Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6984776 | Epidemiology of rheumatic diseases in Finland in 1964-76. | 1982 | Finnish national interview surveys show that the prevalence rate of self-reported chronic rheumatic disease was 8.8% of the adult population in 1964 and 13.3% in 1976. Most of these diseases were back complaints, which also showed a rapid increase. The prevalence rate of osteoarthritis was 3.2% in 1976, and that of rheumatoid arthritis 1.2%. In 1964 45% and in 1976 more than 60% of the chronic rheumatics reported other chronic diseases as well. 10% were severely and one third slightly restricted with mobility in 1976. Also certain psychic symptoms were surprisingly common among them, and 42% used regularly analgesics. The occurrence of these diseases seems to be associated with socioeconomic changes. The prevalence rate was highest in the poorest areas with negative immigration. Of the working-aged population the diseases were commonest among agricultural workers in 1964, and among disability pensioners retired from this occupational group in 1976. Because of its magnitude and multiple problems this group has become a special challenge to the health care system. | |
| 1084941 | Estimation of IgG-antiglobulins in sera of patients with rheumatoid arthritis and chronic | 1976 Jul 1 | Antiglobulin factors of the IgG class were measured in human sera by a modified immunoadsorbent-technique involving absorption to and elution from insoluble preparations of horse IgG. 32 mg of horse IgG insolubilized with bisdiazotized benzidine were used for quantitative immunoadsorption of IgG antiglobulins from 100 mul serum. Different IgG-antiglobulin concentrations could be obtained in two control groups differing in age. Elevated IgG-antiglobulins levels were found both in seropositive (mean value 23.21 +/- 7.08 mug/ml serum) and seronegative (mean value 20.06 +/- 8.39 mug/ml serum) RA patients. High values of IgG-antiglobulins were found in chronic liver disorders, particularly in the group of CAH patients (mean value 25.10 +/- 6.1 mug/ml serum). | |
| 681406 | The Liverpool Mark II knee prosthesis. A preliminary report. | 1978 Aug | This is a preliminary report of the results of knee joint replacements using the Liverpool Mark II knee joint system which consists of a bicondylar prosthesis and a set of stereotactic instruments. The prosthesis has been developed from Gunston's concept, and the special instruments ensure its accurate insertion through meniscectomy-type incisions placed on either side of the patella. Particular features of the prosthesis are near-normal articulation, and the simplicity of the operation. Sixty-two knee replacements were implanted in forty-two patients between the spring of 1974 and January 1977. After the operation fifty-six knees were painless and four others produced only slight pain. Full extension was obtained in fifty-eight knees, and none showed a valgus or varus deformity. Collateral laxity was absent in all knees. There were two failures. These early results are most encouraging. | |
| 6787721 | An oral formulation of gold for the treatment of rheumatoid arthritis. | 1981 Jun 27 | Twenty-two patients with active rheumatoid arthritis were entered into a trial during which an oral gold formulation was administered at two dosages (4 mg/d and 6 mg/d) for 12 weeks. Seventeen patients completed the trial. Both dosages produced a similar improvement in the indices of inflammation. Five patients were not benefited by the treatment, adverse side-effects were reported in 10 and 5 were withdrawn from the trial. | |
| 6903794 | Toward an epidemiology of work disability. | 1980 Summer | The indirect cost of illness due to lost wages exceeds the cost of medical services by a large margin. Social characteristics of persons with physical impairment are more important than the characteristics of their medical condition in predicting whether disability will lead to work loss. Public policy toward disability currently emphasizes the "human capital" with which persons with impairments confront the labor market; this study suggests a new emphasis on social characteristics of the workplace. | |
| 766433 | [Possibilities of differentiation of antinuclear antibodies]. | 1975 Oct 15 | Antinuclear antibodies can give diagnostic informations according to their titre values, the belonging to different classes of immune globulins and on the basis of different patterns of immunofluorescence connection. The determination of granulocyte-specific antibodies which frequently appear in progressive chronic polyarthritis further contributes to the differential-diagnostic classification of diseases of the connective tissue. An antibody against extractable nuclear antigen is specific for the so-called mixed connective tissue disease, an antimitochondrial antibody for the pseudo-LE-syndrome. Moreover, the own examinations resulted in a particularly high and frequent ability of complement fixation of the antinuclear factors in systematic lupus erythematosus and sclerodermy. In contrast to this in the progressive chronic polyarthritis the complement fixation was clearly more insignificant. | |
| 6243465 | Studies of serum immunoglobulin binding to synovial fibroblast cell cultures from patients | 1980 Jan | Using a sensitive 125I-protein A (PrA) binding assay to detect cell surface IgG, we have studied seven different synovial fibroblast cell cultures from patients with rheumatoid arthritis (RA). When these cultures were incubated in the presence of serum from 18 autologous and allogeneic RA patients (all seropositive), we were unable to detect significant IgG binding. Since IgM rheumatoid factor (RF) can block PrA binding, sera were absorbed with aggregated IgG to remove RF without affecting the results. Similar studies on three cell lines with seven rheumatoid sera were performed by antibody-dependent cell-mediated cytotoxicity. No significant cytotoxicity was observed. Since antibodies to collagen are present in rheumatoid sera, several cultures were incubated with ascorbic acid (12.5 microgram/ml) to optimize synthesis of cell surface collagen. These culture conditions did not affect serum immunoglobulin binding by the 125I-PrA assay. Thus, we can find no evidence for a direct humoral immune mediation of synovial proliferation in rheumatoid arthritis. These data do not support the hypothesis that the inflammatory process within the synovium of RA patients is an immunologic response to a fibroblast-associated antigen in the synovial membrane. | |
| 796946 | A clinical study of ketoprofen suppositories. | 1976 | Ketoprofen administered via the rectal route seemed to be valuable when given at night to patients with various rheumatic syndromes and may be particularly useful for patients who show gastric intolerance of the capsules. Anal intolerance was noted in 12% of the patients. | |
| 1104631 | The anatomy of the metacarpo-phalangeal joints, with observations of the aetiology of ulna | 1975 Nov | One hundred normal fingers were dissected and arthrographs obtained by injection of chromopaque-gelatin mixture, allowing comparison between the radiographic and macroscopic configuration of the synovial capsule. Synovial recesses protruding from each side of every metacarpo-phalangeal joint were found in relation to the collateral ligaments and corresponding exactly with the site of radiological erosions. A group of bursae lying on the superficial aspect of collateral ligaments were also demonstrated. A rudimentary intra-articular meniscus was found. The results of examination of the insertions of the interossei showed differences from traditional descriptions. The cause of rheumatoid deformity was suggested to be the rheumatoid process arising in the lateral recesses and lateral bursae, weakening the collateral ligaments, which give way in the directions of the deforming forces. These are derived from the long flexor tendons, which were shown to exert an ulnar and volar strain on the metacarpo-phalangeal joint of every finger during grip. | |
| 4096127 | [Demonstration of increased influenza-A-antibody levels in the serum of patients with chro | 1985 Nov | Patients with rheumatoid arthritis show increased levels of anti-influenza-A antibodies in their sera compared to healthy controls and patients with other inflammatory rheumatic diseases (systemic lupus erythematosus, ankylosing spondylitis and psoriatic arthritis). These antibody levels are dependent on the activity of rheumatoid arthritis. | |
| 6986149 | 5-Thiopyridoxine in rheumatoid arthritis: clinical and experimental studies. | 1980 Jan | Twelve patients with rheumatoid arthritis who had failed to respond to or developed side effects preventing further use of penicillamine were given 5-thiopyridoxine (5-TP). These patients were compared with 48 patients with similar indications randomly assigned to placebo or penicillamine. Both 5-TP and penicillamine were superior to placebo, and the effectiveness of the two active drugs was similar. Both produced a gradual amelioration of symptoms and signs of the disease accompanied by reduction in erythrocyte sedimentation rate, rheumatoid factor titer, and immunoglobulins. Nine patients on 5-TP were able to continue treatment with good control of the disease for at least 18 months. Toxic effects included rashes, proteinuria, loss of taste, and mouth ulcers. Patients who had developed a particular side effect with penicillamine did not necessarily do the same with 5-TP. This is the second mercaptan compound which has suppressive effects on the clinical and laboratory features of rheumatoid arthritis. Because of their similarities, 5-TP and penicillamine were studied in various experimental systems in an attempt to find some common biochemical or pharmacologic action. Among the properties studied were the effects on copper, vitamin B6 metabolism, dermal collagen, and mixed disulfide formation. Results with animal models of inflammation were also examined. The only common action was enhancement of the secondary lesions of adjuvant arthritis. | |
| 6495889 | [Telangiectasias in progressive systemic sclerosis (generalized scleroderma). Observation | 1984 Jul | 120 patients with progressive systemic sclerosis (PSS) were studied and subdivided into five groups according to the PSS classification of Giordano et al. ("acute diffuse scleroderma", "intermediate syndrome", "acrosclerosis sensu stricto", "sclerodactylia" and "sclerosis sine scleroderma"). In all five subgroups telangiectasias incidence was high (from 75% to 100%). The "ramosus" and "telangiectatic mats" types occur more frequently than other forms of telangiectasias. The former particularly involves the face, neck and chest; whereas the latter more usually involves the upper extremities and is the only type which appears at the lips. Cuticular telangiectasia is a third type, as important as the others but less frequent. The incidence of telangiectasias is related to disease duration. Similar telangiectasias have been observed in rarer patients with other connective tissue diseases (SLE, RA, dermatomyositis and undifferentiated connective tissue diseases). | |
| 6484445 | Lactate levels in Brucella arthritis. | 1984 | In this study the synovial fluid cell types and the synovial fluid lactate levels of patients with Brucella, septic rheumatoid, gouty and osteoarthritic mono-arthritis are presented. It is shown that lactate levels coupled with the clinical picture and the cell type of the synovial fluid appear to be an early additional diagnostic marker for the differentiation between septic, inflammatory and brucella-induced mono-arthritis. | |
| 6499302 | The overall mortality rate in patients with total hip arthroplasty, with special reference | 1984 Dec | The mortality rate was calculated in 1385 patients with total hip arthroplasties compared with the population at risk in the period from 1968 to 1981. In elderly women with coxarthrosis, after the age of 70, the mortality rate decreased after the first postoperative year. There was no such effect in men. In women, there were no changes in mortality rate in those who had had revision operations, whereas in men operated on for coxarthrosis who were over the age of 70, there was an increased mortality rate after the first postoperative year following revision. Patients operated on for complications after hip fracture and/or rheumatoid arthritis had an increased mortality rate after the first postoperative year, including both women and men below age 70. | |
| 6699159 | Palm thorn synovitis. | 1984 Mar | This retrospective study compares the results of extensive versus limited synovectomy at the time of palm thorn removal from a joint space. Patients treated by primary extensive synovectomy obtained complete relief of symptoms; patients who underwent limited synovectomy required subsequent extensive synovectomy. | |
| 151703 | [Prolapse of the iris through spontaneous perforation of the cornea and pathological costa | 1978 Jun | A case of spontaneous corneal ulcer with iris prolapse is reported in a patient suffering from rheumatoid arthritis. The concomitant presence of a pathological costal fracture, recognised to be steroid nature, suggests a correlation between the corneal manifestations and the corticosteroid therapy to be established. | |
| 7337967 | Evaluation of six tests for circulating IgG complexes with special reference to IgM rheuma | 1981 Oct | Six tests for circulating immune complexes (CIC) developed in four laboratories and representing four main principles [affinity of human platelets, Clq, of RF for aggregated IgG, and of conglutinin (Kg) for complex-bound C3] were evaluated on series of SLE and definite RA. All tests detected human model complexes in the presence of NHS and discriminated the patient series from the blood donor series, most powerful being the PIPA (platelet test). The high correlation between the RF-binding inhibition tests (RFbI) and the RF-latex test suggested interference due to intrinsic RFs. This received further support from experimental analyses in which RA sera mixed with varying doses of heat-aggregated IgG were assayed by the pRFbI test. | |
| 7274937 | [Interaction problems in the therapy with steroid-free anti-rheumatics]. | 1981 Aug 27 | In a review the known interactions between non-steroidal antirheumatic drugs and others are summarized. Of clinical importance are interactions with digitalis, anticoagulants, oral antidiabetics, beta receptor antagonists, antihypertensive drugs, and diuretics. Interactions may occur if uricosurics or anticonvulsive drugs are administered together with non-steroidal antirheumatic drugs. Interactions are observed between different antirheumatic drugs when administered together. Undesirable side effects induced by drug interactions can be avoided by means of administration of suitable drugs in those cases in which a combined treatment is necessary. | |
| 6406212 | Severe pseudomembranous and ulcerative colitis during gold therapy. | 1983 Mar | A case of severe pseudomembranous and ulcerative colitis is described in a 58-year-old patient with rheumatoid arthritis receiving sodium aurothiomalate. Watery diarrhea occurred after the fourth injection (total amount 130 mg). Several months elapsed prior to full recovery after discontinuation of gold administration. | |
| 6859964 | Inhibition of cartilage breakdown by hydrocortisone in a tissue culture model of rheumatoi | 1983 Jun | Bovine nasal cartilage discs cocultured with human rheumatoid synovial membrane or synovial-membrane-conditioned media release proteoglycan largely as a result of cartilage breakdown. We assessed the effects of hydrocortisone on proteoglycan distribution between cartilage and culture medium, and on cartilage breakdown expressed as the release of either proteoglycan or 35S-products from prelabelled discs. The presence of synovial membrane inhibited the capacity for net proteoglycan synthesis, preventing its accumulation in cartilage; this was little affected by hydrocortisone. The major response to pharmacological concentrations of hydrocortisone was suppression of both spontaneous and synovial-membrane-induced cartilage breakdown. The autolysis of synovial protein that normally occurred during culture was similarly prevented by comparable doses of corticosteroid. Changes in chromatographic distribution of the 35S-labelled degradation products released from cartilage conformed with a corticosteroid-induced inhibition of endogenous lysosomal or related proteinase activity. Additionally, inhibition of the early events in synovial membrane that are responsible for chondrocyte-mediated breakdown of cartilage may contribute significantly to the overall corticosteroid effect. |