Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 975671 | The Modular (Marmor) knee: case report with a minimum follow-up of 2 years. | 1976 Oct | A follow-up of 2 years or more on 105 patients with the Modular (Marmor) knee replacement revealed that 88 per cent of the patients had a successful result. The complications and failures are analyzed in depth. Late loosening of the components was not observed except with the 6 mm tibial plateau. Pain relief was dramatic as well as improved function, stability and motion. | |
| 806188 | [Multicentric ambulatory trial of Trolovol (D-penicillamine) in chronic polyarthritis]. | 1975 Mar | Discontinuation of therapy and non-observance of the prescribed period required in the present evaluation to take the duration of treatment into account as an influential factor. However, due to the limited extent of the trial, it was not possible to process the time influence. Therefore, the conclusions gained are to be interpreted to the effect that they are statistically vertifiable for a selected patient group with a therapy period of 4 months or longer. | |
| 6792691 | Enteric-coated aspirin in rheumatoid arthritis. | 1981 May | Sixty patients with active rheumatoid arthritis (mean ESR = 51 mm/h) were treated for six months with D-penicillamine (15 patients), sodium aurothiomalate (15 patients), hydroxychloroquine (15 patients) or enteric-coated aspirin (15 patients). The three groups receiving specific anti-rheumatoid therapy were also allowed enteric-coated aspirin in the dose of their choice as the only 'back-up' drug; the group treated with aspirin alone was encouraged to take the maximum tolerated dose. The mean duration of treatment tolerated by patients receiving aspirin alone was 12.3 weeks. Only four patients completed a 24-week treatment period and n improvement was seen in acute-phase reactants. Those patients receiving an anti-rheumatoid drug showed serial improvements in ESR as the dose of aspirin required fell. Plasma salicylate concentrations correlated well with aspirin dosage. Even as an enteric-coated formulation, aspirin alone is not the treatment of choice for active rheumatoid disease. | |
| 6974781 | The use of T cell subtyping to distinguish rheumatoid arthritis from systemic lupus erythe | 1981 May | The use of T cell subtyping to distinguish rheumatoid arthritis (RA) from systemic lupus erythematosus (SLE) was evaluated. We determined the distribution of IgG Fe receptor T cells (TG), IgM Fc receptor T cells (TM), and T cells lacking Fc receptors (Tnull) in 17 patients with RA and 7 patients with SLE. All RA patients including 3 antinuclear antibody positive-rheumatoid factor negative cases had normal numbers and percentages of TG, TM, and Tnull, whereas all SLE patients had a relative and absolute deficiency of TG. This TG lymphopenia was a better discriminator for SLE (7 of 7 SLE, 0 of 17 RA) than anti-DNA antibodies, hypocomplementemia, circulating immune complexes or total number of T cells. | |
| 4055544 | The penetration of ceftriaxone into synovial fluid of the inflamed joint. | 1985 Sep | Fifteen patients with acute exacerbation of rheumatoid arthritis each received a 1 g bolus intravenous injection of ceftriaxone. Serum and synovial fluid was sampled at intervals between 1 h and 24 h later and assayed for ceftriaxone. Synovial fluid leucocyte counts and albumin content were measured concomitantly. Detectable levels of ceftriaxone were found in synovial fluid and serum 24 h after injection. Synovial fluid ceftriaxone concentration ranged between 66% and 100% of the concomitant serum levels. No correlation was observed between synovial fluid ceftriaxone concentration and synovial fluid leucocyte count and albumin concentration. | |
| 6967571 | [Rarefying osteopathy in rheumatology. Methods of evaluation and comparison of urinary hyd | 1980 Jul 31 | Serum proline iminopeptidase and (where possible) urinary hydroxyproline were determined in 214 subjects: normal subjects, subjects with chronic kidney disease, subjects with chronic liver disease, subjects with osteitis deformans, subjects with rheumatoid arthritis, and subjects with osteoporosis. The values of the two parameters fully corresponded. It is suggested, therefore, that proline iminopeptidase can be determined instead of hydroxyproline in cases where a primarily destructive bone disease in present. | |
| 804600 | [Camptodactylia. A study of 33 cases]. | 1975 Mar 7 | A marked camptodactylia, or a mere suggestion of it, was found in 91 (56; 5%) of 161 mentally ill patients, particularly in psychopaths, neurotics and patients in a neurotic state. Clinical, psychological, radiological and biological investigations were carried out in 33 patients. The camptodactylia was frequently associated with distrubances of the carbohydrate metabolism, especially with spontaneous hypoglycemias, as well as arthrotic skeletal changes. The mental disease, which had resulted in incapacity for work, had made us aware of the diversity of the anomalies in our patients. | |
| 118527 | Granulomatous glomerulonephritis in a patient with rheumatoid arthritis treated with gold | 1979 | The clinical course of rheumatoid arthritis in the patient described was characterized by two episodes of microhaematuria, both occurring shortly after the administration of gold salt. The second of these episodes developed into progressive renal failure. Renal biopsy disclosed a rarely described granulomatous glomerulonephritis. Various known pathogenic mechanisms of renal injury are evaluated concerning their applicability in this patient. However, although it is believed that the gold salt therapy was the main agent in the pathogenesis of this fatal renal complication, the mechanism whereby such a pathogenesis proceeded remains unclear. | |
| 3913772 | Short term efficacy of methotrexate in the treatment of rheumatoid arthritis. | 1985 Dec | Methotrexate is easily administered, widely accepted by patients, and has a rapid therapeutic effect. With careful attention to known risk factors, such as alcoholism, diabetes, obesity, and renal disease, it is a useful agent for the treatment of refractory rheumatoid arthritis (RA). Although rheumatologists have been using methotrexate in the treatment of RA for some time, controlled studies have been needed to establish the safety and efficacy of this agent. This paper will review the findings of the Cooperating Clinics of the American Rheumatism Association, as well as other studies that have investigated the short term efficacy of methotrexate. | |
| 6469388 | An immunochemical method for assessing the function of the alternative complement pathway. | 1984 | Activation of the alternative pathway of human complement (C) by soluble C activators resulted in a decrease of C9 antigen, measured by single radial immunodiffusion, concomitant with a decrease of C9 hemolytic activity. In the presence of ethylene glycol bis-(beta-aminoethylether)-tetraacetic acid (EGTA) and Mg2+, this decrease of C9 antigen in the presence of soluble activators such as dinitrophenylated bovine serum albumin depends mainly on the activation of the alternative C pathway. Therefore, an assay system to express the total activity of the alternative C pathway in human serum - the C9 depletion test (C9DT) -, was devised. C9DT showed significantly lower values for patients with systemic lupus erythematosus and rheumatoid arthritis than for control patients. | |
| 6273016 | Human serum inhibitors of collagenase as revealed by preparative isoelectric focusing. | 1981 Dec 9 | Single step separation of pooled normal human serum by means of preparative isoelectric focusing in the range from pH 3.5--9.8 revealed more heterogeneous inhibition of collagenolytic activity than previously reported. Essentially three inhibition zones were resolved. According to their electrophoretic behaviour the respective serum fractions displaying inhibitory activity were designated alpha-, beta- and gamma-collagenase inhibitors. The main component responsible for collagenase inhibition in the alpha-zone was found to be alpha 2-macroglobulin. In the beta-zone inhibitory activity focused around pH 6.3. In the gamma-range a non-dialysable cationic component focusing at pH 9.2 was also able to decrease collagenolytic activity derived from rheumatoid arthritis synovial culture supernatant. These findings were supported by single step separation of serum on DEAE-anion exchange chromatography. | |
| 7285396 | Reassessment of levels of secretory IgA in pathological sera using a quantitative radioimm | 1981 Mar | Serum levels of sIgA were quantitated by a new radioimmunoassay in patients with a variety of diseases, lactating women and clinically healthy blood donors. Significantly elevated levels compared to controls were found in lactating women, patients with Crohn's disease and patients with cirrhosis, but not in patients with rheumatoid arthritis, IgA myeloma or neoplastic disease. Patients with inflammatory disease and serum IgA levels at least two-fold greater than the normal mean and patients with a variety of other diseases did not show elevated levels of sIgA. In the two latter groups, patients with hepatic disease were excluded. High levels of sIgA were found in four patients with liver metastases from extrahepatic neoplasms. The results indicate that the liver is important for the maintenance of normal serum levels of sIgA. | |
| 6939306 | Chromosome instability in human and murine autoimmune disease: anticlastogenic effect of s | 1980 | Increased chromosome breakage is observed in lymphocyte cultures from patients with so-called autoimmune diseases also in the animal model, the NZB mouse. A clastogenic agent was detected in the serum of patients and of NZB mice, that induces also chromosome breaks in cells of healthy individuals. In simultaneous cultures set up with or without superoxide dismutase in 5 patients with progressive systemic sclerosis, 5 patients with systemic lupus erythematosus and 5 patients with rheumatoid arthritis, highly significant differences in the incidence of chromosome breakage were observed. The aberration rate produced in blood cultures of healthy individuals by the breakage factor from patients was also reduced essentially to control values by addition of SOD in vitro, but were reduced also in vivo by injection of SOD in lupus patients as well as in NZB mice. | |
| 577870 | [Pharmacological studies on the antiphlogistic effect of pentosanpolysulfate in combinatio | 1977 | In the present study we investigated the antiinflammatory effect of pentosanpolysulfate (SP 54) in combination with metamizol using different forms of rat paw edema (induced by dextrane, hyaluronidase, trypsin, formaldehyde, carragenine or kaolin). After s. c. application Probaphen, a new drug containing pentosanpolysulfate, metamizol, and lidocaine, proved in our experiments to exert an antiphlogistic effect about 40% stronger than the equivalent amount of SP 54 alone. Since pentosanpolysulfate by itself has no analgetic activity, its combination with metamizol results in a formulation which is not only a more potent antiinflammatory drug but will aslo counteract pains which accompany most edematous reactions. Probaphen may therefore be suggested for the treatment of rheumatoid arthritis and similar inflammatory and edematous processes. First clinical studies and reports on Probaphen fully support our pharmacological results. | |
| 393439 | A simple, rapid micro-latex fixation test. | 1979 Oct | A micro-latex fixation test (LFT) for the determination of rheumatoid factor (RF) is presented. Its advantages compared to similar tests are greater precision, simplicity, increased sensitivity, lower cost, reproducibility and adaptibility to large-scale testing. Micro-LFT titres are presented from a wide range of sample populations. The majority of normal samples show measureable titres whereas rheumatoid patients show high titres. A large sampling of pre- and post-transplant sera from kidney patients was studied and the micro-LFT titres were in the range of normal persons. The transplant sera were tested for lymphocytotoxic antibodies and no correlation was observed with the micro-LFT titres. | |
| 356250 | The long-term efficacy and tolerability of Voltaren (diclofenac sodium) and indomethacin i | 1978 | A report is given on a long-term controlled trial in which diclofenac sodium (Voltaren) was compared with indomethacin in 36 patients with rheumatoid arthritis, both drugs being administered in a dosage of 75-125 mg daily. In this trial, planned as a double-blind study, each patient was to participate for six months, after which the patients treated with diclofenac sodium were to be followed up for a further six months. By the end of the first six months, diclofenac sodium had proved to be clearly superior to indomethacin in terms of therapeutic efficacy. Moreover, unwanted effects referable to either the central nervous system or the gastro-intestinal tract were less common and less severe in the patient treated with diclofenac sodium than in those receiving indomethacin. These results demonstrate that, when given as long-term treatment to patients suffering from rheumatoid arthritis, Voltaren is both effective and well tolerated. | |
| 517330 | Protective role of ceruloplasmin in inflammation. | 1979 Oct | Experimental inflammation in copper (Cu)-deficient rats is greater than that induced in controls eating normal diet. Cu-supplementation of the Cu-deficient diet results in a reduced swelling, down to normal levels. Injection of the naturally occurring acute phase reactant, ceruloplasmin (Cp) a Cu-bearing serum protein, also results in reduction of experimental inflammation. Since a rise in serum Cp occurs in normal pregnancy this protective anti-inflammatory action of Cp is proposed as an explanation for the widely-observed phenomenon of spontaneous control of rheumatoid arthritis in pregnancy. | |
| 970991 | Effects of enzyme induction on metabolism of prednisolone. Clinical and laboratory study. | 1976 Aug | The addition of phenobarbitone in therapeutic dosage to the drug regimen of prednisolone-treated subjects with rheumatoid arthritis produced measurable deterioration in the clinical status of the patients associated with a more rapid clearance of prednisolone from plasma. It is considered that phenobarbitone induced the hepatic metabolism of prednisolone, effectively reducing the steady state plasma level and resulting in clinical relapse. A slight but significant improvement in the adrenocortical response to tetracosactrin (Synacthen) was noted after phenobarbitone therapy. | |
| 6340972 | Fentiazac in rheumatoid arthritis: comparison with sulindac and long-term tolerance. | 1983 | Forty patients with definite or classical rheumatoid arthritis were entered for 3 months in a double-blind trial, 20 patients on 400 mg fentiazac or 200 mg sulindac daily. Statistically significant improvements on fentiazac were reported during the course of the study for 3 of 7 parameters: pain score, total joint score and number of swollen joints, while for sulindac a significant improvement was reported for 6 parameters: pain score, grip strength, joint size, total joint score, number of swollen joints and erythrocyte sedimentation rate. Side-effects were reported during the 3-month comparative period for 3 patients receiving fentiazac, consisting of rash, headache, epigastric pain, and for 1 patient receiving sulindac who suffered from gastro-intestinal intolerance. Because of ineffectiveness and/or side-effects, the treatment had to be discontinued for 5 patients in the fentiazac group and for 3 in the sulindac treatment group. The results support earlier evidence that fentiazac and sulindac have analgesic and anti-inflammatory properties controlling disease activity in rheumatoid arthritis, sulindac being the more effective. During a long-term tolerance study, 3 of 33 patients continued on fentiazac developed a reversible hepatotoxicity possibly due to the drug. | |
| 3873397 | [Studies on B cell activation in collagenoses]. | 1985 Apr | An inverse correlation between PWM and anti mu responses of peripheral blood lymphocytes, and a close relationship to clinical activity were demonstrated in 9 patients with systemic lupus erythematosus. |