Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6283076 | Anterior-pituitary adrenal function of gold-treated patients with juvenile rheumatoid arth | 1982 Jan | The hypothesis that gold therapy enhances endogenous cortisol secretion was tested in juvenile rheumatoid arthritis patients. The secretion of cortisol, dehydroepiandrosterone-sulfate (DHEA-S) and several peptide hormones was determined from plasma samples collected every 20 min for 24 hours. In random patients cortisol secretion was significantly greater in gold treated patients than in similar patients not receiving gold. However, when untreated patients were restudied after initiation of gold therapy, there was no significant change in cortisol secretion. Gold therapy also did not significantly alter secretion of the peptide hormones or DHEA-S. Thus, gold does not appear to influence endogenous hormone secretion. | |
| 6467861 | Supportive laboratory findings in psoriatic arthritis. | 1984 Jun | Serum copper, iron and ceruloplasmin concentrations were determined in 45 subjects (22 males and 23 females, medium age 50.3, range 25-76) diagnosed as psoriatic arthritic patients (20 with poliarticular, 12 with mono-oligoarticular and 13 with spondyloarticular form), in 63 patients (30 males and 33 females, medium age 32.4, range 10-78) with psoriasis, and in 60 blood donors (32 women and 28 men) as reference group. Mean serum copper, iron and ceruloplasmin was significantly increased (p less than .001) in psoriatic arthritis as compared with controls or subjects with psoriasis alone. The number of synovial joints affected was significantly correlated to changes in these serum parameters. Indeed, serum copper, iron and ceruloplasmin were found to be significantly different from that of normals in the polyarticular subgroup (p less than .001), while only copper and ceruloplasmin were different in the mono-oligoarticular form (p less than .001 and p less than .01 respectively). No significant changes were found in a spondyloarticular subgroup. In the polyarticular subgroup a direct correlation was found between another disease activity marker (e.g. ESR) and serum changes in iron, ceruloplasmin and copper (p less than .001). Our data indicate that psoriatic arthritis is a multifaceted disease: the polyarticular form behaves like seronegative rheumatoid arthritis, while the monoarticular forms shows a lesser involvement of serum iron; spondylitic arthritis does not show any significant change in serum copper, ceruloplasmin and iron concentrations. | |
| 901037 | Effect of D(-)penicillamine on chronic experimental arthritis in rabbits. | 1977 Aug | Preliminary observations on the effect of D(-)penicillamine on chronic antigen-induced experimental arthritis in rabbits are reported. Daily oral administration of penicillamine, at a dose equivalent to that usually administered to rheumatoid arthritis patients, diminished the arthritis in 2 out of 3 animals as assessed by both measurement of joint circumference and histological examination. | |
| 1156454 | Aspirin-induced hepatotoxicity in juvenile rheumatoid arthritis. A prospective study. | 1975 Jul | Recent reports of and our own experience with biochemical alterations of liver function secondary to salicylate therapy stimulated this prospective study. Thirty-four children with juvenile rheumatoid arthritis, 6 children with acute cartilagenous necrosis of the hipfollowing slipped capital femoral epiphysis, and 2 children with ulcerative colitis and hip disease who were on salicylates were followed over a period of 1-27 months with serial determinations of serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), lactic dehydrogenase (LDH), alkaline phosphatase (AP), bilirubin, and serum salicylate. Prothrombin time was measured in 14 children. Twenty-two of 34 children with rheumatoid arthritis and none of the 8 controls demonstrated abnormalities of various liver functions at serum salicylate levels between 7.0 and mg%. Three children demonstrated severe abnormalities characterized by marked elevation of SGOT, SGPT, LDH, and AP, prolongation of prothrombin time, and epistaxis. This type of reaction occurred within 5-14 days of initiation of aspirin therapy and occurred at serum salicylate levels between 18 and 43 mg%. Moderate changes in various liver function tests were observed in 19 other children. None of those children who were tested showed prolongation of prothrombin time. The serum salicylate level in this group varied between 7.0 and 38.2 mg%. The abnormal liver function tests returned to normal in 6 children upon withdrawal of aspirin and in 12 others even when salicylates were continued. Therefore, despite the occurrence of biochemical abnormalities following chronic salicylate therapy, it does not appear to be necessary to discontinue their use except in those children who develop bleeding. | |
| 114636 | The amyloidosis of juvenile rheumatoid arthritis - comparative studies in Polish and Ameri | 1979 May | The concentration of serum IgG, IgM, IgA, IgD, IgE and complement C3 as well as Kappa and Lambda free and bound light chains were determined in sera from 21 amyloidotic Polish children with juvenile rheumatoid arthritis (JRA), Polish and American children with JRA, and control children from a Polish population. Comparable concentrations of IgG, IgM, IgA, IgE and C3 were found in amyloidotic children when compared to Polish JRA children with active polyarticular disease. However, the amyloidotic Polish children with JRA had significantly higher levels of IgG, IgM, IgA, IgE and complement C3 fraction when compared to American JRA children. The levels of IgA and IgE were significantly elevated in amyloidotic and Polish JRA populations when compared to American JRA patients. Free immunoglobulin light chains were not found in the sera of any of the children tested in this study. However, in the patients with amyloidosis, significantly diminished levels of bound Kappa and Lambda light chains were found. | |
| 6622353 | [Chronic obstructive bronchopneumopathies as manifestations of a Gougerot-Sjögren syndrom | 1983 | The authors report two cases of Sjögren's syndrome presenting as chronic obstructive bronchopulmonary disease. They stress the need to consider the possibility of Sjögren's syndrome when confronted with chronic obstructive lung disease in a woman in her fifties, without history of bronchopulmonary disease or smoking, unexposed to occupational dust and without ENT infection or gastro-oesophageal reflux. | |
| 494629 | [Level of fibrinogen/fibrin degradation products (F/FDP) in certain internal diseases]. | 1979 | Serum FDPs were investigated in 30 healthy and 95 patients with pulmonary thrombembolia, not-stabilized angina pectoris, myocardial infarction, rheumatism, rheumatoid arthritis, lupus erythematodes and dermatomyositis. FDPs are determined by hemagglutination inhibition according to Merskey. They are found in the sera of the healthy in average values of 3.73 mkgr/ml. The highest average values in the first 24 h were found in case of pulmonary thrombembolia up to 106.64 mkgr/ml, followed by rheumatoid arthritis 26.3 mkgr/ml, myocardial infarction with complication 22.4 mkgr/ml, rheumatism +5.58 mkgr/ml, not-stabilized angina pectoris 5.5 mkgr/ml; and noncomplicated myocardial infarction 4.3 mkgr/ml. By the third day of the disease FDP in pulmonary thrombembolia decreased, whereas a negligible elevation was observed in case of non-complicated myocardial infarction. The results were interpreted as well as the cause for the presence of the mentioned products in those groups of diseases. FDP determination is recommended as a routine method in case of: diagnosis of pulmonary thrombembolia, differentiation of myocardial infarction with or without complications, differentiation of pulmonary thrombembolia from myocardial infarction in emergency states, progressing with chest pain, collapse phenomena, dyspnea and establishment of the activity of the process of rheumatoid arthritis. FDP determination in stenocardia and rheumatism is not expedient. | |
| 7132853 | Septic arthritis caused by Pasteurella multocida. | 1982 Feb 6 | A patient with rheumatoid arthritis developed an infection in the right hand after she administered an antibiotic capsule to her cat. Two weeks after this, septic arthritis developed in her right knee. The organism isolated was Pasteurella multocida, which is part of the feline normal oral flora. The infection was treated with penicillin and drainage. | |
| 24194452 | The behavior of a newly described acute-phase protein in inflammatory joint disease. | 1976 Jun | Rho, a newly characterized acute-phase protein, was present in high titer in a group of 109 patients with various rheumatic diseases. Statistically significant titer elevations were demonstrated in patients with rheumatoid arthritis (RA), ankylosing spondylitis, and gout. In individual RA patients, serial titers failed to correlate with disease activity or with rheumatic seropositivity. The natural behavior ofrho antigen is contrasted with that of C-reactive protein. Comments are made regarding the possible association of rubella infection with rheumatoid arthritis. | |
| 6610692 | Specific HLA-DR4-associated histocompatibility molecules characterize patients with seropo | 1984 Jul | The structural and functional heterogeneity of HLA-DR4-associated specificities was investigated in patients with seropositive juvenile rheumatoid arthritis, a DR4-associated disease. Using a combination of HLA-D analysis by mixed lymphocyte culture and electrophoretic analysis of immunoprecipitated Ia molecules by two-dimensional polyacrylamide gels, we observed a surprisingly homogeneous pattern of HLA-D antigen expression. All patients expressed common structural products of the DR and DS loci, and 7/12 homozygous DR4 patients expressed a rare and subtle HLA-D heterozygous phenotype. | |
| 6366227 | Anti-T cell antibody in juvenile rheumatoid arthritis. | 1984 Feb | One hundred-and-seven patients with juvenile rheumatoid arthritis (JRA) were studied for the presence or absence of an autoantibody in their sera directed against T cells. Using an indirect immunofluorescence technique on a fluorescence activated cell sorter, 71% of all patients were found to be positive on at least one sample. When studied according to the mode of onset of disease 75% of those with systemic onset, 70% with a pauciarticular, and 68% of those with a polyarticular onset were positive. Longitudinal studies appeared to suggest a correlation with disease activity, particularly in individual patients who were positive, while remission was almost invariably associated with negative testing for anti-T cell antibodies. These findings suggest that the anti-T cell antibody may be a useful diagnostic test in JRA and of benefit in monitoring disease activity and remission of disease. | |
| 6616816 | An immunoradiometric assay for erythrocyte complement (C3b) receptor activity applied to a | 1983 Oct | The number of receptors for complement component C3b per erythrocyte reportedly is decreased in over half of adults with systemic lupus erythematosus. We have devised an immunoradiometric assay for C3b receptor (CR1) on erythrocytes, with which one can assess CR1 saturation due to in vivo binding of immune complexes or activated complement fragments (C3b). Using this assay, we examined binding by CR1 in normal adults and newborns, in lupus and juvenile rheumatoid arthritis patients, and in a population of patients with various general medical problems, including other connective tissue diseases. Binding by CR1 was decreased in eight of 15 SLE patients, four of 25 juvenile rheumatoid arthritis patients, and one of 14 patients with other diseases. We found no significant correlation between CR1 binding and either C1q binding, antinuclear antibody titer, results for complement C3 and C4, or the presence of renal disease. Using this assay, we were also able to show that the observed reduction in CR1 binding was not ascribable to prior saturation of CR1 or to blocking antibody against CR1. The assay is precise and easy enough for routine application. | |
| 24822807 | Skull-c2 fusion in rheumatoid patients with atlanto-axial subluxation. | 1981 Dec 1 | Four rheumatoid arthritis patients with displacement of the atlanto-axial joint were treated by skull-C2 fusion, with iliac bone graft. Fusion of the skull to C2 is recommended in rheumatoid patients with sublaxation at C1-C2 because it prevents not only further deformity but also danger of cord compression and symptomatic relapse. All four patients have remained symptom-free after surgery. | |
| 935477 | The evaluation of pathologic alterations of juxtaosseous soft tissue by xeroradiography. | 1976 Aug | Xeroradiography proved extremely helpful in (a) evaluation of soft-tissue masses of both the axial and appendicular skeleton; (b) quantifying soft-tissue changes in advanced rheumatoid arthritis; (c) evaluation of bony involvement by an adjacent soft-tissue tumor or infection; (d) evaluation of rib lesions or rib integrity; and (e) assessment of bones in casted extremities. The technique was not helpful in the following conditions: early soft-tissue changes of rheumatoid arthritis; detection of minimal skeletal trauma; arthrography of the knee; evaluation of any portion of the vertebral column; evaluation of submandibular neck masses; or assessment of abdominal films for visceral structures. | |
| 623682 | Micromeasurement of plasma salicylate in arthritic children. | 1978 Jan | A micromethod has been developed for determination of plasma salicylate. Frequent determinations of plasma salicylate levels in children with juvenile rheumatoid arthritis may be expected to provide greater therapeutic efficacy with reduced incidence of aspirin toxicity and consequently less need for use of secondary, more toxic, agents. | |
| 101649 | Neutropenia associated with chrysotherapy for juvenile rheumatoid arthritis. | 1978 Nov | Severe neutropenia, in the absence of generalized bone marrow depression, is a rare complication in adults receiving chrysotherapy for rheumatoid arthritis and has not been described in children. Isolated, severe neutropenia developed in five children with systemic onset JRA while they were receiving gold injections. This potentially fatal complication occurred within eight weeks of beginning therapy in four patients, and after 24 weeks of well-tolerated therapy in the fifth. Leukopenia preceded neutropenia in two children. Localized infection was successfully treated in one child; septicemia was fatal to a second child. Neutropenia resolved within eight to 14 days of its onset in the four survivors; chelation with dimercaprol in one child did not appear to alter the recovery time. It is suggested that a systemic onset of JRA in children less than 6 years of age identifies a higher risk group developing severe neutropenia during chrysotherapy. Cessation of gold therapy upon recognition of a decreasing neutrophil count may prevent or ameliorate a developing neutropenia; careful observation for, and early treatment of, infection may alter its outcome. | |
| 6347150 | Early-onset pauciarticular juvenile rheumatoid arthritis. A histopathologic study. | 1983 Jul | A young girl with early-onset pauciarticular juvenile rheumatoid arthritis suffered from recurrent severe bilateral iridocyclitis. Despite intensive medical therapy, she gradually lost all useful vision and ultimately required bilateral enucleation at the age of 10 years for control of pain and photophobia. Histopathologic study of the eyes revealed in the iris and ciliary body a dense inflammatory infiltrate composed principally of plasma cells, as well as angle closure, a dense cyclitic membrane, retinal detachment, cystoid macula, and optic atrophy. Immunoperoxidase stains showed little immunoglobulin within or around the plasma cells within the ciliary body, although strong reactions for IgG and kappa- and lambda-light chains were seen in other parts of the eyes. | |
| 20468900 | Psychosocial concepts in rheumatoid arthritis. | 1973 Mar | This article reviews and tabulates some of the current concepts of the role of psychosocial factors in rheumatoid arthritis (RA). Concepts prevalent during the 1950's are listed followed by discussion of some of the variable factors that complicate studies in this field. Studies are then cited which lead to the following conclusions:1. Patients with RA tend to have certain personality characteristics, such as depression, rigidity, dependency, neurotic response patterns, emotional instability, feelings of guilt and low ego strength.2. These are not specific to RA.3. They may well be sequelae of the disease rather than pre-morbid features.4. There is no clear evidence as to the role of psychological stress in causing or activating RA.5. Personality factors have an influence on the course of the disease. | |
| 556383 | On the possible anti-rheumatic effects (immuno-effector?)of imidazole derivatives (levamis | 1977 Apr | Some imidazole derivatives (levamisole, clotrimazole) have no significant effect on the rat adjuvant arthritis at dosages used in human therapy. If the effectiveness of these drugs in rheumatoid arthritis is confirmed by double blind studies, it would be necessary to find an explanation other than an immuno-effective action does not occur in some patients. | |
| 657836 | Psoriasis and arthritis. | 1978 Jun | The relationship of psoriasis and arthritis is controversial. It has been reported that 7 percent of patients with psoriasis have arthritis. In approximately half of these cases, it is a sero-negative inflammatory polyarthritis, two-thirds of which clinically resemble rheumatoid arthritis. A distinctive peripheral arthropathy is displayed by 1 percent of psoriatics. One-fifth of this group, or less than 0.2 percent of psoriatics, suffer deforming arthritis multilans. The epidemiologic, clinical, radiologic, serologic, and genetic evidence for and against psoriatic arthropathy as a unique entity are reviewed. The prognosis of psoriatic arthritis appears to be better than previously suggested. Therapeutic measures are also reviewed. |