Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 666351 | Value of monitoring plasma salicylate levels in treating juvenile rheumatoid arthritis. Ob | 1978 May | Plasma salicylate concentration was monitored in 42 children on long-term salicylate therapy for rheumatoid arthritis. A given dose of salicylate per kg resulted in large variations in plasma levels, both between individuals and for a single individual at different times. The factors responsible for such variations were studied; in 6 cases urinary metabolites of salicylate were analysed. The relation between salicylate dosage and plasma half-life accounts for the fact that small changes in dosage can result in large changes in plasma concentration. The addition of corticosteroid or ACTH therapy results in lower plasma levels of salicylate, and necessitates higher dosage of salicylate. After the introduction of routine monitoring of plasma salicylate, the incidence of toxic symptoms fell sharply. | |
| 348131 | No effect of transfer factor in juvenile rheumatoid arthritis by double-blind trial. | 1978 Apr | A previously pilot study of treatment with transfer factor in 3 patients with juvenile rheumatoid arthritis (JRA) gave promising results. However, in this small and open study no definite conclusions could be drawn. Therefore, a double-blind group trial was performed in 12 JRA patients treated with transfer factor, and in 12 placebo-treated control patients. The patients were evaluated clinically, by laboratory tests, and by estimation of different lymphocyte populations and cell-mediated immunity in vitro and in vivo. Transfer factor was not found to be of significant therapeutic value in patients with JRA. The only statistically significant difference between the two groups was a greater reduction in the percentage of T lymphocytes in transfer factor-treated patients than in control patients. The significance of this is difficult to explain and could have appeared by chance. No side effects of treatment with transfer factor were noted. | |
| 6489091 | Monthly fluctuations of active duodenal ulcers. | 1984 Nov | In an attempt to verify whether the periodicity of ulcer-related symptoms would be confirmed by a spring and fall exacerbation of peptic ulcers, we have analyzed the monthly variation of active duodenal ulcers found at endoscopy of the upper gastrointestinal tract in the years 1979-1981. Control diagnoses were active gastric ulcers, gastric and rectal adenocarcinomas, and rheumatoid arthritis. Data were also available on hospital admission for perforated ulcers. The calendar fluctuation of active duodenal ulcer is characterized by a significant fall in August which is associated with July and fall peaks. This pattern of variation for duodenal ulcer was evident in both sexes and across the different decades of age. Duodenal ulcer diagnosis and hospitalization for perforated ulcer fluctuated in a similar way. The shape of monthly variation for active duodenal ulcer was not paralleled by similar changes in gastric ulcers and in the control diagnoses, gastric and rectal carcinomas, and rheumatoid arthritis. | |
| 946273 | Systemic mastocytosis associated with presence of rheumatoid factor. | 1976 Apr 12 | We encountered a case of systemic mast cell disease associated with rheumatoid factor; to our knowledge, this has not been reported in the literature. Rheumatoid arthritis as an unrelated second disease cannot be excluded, but there is support for a relation between joint symptoms, rheumatoid factor, and the mast cell disease. | |
| 20469162 | Recent investigative procedures for diagnosing rheumatic disease. | 1975 Feb | Recent advances in investigative procedures have improved diagnosis of arthritis. Serologic tests such as rheumatoid factor and antinuclear antibody determinations, although not diagnostic, may be used to support or exclude a clinical diagnosis of rheumatoid arthritis or systemic lupus erythematosus. A systematic approach to joint fluid analysis has helped in the differential diagnosis of rheumatic diseases. Radionucleotide joint scanning and determination of histocompatibility antigens appear promising, although they are still under investigation. | |
| 159236 | [Changes in the cervical spine in juvenile rheumatoid arthritis (author's transl)]. | 1979 Oct | Changes in the cervical spine in juvenile rheumatoid arthritis can be shown by A.P., lateral and functional views with maximal flexion and extension, and particularly by tomography. The latter is essential for proper evaluation of the atlanto-occipital and atlanto-axial joints and of the odontoid. Atlanto-axial subluxation was found in eight out of eighty-four patients. Destruction of the odontoid was found in twelve out of fifty-three patients examined by tomography. The earliest tomographic changes at the atlanto-occipital joint consists of isolated joint narrowing, erosions and fusion and were observed in sixty-four out of sixty-six patients examined. Similar findings at the atlanto-axial joint were observed in thirty-seven out of sixty-six cases. The severity of the changes correlated with seropositivity and duration of the disease. The most marked changes were found with a prolonged history and a positive Rose-Waaler reaction. | |
| 4015722 | Sex ratio and sibship size in juvenile rheumatoid arthritis kindreds. | 1985 Jul | In a study of sibship size and sex ratio in juvenile rheumatoid arthritis, the anticipated sex ratios, including a marked female predominance in early onset pauciarticular disease and in polyarticular disease, were found. The size of the sibship showed a progressive increase with increasing age of the proband at onset of disease. In addition, the sex ratios of the sibs deviated from expected, among families where the proband's disease was characterized as either early onset pauciarticular or polyarticular in its presentation. | |
| 6594139 | DR, C4, and Bf allotypes in juvenile rheumatoid arthritis. | 1984 Nov | HLA-DR, C4, and Bf typing was performed in 99 patients with juvenile rheumatoid arthritis (JRA). DR1 was found with higher frequency in patients with polyarticular JRA than in controls (P less than 0.05). DR3 was more common in patients with fever and/or rash than in those without these manifestations (P less than 0.05). A significant negative association between JRA and C4A6 (P less than 0.05), C4BQ0 (P less than 0.0005), and BfF1 (P less than 0.05) was found. It is possible that a disequilibrium between DR and C4/Bf genes plays a role in the pathogenesis of JRA. | |
| 460039 | [D-penicillamine in various diseases in childhood (author's transl)]. | 1979 Jun 29 | D-pencillamine, a stable not physiological amino acid, has a manifold mode of action. Of special importance there is its influence on the collagen-metabolism, the gelose of heavy metals and the effect on immunologic processes. The use of D-penicillamine is possible in different diseases, such as Wilson's syndrome, collagenoses of diverse kinds, especially the rheumatoid arthritis, further chronic hepatitis and lung fibrosis. In this paper we report about 52 children, who were treated with D-penicillamine. The biggest group presented chronic liver diseases in 24 patients and rheumaoid arthritis in 21 patients. The therapy was carried out for a longer time, in some cases over years. The dose varied from 15 to 35 mg/kg of body weight. The number of side-effects was lower in children than in adults. They were more frequent in the group of collagenoses than in the group of liver diseases. Whether later on liver damages will occur is not predictable by the pediatrician. The results were excellent for the chronic active hepatitis; we can recommend D-penicillamine for such affections. Also for the rheumatoid arthritis we could partially obtain good successes, but not as convincing as in liver-diseases. | |
| 6249702 | [Pharmacological studies of new sulfhydryl compounds 2-mercapto-2-methylpropanoyl-L-cystei | 1980 Mar | Oral administration of 2-mercapto-2-methylpropanoyl-L-cysteine (SA 96), a newly synthesized sulfhydryl compound, showed protective and curative effects on adjuvant-induced arthritis in rats similarly to those seen with D-penicillamine (D-PA). However, the effects of these compounds were not dose-dependent, and the maximum effects of SA96 were observed at 10 mg/kg/day. On the contrary, SA96 and D-PA had little effect on the various acute and subacute inflammatory responses induced in rat and mice. Formation of hemolytic plaque forming cells in the spleen of mice immunized with 5 X 10(8) sheep red blood cells was potentiated by the oral administration of both compounds. These stimulatory effects of SA96 and D-PA on the humoral immune responses were also not dose-dependent, and the maximum effects of SA96 were observed with 10 mg/kg/day, as in the case of adjuvant-induced arthritis in rats. In in vitro experiments, the inactivation of rheumatoid factor and the inhibition of collagenase and bone alkaline phosphatase activities were observed with both compounds, but these effects of SA96 were more potent than those of D-PA. As there is a similarity in the pharmacological profiles of SA96 and D-PA, SA96 may prove to be clinically effective for rheumatoid arthritis. | |
| 6086212 | Gold toxicity presenting as peripheral neuropathy. | 1982 Dec | A patient with rheumatoid arthritis developed gold induced peripheral neuropathy after 255 mgs of aurothioglucose. This neuropathy is characterized by weakness and numbness of the hands and feet in association with hyperalgesia of the palmar surface of the hands. The absence of vasculitis permits differentiation of gold neuropathy from the neuritis associated with rheumatoid arthritis or systemic lupus erythematosus. Treatment consists in cessation of gold and possibly the use of dimercaprol; recovery is slow but generally complete. | |
| 7089806 | Development of an inflammatory synovitis following total-dose infusion of iron-dextran. A | 1982 Jul 24 | Total-dose iron-dextran infusions have been reported to cause exacerbation of the disease in patients with rheumatoid arthritis and ankylosing spondylitis. A case of prolonged polyarthritis following a total-dose iron-dextran infusion in a patient with no evidence of rheumatoid arthritis or ankylosing spondylitis is reported. | |
| 6979135 | [Histamine in rheumatic diseases]. | 1982 Jan | Histamine, the decarboxylation product of histidine, was determined in serum, leucocytes, synovial fluid and synovial tissue rheumatic diseases. Histamine level was variable in most of the biological samples. In serum of patients with rheumatoid arthritis histamine was more frequent (50%) than in controls (10%). Leucocyte preparations containing basophile cells did not differ in their histamine concentration. Synovial fluid of rheumatoid arthritis patients showed histamine levels in the range of 1,0 to 23,4 ng/ml. The results were discussed by means of the pertinent literature. | |
| 7271306 | Testicular complications in connective tissue disease. | 1981 Aug | Acute testicular symptoms are described in 2 patients with Schönlein-Henoch syndrome and in 1 with juvenile rheumatoid arthritis. The literature on testicular involvement in connective tissue disease of childhood is reviewed. | |
| 7182014 | Resistance to adjuvant arthritis induced by a genetic mutation, osteopetrosis. | 1982 | Adjuvant arthritis stands as the closest model to human rheumatoid arthritis. A genetic mutation (op) recognized to provoke osteopetrosis in rats, completely inhibits their ability to develop adjuvant arthritis. Osteopetrosis in the op mutant is linked to deficiencies in T-lymphocytes and macrophages functions. Therefore this animal model may be helpful for a better understanding of the immunoregulation impairment involved in adjuvant arthritis. | |
| 6481933 | Leukopenia in Still's disease. | 1984 Nov 2 | Two patients, one a 14-year-old girl and the other a 20-year-old man, with typical manifestations of juvenile rheumatoid arthritis had leukopenia and thrombocytopenia, two heretofore unreported findings. The presence of leukopenia should not be used to exclude a diagnosis of Still's disease. | |
| 578587 | [Current concept of Gougerot-Sjögren syndrome]. | 1977 Jul | The Gougerot-Sjögren syndrome is giving rise to an everincreasing number of publications. Since the initial work by Gougerot in France and Sjögren in Sweden, the most important publications have been coming from the United States of America, particularly the series from the NIH at Bethesda. Since Bunim, Talal, Bloch and colleagues have taken up this topic, the conception of the disease which has become established is that of an auto-immune condition which or may not be associated with a rheumatoid polyarthritis or related diseases. It may be asked whether such a conception does in fact permit a better approach to patients suffering from the Gougerot-Sjögren syndrome. It might seem more useful to separate the exocrine syndromes from the concomittant immunitary symptoms more clearly. A further important problem is that raised by the perfection of the means of detecting the Gougerot-Sjögren syndrome. This poses a key problem : that of the borderlines of this syndrome. | |
| 1007638 | A case report of patella cubiti. | 1976 Nov | Report of a patella cubiti in a patient with juvenile rheumatoid arthritis. The genesis of this patella is unknown up to now. The following hypotheses are discussed: 1. Persistent separation of the non fused epiphyseal bone centre with consecutive independent development. 2. Avulsion of the epiphysis due to muscle tension. 3. Epiphysitis as cause of the new formed patella. | |
| 400831 | Genetics of rheumatic diseases. | 1977 Mar | Evidence favoring genetic predisposition to each of the major classes of rheumatic diseases is reviewed, including juvenile-onset rheumatoid arthritis, rheumatic fever, ankylosing spondylitis and other syndromes associated with spondylitis, adult-onset rheumatoid arthritis, gout and pseudogout, and systemic lupus erythematosus. In addition, simply inherited genetic diseases that may present with arthritis are noted for purposes of differential diagnosis. The importance of heterogeneous causes and mechanisms within each major class of disease is emphasized, both for patient care and for clinical investigation. | |
| 6712455 | Improving compliance with medical regimens: case study with juvenile rheumatoid arthritis. | 1984 May | There is ample literature to suggest that a high percentage of pediatric patients with chronic diseases fail to comply adequately with their medical regimens. This study examined the effectiveness of a token reinforcement program in improving the compliance of a 7-year-old girl with juvenile rheumatoid arthritis. The parents were taught to manage the program in the home. The patient earned tokens for complying with her treatment regimen and lost tokens when she failed to comply. Tokens were exchanged for routine and special privileges. Compliance with medications, splint wearing, and lying prone was assessed by observation. Baseline data showed low levels of compliance, particularly with splint wearing and prone lying. Introduction of the token reinforcement program resulted in immediate improvement in compliance; improvement was maintained during 10 weeks of follow-up. |