Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6412616 | Immunogenetics of rheumatoid arthritis. | 1983 Apr | There is overwhelming evidence that Rheumatoid Arthritis (RA) is under genetic influence, but the mechanisms are unclear. Many studies have implicated HLA-DRA as an important marker for disease susceptibility, though this is not the case in all racial groups. Analysis of familial RA has shown a marked restriction in allelic combinations or supratypes. Mapping of the MHC by complement allotyping has further emphasised the relatively limited number of supratypes associated with RA. Disease associated supratypes may also serve as markers for complications induced by drugs such as D-penicillamine, and be shared by other diseases such as Type I Diabetes. That supratypes may have important biological functions is drawn from studies in complement C2 deficiency and 21-hydroxylase deficiency. Examination of supratypes should allow a more direct approach in understanding the pathogenetic mechanisms in RA, and the role of other markers outside the MHC. | |
| 7024811 | Clinical and immunologic effects of fractionated total lymphoid irradiation in refractory | 1981 Oct 22 | Ten patients with refractory rheumatoid arthritis were given 3000 rad of fractionated total lymphoid irradiation in an uncontrolled therapeutic trial. Total lymphoid irradiation was associated with objective evidence of considerable clinical improvement in eight patients and with reduced blood lymphocyte counts in all 10. On completion of irradiation, there was an abrogation of lymphocyte reactivity in vitro in the patients with clinical responses, but abnormal antibody activities characteristic of rheumatoid arthritis and normal components of humoral immunity were not suppressed. Partial recrudescence of arthritis occurred shortly after a year after the completion of irradiation and was paralleled by a restitution of lymphocyte concentrations and responsiveness to mitogens to levels similar to those observed before irradiation. These data provide further evidence of T-cell involvement in the pathogenesis of rheumatoid arthritis and demonstrate that total lymphoid irradiation can induce temporary relief, but they do not ascertain whether the natural history of this disease was altered. | |
| 3872635 | Anti-Ro(SSA) positive rheumatoid arthritis (RA): a clinicoserological group of patients wi | 1985 Apr | The clinical, laboratory, histological, and radiological manifestations of 90 Greek patients with anti-Ro(SSA) negative rheumatoid arthritis (RA) were compared with those of 15 Greek patients with anti-Ro(SSA) positive RA. Anti-Ro(SSA) positive RA patients had the same articular and extra-articular manifestations as anti-Ro(SSA) negative patients. However, they were predominantly females with lower rheumatoid factor titres and a high incidence of positive minor salivary gland biopsy specimens for Sjögren's syndrome. Finally, anti-Ro(SSA) positive RA patients frequently experienced penicillamine side effects. | |
| 7066208 | Erythropoiesis in the anaemia of rheumatoid arthritis. | 1982 Apr | Erythropoietic activity and mean red-cell lifespan were measured using 59Fe-transferrin in 32 anaemic patients with active rheumatoid arthritis (RA) and in 20 haematologically normal subjects. Marrow iron turnover (MIT) in the patients was normal and in only 11 was red-cell lifespan less than 70 d. Ineffective iron turnover (IIT) was significantly increased in those patients in whom there was evidence of iron deficiency (serum ferritin less than 12 microgram/l) but in the remaining patients IIT was significantly less than in the normal subjects. In a further 19 patients with simple iron deficiency anaemia IIT was significantly increased. The marrow response to chronic inflammatory disease is clearly distinct from that seen in simple iron deficiency and this suggests different pathogenic mechanisms for these two anaemias. | |
| 2933800 | Atrioventricular conduction time in rheumatoid arthritis. | 1985 | The atrioventricular conduction time (P-R interval) was determined in 189 women and 90 men with rheumatoid arthritis (RA). Only three women and one man were found to have pathological prolongation of the P-R interval. However, a significant prolongation of the P-R interval, within normal range, was seen in women with RA compared with healthy controls. Apart from the relation to radiographically enlarged heart, prolonged P-R interval showed no association with other signs of RA and had no prognostic implications in the follow-up period (mean 5.4 years). Current chloroquine therapy delayed the atrioventricular conduction while corticosteroids accelerated it. | |
| 6681153 | Melorheostosis and rheumatoid arthritis. | 1983 Oct | A 63-year-old woman presented with the clinical picture of classical rheumatoid arthritis. X-ray examination also showed typical aspects of melorheostosis involving both femurs by linear hyperostosis. Humoral and bone scan findings were all in keeping with rheumatoid arthritis. Moreover, a reduced renal phosphate reabsorption and hypophosphatemia were found along with mild hypercalcemia and hypercalciuria. No evident relationships among rheumatoid arthritis, melorheostosis and renal phosphate handling were observed in this case. | |
| 7465641 | [Capillaroscopy in rheumatoid arthritis]. | 1981 Jan | Three capillaroscopic features to be found at the base of nails are recognizable in rheumatoid arthritis. This is in conjunction with the clinical picture, the biological data, and the course of development. In the first, the tissue is transparent, there are many small comma-shaped capillary loops; the second feature is characterized by extreme transparency, pale base and long "hair-pin" loops spread in treillis form over the venular plexus in slow, granular circulation. A third feature recalls from the start a state of collagenosis, because of the inhomogenous opacity of the tissue, the presence of capillary hemorrhage and the irregular appearance of the loops, often of the "megacapillary" variety (I.E. congenital capillary dilatation). This division into three categories determines the character prognosis and treatment. It corresponds histologically to "pulp" biopsy and to the region of glomie arterio-venous anastomosis. There is therefore a real rheumatoid histoangiopathy. | |
| 1153306 | [Psoriatic rheumatism. Prospective study of 50 cases, without sacroiliac involvement and w | 1975 May 10 | The authors report the results of a prospective study comparing 50 cases of psoriatic arthropathy with peripheral articular involvement only and negative rheumatoid serology with 50 cases of classical or definite rheumatoid arthritis paired according to sex, age and the duration of the disease. The results were studied using the X2 test of statistical significance. Despite frequent similarity with rheumatoid arthritis, psoriatic arthropathy differs from it significantly on the basis of a series of characteristics which may be summarised as follows: less wide dissemination and decreased severity of clinical and radiological articular lesions; more gradual progression by attacks separated by periods of remission, often total, resulting in less severe degree of invalidity than rheumatoid arthritis and therefore requiring less often the use of oral corticosteroids. The authors discuss the case of psoriatic arthropathy with positive rheumatoid serology and that of psoriatic arthropathy with combined peripheral and vertebral column involvement. | |
| 6467851 | Delayed cutaneous hypersensitivity in rheumatoid arthritis: the influence of nutrition and | 1984 Mar | Significant depression of delayed cutaneous hypersensitivity (DCH) to seven common recall antigens was found in 50 patients with rheumatoid arthritis (RA) compared with 50 matched controls. Complete skin anergy was seen in 12 (24%) of the RA patients but in none of the control subjects. In addition, a nutritional assessment of all subjects tested showed significantly lower serum albumin and body mass indices in the RA compared with the control group. Analysis of these 100 subjects showed a significant correlation (r = 0.53, p less than 0.001) between the number of positive skin reactions and the concentration of serum albumin suggesting an association between nutritional status and DCH. No single factor could be identified to distinguish the reactive and anergic RA patients with the possible exception of drug treatment in that a higher proportion of patients on sodium aurothiomalate or immunosuppressive therapy than D-penicillamine was found in the anergic group. It is likely that the cause of impaired DCH in RA is multifactorial and our findings suggest that drug treatment and nutritional status may be an important contributor to it. | |
| 6608130 | HLA-DR antigens and disease patterns of rheumatoid arthritis. | 1983 | HLA-DR antigens were determined in 111 patients with classic or definite rheumatoid arthritis. HLA-DR4 was significantly (P corr. less than 10(-6] increased in patients with rheumatoid arthritis (54%) compared with controls (23.2%). HLA-DR 5 was decreased in rheumatoid arthritis (12.6% vs 26.4% of controls); however, the corrected P value was not significant. There were no significant differences with regard to various clinical, radiological and serological parameters between HLA-DR 4 positive and negative patients. However, a milder course of rheumatoid arthritis was observed in DR 7 positive patients: Patients with this antigen were associated significantly with seronegativity and low titers of IgM-rheumatoid factor. Despite a similar disease duration patients with DR 7 had a significantly lower number of joints with inflammatory arthritis (synovitic swelling with limitation of movement) and developed less frequently severe radiological changes as joint ankylosis than DR 7 negative patients. In addition to the well known association between rheumatoid arthritis and HLA-DR 4, our data indicate that HLA-DR 7 may have a protective effect on the course of rheumatoid arthritis. | |
| 7425972 | Vasculitis and ischaemic optic neuropathy associated with rheumatoid arthritis. | 1980 Aug | Fundus lesions are said not to be found in direct relationship to rheumatoid arthritis. A vasculitis or retinopathy if present is said to be secondary to concomitant hypertension or due to some connective tissue disease other than rheumatoid arthritis. The case is presented of a 64-year-old female with sero-positive rheumatoid arthritis. During a period of exacerbation of her arthritis she developed anterior ischaemic optic neuropathy (A.I.O.N.) resulting in blindness of one eye, followed two weeks later by a temporary occlusive episode in a cilioretinal arteriole in the other eye. The patient was normotensive and had neither clinical nor immunological evidence of other connective tissue disease. The patient died two months later from cardiac arrhythmia. The autopsy findings confirming posterior ciliary arteritis as the cause of the A.I.O.N. are presented. The subject of rheumatoid vasculitis in relation to the eye is reviewed and immunological mechanisms and investigations discussed. | |
| 7321036 | A method to increase compliance to exercise regimens in rheumatoid arthritis patients. | 1981 Jun | A hand exerciser with an electronic counter and a visual display was used to measure compliance objectively, to investigate the effects of visual feedback on compliance, and to assess the impact of exercise on seven mild and five moderate rheumatoid arthritis patients. A multiple time-series design varying the onset of the visual display was utilized. Compliance was assessed weekly over the 7 weeks of the study. Pretest and posttest measures of various indicators of hand functioning were taken by an occupational therapist. Visual display of the number of exercises completed decreased the number of noncompliant patients from six to two, with the maximum degree of noncompliance reduced from 44 to 5%. Thus the use of visual display is effective in producing compliance to exercise regimens. In light of the small sample size, however, no definitive conclusions can be drawn regarding the effects of exercise on hand functioning. | |
| 6467848 | The natural history of rheumatoid arthritis: a fifteen year follow-up study. The prognosti | 1984 Mar | One hundred patients with definite or classical rheumatoid arthritis have been followed since the early months of their disease; after 15 years the 65 surviving patients were reviewed. Their functional capacity had fallen by comparison with reviews made 3 and 11 years after onset, but half were still unimpaired or only moderately so (grade 1 and 2). The number of affected joints had risen to an average of 8 joints in men and 13 in women, but the ESR and the titre of the Rose test were lower than in the first year. Haemoglobin levels had risen in men, but fallen in women. The first-year titre of the Rose test proved to be of great prognostic significance, regarding ARA grading and number of affected joints after 15 years, but it did not correlate with the functional capacity. However, the functional capacity at 3 years correlated significantly with its value at 11 and 15 years. Patients with rheumatoid nodules were significantly worse than the remainder in many respects. A positive Schirmer test, showing diminished tear secretion, did not relate to any of the clinical parameters. The medical and surgical treatment is briefly reviewed. | |
| 3966939 | Therapeutic value of graded aerobic exercise training in rheumatoid arthritis. | 1985 Jan | Women with rheumatoid arthritis performed 1 of 3 low intensity aerobic exercise protocols (15, 25, and 35 minutes) 3 times per week for 12 weeks. A nontraining group served as controls. All exercise groups improved their aerobic capacity, exercise time, and joint counts. Subjects described improvement in activities of daily living and reduced joint pain and fatigue. Exercise duration up to 35 minutes can be therapeutic, and as little as 15 minutes of exercise 3 times/week is sufficient to improve aerobic capacity in rheumatoid arthritis patients with severe limitations. | |
| 6696517 | Nuclear magnetic resonance (NMR) tomographic imaging for popliteal cysts in rheumatoid art | 1984 Feb | The ability of nuclear magnetic resonance (NMR) tomographic imaging to show a change in proton spin-lattice relaxation time (T1 value) in the joints of patients with rheumatoid arthritis before and after treatment with intra-articular steroid has been assessed. Six patients with seropositive rheumatoid arthritis and clinical evidence of a popliteal cyst were examined by both NMR tomography and arthrography. In all cases the presence of active rheumatoid arthritis was shown by an increase in the T1 values of the synovium of the joints. After arthrography a consistent but small rise in T1 value was noted which fell to below the initial reading after treatment by intra-articular injection of an anti-inflammatory agent. In all cases the presence of the popliteal cyst was clearly shown by both NMR tomography and arthrography. The findings indicate that NMR tomography provides a sensitive method for the demonstration of inflammatory joint disease, popliteal cysts, and possibly for monitoring response to therapy. | |
| 7387217 | A comparison of clinical assessments of disease activity in rheumatoid arthritis. | 1980 Apr | Six clinical assessments of disease activity, including a new summated change scale (SCS), have been compared in a group of 30 patients with rheumatoid arthritis seen on 8 separate occasions during their first 6 months of therapy with either D-penicillamine or hydroxychloroquine. Articular index and grip strength correlate best with erythrocyte sedimentation rate and C-reactive protein, pain score and early morning stiffness less well, and summated change score and joint circumference least well. Articular index and grip strength also correlated well with the other clinical parameters and are therefore judged to be the best clinical indices of change in treatment with these drugs. | |
| 6430250 | Mechanisms of depressed delayed-type hypersensitivity in rheumatoid arthritis: the role of | 1984 Jun | The presence of anergy and its relationship to malnutrition was investigated in patients with rheumatoid arthritis (RA) and in controls. A generalised reduction in delayed cutaneous hypersensitivity to 7 recall antigens were found in 104 RA patients compared with 67 controls. No measured of the disease was capable of predicting cutaneous anergy, which was present in 36% of patients but none of the controls. A detailed dietary assessment in 30 RA patients and 30 controls revealed little evidence of clinically important malnutrition. It is therefore concluded that the cutaneous anergy of rheumatoid arthritis is not a consequence of nutritional factors. | |
| 6202005 | C-reactive protein in the serial assessment of disease activity in rheumatoid arthritis. | 1984 | C-reactive protein (CRP) levels were measured in 105 patients with rheumatoid arthritis (RA) during treatment with slow-acting anti-rheumatoid drugs D-penicillamine, alclofenac, hydroxychloroquine, gold, sulphasalazine and azathioprine. A control group treated with aspirin alone was also included. Patients were assessed clinically (pain score, articular index and summated change score) and in terms of acute-phase reactants (CRP, haptoglobin, fibrinogen, ESR and plasma viscosity) at eight separate clinic visits during the 6-month treatment period. The estimation of CRP was found to be more useful than haptoglobin, fibrinogen or ESR as an index of disease activity. | |
| 7116277 | An investigation of the possible inverse relationships between the occurrence of rheumatoi | 1982 Aug | One hundred and eleven inpatients with schizophrenia and 51 with other psychiatric conditions were compared for the frequency of rheumatoid arthritis, other connective tissue disorders and other physical illness. Evidence both of rheumatoid arthritis and osteoarthritis was significantly less in the schizophrenia group. Latex Agglutination Tests were positive to the same extent in both groups. One possible explanation of the findings is that they are due to the reduced frequency of trauma or stress to the joints in schizophrenic inpatients, many of whom lived in hospital, compared with the control group. Other explanations are also considered. | |
| 434945 | Leucapheresis in severe rheumatoid arthritis. | 1979 Feb | Two patients with severe seropositive rheumatoid arthritis previously unresponsive to conventional therapy have been treated with leucapheresis. This technique involves continuous cell separation daily to remove primarily lymphocytes. Clinical improvement was recorded with the use of standard rheumatological measures of inflammation. It is concluded that leucapheresis may help in the management of severely active rheumatoid arthritis when conventional therapy has been unsuccessful. |