Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 4629438 | The effect of azathioprine on gammaglobulin synthesis in man. | 1972 Sep | The effect of azathioprine therapy on gammaglobulin synthesis was evaluated in nine patients with rheumatic disorders. The rates of synthesis of IgG and IgM were calculated before and after 4 months of azathioprine treatment using turnover studies of radioiodinated gammaglobulins. The synthesis of IgG decreased 33.4% of the initial IgG synthetic rate. Seven of nine patients showed reductions of IgG synthesis ranging from 16.8 to 74.1%. IgM production decreased from 24.5 to 74.2% in eight of nine patients with a mean reduction of 40.9%. Studies before and after a control period of 4 months of placebo in six patients revealed a mean increase in IgG and IgM synthesis. Serum immunoglobulin concentrations after 4 months of azathioprine treatment were not consistently reduced and did not parallel changes in immunoglobulin synthesis. Reduced gammaglobulin synthesis may play a role in the therapeutic action of this and other "immunosuppressive" drugs. | |
| 4050147 | [NMR tomography of the knee joint in patients with rheumatic joint diseases]. | 1985 Jul | Twenty patients with rheumatoid gonarthritis were examined in a NMR tomograph with a 0.2 tesla resistive magnet. Synovial effusions were seen in 18 cases and thickening of the synovium in 15 cases. Discrimination between synovial fluid and synovium was gained by different NMR signals from various spin-echo sequences. In demonstrating a thickened synovium NMR tomography enables the depiction of inflammation inside the joint in earlier stages of illness than is possible with bone erosion detection from X-ray photographs. | |
| 1224932 | [Differential indications in rheumatism therapy on the basis of well-known drug side effec | 1975 | Special effects and side effects of antirheumatic basic treatment and symptomatic drugs, lead to distinct indications in the management of rheumatic diseases. Chloroquine should mainly be administered in "lupoid" rheumatoid arthritis (R.A.), in systemic lupus erythematosus, and in less active initial stages of R.A., whereas gold and D-penicillamine should be used in more active early stages of R.A. In psoriatic arthritis there is no contraindication for gold D-penicillamine, however, is less effective. Immunosuppressive agents may be used in special cases of R.A. and connective tissude diseases. However, strict controls and special care are necessary. Additive organ disorders may lead to individual contra-indications for basic treatment. All these drugs are not harmless and need careful control. In "lupoid" R.A. corticoids are superior to nonsteroidal antirheumatic drugs. The association of the conversion of R.A. into necrotizing vasculitis has been suggested. There is, however, no proof for this assertion. The new nonsteroidal antirheumatic drugs are assumed to have less side effects, but their real position may be evaluated only after much longer periods of administration. Rare, but severe side effects, especially due to the hematopoetic system, are problbly caused by an incompatibility of the patient. One must not forget the advantages for millions of rheumatic patients. Also, in an age of an exaggerated desire for security, special consideration must be given to these advantages, so that the development of new antirheumatic drugs is not suppressed. | |
| 1087674 | Rheumatoid disease without arthritis. | 1976 Dec | A middle-aged man developed multiple subcutaneous rheumatoid granulomata, high titer of rheumatoid factor, diffuse interstitial pulmonary fibrosis and digital clubbing in the absence of clinicoradiological evidence of synovial disease. This patient supports the concept of rheumatoid disease without arthritis. | |
| 7063201 | Duopatellar total knee replacement: the Brigham experience. | 1982 Jan | Over the past 25 years at the Brigham Hospital we have seen prosthetic knee arthroplasty evolve from metal interpositional hemi-arthroplasty to the current generation of metal-to-plastic total knee replacements. Surely this evolutionary process will continue for may more years. Time will help us answer many of the questions and controversies that exist regarding posterior cruciate retention, patellar resurfacing, and unicompartmental replacement. We have yet to establish the optimal tibial stem length and shape and whether metal backing is truely beneficial. It is still to be determined whether the standard condylar femoral component should have condylar lugs to enhance fixation or an intramedullary stem with no condylar lugs. In the meantime, we have the use of a graduated system of prostheses that can be tailored to the individual needs of each patient and can predictably relieve pain and improve function in well over 90 per cent of cases. Late complications requiring revision surgery (most often patellar problems or tibial loosening) are occurring at a rate of 1 per cent per year of follow-up, and we hope these will be minimized by the recent advances we have discussed. | |
| 6209175 | Morphologic alterations in cultured human synovial fibroblasts induced by blood mononuclea | 1984 | Effects of peripheral blood mononuclear cells on cultured synovial fibroblasts were studied. When mononuclear cells from normal or rheumatoid blood were incubated on synovial fibroblast cultures, a part of the cells adhered to the fibroblasts. They were mainly T lymphocytes but also some B lymphocytes and monocytes. After a 10-hour incubation, adhered mononuclear cells induced morphologic alterations to synovial fibroblasts: appearance of stellate cells and thinning and branching of fibroblasts. No changes were seen when the cells were incubated in the presence of indomethacin. Cytotoxicity of peripheral blood mononuclear cells from 8 rheumatoid patients was also tested against three rheumatoid and three normal synovial fibroblast strains. Only 2 out of 48 combinations were cytotoxicity. The potentially cytotoxic mononuclear cells were bound equally well to rheumatoid and control synovial fibroblast cultures. | |
| 6340971 | Oxaprozin and sulindac in rheumatoid arthritis: a double-blind comparative trial. | 1983 | Oxaprozin, an anti-inflammatory agent with a half-life of 50 hours, was compared in regard to efficacy and tolerance with sulindac in a 12-week double-blind parallel treatment trial of rheumatoid arthritis. Oxaprozin was given as a single morning daily dose of 1200 mg, sulindac was given as 200 mg twice daily. Analysis of the results from the 20 patients (10 in each group) who completed the trial indicated that both drugs produced statistically significant improvement in morning stiffness, walking speed and the Ritchie index, but only sulindac produced significant improvement in hand function. Neither drug was associated with significant side-effects. | |
| 100010 | Chrysotherapy-induced aplastic anemia: a case report. | 1978 Sep | A case of gold-induced aplastic anemia occurring in a 58-year-old male with rheumatoid arthritis who received a total dose of 635 mg of gold sodium thiomalate over a 16-week period is reported. The clinical features, treatment, prevention and pathogenesis of gold-induced aplastic anemia are reviewed. The ability to predict patients in whom this hematologic effect may occur is discussed. Chrysotherapy is beneficial in the treatment of rheumatoid arthritis, but gold-induced aplastic anemia may be fatal. Absolute identification of patients at risk of having this hematologic side effect is not possible, but dosage reduction and intense monitoring of laboratory and clinical signs may prevent its occurrence. | |
| 712203 | Properties of fibrinogen-antigenic material on the rheumatoid synovial membrane and in the | 1978 Nov | Fibrin deposits on rheumatoid synovial membranes and fibrinogen-antigenic material in rheumatoid synovial fluid were found to be identical by crossed immunoelectrophoresis into immunoglobulin against fibrinogen, by SDS-polyacrylamide gel electrophoresis, and by gel filtration on Sepharose CL 6B. The material was found to be neither fibrinogen nor fibrin, but degradation products. One of the fragments was purified by preparative agarose electrophoresis, and the physicochemical properties of this fragment were found to be different from those obtained by plasmin digestion of fibrinogen or fibrin. This indicates that other proteases than plasmin are responsible for the degradation products. The material was easily degraded by plasmin to D- and E-antigenic end products, identical to those obtained by plasmin digest of fibrinogen. The solubility of the material was poor in synovial fluid compared to serum and buffer. On the basis of these results, it is suggested that the fibrinlike material on the synovial membrane represents fibrinogen degradation products from the inflamed tissue. These products are likely released into the synovial fluid, and when their concentration here exceeds their solubility, they precipitate on the synovial membrane. | |
| 2867597 | [Anatomic and nosologic analysis of 100 cases of diffuse angiitis seen in rheumatology]. | 1985 Nov | Diffuse inflammatory angiitis is seen in extremely varied aetiological and nosological situations. In some cases, the vascular disease represents the only sign of systemic disease. In other cases, it mays be associated with or complicated by diffuse systemic inflammatory conditions. This study analysed 100 cases of inflammatory angiitis with systemic manifestations seen over a period of 7 years in a rheumatology department. Patients with scleroderma, erythema nodosa, Behçet's syndrome and angiitis associated with microbial infectious diseases were excluded from this study. 24 cases in which the angiitis was clinically certain, but in which the vascular lesion was not confirmed histologically were also excluded. The type of histological lesion and the nosological distribution of these 100 cases are described in detail. The results of this analysis confirm the very great variety of the clinical and histological presentations. A number of rare syndromes were observed. Classical periarteritis nodosa only represented 14 per cent of the whole series and only 3 of the 14 cases had a demonstrable aetiology (2 HBs, 1: desensitisation to Candidin). The authors stress the histological diversity of inflammatory angiitis associated with rheumatoid arthritis and systemic lupus erythematosus. All sizes of vessels may be involved and all types of lesions can be observed in these two diseases. The authors also emphasise the lesser known clinical and histological features (stenosing endarteritis of the great vessels in systemic lupus erythematosus) and previously unreported cases (valvular lesions in 2 cases of Mac Duffie's syndrome, progression of 2 cases of delayed urticaria to pressure towards a clinical lupus with unusual laboratory findings).(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 6442051 | [Parenteral gold therapy (Tauredon) in chronic polyarthritis]. | 1984 | Between 1972 and 1983, 519 patients with rheumatoid arthritis according to ARA criteria underwent basic antirheumatic treatment with Tauredon (sodium aurothiamalate). Patient age was 19 to 78 years, and the disease had been active for 6 months to 8 years. Results of treatment were recorded for periods of 14 days to 8 years. After a test dose of 10 mg intramuscular, patients received weekly injections of 20 to 50 mg for 4 to 6 months and were subsequently placed on a maintenance dose of 50 mg at intervals of 2 to 4 weeks for years. Clinical examinations and laboratory tests were scheduled at weekly intervals in the first month of treatment, at 2-weekly intervals in the next two months and subsequently once every month. In the first years of this trial (up to 1975) response to treatment was evaluated by the criteria reported by Fähndrich [2] and Steinbrocker [10]. Later Ritchie's joint index [6], laboratory parameters (sedimentation rate, CRP and alpha 2 globulin) as well as the consumption of non-steroidal antirheumatics and corticosteroids were equally used. Results were found to be excellent to good in 316 patients (= 60.8%) and satisfactory in 104 (= 20.1%). 99 patients (= 19.1%) were rated as failures. The drug was well tolerated in 391 cases (= 75.37%), but had to be withdrawn in 128 (= 24.6%) because of side effects. Among these, cutaneous and mucosal symptoms, which occurred in 70 patients (= 13.47% of the total), were most prominent. Serious side effects were absent throughout. | |
| 705267 | Penicillamine-induced polymyositis-dermatomyositis. | 1978 | Two patients with classical rheumatoid arthritis developed myopathy during treatment with penicillamine. In both patients, electromyography and muscle biopsies were indicative of polymyositis. In one patient, muscle enzymes were not examined at the appropriate time; in the other patient muscle enzymes were raised. This latter patient also had a rash and, in the dermal epidermal junction of pathological skin, granular deposits of immunoglobulin and complement were found. The myopathy subsided in both patients after withdrawal of penicillamine. | |
| 7419724 | Inheritance of immunoglobulin M rheumatoid-factor idiotypes. | 1980 Oct | The idiotypic determinants on IgM rheumatoid factor (RF) from a single family have been analyzed. Rabbit Fab'2 antiidiotypic antibody was prepared against purified IgM-RF from a patient with rheumatoid arthritis. As measured by radioimmunoassay, the antiidiotype reacted with at least 90% of the patient's RF, but not with non-RF immunoglobulins from the same serum, nor with 10 of 11 polyclonal and monoclonal RF from unrelated individuals. Cross-reacting idiotypes were detected on RF in four of the patients' first degree relatives, spanning three generations, without apparent relation of HLA type or clinical rheumatoid arthritis. These results suggest that IgM-RF associated idiotypes were inherited in this family. | |
| 4013729 | Alterations of auditory evoked potentials during the course of chloroquine treatment. | 1985 Mar | Chloroquine phosphate is now used extensively in the treatment of active rheumatoid arthritis and in some collagen diseases. The ototoxic potential of this drug during long term use was assessed in 74 patients. At a time when pure tone and speech audiometry failed to demonstrate any hearing change, brainstem audiometry became abnormal in 13 patients. Abnormalities disappeared if chloroquine was withdrawn. Pathogenesis will be discussed on the basis of data obtained from animal experiments. | |
| 6816751 | Enterocolitis complicating chrysotherapy. Case report and review of the literature. | 1982 Oct | We report a case of a 71-yr old man with seronegative rheumatoid arthritis, who developed severe enterocolitis during gold therapy. Radiological studies, endoscopy and biopsies showed diffuse involvement of the stomach, duodenum and small and large intestines. The clinical course was prolonged and complicated by multiple infections. Of the 10 cases with chrysotherapy-induced enterocolitis reported in the literature, 3 were from Israel. There may be a relationship between the development of enterocolitis following gold therapy, ethnic group and HLA-B8 and DRw3 antigens. | |
| 3897531 | Rheumatoid arthritis and osteoarthritis synovial fluid effects on primary human endothelia | 1985 Apr | Since vascular proliferation may be important in the pathogenesis of rheumatoid arthritis (RA) and/or osteoarthritis (OA), this study examined the induction of angiogenesis by these synovial fluids (SF). Four of 11 (36%) RA and 2 of 6 (33%) OA SF caused early morphological changes in human endothelial cell cultures. SF from 7 of 11 (63%) RA and 4 of 8 (50%) OA patients resulted in the late formation of tabular networks morphologically resembling capillaries observed in vivo. Early morphological changes in cultures were associated with a significantly (p less than 0.05) longer duration of disease in patients with RA. Factors present in the SF of RA and OA patients may play a role in the excessive vascularization which often occurs in these arthropathies. | |
| 6376800 | Rheumatoid arthritis and membranous glomerulonephritis: a role for immune complex dissocia | 1984 Jun | Although controversial, several reports have linked rheumatoid arthritis (RA) with membranous glomerulonephritis (MGN). In none of these studies was an infectious etiology such as hepatitis B virus (HBV) thoroughly pursued. We evaluated a patient with classic RA and MGN unassociated with nephrotoxic drugs. Although negative by routine serological methods, hepatitis B surface antigen was eventually demonstrated in the serum, using immune complex dissociative techniques, and in the renal glomeruli, using tissue immunofluorescence. A review of the literature provides no conclusive evidence for a causal relationship of RA to MGN. The renal pathogenic potential of HBV, however, is well documented. Future use of immune complex dissociative techniques and tissue immunofluorescence may be of value in clarifying otherwise unexplained MGN in the setting of RA. | |
| 106466 | [Conspicuous accumulation of membranous glomerulonephritis following gold therapy in chron | 1979 Mar 24 | The development of severe proteinuria or nephrotic syndrome as an adverse reaction to gold therapy in rheumatoid arthritis is well known. Morphologic examination reveals membranous glomerulonephritis in almost all cases. Since the beginning of 1978 there has been a striking increase in the number of such cases seen at this institute. 5 patients aged from 17 to 65 years who had been treated with sodium aurothiomalate for rheumatoid arthritis developed severe proteinuria. In all cases only minimal glomerular changes were observable by light microscopy. Electron microscopy demonstrated multiple electrondense, subepithelial deposits which were confirmed by fluorescence microscopy. In all cases characteristic lysosomes ("aurosomes") were demonstrated in the cytoplasm, mainly of the epithelial glomerular cells. This unusual accumulation of almost identical cases coincides with the introduction of a new gold preparation, Na-aurothiomalate (Tauredon), containing 46% metallic gold. | |
| 432557 | Lymphocyte studies in rheumatoid arthritis. III. A comparative study of the responses of p | 1979 | The response of peripheral blood and synovial fluid lymphocytes to three non-specific mitogens has been studied. The paired samples were taken from patients with a range of inflammatory arthritides. Unstimulated synovial fluid lymphocytes (SFL) tended to have a greater uptake of tritiated thymidine than had unstimulated peripheral blood lymphocytes (PBL). This background uptake of tritiated thymidine by SFL showed a positive correlation with the response these SFL then showed to the mitogens. A significant depression was observed in the SFL response to phytohaemagglutinin when compared with the paired PBL response; this was seen in both the rheumatoid arthritis and other inflammatory joint diseases groups. SFL responses to concanavalin A and pokeweed mitogen, although depressed in individual cases, failed to show a significant depression overall. Attempts to restore the SFL response to that of the paired PBL by removal of any possible blocking substance from the cell surface either by pre-incubation of SFL in tissue culture medium or by enzyme treatment were unsuccessful. This suggested that cell surface blockers were possibly not the reason for deficient SFL reponses and that other factors were involved. | |
| 793780 | A comparative trial of large doses of ketoprofen and indomethacin in the treatment of rheu | 1976 | A 4-weeks' double-blind, crossover study in 30 patients with definite or classical rheumatoid arthritis is reported using 300 mg ketoprofen per day and 150 mg indomethacin per day. Both drugs had similar effects upon the patients' subjective improvement of pain. Objectively, the results also suggest that ketoprofen may be more effective in reducing the articular index, i.e. a superior analgesic effect. Further studies are underway to assess the value of ketoprofen administered in high dosage for longer duration. |