Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 983688 | Sjögren's syndrome. | 1976 Sep | Sjögren's syndrome is a multisystemic connective tissue disease. The syndrome is associated with other major connective tissue disorders, such as rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis and others, Reticulo-endothelial malignances have repeatedly been reported in patients with Sjögren's syndrome. A clinical study of 20 patients with Sjögren's syndrome was performed in the Department of otolaryngology, Rikshospitalet, Oslo, Norway. A considerable complexity of symptoms was seen. One patient with malignant lymphoma and one with a thyroid carcinoma were encountered. | |
| 3968425 | Characterization of the natural killer-like lymphocytes in rheumatoid synovial fluid. | 1985 Mar | IgG Fc- cytotoxic cells found in the synovial fluid of patients with rheumatoid arthritis have natural killer (NK)-like characteristics but can kill NK-resistant cell lines as well. The phenotype of these cells was defined by complement-mediated lysis with monoclonal antibodies. The synovial fluid killer cell activity was significantly reduced by treatment with complement and OKT11 and 4F2, but the cytotoxic T cells did not express the NK-related antigens OKM1 and Leu-7, nor the cytotoxic T lymphocyte-specific antigen, OKT8. These results demonstrate that the synovial fluid killer cells resemble the activated T cells generated in an autologous mixed leukocyte reaction or in the treatment of peripheral blood mononuclear cells with interleukin 2, and they are distinct from the conventional NK cells found in blood. | |
| 7004073 | Histopathological analysis of sixteen subcutaneous rheumatoid nodules. | 1980 Nov | An immunopathological study was carried out on subcutaneous nodules (rheumatoid nodules) biopsied from 16 patients with rheumatoid arthritis. Sixteen rheumatoid nodules were histologically classified into three stages, the 1st stage (acute inflammatory stage, 3 cases), the 2nd stage (granulomatous stage, 10 cases), and the 3rd stage (scar-formed stage, 3 cases). In necrotic or granulation tissue of the nodules in the 3 stages, immunofluorescent analysis using FITC-labeled rabbit anti-human immunoglobulins, beta 1C, and fibrinogen serum gamma-globulins and FITC-labeled aggregated human IgG gave results that were strongly positive in the 1st stage, moderately positive in the 2nd stage, and only slightly positive or almost negative in the 3rd stage. Acute or chronic thrombotic endoarteritis was observed around rheumatoid nodules in 6 out of the 16 cases. Among them, 2 cases of the 1st stage showed acute thrombotic endoarteritis with marked infiltration of neutrophils in the wall, and 2 cases of the 2nd and the 3rd stages respectively showed chronic endoarteritis with organized thrombi. | |
| 6779373 | The glomerular filtration rate during penicillamine therapy in rheumatoid arthritis. | 1980 | Twenty-one consecutive patients (14 women and 7 men aged 35-68 years, mean age 50 years) with chronic active RNA for 2-24 years (mean 12.7 years) had a normal glomerular filtration rate (GFR) (mean value 99.8 +/- 14.8% (S.D.) of sex- and age-dependent normal value) before penicillamine treatment. All patients had previously been undergoing gold treatment; no patient had signs of renal disorder, or diabetes. GFR (total 51Cr-EDTA plasma clearance) was measured before and after 3 and 6 months' penicillamine treatment, respectively. Treatment was stopped because of side effects in 4 patients, including one with renal side effects. In the remaining 17 patients there was a mean fall in GFR of 3.8 +/- 12.5 (S.D.) ml/min during 6 months' penicillamine treatment, which was not significant. There was no correlation between individual changes in GFR and penicillamine dose. The individual changes in GFR correlated well to individual changes in plasma creatinine. Repeated determinations of plasma creatinine should be done during penicillamine treatment. | |
| 1080878 | Free rheumatoid factor in dental periapical lesions and gingivae of patients with rheumato | 1975 | To determine whether evidence of rheumatoid inflammation, in the form of free rheumatoid factor, might be found in the teeth-supporting tissues of patients with known rheumatoid disease, tissues from the dental periapical lesions of one group of 50 rheumatoid and 23 control patients, and from the marginal gingivae of a second group of 58 rheumatoid patients were examined by the direct immunofluorescence technique that employed fluroesceinisothiocyanate (FITC)-labelled aggregated human IgG. The gingival tissues contained no free rheumatoid factor. Free rheumatoid factor-producing plasma cells were, however, detected in the dental periapical lesions of 3 of the 50 rheumatoid patients, i.e. in 6%, and in 1 of the control patients i.e., in 4%. This control patient had suffered from nephritis 10 months prior to the investigation. Because free rheumatoid factor did occur, albeit infrequently, in the dental periapical lesions of rheumatoid patients, a search for IgG rheumatoid factor, known to occur in greater abundance than the IgM type although "hidden", was indicated. | |
| 6942668 | Gold-induced thrombocytopenia. A clinical and immunogenetic study of twenty-three patients | 1981 Aug | Thrombocytopenia developed in 23 patients with rheumatoid arthritis treated with gold salts over 25 years. All patients recovered, and there were no episodes of life-threatening hemorrhage; four patients eventually needed splenectomy. The clinical presentation of gold-induced thrombocytopenia and its treatment and outcome are reviewed. Because gold-induced thrombocytopenia is believed to have an immunologic basis, we sought an association between this complication and antigens of the human leukocyte antigen (HLA) region. The most significant finding was the association of the HLA-DR3 alloantigen in 12 of 15 of these patients compared with 26 of 84 in a control population (x2 12.9, p less than 0.001). This study provides further evidence that gold-induced thrombocytopenia is immunologically mediated and that genes of the major histocompatibility complex are involved. | |
| 6162783 | The antigenicity of asialylated IgG: its relationship to rheumatoid factor. | 1981 Mar | Native IgG of human or rabbit origin, from which terminal sialic acid is removed by immobilized neuraminidase, undergoes changes in structure and antigenicity. Such asialylated rabbit IgG's tend to agglutinate, and are immunogenic in autologous hosts. The sialic acid content of rheumatoid factor (RF) isolated from the serum of a rheumatoid patient and identified as IgG and IgM, was also found to be lower than that of normal IgG and IgM. These findings indicate that carbohydrate residues influence the secondary structure of IgG and suggest an enzymic mechanism for the genesis of RF. | |
| 6800961 | Detection of antibodies to streptococcal mucopeptide in patients with rheumatic disorders | 1982 | Bacterial mucopeptide is an integral part of bacterial cell walls and is therefore ubiquitous in our environment. An enhanced degree of humoral immunity has ben detected not only in patients with acute rheumatic fever (ARF), with a known recent response to streptococci, but also in patients with adult and juvenile rheumatoid arthritis (RA and JRA). Our studies confirmed this association with ARF and JRA using a precipitin system as well as a radioimmunoassay to detect IgG anti-mucopeptide antibodies. In those with adult RA, either IgM or IgA rheumatoid factors or IgM or IgA antibodies specific for mucopeptide were responsible for the increased incidence of precipitins to mucopeptide in the RA patients detected in this and other studies. No differences in the specificities of the anti-mucopeptide antibodies were noted between the various patient populations as there were no lines of partial identity or nonidentity when examined by Ouchterlony double diffusion analyses. Additionally, no differences of anti-mucopeptide antibody were observed when the sera from these same patient populations were examined employing inhibition studies utilizing N-acetylglucosamine and rhamnose. | |
| 6352267 | Calcium entry blocking agents in digital vasospasm (Raynaud's phenomenon). | 1983 May | We have evaluated the therapeutic effect of the calcium entry blocking agent nifedipine in Raynaud's phenomenon associated with connective tissue diseases and in idiopathic digital vasospasm. In a preliminary study 16 patients with a digital vasospasm that could be induced by hand-immersion in cold water (4 degrees C) were challenged a second time with cold water 1 and 6h after 20 mg oral nifedipine. Nifedipine provided an effective protection against this cold-induced vasospasm in 14 of the 16 patients. Thirty patients were included in a short-term ambulatory study: Raynaud's phenomenon was associated with progressive systemic sclerosis (PSS) in 10 patients, systemic lupus erythematosus (SLE) in five and rheumatoid arthritis (RA) in three; it was idiopathic (I) in 12 patients. Each patient received, in a double-blind manner and random order, on two consecutive weeks, nifedipine (20 mg three times daily) and placebo. Nifedipine proved to be effective: the mean number of digital vasospastic attacks per week decreased from 27.3 to 5.8 (P less than 0.01). The results in the SLE and RA groups were similar and were pooled. The improvement (in % decrease) was better in the idiopathic group (90.9) than in the SLE and RA group (78.6, P less than 0.02) and the PSS group (64.0, P less than 0.01). | |
| 1189402 | [Treatment of rheumatoid arthritis with a preparation of Sanokrizin--intravenous administr | 1975 | Treatment with the preparation "Sanokrizin", applied i. v. has been carried out to 50 patients with rheumatoid polyarthritis--32 seropositive and 18 seronegative forms, being with a duration of the morbid process from one to 17 years. Therapeutic effect was obtained in 78 per cent of the cases, followed up from six months to one year while that therapy proved to be without effect in 22 per cent of the patients or only separate symptoms of the inflammatory process were partially affected. The preparation has a good tolerance and the side-effects, in the absence of controlled auremia, are overcome with discontinuation of the carried out treatment and only to two of the patients corticosteroids were given additionally. With an average dose, per course, of 1751,60 mg effect was also obtained upon single symptoms of the rheumatoid inflammation. The patients, effected at the earliest in the course of the therapeutic process, are with the best and most durable therapeutic effect and that might be used as a prognostic criterion for the favourable effect of the carried out treatment with the preparation "Sanokrizin". | |
| 6369174 | [Rheumatoid arthritis. Considerations on a rational therapeutic strategy]. | 1984 Feb 28 | Rheumatoid Arthritis (RA) is a progressive disease of unknown aetiology which may be caused by faulty immune mechanisms. Early diagnosis and correct treatment can be extremely effective. Fast and lasting results can only be obtained by an appropriate combination of NSAID and DMARD drugs which both reduce subjective symptoms and halt the progression of the disease. | |
| 7006526 | IgM-rheumatoid factors cross-reactive with IgG and a cell nuclear antigen: immunopathologi | 1980 Dec | The cross-reaction of IgM-rheumatoid factors (IgM-RF) with a cell nuclear antigen has been further investigated by immunofluorescence procedures. This reaction appears to be optimal at pH 8-9, and fails to occur at pH 6.5. No evidence was obtained by immunofluorescence that IgM-RF bound to the cell nuclear antigen fixes complement. It would appear that the nuclear reactivity of IgM-RF may be of limited immunopathological significance, though this reaction is of note in understanding the behavioural nature of rheumatoid factors. | |
| 6183741 | [Seronegative rheumatic spondyloarthropathies (spondarthritis)]. | 1982 Sep 11 | The group of seronegative rheumatic spondylarthropathies (spondarthritis) includes different diseases with common features. The common characteristics of these diseases are sacroiliitis and/or spondylitis, usually oligoarticular arthritis, distinct extraarticular manifestations of the skin, mucous membranes, eyes and internal organs, and a common genetic disposition. To differentiate the diseases within this group, of which spondylitis ankylosans counts as the prototype, allowance must be made for radiomorphological changes of the spine, the various joints involved and the type of extraarticular symptoms. The therapy depends upon the type of disease, although the therapeutic principles remain the same as far as the spine is concerned; pain treatment and conservation of spine mobility are the main factors. | |
| 6340699 | Ia specific antilymphocyte antibodies in rheumatoid arthritis. | 1983 Apr | Antilymphocyte antibodies (ALA) in rheumatoid arthritis (RA) have increased reactivity with phytohemagglutinin (PHA) activated lymphoblasts which are known to have increased expression of Ia antigen. The present experiments suggest that part of this reactivity represents an Ia specificity of ALA. Fifteen of 18 RA sera tested were able to inhibit the binding of monoclonal anti-Ia antibodies as measured by a rosette method. RA sera did not inhibit the binding of other monoclonal antibodies: anti-OKT3, anti-OKT4, and anti-OKT8. The ability of RA sera to inhibit the binding of anti-Ia antibody was eliminated after absorption of the RA sera with an Ia positive human cell line (B35M) but not by an Ia negative line (MOLT4). Blocking of anti-Ia binding was greater in the IgG fraction of the RA sera but also occurred in the IgM fraction. Experiments including ultracentrifugation, pepsin digestion of RA sera, and preincubation of lymphoblasts with aggregated IgG demonstrated that Fc binding by RA sera was not a factor. Both monoclonal anti-Ia and anti-Ia heteroantiserum also had increased reactivity with lymphoblast target cells. Pepsin digested Fab fragments of the anti-Ia heteroantiserum were able to block the activity of cytotoxic RA serum. However, ALA cytotoxic to lymphoblasts did not correlate with anti-Ia by rosette method. Ia-specific ALA by rosette method was associated with donor variability but did not appear to be HLA-DR restricted. Ia-specific ALA did correlate with disease activity. These data suggest that anti-Ia activity is present in RA sera and may play an immunoregulatory role in this disease. | |
| 7014877 | Effects of D-penicillamine on circulating protein complexes in rheumatoid arthritis and pr | 1981 Jan | Not immunosuppressive in conventional test systems, D-penicillamine causes minor reductions in Ig levels and occasionally induces IgA deficiency. Rather limited evidence indicates actual decline in immune complexes; more data show reductions in levels of 9S IgG and alpha1-antitrypsin-IgA complexes. On the other hand, a number of instances of toxic reactions are most readily explained on the basis of autoimmunization. Changes in redox equilibrium, haptenization, and influence on T cell function are possible mechanisms. | |
| 6375174 | [Origin and significance of a thermostable granulocyte antigen]. | 1984 Feb 15 | In 1972 the thermostabile antigen of granulocytes was for the first time isolated by Thoss and Abendroth from punctates of the joint of patients with rheumatoid arthritis. Its origin from mature neutrophil granulocytes was ascertained by fluorescence-microscopic investigations. In the present paper the existence of thermostabile antigen of granulocytes in neutrophil granulocytes could be confirmed. The fluorescence pattern of neutrophil granulocytes of healthy persons did not show any differences in comparison to patients with inflammatory or myeloproliferative diseases as well as granulocytes from punctates of the joint or sternal marrow. With the help of punctates of the lymph-nodes the presence of thermostabile antigens of granulocytes in cells of the lymphatic system could be excluded. In smears of the sternal marrow positive fluorescence could be proved in the myelopoesis in neutrophil metamyelocytes. Quantitative investigations in inflammatory and myeloproliferative diseases as well as in granulocytopenias showed that the TSGA -serum values of the numbers of granulocytes go parallel. In punctates of the joint of patients with rheumatoid arthritis we found concentrations of thermostabile antigens of granulocytes which up to 50-fold were above the normal values of the serum. There was a close correlation to the number of granulocytes in the synovial fluid and to the cytological local activity. The TSGA -level can be regarded as indicator of granulocytic activation. | |
| 6406333 | [Long-term drug therapy in inflammatory rheumatic diseases using chronic polyarthritis as | 1983 Apr 14 | The article reviews the principles of the long-term drug therapy of rheumatoid arthritis. A nomogram is presented which allows selection of adequate antiphlogistic and long-term drugs according to activity and progression of the disease. Steroids, non-steroidal antiphlogistics, gold, D-penicillamine and azathioprine are described in the order of their application during treatment of a severe polyarticular flare-up. Some of the drug regimens are relevant also to diseases other than rheumatoid arthritis, but drug therapy reflects only a single aspect in the treatment of these diseases and has to be applied together with non-pharmacologic methods (surgery, physical therapy, functional therapy, psychology etc.). | |
| 1094965 | Feprazone, a new anti-inflammatory agent. Studies of potency and gastrointestinal toleranc | 1975 Apr | Two studies are reported; a double-blind cross-over trial of feprazone 600 mg daily and aspirin 3.6 g daily in the treatment of rheumatoid arthritis, and an uncontrolled open study of gastrointestinal tolerance in twenty rheumatoid arthritis patients with known intolerance to other drugs. The first study showed that feprazone was significantly superior to aspirin in all the parameters tested. In the second study all twenty patients showed an improvement of their gastrointestinal symptoms, nineteen reporting no symptoms at all when taking the new preparation. | |
| 6334525 | Clonally restricted anti-IgG antibodies in rheumatoid arthritis. | 1984 Dec | Clonally restricted anti-IgG antibodies were detected, by isoelectric focusing (IEF) and chromatofocusing techniques, in the sera of patients with rheumatoid arthritis (RA). Anti-Fab antibodies were predominantly acidic proteins with isoelectric points of 4.5-6.5 and displayed restricted spectrotype patterns. Proteins reactive with the Fc portion of IgG showed polyclonal spectrotype patterns with alkaline pI of 7.5-9.0. A limited array of anti-Fab spectrotypes was consistently detected in RA sera when analyzed by IEF on 6M urea gels. Additional anti-Fab antibody bands were detected when the RA sera were dialyzed against 4-6M urea prior to IEF analysis, indicating that some anti-Fab antibodies exist in a complexed form in serum. Under these dissociating conditions, anti-Fab antibodies could also be detected in normal subjects, but the spectrotype patterns were more restricted than those in RA sera. Because anti-Fab antibodies may regulate normal immune responses, the increased quantity of clonally restricted anti-Fab antibodies in RA may indicate an abnormality of this immunoregulation. | |
| 6785436 | D-penicillamine-induced increase in intracellular glutathione correlating to clinical resp | 1981 Jan | Measurement of glutathione (GSH) in consecutive blood samples from patients with rheumatoid arthritis (RA) revealed, in good responders to D-penicillamine, a 20% to 35% increase in erythrocyte-GSH (E-GSH) levels after 2 to 8 wk of treatment. Usually this rise predicted a clinical response some wk later. Nonresponders to D-penicillamine who did not show an increase in E-GSH could be converted to responders by receiving L-cysteine. E-GSH rose--prior to the clinical response--by up to 50% of pretreatment values. In RA patients with spontaneous changes in disease activity, E-GSH tended to decrease during relapses and increase before remissions. |