Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6367226 | [Comparison of the effects of diflunisal, ibuprofen and placebo in chronic polyarthritis]. | 1983 Dec 23 | Diflunisal, a new nonsteroidal, Aspirin-like anti-inflammatory agent has been compared with Ibuprofen und Placebo in a six-week double-blind randomized crossover controlled study in 24 patients with rheumatoid arthritis. There was a statistically significant improvement for all variables while on Diflunisal and Ibuprofen. Adverse reactions were seen in each of the three treatment groups. Clinical determinations and physiological examinations gave no indication of any potential harm from therapy with Diflunisal. | |
| 6460317 | Autoantibodies to nucleosomal proteins: antibodies to HMG-17 in autoimmune diseases. | 1982 Mar 5 | The relative amounts of autoantibodies against defined nucleosomal proteins present in serums from patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and mixed connective tissue disease (MCTD) have been examined by an enzyme-linked immunoassay. Autoantibodies to nucleosomal proteins were detected in 45 percent of the patients with SLE, 18 percent of the MCTD patients, and none of the RA patients. The results suggest that, in SLE, antibodies are formed against a subset of nucleosomes which contain protein HMG-17. | |
| 7068961 | D-Penicillamine--induced pemphigus syndrome. | 1982 Mar | D-Penicillamine is a chelating agent which is effective in the treatment of Wilson's disease, cystinuria, and lead poisoning. In recent years, it has also been used to treat patients with rheumatoid arthritis with good results. The adverse effects of D-penicillamine are many. These include loss of taste, nephrotic syndrome, lupus erythematosus--like syndrome, polymyositis, dermatomyositis, myasthenia gravis, and agranulocytosis. Beginning in 1969, D-penicillamine was reported to induce a pemphigus eruption. We present a patient with D-penicillamine--induced pemphigus erythematosus and review previously reported cases. | |
| 34380 | [Changes in the pulmonary artery in collagen diseases]. | 1979 | Morphological changes in the pulmonary artery and its major branches were studied histologically and histochemically on autopsy cases of polyarteritis nodosa (23), systemic lupus erythematosus (10), systemic scleroderma (12), and rheumatoid arthritis (5). The ages of the fatalities ranged from 9 months to 77 years. An identical type of lesions was revealed: disorders of the connective tissue, destruction of elastic fibers, alterations of vasa vasorum, with cellular reactions typical of each nosological form reflecting the peculiarities of the immunological processes. The initial stage in the genesis of lesions in the vascular walls of the major pulmonary arteries is the involvement of vasa vasorum as a regular disorder of the microcirculatory ways in all collagen diseases. | |
| 411928 | Pulmonary damage associated with sodium aurothiomalate therapy. | 1977 Autumn | Three patients with rheumatoid arthritis developed acute respiratory distress associated with pulmonary infiltration, during treatment with sodium aurothiomalate. This manifestation of gold toxicity has only recently been recognized. The temporal relationship to the introduction of gold therapy, an exacerbation following further gold injection in one patient, the resolution which followed gold withdrawal and the associated manifestation of gold toxicity in two patients favored a diagnosis of gold-induced pulmonary disease. | |
| 6600515 | Localized rheumatologic diseases. Common diagnostic challenges. | 1983 Feb | Rheumatic pain is usually generalized, but in a variety of conditions it may present as localized and often remain so. These conditions include palindromic rheumatism, osteoarthritis, gout or pseudogout, seronegative spondyloarthropathy, septic arthritis, tendinitis and bursitis, radiculopathy and nerve entrapment, nodular growth, and tendon enlargement. When the presenting feature is focal pain in muscles, joints, or fibrous tissue, the differential diagnosis should include these considerations. | |
| 6978831 | Arthritis: avoiding diagnostic pitfalls. | 1982 Jun | Cervical spondylosis may be the most common cause of arm pain in the elderly. Although patients describe this pain as "severe," they seem able to ease it by massaging the area, which is not the case with other painful rheumatoid conditions. Elevated serum uric acid in an arthritis patient is not always a sign of gout. A definite diagnosis of gout can be made only when urate crystals are found in the joint fluid. | |
| 2858708 | Treatment of active rheumatoid arthritis with slow intravenous injections of thymopentin. | 1985 Apr 13 | 41 patients with active rheumatoid arthritis entered a placebo-controlled double-blind randomised study in which 21 received slow intravenous injections (given in fractions over 10 min) of thymopentin (TP-5) 50 mg 3 times a week for 3 consecutive weeks and 20 received placebo in the same way. After 3 weeks of treatment the TP-5 group showed improvement (p less than 0.05 or p less than 0.01) in all but one of the clinical variables tested. There was improvement in the number of joints painful at rest, the number of joints painful on motion, scores for tenderness on pressure and swollen joints, severity of pain on awakening and morning stiffness, and right-hand grip strength; left-hand grip strength remained unchanged. In the placebo group, only morning stiffness improved significantly. The intergroup comparisons showed that thymopentin was significantly better than placebo in reducing tenderness, joint swelling, severity of pain on awakening, and disease activity. 4 weeks after the end of the TP-5 therapy, the improvement was still present although there was a trend towards relapses. No significant modifications occurred in any of the laboratory variables tested and only minor side-effects were experienced by either group. | |
| 66166 | Serum alpha-fetroprotein concentration in adult patients under corticoid, estroprogestativ | 1977 | The serum alpha-fetoprotein concentration was measured by radioimmunoassy in 41 women with or without hormonal contraception, 21 patients with rheumatoid arthritis given corticosteroids or not, and 6 patients under androgen therapy for aplastic anemia. None of these therapies induced any significant variation of the serum alpha-fetoprotein level. More extensive studies are needed to investigate the possible effect of these hormones on the metabolism of this protein at a cellular level. | |
| 299239 | [New aspects in the pathogenesis of anemia in chronic polyarthritis]. | 1979 | In 44 patients with rheumatoid arthritis and 30 control persons, the activities of the following three hemesynthesizing enzymes were determined: delta-aminolevulinic acid dehydratase (D-ALA-D), porphobilinogen deaminase (PBG-D), and ferrochelatase (FCH). Compared with the control persons in patients with rheumatoid arthritis, statistically significant decreased activities of FCH were determined, whereas no differences between the two groups tested occurred with D-ALA-D and PBG-D. | |
| 847174 | The sesamoid bones of the hands and feet: participators in arthritis. | 1977 Apr | The sesamoids generally appear as small ovoid bones adjacent to articulations or at sites where tendons are angled about osseous surfaces. At either location they participate in joint afflictions, the pattern of abnormality being remarkably constant and predictable. Sesamoids may demonstrate osseous erosion in rheumatoid arthritis, bony proliferation or "whiskering" in rheumatoid variants, joint space narrowing and bony ankylosis in septic arthritis, and eburnation and osteophyte formation in osteoarthritis and diffuse idiopathic skeletal hyperostosis. These changes become particularly important when they occur in the absence of significant adjacent articular disease. In these instances, recognition of sesamoid abnormalities allows accurate radiographic diagnosis. | |
| 6451203 | Morphea-like reaction to D-penicillamine therapy. | 1981 Feb | We report the case of a 48-year-old woman who developed morphea-like plaques after 1 year of treatment with D-penicillamine at 250 mg daily for a seronegative erosive arthritis of rheumatoid type. The rash began as several red itchy patches on the trunk; these became thickened and shiny over about 3 months. The histological appearance was of increased dermal fibrosis with an inflammatory infiltrate round dermal capillaries. However, epidermal changes were not typical of morphea. New lesions ceased to appear within a few months of stopping penicillamine, and by 1 year all the plaques were pale and symptomless. | |
| 366722 | A comparative trial of benoxaprofen and naproxen. | 1978 Nov | A double-blind within-patient trial in rheumatoid arthritis comparing the new anti-inflammatory drug benoxaprofen with naproxen is reported. Patients received naproxen 250 mg b.d. for two weeks and benoxaprofen 200 mg b.d. for three weeks. Both drugs demonstrated efficacy. There was no statistically significant difference between them, except for grip strength which favoured naproxen. Side-effects were mild, infrequent and similar for both drugs. Evidence is presented which confirms the long duration of action of benoxaprofen, a fact which may be of clinical significance. | |
| 7009441 | Comparative evaluation of carprofen and indomethacin in rheumatoid patients. | 1980 Nov | Thirty-six patients with definite or classical rheumatoid arthritis were studied in a 6-week double-blind parallel trial. They were randomly divided into three groups and received either carprofen stepwise 150, 200, and 250 mg/day, carprofen 350, 400, and 450 mg/day or indomethacin 100 mg/day. Classical methods and parameters for evaluating the disease activity of rheumatoid arthritis were used. A large panel of laboratory tests were also involved in the assessment of toxicity. Although the incidence of adverse effects was similar for both drugs, cutaneous and gastrointestinal symptoms were more frequent with carprofen than with indomethacin, whereas central nervous system reactions were elicited more often with the latter drugs. For most of the efficacy variables studied, the carprofen high dosage regimen at weeks 5 and 6 was shown statistically superior or at least not different from the indomethacin group; both of these were superior to the carprofen low dosage regimen. | |
| 6609234 | Serial estimation of anti-RNP antibody titers in systemic lupus erythematosus, mixed conne | 1984 Jan | Anti-nuclear ribonucleoprotein (RNP) antibody titers were estimated serially in 19 anti-RNP antibody-positive patients, which included 10 patients with systemic lupus erythematosus (SLE), 6 patients with mixed connective tissue disease (MCTD) and 3 patients with rheumatoid arthritis (RA). Counterimmunoelectrophoresis was used for antibody detection and a calf thymus extract was utilized as an antigen. Anti-RNP antibody titers in most patients with MCTD and RA did not fluctuate significantly, whereas those in patients with SLE fluctuated by more than a four-fold serum dilution. The anti-RNP antibody titers in SLE seemed to correlate with disease activity. Previous reports have stated that anti-RNP antibody titers do not fluctuate easily throughout the disease course. The present report shows that they do fluctuate in patients with SLE. The use of high dose of steroids in SLE might be responsible for the fall in antibody titer. | |
| 373088 | Double-blind placebo-controlled evaluation of levamisole in chronic rheumatoid arthritis. | 1979 | Thirty-three out-patients with rheumatoid arthritis completed the study intended to compare under double-blind conditions, 50 mg levamisole tablets with placebo. Patients were given the double-blind medication at a dosage of one tablet t.i.d. for 3 months, and at a dosage of one tablet t.i.d., on 2 consecutive days every week for the next 3 months. Pain score, duration of morning stiffness, articular index and E. S. R. were recorded at the start of treatment, after 3 months of treatment and at the end of treatment. The levamisole patients made significantly better progress than did the placebo patients: for E.S.R. after 3 months of treatment, and for E.S.R., pain and morning stiffness by the end of treatment. Ten levamisole patients and 5 placebo patients reported adverse reactions. These were mainly gastrointestinal symptoms in the levamisole-treated patients. | |
| 6204958 | Serological and cellular definition of a new HLA-DR associated determinant, MC1, and its a | 1984 Jul | A new serological HLA-DR associated determinant was defined by a cluster of six B cell alloantisera. This determinant, designated as MC1, was strongly associated with DR1 and DR4 and appeared unrelated to MB, MT, and SB. The antigen frequency of MC1 was 47% in Caucasoids and 43% in Blacks. Mixed leukocyte culture cloning yielded an alloreactive T cell clone with PLT specificity associated with MC1. We have also observed that certain alloreactive clones may also acquire expression of MC1 but not DR4 during long-term culture maintenance in the presence of DR4, MC1-positive feeder cells. Disease association studies showed a significantly increased frequency of MC1 in adult rheumatoid arthritis patients (93.5% vs 47.4% in normals; relative risk 16.1). These findings suggest that MC1 represents a novel HLA-D encoded determinant. | |
| 299749 | Malignancy in rheumatic disease: interrelationships. | 1977 Jan | Patients with inflammatory arthritis and malignancy comprise two distinct populations. One group represents the chance occurrence of malignancy and rheumatic disease. These patients have symmetric polyarthritis, chiefly classic rheumatoid arthritis, and react positively to the rheumatoid factor test. There is no temporal relationship between tumor onset and rheumatic disease onset. In the second group, there may be a causal relationship between the malignancy and the rheumatic disease. These patients have asymmetric rather than symmetric arthritis and test results are negative for rheumatoid factor. There is a close temporal relationship between the onset of the tumor and the onset of the rheumatic disease. The mortality rate is significantly higher than in patients with symmetric polyarthritis. In 80 percent of women with asymmetric arthritis and malignancy, the tumor is mammary carcinoma. This indicates the advisability of a careful breast examination in this group of women. | |
| 6451692 | Treatment complications of rheumatoid arthritis with gold, hydroxychloroquine, D-penicilla | 1980 Nov | One hundred and twenty-five patients with active rheumatoid arthritis unresponsive to nonsteroidal antiinflammatory drugs were treated at the same center with 156 courses of either hydroxychloroquine (43), gold (29), D-penicillamine (40), or levamisole (44). Life table analysis was used to compare the risks of developing various side effects with treatment termination being the endpoint instead of death. Patients treated with levamisole had the highest risk of developing a complication (67%) and antimalarials the lowest (30%). In terms of long term acceptability, hydroxychloroquine showed fewer complications, gold and D-penicillamine were similar with rash and proteinuria being the main difficulties; however, levamisole caused the most frequent terminations mainly due to rash and leukopenia. | |
| 779734 | Arthroplasty of the elbow in rheumatoid arthritis. | 1976 May 21 | The study consists of 208 elbow arthroplasties performed on rheumatoid arthritic patients. A straight resection of the joint was used in 53 cases and a modified Hass arthroplasty with skin interposition in 155 cases. The average postoperative range of motion in these groups was 100 degrees and 96 degrees respectively. Postoperatively the joint was painless in 81 and 67% of the elbows respectively. The Hass arthroplasty gave a better stability and extension power. The most common complications were paresthesias in the region of the ulnar nerve and bone resorption in the region of the ulnar nerve and bone resorption in the region of the olecranon fossa. |