Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1271190 | Histocompatibility antigens in childhood-onset arthritis. | 1976 Jun | One hundred and twelve well-studied patients with a prior diagnosis of juvenile rheumatoid arthritis were differentiated into seven clinically distinct subgroups, including a group in whom recognizable ankylosing spondylitis had developed by time of follow-up. An apparent increased prevalence of HLA-B27 in the entire series (26%) was clearly related to its increased prevalence in only two subgroups: patients whose disease had progressed to overt ankylosing spondylitis (five of five patients) and boys with pauciarticular arthritis whose disease would be consistent with early ankylosing spondylitis (11 of 18 patients). There were no significant associations of B27 with systemic onset JRA, polyarticular JRA, pauciarticular JRA in girls, or JRA with chronic iridocyclitis. The only other significant alterations found were increased prevalences of HLA-A2 and HLA-BW15 in patients with polyarticular disease without identifiable rheumatoid factor. This study emphasizes that the clinical disorders included under the category of juvenile rheumatoid arthritis represent more than a single disease and that this heterogeneity must be considered in interpreting studies such as those of histocompatibility typing. | |
| 6603824 | HLA studies in IgM rheumatoid-factor-positive arthritis of childhood. | 1983 Aug | The clinical course of children with IgM rheumatoid-factor-positive chronic arthritis closely resembles that of seropositive rheumatoid disease in adults. The frequency of HLA DR4 is known to be increased in adults with seropositive rheumatoid arthritis, but the first major report on childhood arthritis did not suggest a correlation, though only 8 seropositive cases were included. Fifty-two children with polyarthritis beginning before the age of 16 who persistently carried IgM rheumatoid factor were studied. HLA DR4 was present in 60% of these children but was found in only 29% of 93 patients with seronegative juvenile arthritis and 27% of a normal adult population. These results suggest immunogenetic similarities in patients with seropositive arthritis irrespective of age of onset. | |
| 7406930 | Heterogeneity of HLA associations in systemic onset juvenile rheumatoid arthritis. | 1980 Jul | Two genetic markers, HLA-Bw35 and HLA-B8, are found to be associated with "febrile" or "systemic" onset juvenile rheumatoid arthritis (JRA). Evidence is presented that JRA patients are probably heterogeneous with respect to these antigens. | |
| 4047116 | Persistent rubella virus infection associated with chronic arthritis in children. | 1985 Oct 31 | We isolated rubella virus from lymphoreticular cells in 7 of 19 children with chronic rheumatic disease, including patients with systemic-onset juvenile rheumatoid arthritis (Still's disease) (1 of 5), polyarticular juvenile rheumatoid arthritis (2 of 2), pauciarticular juvenile rheumatoid arthritis (2 of 6), and seronegative spondyloarthritis (2 of 6). In contrast, rubella virus was not isolated from the control group, which included eight normal subjects and eight patients with other connective tissue diseases or traumatic joint effusion. In most members of the study group, mononuclear cells from both synovial fluid and peripheral blood were examined. Rubella virus was isolated from both cell populations in three patients, from only peripheral blood in one, and from only synovial fluid in two. In the children with systemic-onset juvenile rheumatoid arthritis, only peripheral blood was examined, and of the five samples analyzed, one was shown to have rubella virus. Virus was isolated on more than one occasion from four of seven persons. Persistence of rubella virus in lymphoreticular cells in 35 per cent of these cases of juvenile arthritis supports the view that the virus may be an etiologic agent in chronic human joint disease, but further work will be required to support this suggestion. | |
| 6984467 | An association between HLA-A2 and juvenile rheumatoid arthritis in girls. | 1982 Nov | Correlations between histocompatibility antigens at A and B loci, and onset subtypes were sought in 162 children with juvenile rheumatoid arthritis (JRA). The antigen HLA-A2 was associated with pauciarticular JRA in girls. No significant correlations were determined with other onset subtypes or with chronic asymptomatic uveitis. | |
| 881696 | Dissecting popliteal cyst in a child with juvenile rheumatoid arthritis. | 1977 Summer | A 14 year old white female with juvenile rheumatoid arthritis developed the sudden onset of pain and swelling in the right calf. Arthrography revealed a dissecting popliteal cyst. Symptoms abated following an intra-articular injection of triamcinolone acetonide. | |
| 434952 | Juvenile rheumatoid arthritis with rice bodies: light and electron microscopic studies. | 1979 Feb | Rice bodies obtained from a young man with juvenile rheumatoid arthritis were found by light and electron microscopy to contain cells that appeared viable. The majority of these cells closely resembled type B synovial lining cells. Type A-like cells were also seen. The cells contained few mitochondria but often much lipid and glycogen, observations which suggested a dependence on anaerobic metabolic pathways in the avascular synovial fluid environment. Cells within the rice bodies lay in a matrix of collagen fibres, fibrin, and amorphous material. The source of the collagen appeared to be the cells themselves. The relatively normal appearance of the cells suggested that they were protected from many of the inflammatory stimuli present in rheumatoid synovia. This 'reversion' towards a normal appearance suggested that the stimuli inducing chronic rheumatoid inflammation might not originate in the synovial lining. | |
| 6622924 | Investigations into the induction of chronic experimental arthritis in the common marmoset | 1983 | In an attempt to produce a superior model of rheumatoid arthritis, experiments have been performed to investigate the ease of induction of experimental arthritis in marmosets by immunological means. Marmosets were sensitised with the following combinations of antigen and adjuvant: ovalbumin in Freund's complete adjuvant (FCA), ovalbumin in FCA + Bordetella pertussis, methylated-BSA in FCA + B. pertussis or human fibrin in FCA + B. pertussis, and subsequently injected with the corresponding antigen in saline into one knee joint. Animals receiving ovalbumin, with or without B. pertussis, produced only a weak transient monoarticular synovitis. Animals receiving Met-BSA + B. pertussis produced a chronic synovitis but only mild erosive changes were apparent even 21 weeks after intraarticular injection. Animals receiving human fibrin produced a transient monoarticular synovitis of moderate intensity. These results indicate that the marmoset offers no obvious advantages over the rabbit for the induction of experimental rheumatoid arthritis. | |
| 6749955 | Infectious arthritis. | 1982 Fall | Septic arthritis results from invasion of the synovium by microorganisms, and most infectious organisms can cause arthritis. In children, septic arthritis is usually associated with systemic infections such as pneumonia or meningitis; in young adults, gonococcal arthritis is the most common cause; and in the aged, septic arthritis is usually superimposed on chronic joint disease. Underlying rheumatoid arthritis is common, and Dr. Knights stresses the importance of recognizing septic arthritis as a complication of rheumatoid arthritis. | |
| 6215487 | Longitudinal study of the presence of hidden 19S IgM rheumatoid factor in juvenile rheumat | 1982 Jul | Complement-fixing hidden 19S IgM rheumatoid factor (RF), i.e., 19S IgM RF that can be detected in the IgM-containing fraction by the hemolytic assay after separation of the serum by acid gel filtration, was evaluated serially (3 or more evaluations) over a 4-year period in 26 children with juvenile rheumatoid arthritis (JRA) correlating its presence with disease activity. Six children with continually active disease had consistently elevated hidden RF titers (26 evaluations), and the titers of 4 children with inactive disease remained insignificant (12 evaluations). Sixteen children had disease with variable activity over this period. Of these, 11 (43 evaluations) demonstrated positive correlation between disease activity and hidden RF titers. Five patients (8/20 evaluations) did not show correlation of disease activity with hidden RF titers. Thus, the presence of hidden RF correlated with disease activity in 93 of 101 evaluations. When hidden RF titers and the erythrocyte sedimentation rate were determined simultaneously on 40 occasions, the presence of hidden 19S IgM RF correlated significantly better (p less than 0.001) with disease activity. | |
| 7001617 | Demonstration of antibodies to denatured type I and type II collagen in juvenile rheumatoi | 1980 | From 88 sera of patients with juvenile rheumatoid arthritis 30.6% showed antibodies to denatured type I collagen an 31.8% antibodies to type II collagen, a percentage which corresponds to radioimmunoassay results in adult RA. Rheumatoid factors were demonstrated with Waaler-Rose test in 14.7% and with latex test in 6.8% of investigated patients. Results of investigations with collagen types I and II correlated in 73.7%. Whilst type I collagen antibodies were found with equal frequency in active and non-active stages, type II antibodies were twice as frequent in active stages as in non-active stages. Sixteen sera of children with non-rheumatoid diseases had no collagen antibodies. JRA sera and controls differed with statistical significance in regard to collagen antibodies. 36 sera of children with Still's syndrome showed antibodies to type I collagen in 13.8% and antibodies to type II collagen in 33.3%. Both types of antibodies appeared more frequently in clinically active stages. The sera differed from controls with statistical significance in regard to collagen antibodies. | |
| 6152412 | Juvenile rheumatoid arthritis in two siblings: co-existence with polyarteritis nodosa in o | 1984 Apr | Two siblings with identical HLA profiles developed the clinical picture of Juvenile Rheumatoid Arthritis of the pauciarticular variety with iritis. One parent had Polyarteritis Nodosa while both parents and siblings demonstrated the B15 DR5 antigens. | |
| 4742476 | Digital artery thrombosis and vasculitis in juvenile rheumatoid arthritis. | 1973 Sep 1 | A case of juvenile rheumatoid arthritis with vasculitis is presented. Sixteen months after the onset of the disease the patient developed digital artery thrombosis with incipient gangrene. Both the latter and the skin lesions resolved during treatment with azathioprine. | |
| 868494 | Total radiation dosage from X-ray examinations in rheumatoid arthritis and other chronic s | 1977 | Young patients with rheumatoid arthritis and other chronic diseases of the skeleton are increasingly being operated on with replacement of major joints. The great number of associated X-ray examinations performed on these patients has caused some anxiety amongst orthopaedic surgeons. Two patients with juvenile rheumatoid arthritis have been studied. An attempt was made to calculate the total radiation dose to bone marrow and gonads. For lack of recommendations for the maximum permissible radiation dose to patients, the dose calculated has been compared with the maximum permissible dose of radiation workers, and with the dose limit for non-occupational irradiation of individuals. The yearly absorbed dose in these two patients is much lower than the maximum permissible dose of radiation workers and only slightly higher than the dose limit for non-occupational exposure of individuals. | |
| 6446141 | Excessive suppressor T-cell activity of the rheumatoid synovial tissue in X-linked hypogam | 1980 | Patient K.L. with X-linked hypogammaglobulinaemia showed excessive suppressor T-cell activity both in the lymphocytes from the rheumatoid synovial tissue and in the peripheral blood lymphocyte compartment. This was in marked contrast to the findings in the lymphocytes from synovial tissue of patients with classical rheumatoid arthritis (RA), which were clearly deficient in suppressor T-cell activity. These findings further support the existence of distinctly different pathogenetic mechanisms in the two types of rheumatoid inflammation. It also demonstrates that patients with X-linked hypogammaglobulinaemia may have excessive suppressor T-cell activity not only in their peripheral blood lymphocytes but also in local chronic inflammatory tissue such as the rheumatoid joint inflammation. | |
| 6971102 | Production of agglutinators and rheumatoid factors in plasma cells of rheumatoid and nonrh | 1981 Mar | Immunohistochemical studies were performed in synovial tissues from 40 patients with rheumatoid arthritis (RA), 9 with juvenile rheumatoid arthritis (JRA), 7 with psoriatic arthritis, and 4 with various rheumatic diseases. Overall synthesis of IgG- and/or IgM-rheumatoid factor (RF) was found in all patients with seropositive RA and JRA, in 75% of patients with seronegative RA, and in 1 patient with psoriatic arthritis. Agglutinator producing cells were found in 77% of the samples from seropositive RA and in 44% and 56% from seronegative RA and JRA patients, respectively. The percentage of IgG plasma cells synthesizing one or more of the 5 types of agglutinators studied was approximately 10% of plasma cells synthesizing IgG-RF. Intercellular and intracellular immune complex deposits were also found in patients with seropositive and seronegative RA and JRA. These findings suggest that synthesis of agglutinators by synovial tissue plasma cells of RA and JRA patients is a distinct--but definitely less prominent--function than that of RF synthesis. | |
| 6261342 | [Felty's syndrome. A case report. Review of literature (author's transl)]. | 1981 Mar 18 | The authors report a case of Felty's syndrome in which are discussed over the data of literature: clinical features, hematological characteristics with a study of neutropenia mechanism and therapeutic possibilities. | |
| 687416 | [Juvenile rheumatoid arthritis and scleromalacia perforans]. | 1978 Nov | A 13 year-old-boy with poliarticular seronegative juvenile rheumatoid arthritis (JRA) and bilateral scleromalacia perforans is described. Ocular lesions were thought to be seconadry to vasculitis. Improvement was obtained with systemic and local corticosteroid therapy, and with subconjunctival auto-graft of fascia lata. This is the first report in the literature about scleromalacia perforans in JRA. | |
| 843117 | Distribution of HLA-B27 in patients with juvenile rheumatoid arthritis. | 1977 Feb | HLA antigens were examined in 27 patients with juvenile rheumatoid arthritis. HLA-B27 was found in none. The result was different from most other previously reported studies. The most likely explanation for this difference is the possibility that some patients with juvenile ankylosing spondylitis may have been included among the patients in the other studies. | |
| 7441656 | Clq binding in serum in juvenile rheumatoid arthritis. | 1980 Sep | The Clq assay for antigen-antibody complexes was performed on 79 blood samples from 43 patients with juvenile rheumatoid arthritis (JRA). The results were compared with assays for the activation products of C3 (C3c,d), for the concentration of C3, for rheumatoid factor, and for antinuclear antibodies. A statistically significant association was found between Clq binding and positive tests for latex fixation and C3c,d in systemic and polyarticular JRA, but positive results of each assay were found independently. These 3 assays were usually negative in pauciarticular JRA. No relationship was found between Clq binding and C3 concentration or antinuclear antibodies. |