Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 681407 | The Attenborough total knee replacement. | 1978 Aug | The stabilised gliding knee prosthesis is a compromise between hinged joints and condylar prostheses. It is a two-piece implant designed to allow normal gliding movements of flexion and extension and which, stabilised by a connecting rod between the femoral and tibial components, allows a designed laxity of rotation and lateral movements. A modification of the original femoral component is described. Two hundred and forty-five knee replacement operations have been done between January 1973 and September 1977 and the results are reported. The results using this prosthesis are at least equal to those using hinged or condylar prostheses. So far there has been no case of spontaneous loosening of the components and the implant can be used in patients who, because of severe deformities and instability, are unsuitable for condylar prostheses. | |
| 276704 | The measurement of complement as an aid in diagnosis: 1. Nephritis and collagen disease. | 1978 May 10 | A selection of patients with nephritis and collagen diseases were studied for complement abnormalities. This communication briefly reviews the current comcepts of complement physiology, details standard assay used in this laboratory and describes clinical examples where these tests have provided significant clinical information. Quantitative measurements of individual components, the presence of circulating immune complexes, and the demonstration of in vivo C3 cleavage products were assessed simultaneously. The importance of measuring cleavage products and immune complexes is stressed. Clinical examples are given where misleading or erroneous interpretation of results might have occurred if these tests had not been performed. | |
| 1071008 | Unexpected recoveries from chronic severe psychiatric illness during treatment by psycholo | 1976 Sep | Four patients with psychotic illnesses and two with obsessional neuroses made unexpected recoveries attributable to psychological processes. They had been ill for periods ranging from 6 months to 19 years before first seen. All had physical therapies of several kinds including one who had approximately 500 ECT and another who had bimedial lobotomy. Follow-up after recoveries ranged from 6 to 24 years. In two cases psychotherapy (psychoanalytically orientated) was significant. Changed family dynamics, the support of a psychopomp, and the mobilisation of previously unrealized ego-resources were other significant psychological processes. Exhaustive re-evaluation of patients resistant to physical therapies is urged. | |
| 1083126 | [Rheumatic diseases: a public health problem (author's transl)]. | 1975 Sep | This study surveys the main quantitative data of the literature concerning the morbidity and the functional and socio-economic influence of rheumatic diseases. The cost of medical care and the functional and socio-economic repercussions entailed by these diseases represent a heavy burden on the community. In France, epidemiological surveys must be carried out, which will include medical attendance rates, sickness incapacity and statistics on disability. Once the amplitude of this problem is determined, it must be communicated to the general public, using sanitary education techniques, and an influence must be exerted on the authorities to undertake a general campaign against rheumatic diseases. | |
| 3879577 | [Determination of synovial fibronectin by laser nephelometry. Its diagnostic value in rheu | 1985 | The object of the present study was to define the optimal conditions for the quantitative determination of fibronectin in synovial fluid by laser nephelometry and to determine the diagnostic importance of this analysis in rheumatology. The results show that this technique is sensitive (threshold sensitivity is 70 mg/l if the sample is diluted 1/30 and 5 mg/l for a sample diluted to 1/2), accurate, reproducible (coefficient of variation less than 10%), specific, simple and rapid. The response is linear for dilutions from 1/30 to 1/240. Fibronectin P and fibronectin S were determined in 104 subjects who had contracted an arthropathy; 26 cases of rheumatoid polyarthritis, 43 mechanical arthropathies and 35 cases of non-rheumatoid arthritis. the plasma fibronectin does not vary significantly from one group of arthropathies to another but the mean value for the total population of arthropathies is significantly lower than that for a control group. In the synovial fluid the mean value for fibronectin in the patients with rheumatoid arthritis (583 + 76 mg/l) is very considerably higher than that in non-rheumatoid (379 + 58 mg/l) or mechanical (367 + 32 mg/l) arthritis patients. Thus, the determination of synovial fibronectin may provide useful information for the etiological diagnosis of inflammatory arthropathies. | |
| 6360553 | Relapsing polychondritis. A case report and literature review. | 1983 Nov | Relapsing polychondritis is a systemic disorder characterized by recurrent inflammation and degeneration of cartilaginous tissue. The eyes, ears, nose, larynx, trachea, and articular areas are commonly involved. While ocular involvement, hearing, and vestibular dysfunction are frequently present, aortic valve and root disease as well as vasculitis also may occur. While the cause remains unknown, an autoimmune pathogenesis appears likely. Thus, dapsone and/or systemic corticosteroids remain the predominant effective therapies. Another case of relapsing polychondritis with an associated vasculitis syndrome is presented as well as a review of the current literature. | |
| 7063191 | The kinematic rotating hinge: biomechanics and clinical application. | 1982 Jan | The Kinematic rotating hinge offers a solution as a salvage procedure for severely deformed and unstable "end-stage" knees. Excellent short-term results in terms of pain relief can be achieved, and motion up to 130 degrees is possible, depending on the condition of the quadriceps mechanism and the extent of scarring from previous operations. Care must be taken to avoid cortical penetration, especially in cases of hinge revisions, osteoporosis, thin-walled bones, and the presence of old cement. As with any total knee arthroplasty, care must be taken to achieve optimal rotatory alignment of the tibia beneath the femur to guarantee good patellar tracking. | |
| 4113676 | The comet pattern of nuclear immunofluorescence. | 1972 Mar | The significance of the comet pattern of nuclear staining seen when immunofluorescent tests for antinuclear antibodies (ANA) are carried out on unfixed sections of liver has been studied. Fifty-two of fifty-five ANA positive sera tested gave the pattern; there was no correlation with clinical diagnosis nor with the presence of antibodies to DNA. The demonstration of comet staining was dilution-dependent with many of the sera and experimental evidence suggests that nuclear material in antigen–antibody complexes resulting from reaction with potent ANA is prevented from diffusing, whereas with less potent ANA diffusion occurs. | |
| 3863511 | Synovectomy of the hand and wrist. | 1985 | Synovectomy of tendons gives excellent results with rare recurrence. This is because the local environment is altered from a closed space into a decompressed area of healthy fat. The synovium can invade and destroy tendon, cartilage or bone when in a closed space and under pressure. Unfortunately, the environment can not be so altered in a joint. Joint synovectomy, however, is the only procedure available to prolong function of the patient's own joint (and relieve pain) for an "X" amount of time, which depends upon the course of the generalized disease. After two to three years, the result of a synovectomy is dependent upon the course of the general disease activity and not the surgery. It is absolutely necessary that general medical treatment be carried on before, during, and after surgery, as the surgery is only one incident, often dramatic, in total care of the patient. Chemical synovectomy of the hand has been shown to have variable results with only short-term gains being noted. Surgical synovectomy is indicated when synovitis persists in spite of adequate medical management and there is pain and early correctible deformities. Besides removing the synovium, it is necessary to reconstruct the capsular support and correct alignment. Flexor tenosynovitis in the fingers should be treated with decompression of the digital sheath, not incising the pulley system due to the possibility of accentuating the forces causing ulnar drift. Dorsal tenosynovitis in the wrist is treated by tenosynovectomy, synovectomy, resection of the distal ulna, reconstruction of the ulnar side of the wrist and transposition of the dorsal carpal ligament beneath the extensor tendons.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 6501360 | Unicompartmental arthroplasty of the knee. A follow-up of 3 to 9 years. | 1984 Nov | A retrospective review of medial compartment arthroplasty in 22 patients (22 knees) is reported. The operations were performed between 1973 and 1978. Eighty-six per cent were rated good or excellent using the knee rating system devised by the Hospital for Special Surgery, New York. Excellent or good results were achieved in six patients who had previously had a high tibial osteotomy. At the time of follow-up significant loosening had not occurred, although progression of patellofemoral disease was noted. This study supports the promising results reported for unicompartmental resurfacing arthroplasty in the elderly. | |
| 1189496 | [Early recognition of adverse effects, especially of kidney lesions, in patients with prog | 1975 Aug 1 | A report is given on the control of the course of 36 patients with progressive chronic polyarthritis under treatment of D-penicillamine. Despite the favourable therapeutic effect side effects of various kinds are observed. As the severest complication the development of renal disturbances with proteinuria is to be regarded. With the help of the disc electrophoresis of the urine it is possible to establish the beginning disturbances of the permeability of the basal membrane and to achieve a retrogression by reduction of the dose or finishing of the treatment with the medicament, respectively. | |
| 127042 | Reinstitution of gold therapy in rheumatoid arthritis after mucocutaneous reactions. | 1975 Mar | Gold therapy was successfully reinstituted in 28 of 30 patients with rheumatoid arthritis who had previously developed toxic, mucocutaneous reactions. At least six weeks after the reactions had completely cleared, patients were given 1 to 10 mg of gold sodium thiomalate (Myochrysine). This dose was increased every two to four weeks. An initial dose of 1 or 2 mg, with an interval of at least three weeks between injections, increasing not more than5 mg at each injection, is recommended. | |
| 6430252 | Gold nephropathy due to auranofin obscured by tolmetin pseudoproteinuria. | 1984 Jun | A 63-year-old woman with seropositive rheumatoid arthritis was successfully treated with auranofin for 12 months. Heavy proteinuria then developed and the drug was stopped. However, the proteinuria apparently became worse. This was later recognised to be a spurious effect due to the introduction of tolmetin. Renal biopsy showed a type I membranous glomerulonephropathy. | |
| 3934779 | [Comparative effectiveness of the basic drugs used in rheumatoid arthritis (long-term rand | 1985 | Study of the comparative efficacy of the basic slow-acting drugs for the treatment of rheumatoid arthritis permits considering randomization as necessary for obtaining objective data. It has been established that gold salts (chrisanol and myochrysin) are the most efficacious drugs for the treatment of RA. D-Penicillamine and delagil, in particular, are less efficacious. Administration of levamisole is rather dangerous because of the frequency and intensity of side effects. | |
| 2578776 | Salivary secretion and connective tissue disease in man. | 1985 Jan | Parotid and submandibular gland secretions collected from patients with rheumatoid arthritis or systemic sclerosis have been analysed and the results compared with those obtained from a matched group of healthy individuals. Flow rates were measured and the saliva samples assayed for amylase, kallikrein, protein, and salivary IgA concentration. The results showed that only patients with rheumatoid arthritis had a reduced salivary flow, especially parotid flow, with a significantly increased concentration of salivary IgA in both parotid and submandibular saliva. Patients with systemic sclerosis did not show significantly altered salivary flow rates, but there was a marked depletion of salivary IgA content in both parotid and submandibular saliva. Neither disease states appeared to alter the kallikrein or amylase content of saliva. The possible clinical value of these findings is discussed. | |
| 871274 | A comparison of osteotomy and joint replacement in the surgical treatment of the arthritic | 1977 Apr 22 | The relatively small numbers of knees compared in this study make it impossible to draw conclusions with great confidence. On the other hand we believe that the quality of our comparison has been improved by our effort to match the groups of knees under study. Our results lead to the controversial conclusion that, at least in RA and in elderly patients with OA, ICLH arthroplasty is preferable to osteotomy regardless of the pathology and preoperative deformity and that osteotomy should not be used as a temporizing procedure before ICLH arthroplasty. We are unable to say whether or not similar conclusions would apply to other forms of arthroplasty but we suspect that they would. Certainly joint replacement is now widely preferred to osteotomy at the hip and it is difficult to see why the knee should be different. It should not be concluded from these results that replacemnt is to be preferred to osteotomy for the mildly damaged knee. It does however appear that if osteotomy fails (for technical or other reasons), it may then be difficult to obtain a satisfactory result even by replacement. Thus if a patient with a mildly damaged knee is not to be disabled irreparably, it may be better to avoid osteotomy until the day comes when the causes of failure after this operation can be predicted preoperatively and prevented. The data presented here suggest (as do those in many other studies) that one step in this direction is to confine osteotomy to the varus OA knee. Even in this group the surgeon should, we believe, do his utmost to avoid surgery altogether until the parents' disability is unacceptable. In summary therefore, we now advance the view that if the arthritic knee is sufficiently disabling to require major surgery, it should be replaced. If the disability is less severe, the joint should be treated conservatively. | |
| 1102060 | The forgotten nodule: complications of sacral nodules in rheumatoid arthritis. | 1975 Oct 11 | Nodules commonly occur in rheumatoid arthritis and occasionally give rise to complications. The sacral nodule is easily missed and may ulcerate to produce extensive sacral sores which may lead to serious and even fatal complications in patients with rheumatoid arthritis. Seven cases are reported which illustrate some of these features. | |
| 5045879 | Peroxidase arthritis. I. An immunologically mediated inflammatory response with ultrastruc | 1972 Apr | Synovitis was produced in rabbits by daily intra-articular injections of the heterologous antigen horseradish peroxidase. The resulting "peroxidase arthritis" resembled rheumatoid arthritis histologically. Many of the subsynovial plasma cells, plasmablasts and immunoblasts contained specific antibody to horseradish peroxidase; the remainder appeared to contain immunoglobulins of other specificities. Peroxidase arthritis has unique advantages for the study of the cellular and subcellular events in the pathogenesis of the local immune inflammatory response to heterologous antigen. Antigen and specific antibody can be localized precisely by ultrastructural cytochemical technics. The reaction can be terminated at any stage, permitting observation of the early events in its pathogenesis. | |
| 1084575 | Granulocyte reactive antinuclear factors in juvenile rheumatoid arthritis. | 1976 | The prevalence of mouse liver reactive antinuclear factors (L-ANF) and human granulocyte reactive antinuclear factors (G-ANF) was determined in sera from 34 age- and sex-matched pairs of patients with juvenile rheumatoid arthritis (JRA) and controls. Neither type of antinuclear factor was found in any of the control sera, whereas of the patient sera, 35% were L-ANF positive and 59% were G-ANF positive. 90% of the G-ANF positive sera were of the IgG class and 50% were able to fix complement. L-ANF was most frequent in female patients. Several types of ANF were associated with the polyarticular form of the disease. Such varying prevalences of ANF with disease types might indicate that JRA is a syndrome rather than a disease. In particular, the complement fixing G-ANF titre was positively correlated with parameters related to disease activity. The great variation in prevalence figures of different ANF types previously reported and the possible clinical significance of these auto-antibodies are discussed. | |
| 6941392 | Effect of anti-inflammatory drug administration in patients with rheumatoid arthritis. An | 1981 | A prospective endoscopic study was carried out in 65 patients with rheumatoid arthritis to assess the prevalence of gastroduodenal lesions on aspirin alone or aspirin plus another anti-inflammatory drug (n = 26). All patients were taking greater than or equal to 8 tablets aspirin/day for greater than or equal to 3 months. Drug therapy consisted of regular, buffered or enteric-coated aspirin +/- one other non-steroidal anti-inflammatory drug or less than or equal to 10 mg prednisone/day. Endoscopic findings were graded as normal, or gastric and/or duodenal erythema, erosions, or ulcer; only the most serious lesion was tabulated. Fifty-three percent of patients on aspirin alone has a gastric ulcer or erosions, and 13% duodenal ulcer or erosions compared to 35% with gastric lesions and 4% with duodenal lesions on aspirin plus a second drug. Twenty-two percent of patients taking regular aspirin had gastric ulcers compared to only 6% taking enteric coated. Patients on enteric coated aspirin and prednisone had only a 10% prevalence of severe gastro-duodenal lesions. In conclusion, the combination of a second anti-inflammatory drug and aspirin therapy did not result in a higher prevalence of gastro-duodenal damage over that produced by aspirin therapy alone. Enteric coated aspirin produced significantly fewer serious lesions than regular or buffered aspirin. The combination of enteric-coated aspirin plus low dose prednisone caused a low prevalence of severe gastro-duodenal lesions. |