Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6725354 | A new operation for atlanto-axial arthrodesis. | 1984 May | Thirty patients with atlanto-axial subluxation were operated on using the Mitsui Memorial Hospital System. The follow-up averaged one and a half years, and the results were satisfactory in comparison with other operative methods, all patients regaining almost normal function. Stability and safety are the main advantages of this procedure, with almost complete correction of subluxation in most patients. | |
| 609908 | Resection arthroplasty of the metacarpophalangeal joint a.m. Tupper using interposition of | 1977 | Tupper's resection arthroplasty with interposition of the volar plate was performed 75 severely destroyed metacarpophalangeal joints in 22 patients during the period 1970--74. The average passive mobility obtained was 63 degrees. The operative technique and complications are described, and the obvious advantages of the method are emphasized. This procedure is one part of a more comprehensive reconstruction whose functional result is influenced by the overall condition and balance of the hand. | |
| 2419556 | Is there more than one signal for an acute phase response? | 1985 Dec | Prealbumin was shown to be a sensitive indicator of disease activity in a prospective study of 21 patients with active ankylosing spondylitis (AS) who were treated with 3 intravenous pulses of methylprednisolone and its concentration was found to change at a different rate to C-reactive protein (CRP). In those diseases in which CRP concentration rises with active disease, i.e., rheumatoid arthritis, AS and Crohn's disease, prealbumin fell, but in those diseases in which CRP rises only slightly, i.e., systemic lupus erythematosus, progressive systemic sclerosis and ulcerative colitis, there was nevertheless a fall in serum prealbumin, indicating that there was an acute phase response occurring. Fever, arthritis and infection were the only disease manifestations that were associated with an elevated CRP in both groups of diseases. There is therefore more than one signal for an acute phase response depending on the nature of the disease pathology. | |
| 6978781 | Autoantibodies against Tmu and B lymphocytes in patients with rheumatoid arthritis. | 1982 Feb | Patients with rheumatoid arthritis have decreased numbers of T mu lymphocytes in their peripheral blood. To find out whether these low number of T mu lymphocytes were associated with the presence of anti-lymphocyte antibodies, the sera of 27 patients with definite or classical rheumatoid arthritis (RA) were investigated for the presence of autoantibodies against subsets of lymphocytes. In addition the numbers of T, T mu, T gamma and B lymphocytes in the peripheral blood of these patients were investigated. Patients with active RA showed lower numbers of T mu lymphocytes in their peripheral blood than patients with inactive RA. However, both groups of RA patients had significantly decreased numbers of T mu lymphocytes in their peripheral blood as compared with 22 age matched healthy donors. Moreover, mainly in patients with active RA cold reactive antibodies were found directed against T mu and B lymphocytes, but never against T gamma lymphocytes of healthy donors. Similar results were found in the indirect immunofluorescence procedure when tested for reactivity against T-cell subsets. This serum reactivity was not caused by rheumatoid factors or antinuclear antibodies. Since RA sera after precipitation with 2.5% polyethyleneglycol, still showed cytotoxicity against T and B lymphocytes, it is suggested that this serum reactivity is not caused by immune complexes but by antibodies. | |
| 3936931 | Neutropenia occurring during the course of chrysotherapy: a review of 25 cases. | 1985 Oct | The records of 25 patients who developed neutropenia (granulocyte count less than or equal to 2500 mm3) while receiving intramuscular gold sodium aurothiomalate (GSTM) were reviewed. According to commonly used clinical criteria, 3 patients developed Felty's syndrome, 8 gold myelotoxicity, and 14 mild, chronic benign granulocytopenia. Myelotoxicity occurred exclusively during the initial course of therapy (less than or equal to 1 g GSTM). Twelve of the patients with chronic granulocytopenia continue to receive gold without other signs of serious toxicity. We conclude that Felty's syndrome can develop during gold administration, and that many patients may continue safely to receive gold despite neutropenia. | |
| 4078262 | Flexible implant arthroplasty in the proximal interphalangeal joint of the hand. | 1985 Nov | Between 1966 and 1981, 812 proximal interphalangeal joints were reconstructed by the senior author using the flexible silicone rubber implant resection arthroplasty method. Within this series, a group of 182 patients with 424 proximal interphalangeal joint implants were available for a detailed clinical and roentgenographic review. Increased motion in a more functional arc with good pain relief and a favorable bone response pattern were noted in most cases after surgery. Complications were rare and included implant dislocation or fracture, recurrence of deformity, and infection. The highest complication rate was noted in implant reconstructions performed to correct rheumatoid swan-neck deformities. | |
| 735452 | [Findings on the saddle and multangulum-naviculare joints in erosive polyarthritis]. | 1978 Nov | The x-rays of 110 patients with erosive Heberden-Bouchard arthrosis and the x-rays of 104 patients with non-erosive Heberden-Bouchard arthrosis were compared in order to determine the frequency and the severity of arthrotic changes in the thumb-saddle and the multangulum-navicular joints. In erosive Heberden-Bouchard arthrosis we found more characteristic arthrotic changes than in the non-erosive form. The more characteristic the erosive changes of the finger joints, the more extended the changes were in the thumb-saddle and the multangulum-navicular joints. Erosions of the carpal joints do occur during an erosive Heberdandan-Bouchard arthrosis, but seem to be very rare. | |
| 3885961 | Intraarticular volume and clearance in human synovial effusions. | 1985 Apr | Intraarticular volumes were measured by radiolabeled albumin (RISA) distribution in chronic knee effusions from 11 rheumatoid arthritis patients and 9 osteoarthritis patients. Volumes of synovial fluid obtained at joint aspiration were substantially less than those found by RISA dilution. Up to 24 hours was needed for full distribution of RISA throughout the intraarticular compartment. Measured 123I and RISA radioactivity over the knee described monoexponential rate constants, lambda (minute-1). The clearance of 123I and RISA from synovial effusions was derived by the formulation volume (ml) X lambda (minute-1) = clearance (ml/minute). RISA clearance in rheumatoid effusions was significantly greater than that found in osteoarthritis effusions. Intraarticular volume and isotope clearance were easily quantified and provide measures for further evaluating the microvascular physiology of synovial effusions. | |
| 6217974 | Virus infections and chronic rheumatic disorders. | 1982 | There is little direct evidence that viruses cause inflammatory arthritis in the sense that infectious agents classically cause disease. However, there are several mechanisms by which virus infections could be implicated in the pathogenesis of such disorders. In particular virus infection of lymphocytes could produce the combination of selective immunodeficiency and immune stimulation that characterizes many rheumatic disorders. In addition re-combination events between integrated pro-viruses in DNA and exogenous infections would account for the lack of any obvious correlation between the appearance of these disorders and any obvious preceding viral infection. Certainly, more sophisticated approaches will be needed to test such hypotheses rather than relying on classical techniques for viral isolation. | |
| 4006986 | Synovectomy of the knee with 90Y. | 1985 | In 33 patients with chronic arthritis of the knee, 48 knees were treated with an intra-articular injection of 5 mCi yttrium silicate (90Y). There were 27 patients with rheumatoid arthritis (RA) and 6 with osteoarthrosis (OA); the mean follow-up period was 33 months. At clinical investigation after 1 year, no signs of pain or swelling were found in 15 knees. In most cases, pain and swelling improved subjectively, with a mean duration of 11 months; in 20 knees, the improvement lasted more than 22 months. When radiographs showed severe destruction, 90Y treatment was unsuccessful, but an important new finding was that most patients with mild or moderate radiological abnormalities appeared to have a long-lasting improvement. The result did not correlate with erythrocyte sedimentation rate (ESR), haemoglobin or Rose titre at the time of injection or at follow up, suggesting that the result of the treatment is more dependent on local factors than on the disease activity. The results of 90Y treatment in 6 OA knees with persistent swelling were promising regarding swelling, even in patients with moderate radiological abnormalities. The main side-effect was a sometimes painful swelling of the knee, which was always successfully treated with an intraarticular corticosteroid injection. In 90Y-treated knees, the incidence of unstable joints was not significantly higher than in non-treated knees. In conclusion, 90Y synovectomy may be a successful treatment for patients older than 50 years with chronic arthritis of the knee due to RA and probably also OA, even when moderate radiological abnormalities are present. | |
| 4026406 | Lung involvement in Sjögren's syndrome: a comparison between patients with primary and wi | 1985 Jul | Lung function was assessed in 20 patients with primary Sjögren's syndrome (SS) and in a group of patients with SS associated with a variety of connective tissue diseases. Signs of small airway disease and of altered diffusion capacity, together with chest x-ray features of mild interstitial involvement, were the most common findings in primary SS. On the whole, lung involvement was more frequent and severe in patients with the secondary form of the syndrome. In both primary and secondary SS lung function changes did not correlate with the other clinical and serological parameters, except for a more severe impairment of diffusion capacity in patients with Raynaud's phenomenon. | |
| 6253854 | Subcellular particles in synovial fluids and synovial cells. | 1980 Jul 9 | Membranous particles of mycoplasma-like appearance (100 to 300 nm in diameter) and non-membranous particles which are viral-like (20 to 80 nm in diameter) were observed in negatively-stained preparations of synovial fluid pellets from patients with rheumatoid arthritis (RA), osteoarthrosis (OA) or psoriatic arthritis (PA). The incidence of positive fluids were: membranous particles--22/28 (RA), 7/11 (OA), 1/3 (PA); non-membranous particles--12/28 (RA), 1/11 (OA), 1/3 (PA). Eight of the RA fluids, one OA and one PA fluid were positive for both types of particle. The observation of an increased frequency of viral-like particles in RA synovial fluids compared to OA and PA fluids is of possible aetiological interest. Viral-like particles were also observed in the nuclei of rheumatoid synovial macrophage syncytia by electron microscopy of ultra-thin sections of cultured cells. | |
| 4096771 | Synovial proliferative disorders: role of synovectomy. | 1985 | Synovectomy is an effective procedure in many of the synovial proliferative diseases. It is the treatment of choice in pigmented villonodular synovitis and synovial chondromatosis. In addition, it may be a useful adjunct to treatment in carefully selected patients with rheumatoid arthritis and hemophilia. Synovectomy can now be accomplished effectively with arthroscopic techniques, and this has greatly diminished the previous morbidity and cost associated with open synovectomy. However, the indications for synovectomy remain the same, regardless of the technique. | |
| 6690443 | Methylmethacrylate stabilization of the cervical spine. | 1984 Jan | Several conditions that lead to instability of the cervical spine require surgical fixation, and on occasion that procedure may include the use of methylmethacrylate. In the series that we are reporting, there were eighteen patients with malignant disease, seventeen with fractures, twelve with rheumatoid arthritis, and five with osteoarthritis. In the survivors, a four-year follow-up showed excellent relief of instability and no complications attributable to the methacrylate except for one fracture of the methacrylate that did not produce symptoms. | |
| 89921 | Inhibition of human neutrophil migration by aggregated gammaglobulin. | 1979 May | Heat-aggregated human gammaglobulin has been shown to inhibit the random migration of human neutrophils in serum-containing medium. This inhibition was not due to metabolic exhaustion or deactivation of the cells, since migration in the presence of aggregated gammaglobulin and casein as a chemotactic stimulus was not inhibited. The inhibition of migration was not mediated by a negative chemotactic gradient produced as a result of complement activation, and could be demonstrated in complement-depleted serum. Sera obtained from patients with rheumatoid arthritis with evidence of circulating immune complexes were able to significantly inhibit neutrophil migration, indicating that this phenomenon may be a useful means for the detection of circulating immune complexes. It is suggested that aggregated gammaglobulin or immune complexes can inhibit the chemokinetic effect of serum on neutrophils by a reversible interaction with the neutrophil surface, and that this inhibition could contribute to the accumulation of neutrophils at sites of immune complex deposition in vivo. | |
| 950631 | Immunopathology of penicillamine-induced glomerular disease. | 1976 Jun | Four patients with rheumatoid arthritis developed heavy proteinuria after five to 12 months of treatment with D-penicillamine. Light microscopy of renal biopsy samples showed minimal glomerular capillary wall thickening and mesangial matrix increase, or no departure from normal. Electron microscopy, however, revealed subepithelial electron-dense deposits, fusion of epithelial cell foot processes, and evidence of mesangial cell hyperactivity. Immunofluorescence microscopy demonstrated granular capillary wall deposits of IgG and C3. The findings were similar to those in early membranous glomerulonephritis, differences being observed however in the results of staining for the early-acting complement components C1q and C4. It is tentatively concluded that complement was activated by the classical pathway. | |
| 3898298 | Confirmative study of the effectiveness of thymopentin in active rheumatoid arthritis. | 1985 | Forty-one patients with active rheumatoid arthritis entered a controlled double-blind randomized study. Of these patients, 21 received prolonged intravenous injections (10 min) of thymopentin 50 mg three times a week for 3 consecutive weeks, whereas 20 received placebo. Both groups were comparable with regard to clinical parameters. No immunological tests were performed. Analysis of the results after 3 weeks showed that the improvement in the thymopentin group was statistically significant (p less than 0.05 or p less than 0.01) for all clinical parameters, except for the left-hand grip strength. On the other hand, no significant improvement was observed for any parameter, except morning stiffness, in the patients on placebo. The intergroup comparison showed statistically significant differences, favoring thymopentin over placebo treatment, in the Ritchie index, the scores of swollen joints, the assessment of severity of pain, and the scores for changes in the activity of the disease. The present placebo-controlled double blind study thus confirms the positive results generated in a similar open study, i.e., the beneficial therapeutic effect of prolonged intravenous injections of thymopentin in patients with severe rheumatoid arthritis. The drug appears to be safe at the dose regimen used. | |
| 1273483 | [Antibody-dependent cytotoxicity of blood lymphocytes during rheumatoid polyarthritis]. | 1976 May | Lymphocyte dependent-antibody cytotoxicity (LDAC) was studied in 29 patients with rheumatoid arthritis (RA) and 22 controls. A significant increase of cytotoxic index has been noted in RA patients (p less than 0.0001) whatever the ratio effector-target cells could be. There is a correlation between cytotoxic activity and so called "rheumatoid rosettes" (RR) level. This cytotoxic activity is linked to EA rosette forming cells without T cell markers or surface immunoglobulins, as shown by fractionation experiments. EA rosette forming cell depletion is followed by the disappearance of RR and a very important decrease of cytotoxic index. Cytotoxic activity is abolished after RR forming cell depletion while EA rosette level is nearly unmodified. RR forming cells belong to Fc receptor bearing lymphoïd population. They take place in EA rosette forming cell population. Increase of cytotoxicity in RA seems to be directly linked to these so called RR forming cells. | |
| 6331973 | Salpingitis and cervicitis in uro-arthritis. | 1984 Jun | To compare anamnestic cervicitis and salpingitis as a relative risk for uro-arthritis the medical history of 60 consecutive females with uro-arthritis was compared with that of 311 interviewed controls. Salpingitis was revealed to be a relative risk factor of 3.2 as compared to cervicitis 1.4 in connection with uro-arthritis. HLA-B27 was tested in the 60 patients and in an additional 7 females with uro-arthritis, all of whom had a history of salpingitis. HLA-B27 was positive in 42% (28/67). There were no significant differences between those with or without cervicitis or salpingitis or both. Salpingitis could thus as justifiably be accepted as a diagnostic criterion for RS as cervicitis. These findings and clinical observations, including comprehensive histories of the patients concerned, serve as a basis for our hypothesis of rheumatic salpingitis. Further prospective and co-operative investigations will be needed to confirm or disprove this hypothesis. | |
| 6230706 | Depressed exocytosis by rheumatoid neutrophils in vitro. | 1983 | Polymorphonuclear leucocytes and monocytes have been isolated from the peripheral blood of patients with rheumatoid arthritis and healthy controls using Percoll gradient centrifugation. These cells have been tested for their ability to release superoxide anion and to undergo exocytosis following stimulation with heat-aggregated IgG. Monocytes from patients and controls react similarly in these assays but neutrophils from the patients release less beta-glucuronidase than do normal cells. This could not be related either to the expression of cell surface Fc receptors or to oxidative metabolism and does not appear to be an effect of the administration of non-steroidal anti-inflammatory drug therapy. It is suggested that rheumatoid neutrophils are not inherently defective but are less responsive to activation in vitro because of prior exposure to immune complexes in vivo. |