Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 224682 | Effects of D-penicillamine on lymphocyte modulation of synovial collagenase production. | 1979 Jun | While D-Penicillamine is effective in the treatment of rheumatoid arthritis, its mechanism of action is unknown. In this study, effects of D-Penicillamine on collagenase production by adherent rheumatoid synovial cells were investigated. D-Penicillamine did not directly affect the synovial collagenase production. However, lymphocyte-free-supernatant (LFS) recovered from lymphocytes exposed to D-Penicillamine in vivo and in vitro significantly reduced collagenase production by adherent synovial cells. LFS from lymphocytes of normal subjects and from non-D-Penicillamine treated rheumatoid patients stimulated collagenase production. These investigations indicate that D-Pencillamine indirectly affects collagenase production by cultured synovial cells and suggests beneficial effects on controlling the primary disease process. | |
| 6612201 | [Lymphocytic arthritis. 54 cases, of which 25 appear to be idiopathic]. | 1983 Jun | The authors studied rheumatological disorders possibly accounting for significant articular lymphocytosis (greater than or equal to 90 percent). A precise diagnosis was established in 29 of 54 cases: haemophilic arthritis (3 cases), villonodular synovitis (3 cases), tubercular arthritis (1 case), rubella (1 cases), aseptic arthritis of Osler's endocarditis (2 cases), necrosis of the inner condyl (1 case), Gougerot-Sjögren syndrome (1 case), classical rheumatoid polyarthritis (8 cases), probable (7 cases). The other 25 patients suffered from: polyarthritis (7 cases), oligoarthritis (1 case), biarthritis (8 cases) and monoarthritis (9 cases) of undetermined etiology. Besides articular lymphocytosis, clinical radiological and histological study of these patients indicates that this is a distinct rheumatological entity. | |
| 6771070 | Antibodies to extractable nuclear antigens in rheumatoid arthritis: relationship to vascul | 1980 Jan | Antibodies to extractable nuclear antigens (ENA) were analysed in the sera of fifty-two patients with severe rheumatoid arthritis (RA) who were divided into two categories: twenty-five with arthritis only and twenty-seven with extra-articular disease. Using haemagglutination, counterimmunoelectropheresis (CIE) and double diffusion, antibodies to ENA were detected in three (12%) of the patients with arthritis only. In the group with extra-articular disease, antibodies were found in sixteen (59%) of the patients. In ten patients the antibodies reacted with an RNase and DNAse resistant, but trypsin sensitive protein component of ENA. These patients all had extraarticular disease with digital vasculitis being a particularly common feature. Their sera also contained circulating immune complexes detected by elevated cryoprecipitate protein levels associated with relatively low complement levels. It is suggested that antibodies to soluble proteins of nuclear origin may be markers of circulating immune complexes in extra-articular RA. | |
| 6208856 | Immunisation of guinea-pigs with circulating immune complexes from patients with rheumatoi | 1984 Oct | Sixteen guinea-pigs were immunised with immune complexes isolated from serum of nine patients with rheumatoid arthritis. The resulting antisera were analysed by radioimmunoassays. All guinea-pig sera were extensively absorbed with normal human serum. After this absorption eight guinea-pig sera contained antibodies specific for immune complexes isolated from the sera of three patients. One of these antisera reacted not only with immune complexes (and serum) from the corresponding patient but also with immune complexes (and sera) from other patients with rheumatoid arthritis. The antigen(s) to which the guinea-pig antibodies were directed sedimented as IgM, and they bound to IgG Sepharose. Therefore the guinea-pig sera were absorbed with IgM-rheumatoid factors isolated from the serum of the corresponding patient. After this absorption, the guinea-pig sera had lost their reactivity with immune complexes. We conclude that these antisera did not detect an exogenous antigen in immune complexes from patients with rheumatoid arthritis. The positive reactions found were due to antibodies specific for (idiotypic?) antigenic determinants on IgM-rheumatoid factors. | |
| 1079727 | Immunoglobulin synthesis by peripheral blood cells in systemic lupus erythematosus. | 1975 May | A study of the immunoglobulin (Ig) synthesis by peripheral blood cells of patients with systemic lupus erythematosus (SLE), rheumatoid arthritis, and controls was carried out. Synthesis was markedly elevated in patients with active SLE, whereas patients with the active SLE or RA showed normal values. Treatment of 3 patients with active SLE resulted in a reduction of Ig synthesis that correlated well with the disappearance of disease activity. There results indicate that the abnormal immune process in active SLE, characterized by intense B-lymphocyte stimulation, is associated with the appearance of more highly differentiated B cells in the blood. | |
| 6751336 | Serum pepsinogen I in rheumatic diseases. Reduced levels in Sjögren's syndrome. | 1982 Sep | Group I pepsinogens were measured by radioimmunoassay in the sera of 93 patients with rheumatic diseases and 99 controls. Patients with rheumatoid arthritis and systemic lupus erythematosus had levels of pepsinogen I similar to controls, whereas patients with Sjögren's syndrome had levels significantly lower than either controls (P less than 0.001) or patients with rheumatic diseases not associated with sicca syndrome (P less than 0.001). The concentrations of serum pepsinogen I were lower in patients with sicca syndrome alone than in those with sicca syndrome associated with some other connective tissue disease (P less than 0.05). In patients with Sjögren's syndrome, a negative correlation was found between serum concentrations of beta 2-microglobulin and pepsinogen I (r = -0.46, P less than 0.05). | |
| 3906252 | [Keratomalacia perforans, clinical and pathohistologic findings]. | 1985 Oct | This report deals on the course of disease in an 82-year-old patient with keratomalacia perforans with seropositive chronic polyarthritis. In the more severely affected eye there was a marginal corneal ulcer extending over two quadrants and close to perforation. Six months after total keratoplasty, in which the corneal transplant including marginal scleral tissue was resected and transplanted, a recurrent ulcer was observed at the same location. It proved impossible to prevent rejection of the transplanted tissue despite therapy with antiphlogistic and immunsuppressive drugs. The ulcer subsequently perforated. Histologically a plasmacellular infiltration was observed which was more severe in the areas close to the perforation. | |
| 860964 | [Forefoot reconstruction. The frequency and importance of the toe and metatarsal formula ( | 1977 Apr 22 | The forefoot reconstruction as a routine treatment, is increasing in significance, not only in treating polyarthritic patients, but also after numerous surgical failures in treating halux valgus or hammer toes. Far from being a simple operation, the reconstruction requires an exact knowledge of the physiopathology of the foot. Special attention should be given to the digital and metatarsal formula. Based on an analysis of 200 forefoot reconstructions, the advantages and the disadvantages of the various methods are discussed. For the first time in the German speaking countries, the frequency of occurrences of the different digitial and metatarsal formulas has been compiled in tables from an examination of 500 forefeet. | |
| 1221654 | [Experiences with a standardized questionnaire for determination of the vegetative labilit | 1975 Dec 15 | 180 students without pathological psychic findings, 233 students with psychic disturbances, 168 internal patients with vegetative disturbances and 231 patients with progressive chronic polyarthritis were interrogated with the VELA-questionnaire of Fahrenberg and the ENR-questionnaire according to Brengelmann and Brengelmann. Compared with the normal group all other groups had significantly higher VELA-values. The combination E less than 10, N greater then 26 was found in students without pathological psychic findings in 2.8%, in patients with rheumatism in 7.4%, in internal patients in 21.4% and in students with psychic disturbances in 24.1%. With this combination and another one with extreme values 5.1% of the comparative group, 9.6% of the patients with somatic diseases and approximately 61.4% of the patients with a high number of vegetative complaints are suspicious of a psychic disturbance which must be treated. | |
| 637891 | Demonstration of anticollagen antibodies in rheumatoid arthritis synovial fluids by 14C-ra | 1978 Mar | Twenty-seven synovial fluids from rheumatoid arthritis (RA) patients and 17 synovial fluids from controls were investigated in a new radioimmunoassay for anticollagen antibodies. In vitro labeled human 14C-collagen of type I in native or denatured state was used as antigen. Passive hemagglutination was used in comparison. Parameters for defining positive results in radioimmunoassay were evaluated on the basis of control synovial fluids. Synovial fluids from 20 RA patients (74%) showed antibodies to denatured collagen; synovial fluids from 8 RA patients (30%) also demonstrated antibodies to native collagen. Control fluids of posttraumatic effusions were negative; among the other controls synovial fluid from 1 psoriatic arthritis patient reacted positively. Inhibition experiments showed that antibodies to denatured collagen cross-reacted with native collagen. Inhibition with human denatured type III collagen displayed strong cross-reactivity of anti-type I collagen antibodies with type III collagen. | |
| 6228589 | Suppression of pokeweed mitogen-stimulated immunoglobulin production in patients with rheu | 1984 Feb | Patients with intractable rheumatoid arthritis (RA) were treated with total lymphoid irradiation (TLI, 2000 rad). We previously reported long-lasting clinical improvement in this group associated with a persistent decrease in circulating Leu-3 (helper subset) T cells and marked impairment of in vitro lymphocyte function. In the present experiments, we studied the mechanisms underlying the decrease in pokeweed mitogen stimulated immunoglobulin (Ig) secretion observed after TLI. Peripheral blood mononuclear cells (PBL) from TLI-treated patients produced 10-fold less Ig (both IgM and IgG) in response to pokeweed mitogen than before radiotherapy. This decrease in Ig production was associated with the presence of suppressor cells in co-culture studies. By using responder cells obtained from normal individuals (allogeneic system), PBL from eight of 12 patients after TLI suppressed Ig synthesis by more than 50%. In contrast, PBL from the same patients before TLI failed to suppress Ig synthesis. Suppression by post-TLI PBL was also demonstrated in an autologous system by using responder cells cryopreserved before TLI. Again, only cells obtained after TLI were suppressive in four of seven patients. PBL with suppressive activity contained suppressor T cells, and the latter cells bore the Leu-2 surface antigen. In 50% of the patients studied, suppressor cells were also found in the non-T fraction and were adherent to plastic. Interestingly, the Leu-2+ cells from TLI-treated patients were no more potent on a cell per cell basis than purified Leu-2+ cells obtained before TLI. Additional experiments suggested that the suppression mediated by T cells after TLI is related to the increased ratio of Leu-2 to Leu-3 cells observed after radiotherapy. | |
| 6604158 | Antibody to Ro in a population of patients with systemic lupus erythematosus: distribution | 1983 Jun | Anti-Ro occurs in 1/3 of systemic lupus erythematosus (SLE) patients with equal prevalence at all ages, ages at onset of SLE, and disease durations. In SLE anti-Ro is associated with xerophthalmia but not rheumatoid factor (RF). Anti ds-DNA rather than anti-Ro or RF is associated with SLE arthritis. We found a positive correlation between increased anti ds-DNA levels and the prevalence of anti-Ro in SLE patients' sera. This reinforces the thesis that anti-Ro may have considerable value as a diagnostic marker for SLE. | |
| 7054191 | Total ankle arthroplasty. Clinical study of fifty cases. | 1982 Jan | A prosthesis for the ankle joint that I designed in 1973 was implanted in fifty patients who otherwise would have required fusion of the ankle to relieve severe pain. The design of the device allows about as much motion as in the normal ankle. During implantation of the prosthesis the dome of the talus is not resected and only one centimeter of the distal end of the tibia is removed. If the prosthetic replacement is unsuccessful, fusion of the ankle can more easily be achieved secondarily if it should become necessary. Review of the cases of these fifty patients showed that the best results were obtained in the patients with degenerative arthritis whose ankles were stable and not unduly deformed. A few patients with rheumatoid arthritis (four of ten) who were not on long-term steroid therapy also did well. Contraindications revealed by my experience include avascular necrosis of the talus, pseudarthrosis at the site of a previously attempted ankle fusion, and conditions causing talar tilt of 20 degrees or more. | |
| 7028626 | Diflunisal in rheumatoid arthritis. | 1981 Sep | In an eight-week double-blind study comparing the new long-acting aspirin derivative, diflunisal, in doses up to 1 g/day with aspirin in doses up to 4 g/day in 16 patients with classical or definite rheumatoid arthritis, diflunisal was more effective in reducing the total articular index (Ritchie) and erythrocyte sedimentation rate and in increasing grip strength. Diflunisal had an earlier effect on erythrocyte sedimentation rate than antiinflammatory doses of aspirin. Patients on diflunisal experienced fewer side effects than patients on aspirin. Ten patients with rheumatoid arthritis who previously participated in the eight-week study comparing diflunisal to aspirin (five patients from each group) were continued on 1 g diflunisal per day for six months. The efficacy of diflunisal therapy persisted during a six-month period, and there were no side effects. The switchover from 4g aspirin to 1g diflunisal a day was accompanied by further improvement in the Ritchie total score, erythrocyte sedimentation rate, and grip strength and by disappearance of side effects. Diflunisal 1 g/day proved to be an efficient and well-tolerated drug in patients with rheumatoid arthritis. | |
| 6350377 | Long-term efficacy and safety of tolmetin sodium in treatment of geriatric patients with r | 1983 Jul | In order to evaluate the effectiveness and safety of tolmetin sodium in the treatment of both rheumatoid arthritis (RA) and osteoarthritis in geriatric patients, a retrospective study was made of patients 65 years and older who participated in long-term, controlled, double-blind and open trials during both the investigational period and since marketing of the drug. Standard entrance criteria, methods of evaluating disease activity, and statistical methods were used in the study of both arthritic diseases. A total of 847 geriatric patients were studied for periods of up to one year; 171 had RA, while 676 had osteoarthritis of large or small joints. Average daily dose of tolmetin sodium was 1141 mg for patients with RA and 953 mg for patients with osteoarthritis. The results of this retrospective study of both RA and osteoarthritis patients show that tolmetin was as effective in geriatric patients as in nongeriatric patients. Symptoms responded rapidly to treatment with tolmetin, and both the inflammatory symptoms of RA and the joint pain and functional parameters of osteoarthritis showed improvement that was both statistically and clinically significant throughout the major course of therapy. Tolmetin was also found to be safe and well tolerated by the elderly patient population. The major complaints were gastrointestinal, but serious or limiting side effects occurred in few patients. The dropout rates due to adverse effects during the entire year of therapy were 15.8 per cent in the RA population and 15.4 per cent in osteoarthritis patients. This retrospective evaluation of tolmetin therapy shows significant relief of the symptoms of both RA and osteoarthritis in a geriatric population and fails to reveal any unusual or serious conditions which would contraindicate its use in the elderly patient. Tolmetin, which is an antiinflammatory agent with a short half-life, can provide adequate, safe therapy in the geriatric population. | |
| 4090946 | Hip replacement in acetabular protrusion. | 1985 Dec | The medial defect in acetabular protrusion makes it necessary to construct a strong implant bed for the cup prosthesis. Autogenous spongiosaplasty of the floor of the acetabulum combined with wire reinforcement of the cemented plastic cup has given good results in 28 patients followed for 3 (1-6) years. | |
| 6236760 | Measures of functional ability (disability) in arthritis in relation to impairment of rang | 1984 Aug | In the World Health Organisation's supplementary classification of the consequences of disease a distinction is made between impairments, such as are related to the site and nature of joint involvement, and any disabilities in everyday activities to which these may give rise. This paper considers the application of these ideas to people with arthritis by examining the extent of graded relationship between individual impairments, reflected by limitations in the range of joint movement, and the number or type of disabilities. Ninety-five people with three different types of arthritis were studied. A 41-item disability questionnaire was completed. Most of the variation was described by only 24 of the latter items. These fell into five broad functional groups--predominantly concerned with mobility, bending down, manual dexterity, bending the arm, and reaching above the head. The constituent activities could be scaled in order of difficulty of accomplishment. Aggregated scores for each of the functional groups were correlated with observed ranges of motion in relevant joints, and the ordering of difficulty was related to decreasing ranges of movement. These findings shed light on the genesis of disability and have implications for the development of more sensitive, specific, and simple methods of assessment in rheumatology. Appreciation of how disability relates to the localisation of disease manifestations provides a means for evaluating current methods of functional assessment and exposes potential biases in such appraisals. | |
| 6213027 | Augmented numbers of HLA-DR-positive T lymphocytes in the synovial fluid and synovial tiss | 1982 Feb | Twenty to 40% of T cells from synovial fluid and synovial tissue and 3-11% of the peripheral blood T lymphocytes from patients with rheumatoid arthritis (RA) and juvenile rheumatoid arthritis (JRA) expressed HLA-DR antigens as detected by monoclonal anti-HLA-DR antibodies in direct immunofluorescence. Synovial fluid and synovial tissue T lymphocytes had a stimulating capacity comparable to that of non-T cells in the allogeneic primary mixed lymphocyte reaction (MLR). The MLR was inhibited by monoclonal anti-HLA-DR antibodies. This is, to our knowledge, the first report on in-vivo-activated T lymphocytes as stimulator cells in MLR. The results suggest that T cells from synovial fluid and synovial tissue are locally activated by stimuli so far unidentified. | |
| 4055841 | Unicompartmental and bicompartmental arthroplasty of the knee with a finned metal tibial-p | 1985 Oct | We followed a series of ten patients (ten knees) who had a unicompartmental and twenty patients (twenty-two knees) who had a bicompartmental arthroplasty of the knee, in which a finned metal tibial-plateau implant had been used, for two to fourteen years (average, five years) postoperatively. According to the modified criteria of MacIntosh and Hunter, thirty knees (94 per cent) had a good result and two (6 per cent), a fair result. There were two complications: one intraoperative and one postoperative fracture of the tibial plateau. One patient with rheumatoid arthritis required a revision to a total knee arthroplasty at six months because of rapid progression of disease in the contralateral, untreated compartment. Our results suggest that with the proper indications this arthroplasty has a place in reconstructive surgery of the arthritic knee joint. | |
| 114635 | Quantitation of gold lymphocyte binding during chrysotherapy. | 1979 May | Carbon rod atomic absorption analysis (CRA) was applied to the quantiation of gold lymphocyte content (GLC) during chrysotherapy. Sensitivity and accuracy of CRA compared favorably with 195Au isotopic scintillation counting, circumventing the limitations and hazards of the latter in clinical applications. Picogram gold quantification of limited sample volume, less than 10 ml blood, e.g., 10(4)-10(5) lymphocytes (5 microliters) containing 5-10 pg was achieved. GLC after IM administration increased significantly in 60% of patients; for the remainder, GLC was observed to be independent of plasma gold content or cumulative dosage. GLC during auranofin administration (6 mg/day p.o.) approached values for IM gold despite significantly lower plasma levels. Unique sensitivity of CRA enables analysis of GLC under therapeutic conditions that could elucidate whether gold alters functional determinants. |