Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1079527 | Low free serum histidine concentration in rheumatoid arthritis. A measure of disease activ | 1975 Jun | A study of sera from 285 patients with definite or classical rheumatoid arthritis (including 37 patients receiving no anti-inflammatory drugs) and sera from 67 healthy subjects has confirmed 10 published reports of a statistically significant decreased blood histidine concentration in patients with rheumatoid arthritis. Contrastingly, in sera from 231 patients with a variety of acute and chronic illnesses other than rheumatoid arthritis, no statistically significant hypohistidinemia was observed either in the group as a whole or in association with the administration of aspirin, prednisone, indomethacin, phenylbutazone, or dextropropoxyphene. In the patients with rheumatoid arthritis there was a statistically significant correlation between the serum histidine concentration and the following: Westergren sedimentation rate (r=-0.33, P smaller than 10- minus 9), grip strength (r=0.26, P smaller than 10- minus 9), hematocrit (r=0.23, P smaller than 10- minus 9), duration of morning stiffness (r=-0.14, P=10- minus 5), walking time (r=-0.13, P=10- minus 4), latex titer of rheumatoid factor (r=-0.11, P=0.001), and the duration of arthritis (r=-0.06, P=0.05). There was no statistically significant association between the serum histidine concentration and the duration of rheumatoid arthritis in the 151 patients with disease of 0-10-yr duration (r=0.02, P=0.5), the sex of the patient, or the presence of antinuclear antibody (R=0.007, P=0.9). The serum histidine concentration was less in rheumatoid patients receiving steroids (P=0.00001), gold (P=0.009), and aspirin (P=0.15) than in rheumatoid patients not receiving these drugs. This study indicates that histidine determinations on properly preserved casual serum samples can be helpful in the diagnosis of rheumatoid arthritis and in the evaluation of the activity of the disease. | |
| 6144796 | Rheumatoid arthritis: is serum vitamin B12 high in active disease? | 1984 Apr | Seven clinical and laboratory indices of disease activity were compared with serum vitamin B12 levels in 32 patients with rheumatoid arthritis treated with penicillamine (16 patients) or sulphasalazine (16 patients) for up to 24 weeks. Prior to treatment each patient had active disease but a normal or low serum vitamin B12 concentration. During treatment, significant improvements occurred in all clinical and laboratory measurements but vitamin B12 levels were unchanged. We have been unable to confirm a reported positive association between rheumatoid disease activity and serum B12 concentration. | |
| 7008552 | Possible role of a copper complex in the pathogenesis of rheumatoid arthritis. | 1981 | Clinical and experimental evidence suggest that rheumatoid arthritis may be due to a deficiency in joint fluid of an inhibitor of protein denaturation. This inhibitor may be a histidine-cystine-copper complex. A deficiency of this inhibitor may permit the nonimmunological alteration of joint fluid IgG to a pseudoimmune complex which could initiate the inflammation and immunological abnormalities of rheumatoid arthritis. | |
| 6596431 | Fibrositis (Fibromyalgia) in rheumatoid arthritis. | 1984 Dec | We studied demographic socioeconomic and clinical characteristics of 38 patients with fibrositis (fibromyalgia) that occurred in association with rheumatoid arthritis (RAFIB) and 242 patients with rheumatoid arthritis (RA) alone. Fewer RAFIB patients were married (57.1%), and most (97.4%) were women. No statistically significant differences in income, medical expenditures or other demographic variables were identified. All measures of function, pain, disease activity and psychological status were more abnormal in RAFIB patients. The clinical characteristics that best differentiated RAFIB and RA patients were pain, depression, anxiety and erythrocyte sedimentation rate, in logistic and stepwise regression models. Evaluation of disease severity markers, including radiographic erosions and frequency of total joint replacement, suggested that disease severity in RAFIB and RA is similar. | |
| 843113 | Rheumatoid arthritis in a tribal Xhosa population in the Transkei, Southern Africa. | 1977 Feb | An epidemiological survey of rheumatoid arthritis (RA) was undertaken in a tribal Xhosa community in the Transkei of Southern Africa. 577 respondents aged 18 and over were examined clinically and of these, 549 were investigated radiologically and 482 serologically. The presence of RA was then assessed by means of a modification of the Rome criteria, as used in previous comparable surveys. The prevalence of 'definite' RA in the adults aged 18 and over in this population was 0-68% and of 'probable' RA, 1-6%. The combined 'definite' and 'probable' prevalence was 2-2%. The relatively low prevalence of RA in this population is consistent with the results of other surveys in unsophisticated African Negro populations in West Africa and South Africa, and contrasts with the higher prevalence encountered in an urbanized South African Negro community and in populations in Europe and the USA. | |
| 1260338 | Rheumatoid arthritis and ankylosing spondylitis occurring together. | 1976 Apr 3 | Rheumatoid arthritis and ankylosing spondylitis are often difficult to differentiate, though it is important to do so as the natural history and treatment of the two conditions differ. Nine patients have recently been seen, each of whom fulfilled the criteria for both rheumatoid arthritis and ankylosing spondylitis. In eight of the nine patients the histocompatibility antigen HLA-27 was present. A possible explanation of these cases is that one of the diseases occurred by chance in patients already suffering from the other, but this is extremely unlikely. If a chance association is not the correct explanation the basic concepts defining rheumatoid arthritis and ankylosing spondylitis must be reconsidered. | |
| 866905 | Reumatoid arthritis in Iraq. | 1977 May | Altogether 198 patients (149 female and 49 male) with rheumatoid arthritis, 133 classical and 65 definite by A.R.A. diagnostic criteria, have been studied in Baghdad. The disease pattern and the joint distribution are similar to those in Europe but the disease appears to be generally less destructive; hands are involved more often than the feet, and rheumatoid nodules, severe systemic upset and extra-articular manifestations appear to be less common. | |
| 466338 | Autonomic neuropathy in rheumatoid arthritis. | 1979 Jul 21 | Patients with seropositive and seronegative rheumatoid arthritis (RA) and age-matched controls were investigated for the presence of autonomic neuropathy. Significantly more patients with RA had abnormal autonomic function, suggesting that autonomic neuropathy occurs more commonly in RA than hitherto suspected. The existence of an autonomic neuropathy may be an important complicating factor in rheumatoid disease and may lead to increased morbidity and mortality. | |
| 4090478 | 'Pseudoseptic' arthritis in patients with rheumatoid arthritis. | 1985 Oct | It is generally recognized that patients with rheumatoid arthritis are at greater risk than the general population for the development of bacterial joint infection. It is not usually appreciated, however, that such patients may present with a clinical syndrome that mimics septic arthritis in most respects except that all cultures are consistently negative and antibiotics are not essential for treatment. We report our experience with five cases of "pseudoseptic" arthritis in patients with rheumatoid arthritis and suggest an approach for management. | |
| 970996 | Radiological cervical arthritis in populations. | 1976 Aug | The prevalence of cervical rheumatoid arthritis and its relationship to rheumatoid serum factors and erosive arthritis in peripheral joints has been studied in radiographs of the cervical spine and of the hands and feet drawn from 12 population samples. The changes were graded in accordance with the Atlas of Standard Radiographs of Arthritis. Rheumatoid arthritis of the cervical spine (grades 2-4) was observed in 4.1% of males and 4.7% of females aged 15 and over. Prevalence was greatest in those born before 1900, 15% of whom were affected. There was a significant association with the sheep cell agglutination test but not with the bentonite flocculation test, though the latter correlated well with erosive arthritis in the joints of the hands and feet. Arthritis of the cervical spine showed a significant correlation with both seropositive and seronegative erosive arthritis in the peripheral joints. A significantly higher prevalence of cervical arthritis than expected was noted in two population samples, one in Germany and the other in West Africa, though in neither was there a high prevalence of peripheral arthritis. The German population had relatively high antistreptolysin titres. A low prevalence of cervical arthritis was noted in populations in Czechoslovakia and in Arizona. 'Congenital' block vertebra had a prevalence of 0.9% in persons born before 1935, but none was observed in those born since. The figures suggest that environmental influences predisposing to cervical arthritis and block vertebra have changed in the last 40 years. | |
| 1165149 | Rheumatoid arthritis in the Pima Indians of Arizona: an assessment of the clinical compone | 1975 Jun | When a prevalence study of Rheumatoid Arthritis (RA) was made in the adult Pima Indian population living on the Gila River Reservation, a high prevalence was found using the New York criteria (5-9 per cent). This was mainly due to the high frequency of limitation of motion which brought in many undesirable subjects. After excluding it as a component of New York criteria we found a prevalence for RA of 3 per cent with a predominance among the females (3-8 as against 2-0 per cent in males). The group so defined fulfilled the requirements of the Rome criteria, showed a higher concordance with serological or radiological evidence of RA, and appeared to identify subjects in whom the experienced clinical rheumatologist would more often agree with the diagnosis. | |
| 367177 | Paleopathologic evidence for the evolution of rheumatoid arthritis. | 1978 Jan | A human skeleton recovered from a Sicilian archaeological site and dating from the Hellenistic period (330-210 B.C.) presents a pathological pattern suggesting a transition between ankylosing spondylitis and rheumatoid arthritis, providing evidence in support of the hypothesis that rheumatoid arthritis may have recently evolved out of ankylosing spondylitis. | |
| 490523 | Rheumatoid markers in the absence of arthritis. | 1979 May | A 45-year-old man had high titer rheumatoid factor in his serum, marked elevation of his erythrocyte sedimentation rate, and a histologically proven rheumatoid nodule in the absence of other manifestations of rheumatoid disease. These findings are most unusual and emphasize that serologic and histologic markers of rheumatoid arthritis may be present without arthritis or other disease manifestations. | |
| 623705 | Pulmonary infection and rheumatoid arthritis. | 1978 Jan | Five of eleven patients with bronchiectasis and/or cystic fibrosis developed a polyarthritis with positive tests for rheumatoid factor. Possible mechanisms of this complication are discussed. | |
| 422636 | Synovectomy of the elbow in rheumatoid arthritis: the place of excision of the head of the | 1979 Feb | The results of thirty synovectomies of the elbow for rheumatoid arthritis are reported. Satisfactory relief of pain was obtained in twenty-seven elbows and the range of movement was improved in twenty-one. The classical operation includes excision of the radial head but in this series approximately half the radial heads were conserved with comparable results. The results of synovectomy do not significantly deteriorate with time up to ten years and the operation can be done with good results, especially in respect of relief of pain, even in elbows with relatively advanced rheumatoid disease. Radiographic assessment is not of much help in evaluating the results of the operation, but is essential in selection of elbows for synovectomy. | |
| 918958 | Catecholamine metabolism in the patients with rheumatoid arthritis. | 1977 May | The amount of urinary catecholamine of healthy subjects and patients with rheumatoid arthritis, particularly before and after synovectomy, was studied. (1) The urinary catecholamine of patients with rheumatoid arthritis showed a lower value than that of healthy subjects. The greater the amount of intraarticularly injected steroids was and the more severe the stage and class of rheumatoid arthritis were, the lower the level of adrenaline was and the more reduced the activity of phenylethanolamine-N-methyltransferase was. (2) The level of urinary noradrenaline in patients with rheumatoid arthritis was lower than that of healthy subjects, but there was no relationship between the level of noradrenaline and the amount of intraarticularly injected steroids. Considering that noradrenaline tended to approach to the normal level as the stage of class of rheumatoid arthritis was more severe, the level of urinary noradrenaline in patients with rheumatoid arthritis seems to reflect the existence of a certain compensatory system in the enzyme system of catecholamine metabolism rather than the influence of the adrenal cortex system. (3) The urinary catecholamine was decreased after synovectomy; especially, noradrenaline level was remarkably decreased. These results suggest that catecholamine plays an important role in the appearance of pain or other clinical signs in rheumatoid arthritis. | |
| 748552 | Rheumatoid arthritis with a normal erythroycte sedimentation rate. | 1978 Fall | A persistently normal erythrocyte sedimentation rate in the presence of active synovitis was found in 17 out of 500 patients with rheumatoid arthritis. These were compared with 17 age- and sex-matched random rheumatoid arthritis controls. The patients were mostly female (15/17) and seronegative (12/17). Other acute phase reactants were measured in some cases and were also normal. Athough erosion and deformity occurred in more than half, significant involvement was restricted to the small, peripheral joints. The limited mass of inflamed synovial tissue may account for the absence of an acute phase response. | |
| 6660237 | Articular patterns in the early course of rheumatoid arthritis. | 1983 Dec 30 | Articular patterns of rheumatoid arthritis were determined based upon the numbers of joints found to be tender or swollen in 50 younger adult patients with early-diagnosed rheumatoid arthritis examined semi-annually over a mean interval of 5.7 years. Numbers of joints involved were analyzed according to (1) cross-sectional frequency distributions, (2) cumulative probability plots of each patient's linear regression slope during follow-up, and (3) clinically intuitive definitions of course patterns. These approaches converged on three articular patterns, that is, monocyclic, polycyclic, and progressive. Monocyclic course was observed more frequently in men, in patients without rheumatoid factor, and in those with the fewest numbers of joints involved at entry. Polycyclic course was the most common and characterized by a level regression slope of involved joints during follow-up, although fluctuating over time. This course could be subdivided into the intermittent (having at least one remission of joint involvement for at least six months) and the continuing patterns. Progressive course was least common and found in patients with the greatest numbers of joints involved at entry. These data indicate that articular patterns in rheumatoid arthritis are usually established within the early course of disease. Further study of the early course of rheumatoid arthritis should be pursued for proper understanding of its host determinants, prognostic factors, and optimal patient management. | |
| 6612175 | A comparison of patients with seropositive and seronegative rheumatoid arthritis. | 1983 | It has recently been suggested that a subpopulation of patients with rheumatoid arthritis, diagnosed on clinical, radiologic and pragmatic grounds, but with negative rheumatoid factor tests, represents a clinical entity quite distinct from that of seropositive rheumatoid arthritis. We have studied 60 sequentially presenting patients, 30 of whom were selected because they were seronegative, and 30 selected because they were seropositive in regard to IGM rheumatoid factor. The only major differences detected between the two groups on "blind' assessment were a greater tendency to deformity, a greater degree of erosion and the presence of subcutaneous nodules in the seropositive group. Seronegative and seropositive rheumatoid arthritis appear to have very similar clinical features, but differing degrees of severity. | |
| 7236327 | HLA and rheumatoid arthritis in the Japanese. | 1981 May | Sixty-three Japanese patients with rheumatoid arthritis (RA) were typed for HLA-A, -B, and -DR locus specificities. A significant association was found only with increased frequency of HLA-DR4 in the patients (71.4%) compared with controls (41.8%) (corrected P = 0.007, relative risk = 3.5). No association was found with HLA-A9 or HLA-Bw54, which are in linkage disequilibrium with HLA-DR4 in the Japanese. The association between HLA-DR4 and RA observed in these Japanese patients has also been demonstrated in the white population. |