Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7305474 | Serum histidine in rheumatoid arthritis: a family study. | 1981 Oct | We have compared free serum histidine in patients with rheumatoid arthritis, their blood relatives, and their non-blood relatives. The hypohistidinaemia of rheumatoid arthritis is acquired with the disease and does not provide a biochemical marker of those at risk. | |
| 7396595 | Rheumatoid-like arthritis associated with a colonic carcinoma. | 1980 May | A 76-year-old woman with rapidly progressive athritis associated with a rising rheumatoid factor, acute joint effusion, and fever had remission of her symptoms and return of her laboratory values to normal following removal of a colonic carcinoma. | |
| 6788180 | Rheumatoid arthritis and food: a case study. | 1981 Jun 20 | Clinical and laboratory studies in a patient whose rheumatoid arthritis appeared to be exacerbated by dairy produce showed that challenge with milk and cheese resulted in a produced increase in synovitis and changes in immune complexes, IgE antibodies, and heat-damaged red cell clearance rates. Exclusion of dairy products from the diet produced a considerable improvement in her previously aggressive disease. | |
| 6605121 | Thrombocytosis of active rheumatoid disease. | 1983 Oct | Two cross-sectional and one longitudinal study of patients with rheumatoid arthritis showed that platelet number correlated with both clinical and laboratory parameters of disease activity, including erythrocyte sedimentation rate, zeta sedimentation ratio, viscosity of plasma and blood, white cell count, liver enzymes, rheumatoid factor, and several acute-phase proteins. There was also an inverse relationship between platelet number and the haemoglobin and serum albumin levels. III Indium-labelled platelet survival was reduced in 4 patients with active rheumatoid arthritis despite a raised platelet count, with labelled platelets being localised to inflamed joints in the 2 patients studied. Platelet aggregation was normal. We suggest that the raised platelet count of active rheumatoid arthritis may be a useful index of disease activity and may represent a bone marrow stress (syndrome) response to shortened platelet survival, with platelet sequestration occurring in areas of synovial inflammation. | |
| 6678193 | Rheumatoid vasculitis: diagnostic and therapeutic decisions. | 1983 Dec | Rheumatoid vasculitis is an uncommon but potentially catastrophic complication of RA. There are few extensive experiences recorded in the current literature and there is no consensus regarding the clinical features, laboratory findings, histologic pattern, prognosis, or appropriate management of this syndrome. We therefore surveyed 1,947 North American ARA members for their perceptions of rheumatoid vasculitis. Four hundred twenty-eight surveys were returned, of which 290 were suitable for analysis. The majority of respondents were within 10 years of fellowships and were evenly distributed among private practice, and part-time and full-time academic positions. The respondents saw 15-50 rheumatoid arthritis (RA) patients weekly and less than five RA vasculitis patients annually. The majority correctly diagnosed two actual and complex case histories from patients with and without autopsy-proven vasculitis. Respondents associated the following features most strongly with rheumatoid vasculitis - mononeuritis multiplex, digital gangrene, digital ischemic lesions, nailfold ischemic lesions, non-healing leg ulcers, palpable purpura, fingertip nodules, sensory neuropathy, scleromalacia perforans, high titer rheumatoid factor, positive visceral angiography, cryoglobulinemia, hypocomplementemia, circulating immune complexes, and histologic necrotizing vasculitis or vascular transmural neutrophilia. Digital lesions or sensory neuropathy alone were not viewed as portending an ominous prognosis by most respondents and would have been treated with nonsteroidal anti-inflammatory drugs, antimalarials, gold salts, or D-penicillamine. Other clinical manifestations considered as reflecting rheumatoid vasculitis (gangrene, mononeuritis multiplex, ulcers) were thought to worsen prognosis and would have been managed more often with corticosteroids, D-penicillamine, cytotoxic agents or plasmapheresis. Rheumatoid vasculitis is viewed as a heterogeneous group of syndromes with varying clinical and histopathologic features,which have different prognostic implications, and therefore should be managed differently. While these dta do not substitute for an extensive recorded series of patients, they provide useful information about community perceptions of an uncommon but difficult clinical problem. They identify the need for additional data to examine the validity of these attitudes. | |
| 4026404 | Disease activity indexes in rheumatoid arthritis; a prospective, comparative study with th | 1985 Jul | There are many difficulties associated with the assessment of disease activity in rheumatoid arthritis. Infrared thermography has been used to quantify joint inflammation. The heat distribution index (HDI) is reproducible, sensitive, quantifiable, and not subject to circadian variation or interobserver error. In this study the HDIs for both elbows, wrists, knees, and ankles were summated and compared with other parameters of disease activity. There were 167 sets of observations in 20 patients with classical, seropositive, rheumatoid arthritis followed up over 12 months. There was a significant correlation (p less than 0.001) for thermography with the Ritchie articular index, Mallya score, grip strength, morning stiffness, erythrocyte sedimentation rate, and pain score. Significant correlations (p less than 0.05) for thermography with these parameters were found in individual patients. The summated HDI is a suitable, objective method for the assessment of response to therapy in patients with rheumatoid arthritis. | |
| 6364806 | Rheumatoid nodules. Review of the spectrum of associated conditions and proposal of a new | 1984 Feb | The literature relating to prevalence, characteristics, differential diagnosis, histologic features, pathogenesis, complications, and prognosis of rheumatoid nodules is tabulated and reviewed. The broad spectrum of conditions associated with rheumatoid nodules is discussed. A new classification of these clinical entities, reflecting disease characteristics and prognosis, is proposed. This classification is based on age, association or lack thereof with rheumatoid arthritis or rheumatic features, the presence or absence of rheumatoid factors, and the location of the rheumatoid nodules. Four cases of rheumatoid nodules in patients without rheumatoid factor are presented. Three patients had classic or definite rheumatoid arthritis, and one had palindromic rheumatism. In follow-ups lasting one to 15 years, significant permanent joint deformities, bony erosions, or extra-articular manifestations of rheumatoid arthritis have not developed in any of the patients. All have experienced significant periods of remission. | |
| 3971090 | Rheumatoid neck. | 1985 Feb | Rheumatoid arthritis of the cervical spine may cause spinal cord compression. The diagnosis may be delayed if the neurological features are wrongly attributed to an entrapment neuropathy or rheumatoid peripheral neuropathy. Neurological progression should be treated by a cervical fusion in patients who are otherwise fit. | |
| 517640 | Efficacy of compression gloves in rheumatoid arthritis. | 1979 Dec | Twenty-three patients with rheumatoid arthritis whose disease had become stabilized while receiving non-steroidal, anti-inflammatory drugs and/or gold salt injections entered an 8 week crossover study in which the effect of a compression glove worn during sleep was compared to a loosely fitting glove made of the same material. Improvement in hand symptoms was greater with the compression glove than with the control glove as regards morning stiffness, pain, night time throbbing, numbness or heaviness and a subjective assessment of swelling (p = 0.01). In addition, swelling of the proximal interphalangeal joints was slightly reduced (p = 0.05). These data suggest that the night time use of compression gloves in patients with rheumatoid arthritis can improve hand symptoms and exert a mild, transiently beneficial effect upon the degree of hand swelling. | |
| 6742900 | Nutritional status in patients with rheumatoid arthritis. | 1984 Jun | A nutritional assessment of 50 patients with rheumatoid arthritis (RA) showed evidence of malnutrition in 13 (26%), while all 50 control subjects had normal nutritional status. Of the anthropometric measurements the body-mass index and triceps skinfold thickness values in men and women were significantly reduced in RA patients compared with controls. Upper arm muscle circumference was significantly less in male but not female rheumatoid patients. In addition all six biochemical determinants of nutrition assayed-serum albumin, transferrin, retinol-binding protein, thyroxine-binding prealbumin, zinc, and folic acid-were significantly lower in the RA group of patients. Malnourished patients had more active disease than the remaining RA patients, with significantly higher ESR, C-reactive protein, and alpha 1 antichymotrypsin measurements. Significant inverse correlations were found between some biochemical measurements of nutrition and indices of disease activity. Our results suggest that in RA the severity of disease adversely affects the nutritional status. | |
| 7375870 | Early rheumatoid arthritis in the USSR and in Finland. | 1980 | In 1974-76 patients with early rheumatoid arthritis (duration less than or equal to 6 months) were investigated at the Institute for Rheumatism, Moscow, and at the Rheumatism Foundation Hospital, Heinola, Finland. Of 200 patients in each centre, 142 sex- and age-matched patients were chosen and followed up for one year. Despite common selection criteria, appreciable differences were found in clinical involvement, X-ray findings and laboratory results. Many of these may be due to difficulties in the standardization of methods rather than to actual national differences in the clinical picture and course of the disease. In both institutions, almost every patient was given systemic antirheumatic drugs, but there were notable differences in the choice of drugs: gold was preferred at Heinola, chloroquine or cytostatics were more commonly used in Moscow. The use of both local and peroral corticosteroids was similar, while surgery was used only in Heinola and spa treatment only in Moscow. | |
| 1275586 | Objective measurement of rheumatoid arthritis using technetium index. | 1976 Feb | The technetium index was measured in 22 patients with rheumatoid arthritis, before and after 6 months' treatment either with penicillamine or with anti-inflammatory drugs. The index was calculated by dividing the sum of the count rates over both knees and both wrists by the dose of technetium given. In the penicillamine group there was a significant reduction in the technetium index and the changes correlated well with some clinical measurements of improvement. It is suggested that the technetium index is a useful objective measure of the effects of drugs with a specific activity in rheumatoid arthritis. | |
| 6601550 | Correlation of antibody to rheumatoid arthritis associated nuclear antigen and immune comp | 1983 Feb | Twenty-seven patients with rheumatoid arthritis (RA) maintained on drug regimens were studied monthly for 6-10 months. Disease activity was assessed and levels of anti-RA associated nuclear antigen (RANA) and immune complexes were determined. Anti-RANA generally paralleled disease activity in 64% of cases. Immune complex levels paralleled disease activity in 56% of cases and paralleled anti-RANA in 52% of patients. Immune complexes paralleled anti-RANA together with disease activity in only 33% of patients. Anti-RANA and/or immune complex levels paralleled disease activity indices in 82% of cases. Significant fluctuations (greater than or equal to four-fold) in anti-RANA were frequently found (65%) and were associated with concordant changes in immune complex levels 50% of the time and with changes in disease activity indices 59% of the time. The data suggest that levels of anti-RANA and immune complexes may be important in RA and warrant further investigation. | |
| 6713801 | Terminal phalangeal sclerosis in rheumatoid arthritis. | 1984 May | The incidence of terminal phalangeal sclerosis in the hand radiographs of 150 patients with rheumatoid arthritis was compared with a control group of radiographs of non-rheumatoid patients. Terminal phalangeal sclerosis was more common in females than in males and was more common in females with rheumatoid arthritis than in female controls. In rheumatoid arthritis terminal phalangeal sclerosis may occur with or without erosive changes. | |
| 6696524 | Progression of radiological changes in rheumatoid arthritis. | 1984 Feb | A prospective study over one year of patients who had active rheumatoid arthritis discovered 64 who had received treatment for an adequate time with second-line drugs. In these patients there was evidence of continuing joint destruction as shown by radiological progression. During the year there were highly significant correlations between improvements in clinical and laboratory measurements, but neither group of tests was related to the degree of radiological change. However, in the second 6 months of treatment there was evidence that radiological progression was reduced. In a second prospective study of 88 patients with rheumatoid arthritis given prolonged, intensive therapy with second-line drugs and followed up for 10 years two-thirds showed radiological progression. However, the number of joints damaged per year fell significantly during the study period. There was a divergence between deterioration in radiological features and improvements in the ESR and functional capacity, though patients with a persistently low ESR had less radiological progression. These studies provide evidence that treatment may be associated with a reduced rate of radiological progression but suggest that changes in radiological progression and clinical and laboratory measurements may result from different mechanisms. | |
| 935823 | The value of individual joints for radiologic assessment of rheumatoid arthritis. | 1976 | Twenty-seven bilateral joints of 28 patients with rheumatoid arthritis were radiographed and divided into six grades of severity by means of standard reference films. The results indicated that the four lateral metatarsophalangeal joints and the wrists are the most valuable joints for the assessment of rheumatoid arthritis as they show the strongest correlation of involvement with duration, the highest slope value, and the lowest standard deviation of involvement. It was concluded that many currently used methods of radiologic assessment could be improved by evaluating proper radiologic changes in joints representative of rheumatoid arthritis. The need for a new generally accepted classification of severity of rheumatoid arthritis is evident from this paper. | |
| 4142110 | Rheumatoid arthritis and cancer arthritis. II. | 1974 | A total of 394 patients with rheumatoid arthritis were followed-up over a 10-year period from 1963 to 1973, particularly with reference to the aetiological circumstances and in particular, cancer. Cancer was found as cancer arthritis in 50 cases (13 percent) at a stage where it was not possible to find focal cancer symptoms. No definite difference was found in the clinical course of the rheumatoid arthritis, no matter the varying aetiology, A series of statistically significant differences in the laboratory values for rheumatoid arthritis and cancer arthritis, respectively, are indicated and discussed. For that matter, the above observations are not original, in spite of what has been claimed, as Uncle Vanja in the play of the same name by Chekhov says: "They say that Turgenev got cancer as a result of his arthritis." | |
| 901029 | Carpal instability in rheumatoid arthritis and calcium pyrophosphate deposition disease. P | 1977 Aug | The roentgen appearance and pathogenesis of carpal instability are described in an evaluation of patients and cadavers with rheumatoid arthritis and calcium pyrophosphate deposition disease. Dorsiflexion (16%) and palmar flexion (8%) instability occurs in rheumatoid arthritis, particularly in patients with moderate to advanced disease. Navicular-lunate dissociation frequently accompanies dorsiflexion instability and results from involvement of the interosseous ligament between the two bones by rheumatoid pannus. Carpal instability and navicular-lunate dissociation also accompany pyrophosphate arthropathy, resulting from calcific deposition and cystic degeneration of ligamentous structures. | |
| 413361 | Subchondral pseudocysts in rheumatoid arthritis. | 1977 Dec | Subchondral cyst formation (geode) is a not uncommon manifestation of rheumatoid arthritis which may at times impede correct radiologic interpretation. Four patients with rheumatoid arthritis who demonstrated striking subarticular cystic erosive disease are described. These cases emphasize the nature and appearance of this interesting finding. | |
| 6602593 | The association between rheumatoid arthritis and the HLA antigen DR4. | 1983 Jun | One hundred and forty-two patients with 'definite' or 'classical' rheumatoid arthritis (RA) were studied for the frequency and possible prognostic significance of HLA DR4. Of these, 122 were seropositive, while 20 were negative for rheumatoid factor (RF) in serum. The HLA antigen DR4 was significantly increased in the seropositive group (65%) as well as in the seronegative group (55%) in comparison with a frequency of 27% in 116 healthy controls. Among seropositive patients a higher frequency of DR4 was found in females (73%) than in males (50%), the difference being statistically significant (p less than 0.01). DR4 was more frequent among patients with a family history of RA (74%) than among patients without affected relatives (57%). DR4 appeared to be associated with an early onset of RA. No significant differences in general disease activity or functional capacity between DR4-positive and DR4-negative RA patients were found. Patients without the HLA antigen DR4 had a significantly (p less than 0.05) higher mean titre of RF than those with the antigen. |