity, an increased amplitude oscillations of the body center of gravity while standing on the affected extremity and others. | |
| 4377557 | Antiviral antibodies in rheumatoid synovial fluid and cryoprecipitates. | 1974 Sep | Distribution of viral antibodies was examined by the indirect fluorescent antibody technique in specimens from rheumatoid arthritis and from systemic lupus erythematosus patients. Titres in sera from rheumatoid arthritis patients were usually equal to, or greater than, those in joint fluids. Viral antibodies were found in whole cryoprecipitates from joint fluids and in the IgG fractions of the cryoprecipitates. Anti-herpes simplex antibodies were most frequently found in cryoprecipitates and were at highest titre in sera and joint fluids. Anti-respiratory syncytial virus antibodies were next in frequency and in titre. No evidence was presented to support the concept of localized viral antibody synthesis in joints of rheumatoid arthritis patients. Serum antibody titres in systemic lupus erythematosus patients were similar to those in rheumatoid arthritis patients; however, viral antibodies were not found in the serum cryoprecipitates of systemic lupus erythematosus patients. | |
| 6623020 | Comparison of three slow-release acetylsalicylic acid preparations in rheumatoid arthritis | 1983 | Nine patients suffering from chronic rheumatoid arthritis were each given single doses of 1 g acetylsalicylic acid, in the form of each of the preparations studied: an enteric-coated tablet, a microcrystalline tablet, and a capsule containing enterosoluble granules. Absorption from each preparation was good in all patients. Onset of absorption varied to some degree, but similar salicylate levels were reached within 5 hours with all preparations. In the case of enteric-coated tablets, relatively high salicylate levels persisted 12 hours after dosing, which would seem to permit twice daily dosage, regardless of the total daily dose. | |
| 7042362 | Double-blind, cross-over, international multicentre investigation of two doses of indoprof | 1981 | Indoprofen 600 mg or 1000 mg/day, ASA 3600 mg/day and placebo were administered in randomized sequences according to a multiple 4 x 4 latin square design, balancing the treatments, periods and residual effects. Each treatment lasted 7 days. A total of 98 patients suffering from classical or definite rheumatoid arthritis completed the study. Analysis of the effectiveness indicates that both doses of indoprofen and ASA are significantly more active than placebo; indoprofen 1000 mg/day was the treatment preferred in most of the cases. Both doses of indoprofen were better tolerated than ASA. | |
| 815165 | [On the mode of action of antirheumatic drugs (author's transl)]. | 1976 Feb | Since the etiology of rheumatoid arthritis presently is mostly unknown, the therapeutical efforts are focussed on attempts to influence the pathogeneic events occurring in this disease. Among the discussed pathogenic mechanisms aberration of immunereactions seem to play an important role. The drugs mainly used for basical treatment of rheumatoid arthritis are cytostatics, D-penicillamine, gold salts and chloroquine. The clinical experiences with these drugs and their mode of action are reviewed. | |
| 6608263 | Composite lymphoma: a unique case with two immunologically distinct B-cell neoplasms. | 1984 Apr | The authors recently have encountered a unique case of composite lymphoma arising in a 69-year-old man with severe long-standing rheumatoid arthritis. The neoplasm was composed of two B-cell lymphomas occurring within a single axillary lymph node: nodules of IgG-kappa nodular poorly differentiated lymphocytic lymphoma were surrounded by a diffuse growth of IgM-lambda well-differentiated lymphocytic lymphoma. It was the immunohistologic studies performed in this case that demonstrated the simultaneous occurrence of two separate monoclonal lymphocyte proliferations. Without the immunohistologic procedures, this composite lymphoma easily may have been overlooked. This unusual malignancy arose in the background of a long-standing autoimmune disease that may have played a role in its genesis. | |
| 4030848 | Long-term results of Geomedic total knee replacement. | 1985 Aug | Seventy-one Geomedic total knee replacements were reviewed retrospectively at a maximum of eight and a half years. The prosthesis was found to be successful in its primary aim of relieving pain. However, there was an overall failure rate of 18.3%. Analysis of the results by an actuarial method allowed comparison with other prostheses. The factors involved in failure are discussed. | |
| 7004171 | A quantitative enzyme immunoassay for IgM rheumatoid factor using human immunoglobulin G a | 1980 Dec | A quantitative "sandwich" enzyme-immunoassay for IgM rheumatoid factor (RF) using human immunoglobulin G as substrate covalently bound to small plastic discs is described. The findings indicate that it is a simple, sensitive, reproducible, and specific method for measuring RF activity. Test results are reported in IU/ml on the basis of the World Health Organization reference RF serum, permitting standardized reporting of this determination between laboratories using this method. Interassay and interlaboratory variability of results are less than 7%. The enzyme-linked immunosorbent assay (ELISA) results correlated well with those found by latex and bentonite flocculation titrations. A number of ELISA RF-positive specimens that were latex-negative and/or Waaler-Rose-negative were confirmed positive by inhibition of the assay with soluble aggregated human IgG, but not with nonaggregated human IgG. Comparison was made between ELISA RF results when using goat or human IgG as substrate. Human IgG was usually more reactive with RFs than was goat IgG. | |
| 1275578 | Antibody-mediated leucocyte cytotoxicity to Chang human liver cells in rheumatoid arthriti | 1976 Feb | The incidence of an IgG-antibody which induces lymphocyte cytotoxicity to Chang human liver cells in culture was estimated in the sera of patients with rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, psoriatic arthritis, Crohn's disease, ulcerative colitis, and in healthy controls. It was found in 4.1% of control subjects and in 31% of patients with rheumatoid arthritis. None of the other patient groups differed from the control group. This may be the first demonstration of an antibody response to an antigen or antigens which is almost entirely confined to patients with rheumatoid arthritis. The possibility that an antigenic similarity exists between the rheumatoid synovial membrane and Chang cells is currently under investigation. | |
| 4037888 | Ultrastructural changes in the rectal mucosa of patients with rheumatoid arthritis. | 1985 Sep | The rectal mucosa from patients with severe rheumatoid arthritis has been examined by electron microscopy. Initially the patients were biopsied for investigation into the diagnosis of amyloidosis or vasculitis, which proved to be negative. A range of ultrastructural abnormalities was found which included proliferation of the rough endoplasmic reticulum, mitochondrial inclusions, association of the mitochondria with cytoplasmic filaments, and marked increase in the number of iron containing siderosomes. Most of these abnormalities have already been reported in rheumatoid synovial tissue, and attention is drawn to the similarity in findings between these two sites. | |
| 844929 | Blood and saliva salicylate measurement in the monitoring of salicylate therapy. | 1977 Mar | Total and free plasma salicylate as well as saliva salicylate was measured in 13 patients with rheumatoid arthritis treated with different doses of acetylsalicylic acid alone. Although the clinical response was judged moderately effective to effective in all cases, total and free plasma salicylate varied markedly. Saliva salicylate correlated well with both total plasma salicylate and fre plasma salicylate. Determination of saliva salicylate may be a simple and useful technique for the monitoring of salicylate therapy. | |
| 6218948 | Once weekly administration of levamisole in rheumatoid arthritis. | 1982 | The therapeutic as well as the unwanted effects, in rheumatoid arthritis patients, of once weekly administration of 150 mg levamisole were compared, under double-blind conditions, with 3 50-mg daily doses of levamisole for 3 consecutive days weekly and placebo. The applied minimization method was used to assign patients to treatment groups so that all groups were comparable at the start of the trial. All patients were evaluated monthly, for 26 weeks. Three patients on the levamisole 3-day-weekly dosage interrupted their treatment because of side-effects. Except for the unwanted effects, the differences in the therapeutic efficacy in the 2 levamisole groups were not statistically significant. Twenty-one patients (3 in the levamisole once weekly administration group and 18 in the placebo group) interrupted their treatment because of inefficacy. Placebo was statistically less effective than the active drug. It is concluded that once weekly is as effective as 3-day-weekly administration of levamisole, but has fewer side-effects. | |
| 317895 | Markers of activated T cells on synovial fluid lymphocytes in rheumatoid arthritis. | 1979 Jan 31 | Membrane markers of activated T lymphocytes of synovial fluid of two groups of patients with various forms of arthritis were studied. The first group (group A) concerns patients affected by rheumatoid arthritis (RA), and the other (group B) includes those affected by not immunologically-mediated arthropathies as osteoarthrosis, crystal synovitis, post-traumatic arthritis. Some other arthropathies included in a third group (group C) have been considered separately. Both the receptor for human group O Rh negative erythrocytes (H rosettes forming cells) and the receptor able to bind at 37 degrees C sheep red blood cells (stable-E-rosette forming cells) respectively were used as markers for the identification of activated T lymphocytes. The results show a marked increase of activated T cells in group A in comparison to group B. So the possible causes of this lymphocyte activation in rheumatoid patients are suggested. | |
| 6614838 | Medical management of rheumatoid arthritis with emphasis on the Western Pacific Region. | 1983 Apr | There are regional differences in the prevalence and severity of Rheumatoid Arthritis in the Asian and Western Pacific Regions. Medical management of the condition will depend very much on the assessment of disease activity. Non-steroidal anti-inflammatory drugs in full dosage should always be the first choice of treatment. Their popularity however varies from country to country depending partly on the availability and partly on the cost structure that the Department of Health has been able to negotiate with the manufacturer. | |
| 6158571 | Alternative pathway complement activation in rheumatoid arthritis. | 1980 Jul | Serum and synovial fluid (SF) levels of the complement components C3, C5, factor B (B), properdin (P), beta 1H and C3b inactivator (C3bINA), and EDTA-plasma and SF concentrations of C3d and Ba were measured in 40 rheumatoid arthritis (RA) and 5 patients with osteoarthritis. Decreased SF concentration of B and P and increased levels of Ba showed that increased alternative pathway turnover occurred in RA. Reduced SF C3bINA concentrations occurred, but levels of beta 1H were not reduced. The results showed that alternative pathway turnover was dependent upon C3 turnover, but failed to support the notion that levels of C3bINA or beta 1H control alternative pathway turnover in RA. | |
| 4564764 | Orudis in management of rheumatoid arthritis and osteoarthrosis of the hip: comparison wit | 1972 Nov 18 | In double-blind cross-over studies in 46 patients with rheumatoid arthritis and in 42 patients with osteoarthrosis of the hip, Orudis-a new non-steroidal anti-inflammatory agent-has been shown to be well tolerated and to have comparable therapeutic efficacy with indomethacin when given in equal dosage. Side effects were less severe with Orudis. The results suggest that Orudis will prove valuable in the clinical management of rheumatic diseases. | |
| 6240837 | [Etiopathogenetic aspects of psoriatic arthritis with special reference to immunologic fac | 1984 Nov 1 | On 21 patients with psoriasis and 22 with psoriatric arthritis examinations for the recognition of the immune regulation were performed and the results were compared with those of healthy control persons and patients with rheumatoid arthritis. The psoriatric arthritis shows humoral as well as cellular disturbances of immune regulations which in the group comparison with the psoriasis and the rheumatoid arthritis partly have communities, but partly also have differences. With regard to size and distinction of the disturbances the patients with rheumatoid arthritis have the highest degree of severity. With the help of the techniques used by us systemic cellular disturbances of the immune regulations could not be proved in the psoriasis. The psoriatic arthritis to a certain extent occupies a medium position. But a clear coordination of these disturbances into the pathogenetic process is not yet possible. | |
| 581629 | [Rheumatoid factors in Basedow's disease]. | 1978 Nov | In patients with untreated Basedow's disease rheumatoid factors were determined by Waaler-Rose and Latex tests. The Waaler-Rose test was positive in 61.5% of 143 cases. After the acute disease stage settled the titers fell in more than 90% of the re-tested cases. In 50% the decrease in titre was of two dilutions or more. The Latex test was carried out in 152 patients. It was positive in 9.2% of the cases and became negative in 50% of the cases after the acute disease stage settled. In 5 out of 6 patients in whom the test remained positive there was in addition a rheumatic disease. The detectable rheumatoid factors are regarded as auto-antibodies against immuno-globulins. This suggests that polyarthritis in Basedow's disease is based on the same pathogenetic mechanisms as rheumatoid arthritis. | |
| 6586181 | Extended haplotypes of chromosome 6 in adult rheumatoid arthritis. | 1984 May | In 46 patients with rheumatoid arthritis (RA) the allele C4B*3 occurred in 6 patients, while among 350 normal controls, it occurred 6 times (P less than 0.00002). Among 9 white and 1 black families, each of which had 2 or more members with RA, there were 36 haplotypes associated with RA. An extended haplotype (specific HLA-B, DR, complotype haplotypes in significant linkage disequilibrium) containing C4B*3: HLA-B15, DR4, BF*S, C2*C, C4A*3, C4B*3, was found twice (P less than 0.001) among whites with the disease-associated chromosomes. | |
| 6514305 | The use of Amsler grids in early chloroquine retinopathy. | 1984 Nov | A survey of Canadian ophthalmologists and rheumatologists suggests that there is a significant incidence of definite chloroquine retinopathy in their patients. As hydroxychloroquine and chloroquine appear to be better tolerated and less toxic than some other drugs used in the treatment of rheumatoid arthritis and systemic lupus erythematosus, there is a need for a simple, patient-administered test for early diagnosis of chloroquine retinopathy. The Amsler grid and smaller Yannuzzi modified Amsler grid are simple, inexpensive, and correlate well with scotomas found with static and kinetic perimetry. |