Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6525967 | [Photoallergic reaction to carprofen]. | 1984 | Carprofen, a non-steroidal anti-inflammatory drug of the arylpropionic acid derivative type, can provoke both phototoxic and--as in the reported case--photoallergic reactions. | |
| 6605081 | [Detection and clinical evaluation of antibodies against soluble nuclear antigens]. | 1983 May | The presence of anti-nuclear antibodies (ANA) is particularly common in the group with so-called "systemic rheumatic disease". Routinely these antibodies are detected by indirect immunofluorescence techniques using different substrates since they are non-organ and non-species specific. Nowadays the detection o ANA in a particular patient is not enough further study must be done to identify the antigen responsible for that pattern. Many different nuclear antigens have been described. In this review, we comment on the detections, clinical significance and incidence of antibodies produced against certain specific nuclear antigens: the saline extractable nuclear antigen (ENA). These antigens have been detected indirectly by using immunodiffusion, counterimmunoelectrophoresis by bringing into contact the patient's serum and nuclear antigenic extracts from different sources. | |
| 6488639 | Fusion of the first metatarsophalangeal joint in forefoot arthroplasty. | 1984 Nov | Forefoot arthroplasty is often recommended for the management of metatarsalgia secondary to rheumatoid arthritis. Concurrently, the first metatarsophalangeal (MP) joint can be fused rather than excised. The results in 37 patients with 64 arthroplasty operations (34 with fusion and 30 with excision of the first joint) show that fusion produced a better cosmetic appearance of the foot, facilitated fitting with normal shoes, and improved overall balance. Pedobarograph measurements during gait indicated that relatively more weight was transmitted through the medial ray when the first metatarsophalangeal joint was fused. Residual pain in the foot was often caused by irregular trimming of the metatarsals. There was no difference in relief of pain between fused and unfused patients. Failure of fusion at the first metatarsophalangeal joint generally was painless. Radiologic degeneration of the interphalangeal (IP) joint of the great toe was relatively common following fusion. MP joint fusion is inadvisable if there is already disease in the IP joint. | |
| 6413686 | Family studies in RA - the importance of HLA-DR4 and of genes for autoimmune thyroid disea | 1983 Aug | The segregation of HLA haplotypes with rheumatoid arthritis (RA) was studied in 13 selected, multicase families. HLA-DR4 was present in 77% of RA probands (32% controls). No single haplotype was associated with RA in different families. Analysis of HLA haplotype sharing in affected relatives showed no significant difference to the expected distribution. It seems likely therefore that the HLA-DR4 antigen itself rather than a linked susceptibility gene predisposes to RA. In 2 of 3 HLA-DR4 negative families, there were members with autoimmune thyroid disease. It is suggested that genetic susceptibility to RA may be associated with both HLA-DR4 and genes for autoimmune thyroid disease. | |
| 7203455 | Nodular transformation (nodular "regenerative" hyperplasia) of the liver. A clinicopatholo | 1981 Jan | Nodular transformation, a rare hyperplastic condition of the liver, has been reported in patients with rheumatoid arthritis, Felty's syndrome, the CRST syndrome, and myeloproliferative disorders. Associated disorders in the present clinicopathologic study of 30 cases included the foregoing as well as extrahepatic neoplasms, endocrine disorders, and other diseases producing immune dysfunction; some patients had received drug therapy for a prolonged time. Clinically nodular transformation may be confused with cirrhosis; histologic evaluation of liver biopsy material is essential for diagnosis. Complications include portal hypertension, hepatic failure, and rupture of the liver. Histologic and experimental evidence suggests that nodular transformation is preneoplastic, possibly giving rise to hepatocellular adenomas or carcinomas. Experimental and clinical data suggest that drugs should be considered as possible etiologic factors in the development of the nodules. | |
| 75659 | Antibodies against double-stranded DNA in patients with connective tissue diseases. Compar | 1978 | Antibodies against double-stranded (ds) DNA were demonstrated by an immunofluorescence technique using Crithidia luciliae kinetoplast as antigen, and by means of the Farr technique. Both techniques were used simultaneously in 172 sera from patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), temporal arteritis (TA) and from healthy controls. Comparable results were obtained with the two techniques. SLE patients with active disease had higher titres of IgA antibodies than patients with inactive disease. Of the patients with RA and JRA, 10% had significant titres of dsDNA antibodies. Patients with TA and normal controls had either no dsDNA antibodies in their sera or very low titres without complement-fixing properties. | |
| 213904 | [Detection of collagenase in passive haemagglutination using collagen-coated erythrocytes | 1978 Oct 27 | Human rheumatoid arthritis (RA) collagenase and bacterial collagenase were shown to agglutinate collagen-coated erythrocytes. Native collagens of type I and type II reacted equally well, while denatured collagens showed less distinct agglutination activity. The sensitivity of the method for the detection of purified bacterial collagenase from Clostridium histolyticum is very high (100 pg). It is, however, low for human RA collagenase. The agglutination reaction is not inhibited by concentrations of native collagen causing distinct inhibition of anticollagen sera (2mg%). EDTA inhibits the agglutination completely. | |
| 310998 | Diagnosis of rheumatic disease. 1. Radiographs. | 1979 Mar | Radiographs are a clinician's most valuable tool in differential diagnosis of rheumatic disease and in assessment of its severity. The patterns of joint involvement and the specific bony changes characteristic of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, Reiter's syndrome and psoriatic arthritis, gout, and systemic lupus erythematosus are discussed here. | |
| 942501 | Antibody-dependent cell-mediated cytotoxicity in rheumatoid arthritis. Effect of rheumatoi | 1976 Jul | Reduced antibody-dependent cell-mediated cytotoxicity (ADCC) was demonstrated in lymphocytes of patients with rheumatoid arthritis (RA). Rheumatoid factor (RF) positive sera inhibited ADCC of normal lymphocytes by reacting both with effector and target cells (sensitized chicken red blood cells). These sera were fractionated by specific adsorption or gradient ultracentrifugation, and isolated RF or RF negative fractions were tested for their ability to inhibit ADCC by reacting with normal human lymphocytes or target cells. RF was ineffective on normal lymphocytes but it strongly inhibited the reaction by interaction with target cells. IgG RF negative fractions of certain sera were inhibitory by direct interaction with effector cells. | |
| 6762043 | Cell-mediated immune reactivity to ocular antigens in rheumatoid arthritis. | 1982 Oct | Fourteen patients with rheumatoid arthritis were tested for the presence of cell-mediated immune reactivity to various ocular antigens by means of the leucocyte migration inhibition test. A significant difference in leucocyte migration was found between patients and healthy controls after incubation of their cells with purified rhodopsin, uveal pigment granules or soluble uveal antigens, but not with rod outer segments or soluble retinal antigens. Some indications have been obtained that the sensitization to rhodopsin in fact originates from a sensitization to connective tissue structural glycoproteins. | |
| 2990628 | Radio-isotopic joint scans in haemophilic arthritis. | 1985 Aug | The majority of severe haemophiliacs will develop a crippling arthritis consequent upon recurrent haemarthroses although the pathogenic mechanism remains unclear. We have carried out technetium-99 pertechnetate joint scans in the elbows, knees and ankles of 23 haemophilic patients and compared the isotope uptake of the 15 patients with clinical and radiological evidence of arthritis to that of eight patients without arthritis, to 13 age-matched healthy male controls, and to 10 age-matched males with active rheumatoid arthritis. Isotope uptake into the knee joints was significantly higher in haemophilic arthritis than in controls, haemophiliacs without arthritis, and patients with rheumatoid arthritis [median percentage uptake of administered technetium (Tc) dose X 10(3) in right knee = 9.4, 6.2, 6.4 and 6.6, respectively]: and the differences from haemophilic arthritis were all significant (p less than 0.01, Mann-Whitney U test). Similar differences were seen in the elbows and ankles. Increased Tc uptake correlated strongly with frequency of haemarthrosis, pain, synovitis, range of movement and radiological changes in knees and elbows, but poorly with the lesser changes seen in the ankles. These results would support the theory that haemophilic arthritis amongst the inflammatory arthropathies and that scanning is an appropriate technique for following progression of joint disease. | |
| 7012343 | A controlled study of group counseling in rheumatoid arthritis. | 1981 Jan | Group counseling and education were studied in patients with rheumatoid arthritis (RA). Patients were matched and randomly assigned to a control (CG) or experimental (EG) group. Each group attended an educational session but only the EG participated in 12 weekly group counseling sessions. A test of knowledge about RA and psychological tests were administered before and after these sessions. The EG improved their scores in 2 areas of self-concept and in factual knowledge. There was no increase in depression level. These results provide evidence that formal educational sessions and group counseling may be important in the management of patients with RA. | |
| 7204431 | The role of manipulation following total knee replacement. | 1981 Mar | During a twelve-month period, 23 per cent of a series of knees undergoing total replacement were manipulated two weeks postoperatively to increase flexion. While manipulation achieved an immediate increase in flexion from a mean of 71 degrees to a mean of 108 degree, by one week after manipulation the mean flexion was reduced to 88 degrees. By one year postoperatively, the manipulated knees were found to have a range of motion similar to that of their non-manipulated counterparts. Such factors as preoperative flexion and diagnosis appear to be the major determinants of ultimate flexion, and they seem to offset the temporarily increased flexion afforded by manipulation. The primary reason for manipulation is to facilitate the postoperative rehabilitation program for patients with painful, limited motion of the knee. | |
| 4425914 | Vitamin D deficiency, spontaneous fractures, and osteopenia in rheumatoid arthritis. | 1974 Nov 23 | Spontaneous, undisplaced fractures occurred in the long bones of five patients with longstanding rheumatoid arthritis. The results of biochemical, radiological, and dietary investigations in these patients were compared with those in a larger group of elderly women with rheumatoid arthritis without fractures. A significant association between skeletal rarefaction, calcium x phosphate product, and vitamin-D intake was shown in the whole group. Bone biopsies were performed in three patients with fractures, and histological evidence of osteomalacia was found in two patients. Dietary vitamin-D deficiency seems to play an important role in causing both the fractures and the osteopenia of longstanding rheumatoid arthritis. | |
| 6602308 | [Proglumetacin: a flexible and broad-spectrum antirheumatic agent]. | 1983 Jun 23 | Fifty-five patients with osteoarthritis, rheumatoid arthritis or spondyloarthritis, joint pain and other rheumatic-inflammatory disorders were treated with proglumetacin, at different doses, during 3-60 days. Assessment of therapeutic efficacy indicated 88.9% of good results. Joint pain progressively decreased during the whole period of observation. Tolerance was considered good or very good in 78% of patients. | |
| 1271390 | Abnormal esophageal motility in primary Sjögren's syndrome. | 1976 Mar | Esophageal monometric studies were done in 10 unselected patients with Sjögren's syndrome, not associated with other connective tissue or chronic active hepatic disease. Nine of the patients revealed abnormal esophageal motility, consisting of absent or decreased contractility in the upper third of the esophagus. In four patients, the dysfunction also extended to other portions of the organ. Dryness of the mouth and oropharynx, or mucosal atrophy, does not explain these findings. The uniform pattern of the esophageal dysfunction found in patients with primary Sjögren's syndrome, which differs from the patterns of involvement observed in other connective tissue diseases, suggests that primary Sjögren's syndrome is probably a distinct entity. | |
| 6907089 | Therapeutic uses of copper-chelating agents. | 1980 | Equilibrium analysis of a model system for the in vivo reactions between penicillamine and copper (I), the penicillamine--glutathione--Cu(I) system, indicates that in a certain concentration range the therapeutic use of penicillamine will not disturb the normal Cu(I) metabolism. The equilibrium data required for this analysis were obtained by e.m.f. titrations on the Cu(I)-glutathione (H3A) and on the Cu(I)-penicillamine (H2A) systems at 25 degree C, in 0.5 M NaClO4 medium, using glass and copper amalgam electrodes; the data were analysed first by various graphical methods and then by a general least-squares computer program. The results show that mononuclear Cu(I) species, Cu(HA)2, from in both systems; in addition, the polynuclear Cu5A4(3-) species forms in the penicillamine system and the mononuclear CuHA- species might form in the glutathione system. The results are discussed in relation to the therapeutic use of penicillamine. | |
| 675210 | [Correlations between inflammatory activity, immunoglobulins and complement components in | 1978 Jul 29 | In 81 synovial fluids (39 from rheumatoid arthritis and 42 from osteoarthritis patients), levels of IgG, IgM, IgA, and complement components C3, C4, and C3-proactivator were estimated. Lactatedehydrogenase (LDH) was used as the parameter of inflammatory activity. With increased LDH activity, the concentrations of all immunoglobulins rose in both groups. In the complement components, this positive linear correlation was demonstrated only in the osteoarthritic group. In rheumatoid arthritis, the results were best demonstrated by means of a regression type curve of the 3rd degree (p less than 0.01). In low inflammatory activity there was a rise in the level of the complement components. With higher LDH activity (greater than 500 U/l), however, there was a drop in the curve and the positive correlation changed to negative. | |
| 6984537 | Clinical rheumatoid vasculitis associated with the B8 DR3 phenotype. | 1982 | A statistically significant association of clinical rheumatoid vasculitis (excluding nodules or nail-fold infarcts only) with the HLA B8 DR3 phenotype was found when comparing 30 patients with vasculitis with 84 classic or definite rheumatoid patients without clinical vasculitis. The previously reported association on HLA DR4 with rheumatoid disease was also confirmed. | |
| 313796 | A review of the use, evaluations, and criticisms of the preliminary criteria for the class | 1979 Aug | The use of the Preliminary Criteria for the Classification of Systemic Lupus Erythematosus (SLE) has been reviewed. Most authors describing 10 or more patients have used the criteria. Although originally designed for classification of patients, the criteria have often been used for the diagnosis of SLE. The sensitivity of the criteria was evaluated and found to be similar to the 90% reported in the original ARA trial. Studies on specificity yielded conflicting results. Various suggestions to improve the criteria have been made, including a more detailed description of some of the organ involvements and the adoption of laboratory tests that have been improved since or were unavailable at the time of original publication of the criteria. |